RU2019138177A - Производные 2-аминохинолина - Google Patents
Производные 2-аминохинолина Download PDFInfo
- Publication number
- RU2019138177A RU2019138177A RU2019138177A RU2019138177A RU2019138177A RU 2019138177 A RU2019138177 A RU 2019138177A RU 2019138177 A RU2019138177 A RU 2019138177A RU 2019138177 A RU2019138177 A RU 2019138177A RU 2019138177 A RU2019138177 A RU 2019138177A
- Authority
- RU
- Russia
- Prior art keywords
- optionally substituted
- salt
- quinolin
- ethoxymethyl
- imidazo
- Prior art date
Links
- 150000005013 2-aminoquinolines Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 51
- 150000001875 compounds Chemical class 0.000 claims 30
- -1 4 - ((4-amino-2-ethoxy-methyl-1-methyl-1H-imidazo [4,5-c] quinolin-9-yl) oxy) -2-methylbutan-2-ol Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 4
- HSEMFIZWXHQJAE-UHFFFAOYSA-N hexadecanamide Chemical compound CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 claims 4
- VOZORYRGGNVPJW-UHFFFAOYSA-N 10-oxa-4,14-diazatricyclo[7.5.1.05,15]pentadeca-1(15),2,4,6,8,11,13-heptaen-12-ol Chemical compound N1=CC=C2C=3C(=CC=CC1=3)OC=C(C=N2)O VOZORYRGGNVPJW-UHFFFAOYSA-N 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- GKFPOIUULJGQPN-UHFFFAOYSA-N 1-[4-amino-2-(2-hydroxyethyl)-9-methoxyimidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2CC(C)(O)C)CCO)OC GKFPOIUULJGQPN-UHFFFAOYSA-N 0.000 claims 1
- WZRGIGQHNDGFIG-UHFFFAOYSA-N 1-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxy-2-methylpropan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2C)COCC)OCC(C)(O)C WZRGIGQHNDGFIG-UHFFFAOYSA-N 0.000 claims 1
- QOYVKJKPMJGWOA-UHFFFAOYSA-N 1-[4-amino-2-(ethoxymethyl)-9-methoxyimidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2CC(C)(O)C)COCC)OC QOYVKJKPMJGWOA-UHFFFAOYSA-N 0.000 claims 1
- YHYFYUKNKQMNOK-UHFFFAOYSA-N 1-[4-amino-9-methoxy-2-(2-methoxyethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2CC(C)(O)C)CCOC)OC YHYFYUKNKQMNOK-UHFFFAOYSA-N 0.000 claims 1
- BLYHFWNPCIGTHH-UHFFFAOYSA-N 1-[[4-amino-2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-9-yl]oxy]propan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2)COCC)OCC(C)O BLYHFWNPCIGTHH-UHFFFAOYSA-N 0.000 claims 1
- CPAODTBRTBTGDI-UHFFFAOYSA-N 10-oxa-4,14-diazatricyclo[7.5.1.05,15]pentadeca-1(15),2,4,6,8,13-hexaen-12-one Chemical compound N1=CC=C2C=3C(=CC=CC1=3)OCC(C=N2)=O CPAODTBRTBTGDI-UHFFFAOYSA-N 0.000 claims 1
- UEFOMEYNTZNHQB-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-(2-methylpropoxy)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OCC(C)C)N)N=1)C UEFOMEYNTZNHQB-UHFFFAOYSA-N 0.000 claims 1
- HJNCPVOAGHSHPK-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-(2-morpholin-4-ylethoxy)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OCCN2CCOCC2)N)N=1)C HJNCPVOAGHSHPK-UHFFFAOYSA-N 0.000 claims 1
- XDTSMYJPPAAGLU-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-(2-propan-2-yloxyethoxy)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OCCOC(C)C)N)N=1)C XDTSMYJPPAAGLU-UHFFFAOYSA-N 0.000 claims 1
- AZTFHSKKWCHQKW-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-(oxolan-3-yloxy)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC2COCC2)N)N=1)C AZTFHSKKWCHQKW-UHFFFAOYSA-N 0.000 claims 1
