AR047974A1 - Derivados de alquilpiperazina y alquilhomopiperazina-carboxilatos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de alquilpiperazina y alquilhomopiperazina-carboxilatos, su preparacion y su aplicacion en terapeutica

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Publication number
AR047974A1
AR047974A1 ARP050100669A ARP050100669A AR047974A1 AR 047974 A1 AR047974 A1 AR 047974A1 AR P050100669 A ARP050100669 A AR P050100669A AR P050100669 A ARP050100669 A AR P050100669A AR 047974 A1 AR047974 A1 AR 047974A1
Authority
AR
Argentina
Prior art keywords
cycloalkyl
carboxilatos
alquilpiperazina
alquilhomopiperazina
therapeutics
Prior art date
Application number
ARP050100669A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Adrien Tak Li
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR047974A1 publication Critical patent/AR047974A1/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/16—Tryptamines
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Compuesto que responde a la formula general (1) en donde n = 1 o 2; p representa un numero entero de 1 a 7; A es seleccionado entre uno o más grupos X, Y y/o Z; X = metileno eventualmente sustituido; Y = alquenileno C2-eventualmente sustituido o alquinileno C2; Z = cicloalquilo C3-7; G = enlace simple, O, S, SO, SO2, C=O o CH(OH); R1 representa un grupo del tipo arilo o heteroarilo; R2 representa un átomo de H o un grupo alquilo C1-6; R3 representa un átomo de H o un grupo alquilo C1-6; cicloalquilo C3-7, cicloalquilo C3-7-alquileno C1-3; en el estado de base, de sal de adicion de un ácido, de hidrato o de solvato. Aplicacion en terapéutica.
ARP050100669A 2004-02-26 2005-02-24 Derivados de alquilpiperazina y alquilhomopiperazina-carboxilatos, su preparacion y su aplicacion en terapeutica AR047974A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0401953A FR2866888B1 (fr) 2004-02-26 2004-02-26 Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR047974A1 true AR047974A1 (es) 2006-03-15

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ID=34834070

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ARP050100669A AR047974A1 (es) 2004-02-26 2005-02-24 Derivados de alquilpiperazina y alquilhomopiperazina-carboxilatos, su preparacion y su aplicacion en terapeutica

Country Status (29)

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US (2) US7482346B2 (es)
EP (1) EP1720848B1 (es)
JP (1) JP4787234B2 (es)
KR (1) KR20060133592A (es)
CN (1) CN100567279C (es)
AR (1) AR047974A1 (es)
AT (1) ATE380184T1 (es)
AU (1) AU2005223422B2 (es)
BR (1) BRPI0508047A (es)
CA (1) CA2554855A1 (es)
CY (1) CY1107182T1 (es)
DE (1) DE602005003648T2 (es)
DK (1) DK1720848T3 (es)
ES (1) ES2296162T3 (es)
FR (1) FR2866888B1 (es)
HK (1) HK1101284A1 (es)
HR (1) HRP20080024T3 (es)
IL (1) IL177422A (es)
MA (1) MA28370A1 (es)
NO (1) NO20064364L (es)
NZ (1) NZ549471A (es)
PL (1) PL1720848T3 (es)
PT (1) PT1720848E (es)
RS (1) RS50542B (es)
RU (1) RU2331637C2 (es)
SI (1) SI1720848T1 (es)
TW (1) TWI350286B (es)
WO (1) WO2005090322A1 (es)
ZA (1) ZA200607092B (es)

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HK1101284A1 (en) 2007-10-12
AU2005223422B2 (en) 2010-06-24
CN1922162A (zh) 2007-02-28
HRP20080024T3 (en) 2008-02-29
IL177422A0 (en) 2006-12-10
KR20060133592A (ko) 2006-12-26
CA2554855A1 (fr) 2005-09-29
PL1720848T3 (pl) 2008-03-31
US7482346B2 (en) 2009-01-27
CN100567279C (zh) 2009-12-09
EP1720848A1 (fr) 2006-11-15
EP1720848B1 (fr) 2007-12-05
DK1720848T3 (da) 2008-03-25
NZ549471A (en) 2010-07-30
ATE380184T1 (de) 2007-12-15
NO20064364L (no) 2006-09-26
US20070027141A1 (en) 2007-02-01
JP4787234B2 (ja) 2011-10-05
TW200530201A (en) 2005-09-16
US7973042B2 (en) 2011-07-05
RU2331637C2 (ru) 2008-08-20
DE602005003648T2 (de) 2008-11-13
ZA200607092B (en) 2008-05-28
CY1107182T1 (el) 2012-10-24
BRPI0508047A (pt) 2007-07-17
US20090143365A1 (en) 2009-06-04
RS50542B (sr) 2010-05-07
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SI1720848T1 (sl) 2008-04-30
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RU2006134047A (ru) 2008-04-10
MA28370A1 (fr) 2006-12-01
PT1720848E (pt) 2008-01-31
FR2866888A1 (fr) 2005-09-02
IL177422A (en) 2011-04-28
FR2866888B1 (fr) 2006-05-05
DE602005003648D1 (de) 2008-01-17
AU2005223422A1 (en) 2005-09-29

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