- IXJQFWNIWIELNR-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-piperidin-4-yloxyimidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC2CCNCC2)N)N=1)C IXJQFWNIWIELNR-UHFFFAOYSA-N 0.000 claims 1
- UIVUUEFCKIJLNB-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-propan-2-yloxyimidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC(C)C)N)N=1)C UIVUUEFCKIJLNB-UHFFFAOYSA-N 0.000 claims 1
- WAFQYUYNGVIVNG-UHFFFAOYSA-N 2-(ethoxymethyl)-1-methyl-9-pyrrolidin-3-yloxyimidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC2CNCC2)N)N=1)C WAFQYUYNGVIVNG-UHFFFAOYSA-N 0.000 claims 1
- XKMXEEZJOCABSN-UHFFFAOYSA-N 2-(ethoxymethyl)-9-(2-methylpropoxy)-3H-imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1NC2=C(C(=NC=3C=CC=C(C2=3)OCC(C)C)N)N=1 XKMXEEZJOCABSN-UHFFFAOYSA-N 0.000 claims 1
- HRWIFFDHQMFGNN-UHFFFAOYSA-N 2-(ethoxymethyl)-9-(2-propan-2-yloxyethoxy)-3H-imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1NC2=C(C(=NC=3C=CC=C(C2=3)OCCOC(C)C)N)N=1 HRWIFFDHQMFGNN-UHFFFAOYSA-N 0.000 claims 1
- YGDTZZRKAQEXFO-UHFFFAOYSA-N 2-(ethoxymethyl)-9-(3-methylbutoxy)-3H-imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1NC2=C(C(=NC=3C=CC=C(C2=3)OCCC(C)C)N)N=1 YGDTZZRKAQEXFO-UHFFFAOYSA-N 0.000 claims 1
- PLKWRVIXFITHLR-UHFFFAOYSA-N 2-(ethoxymethyl)-9-methoxy-1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC)N)N=1)CC(C)C PLKWRVIXFITHLR-UHFFFAOYSA-N 0.000 claims 1
- VUJGOQDZTMOKFV-UHFFFAOYSA-N 2-(ethoxymethyl)-9-methoxy-1-(2-propan-2-yloxyethyl)imidazo[4,5-c]quinolin-4-amine Chemical class C(C)OCC=1N(C2=C(C(=NC=3C=CC=C(C2=3)OC)N)N=1)CCOC(C)C VUJGOQDZTMOKFV-UHFFFAOYSA-N 0.000 claims 1
- KEXGXOJEMYADSG-UHFFFAOYSA-N 2-butyl-9-(3-methylbutoxy)pyrazolo[3,4-c]quinolin-4-amine Chemical class C(CCC)N1N=C2C(=NC=3C=CC=C(C=3C2=C1)OCCC(C)C)N KEXGXOJEMYADSG-UHFFFAOYSA-N 0.000 claims 1
- FLKJVZNZWBSCNA-UHFFFAOYSA-N 4-[4-amino-2-(ethoxymethyl)-1-(2-methylpropyl)imidazo[4,5-c]quinolin-9-yl]oxy-2-methylbutan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2CC(C)C)COCC)OCCC(C)(O)C FLKJVZNZWBSCNA-UHFFFAOYSA-N 0.000 claims 1
- OCIADYZDROIKDL-UHFFFAOYSA-N 4-[4-amino-2-(ethoxymethyl)-9-methoxyimidazo[4,5-c]quinolin-1-yl]-2-methylbutan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2CCC(C)(O)C)COCC)OC OCIADYZDROIKDL-UHFFFAOYSA-N 0.000 claims 1
- ITPHJKRCXVELDB-UHFFFAOYSA-N 4-[[4-amino-2-(2-methoxyethyl)-3H-imidazo[4,5-c]quinolin-9-yl]oxy]-2-methylbutan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2)CCOC)OCCC(C)(O)C ITPHJKRCXVELDB-UHFFFAOYSA-N 0.000 claims 1
- REWHSGXVPGPMCX-UHFFFAOYSA-N 4-[[4-amino-2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-9-yl]oxy]-2-methylbutan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2)COCC)OCCC(C)(O)C REWHSGXVPGPMCX-UHFFFAOYSA-N 0.000 claims 1
- JWARRFKQCPVLSR-UHFFFAOYSA-N 4-[[4-amino-2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-9-yl]oxy]butan-2-ol Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2)COCC)OCCC(C)O JWARRFKQCPVLSR-UHFFFAOYSA-N 0.000 claims 1
- AMPBTPQXPBRJCY-UHFFFAOYSA-N 4-amino-2-(3-methylbutyl)pyrazolo[3,4-c]quinolin-9-ol Chemical class NC1=NC=2C=CC=C(C=2C=2C1=NN(C=2)CCC(C)C)O AMPBTPQXPBRJCY-UHFFFAOYSA-N 0.000 claims 1
- PCQZTOCRIVZHOB-UHFFFAOYSA-N 4-amino-3H-pyrazolo[3,4-c]quinolin-9-ol Chemical class NC1=NC=2C=CC=C(C=2C=2C1=NNC=2)O PCQZTOCRIVZHOB-UHFFFAOYSA-N 0.000 claims 1
- FSIDHUJJSWXKCQ-UHFFFAOYSA-N 9-(3-methylbutoxy)-2-(3-methylbutyl)pyrazolo[3,4-c]quinolin-4-amine Chemical class C(CC(C)C)N1N=C2C(=NC=3C=CC=C(C=3C2=C1)OCCC(C)C)N FSIDHUJJSWXKCQ-UHFFFAOYSA-N 0.000 claims 1
- HTLWKFKYFYPSCH-UHFFFAOYSA-N 9-methoxy-3H-imidazo[4,5-c]quinolin-4-amine Chemical class COC=1C=2C3=C(C(=NC=2C=CC=1)N)N=CN3 HTLWKFKYFYPSCH-UHFFFAOYSA-N 0.000 claims 1
- ICOJRQWKSUISLK-UHFFFAOYSA-N 9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine Chemical class COc1cccc2nc(N)c3n[nH]cc3c12 ICOJRQWKSUISLK-UHFFFAOYSA-N 0.000 claims 1
- BQICROVULNIKFQ-UHFFFAOYSA-N N-[2-[2-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxyethoxy]ethyl]methanesulfonamide Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2C)COCC)OCCOCCNS(=O)(=O)C BQICROVULNIKFQ-UHFFFAOYSA-N 0.000 claims 1
- IXGVMYREGNTOBW-UHFFFAOYSA-N N-[3-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxypropyl]acetamide Chemical class C(C)(=O)NCCCOC=1C=2C3=C(C(=NC=2C=CC=1)N)N=C(N3C)COCC IXGVMYREGNTOBW-UHFFFAOYSA-N 0.000 claims 1
- FQDKRRYLMFABOK-UHFFFAOYSA-N N-[3-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxypropyl]methanesulfonamide Chemical class CS(=O)(=O)NCCCOC=1C=2C3=C(C(=NC=2C=CC=1)N)N=C(N3C)COCC FQDKRRYLMFABOK-UHFFFAOYSA-N 0.000 claims 1
- KPRPJCGNUMXCGE-UHFFFAOYSA-N N-[3-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxypropyl]octadecanamide Chemical class C(CCCCCCCCCCCCCCCCC)(=O)NCCCOC=1C=2C3=C(C(=NC=2C=CC=1)N)N=C(N3C)COCC KPRPJCGNUMXCGE-UHFFFAOYSA-N 0.000 claims 1
- DUCMVTIPWNWNEK-UHFFFAOYSA-N N-[4-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxybutyl]acetamide Chemical class C(C)(=O)NCCCCOC=1C=2C3=C(C(=NC=2C=CC=1)N)N=C(N3C)COCC DUCMVTIPWNWNEK-UHFFFAOYSA-N 0.000 claims 1
- XSTUUKIVJMZMLY-UHFFFAOYSA-N N-[4-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxybutyl]methanesulfonamide Chemical class CS(=O)(=O)NCCCCOC=1C=2C3=C(C(=NC=2C=CC=1)N)N=C(N3C)COCC XSTUUKIVJMZMLY-UHFFFAOYSA-N 0.000 claims 1
- NDNROUSBPSFIOA-UHFFFAOYSA-N N-[4-[4-amino-2-(ethoxymethyl)-1-methylimidazo[4,5-c]quinolin-9-yl]oxybutyl]octadecanamide Chemical class NC1=NC=2C=CC=C(C=2C2=C1N=C(N2C)COCC)OCCCCNC(CCCCCCCCCCCCCCCCC)=O NDNROUSBPSFIOA-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710287322.2A CN108794467A (zh) | 2017-04-27 | 2017-04-27 | 2-氨基-喹啉衍生物 |
| CN201710287322.2 | 2017-04-27 | ||
| PCT/CN2018/084674 WO2018196823A1 (en) | 2017-04-27 | 2018-04-26 | 2-amino-quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019138177A true RU2019138177A (ru) | 2021-05-27 |
| RU2019138177A3 RU2019138177A3 (https=) | 2021-05-27 |
Family
ID=63918846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019138177A RU2019138177A (ru) | 2017-04-27 | 2018-04-26 | Производные 2-аминохинолина |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11053240B2 (https=) |
| EP (1) | EP3615539B1 (https=) |
| JP (1) | JP7179357B2 (https=) |
| KR (1) | KR102541238B1 (https=) |
| CN (3) | CN118515666A (https=) |
| AU (1) | AU2018259831B2 (https=) |
| BR (1) | BR112019022246A2 (https=) |
| CA (1) | CA3061187A1 (https=) |
| IL (1) | IL270219B (https=) |
| MX (1) | MX2019012676A (https=) |
| RU (1) | RU2019138177A (https=) |
| SG (1) | SG11201909325RA (https=) |
| WO (1) | WO2018196823A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| CN105899539B (zh) | 2014-01-10 | 2021-11-09 | 博笛生物科技有限公司 | 用于免疫疗法的化合物和组合物 |
| EP3166976B2 (en) | 2014-07-09 | 2026-04-08 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1 combinations for treating tumors |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| KR102726248B1 (ko) | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| CN118515666A (zh) * | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| IL312120B2 (en) | 2017-06-23 | 2025-06-01 | Birdie Biopharmaceuticals Inc | Pharmaceutical compositions |
| JP7287708B2 (ja) | 2019-02-08 | 2023-06-06 | プロジェニア インコーポレイテッド | Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途 |
| CN113518775B (zh) * | 2019-03-07 | 2024-10-29 | 生物技术公司 | 用于制备经取代的咪唑并喹啉的方法 |
| AU2020241686A1 (en) | 2019-03-15 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting HER2 |
| US11339159B2 (en) * | 2019-07-17 | 2022-05-24 | Pfizer Inc. | Toll-like receptor agonists |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| JP7811014B2 (ja) | 2020-03-02 | 2026-02-04 | プロジェニア インコーポレイテッド | 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法 |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| CN116322751A (zh) | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
| JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| US20230355750A1 (en) | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| KR20230148180A (ko) * | 2021-02-22 | 2023-10-24 | 리전츠 오브 더 유니버스티 오브 미네소타 | 면역조절제 및 면역조절제 컨쥬게이트 |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| MX2024000357A (es) | 2021-07-07 | 2024-02-12 | Incyte Corp | Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras). |
| US12600717B2 (en) | 2021-07-14 | 2026-04-14 | Incyte Corporation | Tricyclic compounds as inhibitors of KRAS |
| US12441742B2 (en) | 2021-08-31 | 2025-10-14 | Incyte Corporation | Naphthyridine compounds as inhibitors of KRAS |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| CA3234375A1 (en) | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
| WO2025245175A1 (en) * | 2024-05-22 | 2025-11-27 | Ajax Therapeutics, Inc. | Macrocyclic heteroaromatic inhibitors of jak2 |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1271477A (en) | 1983-11-18 | 1990-07-10 | John F. Gerster | 1h-imidazo[4,5-c]quinolin-4-amines |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US6608201B2 (en) | 1992-08-28 | 2003-08-19 | 3M Innovative Properties Company | Process for preparing 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5352784A (en) | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| US5482936A (en) | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
| UA67760C2 (uk) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| US6110929A (en) | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US6451810B1 (en) | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| EP1191944A2 (en) | 1999-06-25 | 2002-04-03 | Genentech, Inc. | METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES |
| US6635677B2 (en) | 1999-08-13 | 2003-10-21 | Case Western Reserve University | Methoxyamine combinations in the treatment of cancer |
| US6376669B1 (en) | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| US20060057651A1 (en) | 2000-12-08 | 2006-03-16 | Bowdish Katherine S | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| UA74593C2 (en) | 2000-12-08 | 2006-01-16 | 3M Innovative Properties Co | Substituted imidazopyridines |
| US20060142202A1 (en) | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| UA75622C2 (en) | 2000-12-08 | 2006-05-15 | 3M Innovative Properties Co | Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon |
| US6664264B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| JP2005519990A (ja) | 2001-10-12 | 2005-07-07 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | イミダゾキノリン化合物を用いて免疫応答を増強するための方法および産物 |
| AU2002343728A1 (en) | 2001-11-16 | 2003-06-10 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor pathways |
| EA008380B1 (ru) | 2001-11-27 | 2007-04-27 | Анадис Фармасьютикалз, Инк. | 3-β-D-РИБОФУРАНОЗИЛТИАЗОЛО[4,5-d]ПИРИМИДИННУКЛЕОЗИДЫ И ИХ ПРИМЕНЕНИЯ |
| IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| EP1413316A1 (en) | 2002-09-27 | 2004-04-28 | Bruno Robert | Bifunctional conjugates or fusion proteins |
| MXPA05006740A (es) | 2002-12-20 | 2005-10-05 | 3M Innovative Properties Co | Imidazoquinolinas arilo-sustituidas. |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| US20050036951A1 (en) | 2003-01-09 | 2005-02-17 | Arizeke Pharmaceuticals, Inc. | Methods of treating lung diseases |
| US9259459B2 (en) | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| JP2006517974A (ja) | 2003-02-13 | 2006-08-03 | スリーエム イノベイティブ プロパティズ カンパニー | Ｉｒｍ化合物およびトル様受容体８に関する方法および組成物 |
| EP1667694B1 (en) | 2003-09-05 | 2010-04-28 | Anadys Pharmaceuticals, Inc. | Tlr7 ligands for the treatment of hepatitis c |
| TW200526656A (en) | 2003-10-03 | 2005-08-16 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
| RU2426734C2 (ru) | 2003-10-03 | 2011-08-20 | Зм Инновейтив Пропертиз Компани | Пиразолопиридины и их аналоги |
| CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| EP1675614A2 (en) | 2003-10-11 | 2006-07-05 | Inex Pharmaceuticals Corp. | Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| JP2007517055A (ja) | 2003-12-30 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答の増強 |
| WO2005092893A1 (ja) | 2004-03-26 | 2005-10-06 | Dainippon Sumitomo Pharma Co., Ltd. | ９置換−８−オキソアデニン化合物 |
| CA2574090A1 (en) | 2004-07-18 | 2006-12-21 | Coley Pharmaceutical Group, Ltd. | Methods and compositions for inducing innate immune responses |
| EP1809671B1 (en) | 2004-11-09 | 2014-07-16 | University Of Southern California | CpG/antibody conjugate against cancer |
| CA2594253C (en) | 2004-12-30 | 2015-08-11 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
| WO2006091769A1 (en) | 2005-02-24 | 2006-08-31 | Janssen Pharmaceutica N.V. | Novel quinoline derivatives as potassium ion channel openers |
| KR20080003422A (ko) | 2005-04-14 | 2008-01-07 | 메르크 파텐트 게엠베하 | 종양 조직 내의 ｅｇｆｒ 유전자의 증가된 복제수에 기초한항-ｅｇｆｒ 항체 치료 |
| CN101203241B (zh) | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
| EP1874342B1 (en) | 2005-04-26 | 2018-06-06 | Eisai R&D Management Co., Ltd. | Compositions and methods for cancer immunotherapy |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| TWI404537B (zh) | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| US20090304721A1 (en) | 2005-09-07 | 2009-12-10 | Medlmmune, Inc | Toxin conjugated eph receptor antibodies |
| ZA200803029B (en) | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| EP1988896A4 (en) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
| WO2007103048A2 (en) | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| US20080031887A1 (en) | 2006-06-30 | 2008-02-07 | Joseph Lustgarten | Conjugates for inducing targeted immune responses and methods of making and using same |
| EP2041135A4 (en) | 2006-07-05 | 2010-12-01 | Astrazeneca Ab | As TLR7 MODULATORS, 8-OXOADENINE DERIVATIVES WORK |
| KR20140116546A (ko) | 2006-10-27 | 2014-10-02 | 제넨테크, 인크. | 항체 및 면역접합체 및 이들의 용도 |
| ES2577391T3 (es) | 2006-12-21 | 2016-07-14 | F. Hoffmann-La Roche Ag | Polimorfos de un antagonista del receptor mglur5 |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| TWI422594B (zh) | 2007-02-02 | 2014-01-11 | Baylor Res Inst | 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑 |
| ES2552471T3 (es) | 2007-02-07 | 2015-11-30 | The Regents Of The University Of California | Conjugados de agonistas de TLR sintéticos y usos de los mismos |
| EP2136788B1 (en) | 2007-03-30 | 2011-10-26 | Bind Biosciences, Inc. | Cancer cell targeting using nanoparticles |
| KR20100016289A (ko) | 2007-05-08 | 2010-02-12 | 아스트라제네카 아베 | 면역-조정 특성의 이미다조퀴놀린 |
| RU2010107199A (ru) | 2007-07-31 | 2011-09-10 | Дзе Джонс Хопкинс Юниверсити (Us) | Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии для неопластических или инфекционных нарушений |
| GB0715428D0 (en) * | 2007-08-08 | 2007-09-19 | Imp Innovations Ltd | Compositions and uses thereof |
| NZ586161A (en) | 2008-01-15 | 2012-05-25 | Meda Ab | Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives |
| WO2009093250A2 (en) | 2008-01-25 | 2009-07-30 | Gavish-Galilee Bio Applications Ltd | Targeting of innate immune response to tumor site |
| EA201001264A1 (ru) | 2008-02-07 | 2011-04-29 | Дзе Регентс Оф Дзе Юниверсити Оф Калифорния | Способ лечения заболеваний мочевого пузыря с помощью активатора tlr7 |
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| EP2316032A1 (en) | 2008-08-20 | 2011-05-04 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8 |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| EP2427485B1 (en) | 2009-05-07 | 2016-12-07 | ImmunoCellular Therapeutics, Ltd. | Cd133 epitopes |
| WO2010132622A2 (en) | 2009-05-14 | 2010-11-18 | The Regents Of The University Of California | Anticd20-cpg conjugates and methods of treating b cell malignancies |
| US20110077263A1 (en) | 2009-09-29 | 2011-03-31 | University Of Southern California | Methods and Compositions of Toll-Like Receptor (TLR) Agonists |
| NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| WO2011084726A1 (en) | 2009-12-21 | 2011-07-14 | 3M Innovative Properties Company | BIS [4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM] 4-[(3-CARBOXYLATO-2-HYDROXYNAPHTHALEN-1-YL)METHYL]-3-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS |
| WO2011084725A1 (en) | 2009-12-21 | 2011-07-14 | 3M Innovative Properties Company | 4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM 1-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS |
| EP3165540A1 (en) | 2010-04-13 | 2017-05-10 | Celldex Therapeutics, Inc. | Antibodies that bind human cd27 and uses thereof |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| BR112013002940A2 (pt) | 2010-08-13 | 2019-09-24 | Baylor Res Institute | adjuvantes de nova vacina baseados no direcionamento dos adjuvantes para os anticorpos diretamente às células que apresentam antígenos |
| JP5951615B2 (ja) | 2010-10-01 | 2016-07-13 | ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｔｌｒアゴニストの治療用途および組み合わせ治療 |
| BR112013014316A2 (pt) | 2010-12-09 | 2016-09-27 | Genentech Inc | tratamento de câncer her2-positivo com paclitaxel e trastuzumabe-mcc-dm1 |
| CN103562201B (zh) | 2011-01-12 | 2016-10-19 | 帆德制药股份有限公司 | 作为toll样受体调节剂的取代的苯并氮杂卓 |
| WO2012104344A1 (en) | 2011-02-01 | 2012-08-09 | Genmab A/S | Human antibodies and antibody-drug conjugates against cd74 |
| TW201247706A (en) | 2011-03-08 | 2012-12-01 | Baylor Res Inst | Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| UY34032A (es) * | 2011-04-21 | 2012-11-30 | Origenis Gmbh | Nuevos inhibidores de quinasa |
| EP2699572B1 (en) | 2011-04-21 | 2016-08-10 | Origenis GmbH | Heterocyclic compounds as kinase inhibitors |
| US8728486B2 (en) | 2011-05-18 | 2014-05-20 | University Of Kansas | Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds |
| JP6240600B2 (ja) | 2011-07-24 | 2017-11-29 | キュアテク リミテッド | ヒト化免疫モノクローナル抗体の変異体 |
| JP6238459B2 (ja) | 2011-08-01 | 2017-11-29 | ジェネンテック， インコーポレイテッド | Ｐｄ−１軸結合アンタゴニストとｍｅｋ阻害剤を使用する癌の治療方法 |
| KR101899801B1 (ko) | 2011-08-11 | 2018-09-20 | 헌츠만 어드밴스드 머티리얼스 아메리카스 엘엘씨 | 벤족사진 화합물의 제조 방법 |
| US9308253B2 (en) | 2011-09-19 | 2016-04-12 | The Johns Hopkins University | Cancer immunotherapy |
| US11707409B2 (en) | 2011-10-25 | 2023-07-25 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| IN2014CN04251A (https=) | 2011-11-09 | 2015-07-17 | Ascend Biopharmaceuticals Ltd | |
| US9556167B2 (en) | 2012-05-02 | 2017-01-31 | Yale University | TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs) |
| CN113967253A (zh) | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| JP6403166B2 (ja) | 2012-08-03 | 2018-10-10 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 単一抗原抗ｐｄ−ｌ１およびｐｄ−ｌ２二重結合抗体およびその使用方法 |
| EP3494996B1 (en) | 2012-08-23 | 2026-04-15 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to 158p1d7 proteins |
| WO2014060112A1 (en) * | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| US10000482B2 (en) * | 2012-10-19 | 2018-06-19 | Origenis Gmbh | Kinase inhibitors |
| EP2787005A1 (en) | 2013-04-02 | 2014-10-08 | Activartis Biotech GmbH | Targeted cancer immune therapy |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| CN105899539B (zh) | 2014-01-10 | 2021-11-09 | 博笛生物科技有限公司 | 用于免疫疗法的化合物和组合物 |
| AU2015279738A1 (en) | 2014-06-25 | 2016-12-22 | Selecta Biosciences, Inc. | Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors |
| EP3166976B2 (en) | 2014-07-09 | 2026-04-08 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1 combinations for treating tumors |
| CN105233291A (zh) | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| CN105732635A (zh) | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
| BR112018004175B8 (pt) | 2015-09-01 | 2023-10-31 | Taiho Pharmaceutical Co Ltd | Composto pirazolo[3,4-d]pirimidina, composição farmacêutica e usos terapêuticos do dito composto |
| US10821127B2 (en) | 2015-11-09 | 2020-11-03 | Shaperon Inc. | Composition for inhibiting myeloid-derived suppressor cells comprising decitabine or its pharmaceutically acceptable salt as active ingredient |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| IL312120B2 (en) | 2017-06-23 | 2025-06-01 | Birdie Biopharmaceuticals Inc | Pharmaceutical compositions |
| US20210214354A1 (en) | 2018-09-07 | 2021-07-15 | Birdie Biopharmaceuticals, Inc. | Imidazoquinoline compounds and uses thereof |
| JP2022516093A (ja) | 2018-12-26 | 2022-02-24 | バーディー バイオファーマシューティカルズ インコーポレイテッド | 癌の治療のための免疫調節薬の組み合わせおよび方法 |
| US20220175762A1 (en) | 2019-03-15 | 2022-06-09 | Birdie Biopharmaceuticals, Inc. | Immune modulatory compositions and methods for treating cancers |
| CA3192776A1 (en) | 2020-08-26 | 2022-03-03 | Lixin Li | Cancer treatment with tlr agonist |
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2017
- 2017-04-27 CN CN202410623331.4A patent/CN118515666A/zh active Pending
- 2017-04-27 CN CN201710287322.2A patent/CN108794467A/zh active Pending
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2018
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- 2018-04-26 WO PCT/CN2018/084674 patent/WO2018196823A1/en not_active Ceased
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2021
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| US20210261549A1 (en) | 2021-08-26 |
| JP2020517711A (ja) | 2020-06-18 |
| WO2018196823A1 (en) | 2018-11-01 |
| CN110637018B (zh) | 2025-06-06 |
| EP3615539B1 (en) | 2023-08-09 |
| BR112019022246A2 (pt) | 2020-08-11 |
| US11053240B2 (en) | 2021-07-06 |
| EP3615539A1 (en) | 2020-03-04 |
| IL270219A (https=) | 2019-12-31 |
| CN108794467A (zh) | 2018-11-13 |
| US20200055851A1 (en) | 2020-02-20 |
| CN118515666A (zh) | 2024-08-20 |
| US20210261548A1 (en) | 2021-08-26 |
| CA3061187A1 (en) | 2018-11-01 |
| RU2019138177A3 (https=) | 2021-05-27 |
| AU2018259831B2 (en) | 2022-06-16 |
| MX2019012676A (es) | 2020-02-05 |
| JP7179357B2 (ja) | 2022-11-29 |
| US11834448B2 (en) | 2023-12-05 |
| AU2018259831A1 (en) | 2019-10-31 |
| KR102541238B1 (ko) | 2023-06-08 |
| CN110637018A (zh) | 2019-12-31 |
| SG11201909325RA (en) | 2019-11-28 |
| EP3615539A4 (en) | 2020-08-19 |
| KR20190141174A (ko) | 2019-12-23 |
| IL270219B (en) | 2022-09-01 |
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