CN108794467A - 2-氨基-喹啉衍生物 - Google Patents

2-氨基-喹啉衍生物 Download PDF

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Publication number
CN108794467A
CN108794467A CN201710287322.2A CN201710287322A CN108794467A CN 108794467 A CN108794467 A CN 108794467A CN 201710287322 A CN201710287322 A CN 201710287322A CN 108794467 A CN108794467 A CN 108794467A
Authority
CN
China
Prior art keywords
quinolin
optionally substituted
ethoxymethyl
imidazo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710287322.2A
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English (en)
Chinese (zh)
Inventor
李立新
关慧平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Birdie Biopharmaceuticals Inc Cayman Islands
Original Assignee
Birdie Biopharmaceuticals Inc Cayman Islands
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Birdie Biopharmaceuticals Inc Cayman Islands filed Critical Birdie Biopharmaceuticals Inc Cayman Islands
Priority to CN201710287322.2A priority Critical patent/CN108794467A/zh
Priority to CN202410623331.4A priority patent/CN118515666A/zh
Priority to AU2018259831A priority patent/AU2018259831B2/en
Priority to EP18792253.9A priority patent/EP3615539B1/en
Priority to CN201880014574.0A priority patent/CN110637018B/zh
Priority to MX2019012676A priority patent/MX2019012676A/es
Priority to RU2019138177A priority patent/RU2019138177A/ru
Priority to SG11201909325R priority patent/SG11201909325RA/en
Priority to PCT/CN2018/084674 priority patent/WO2018196823A1/en
Priority to KR1020197033158A priority patent/KR102541238B1/ko
Priority to CA3061187A priority patent/CA3061187A1/en
Priority to US16/608,581 priority patent/US11053240B2/en
Priority to BR112019022246-4A priority patent/BR112019022246A2/pt
Priority to IL270219A priority patent/IL270219B/en
Priority to JP2019558496A priority patent/JP7179357B2/ja
Publication of CN108794467A publication Critical patent/CN108794467A/zh
Priority to US17/315,156 priority patent/US11834448B2/en
Priority to US17/315,162 priority patent/US20210261549A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201710287322.2A 2017-04-27 2017-04-27 2-氨基-喹啉衍生物 Pending CN108794467A (zh)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CN201710287322.2A CN108794467A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物
CN202410623331.4A CN118515666A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物
KR1020197033158A KR102541238B1 (ko) 2017-04-27 2018-04-26 2-아미노-퀴놀린 유도체
US16/608,581 US11053240B2 (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
CN201880014574.0A CN110637018B (zh) 2017-04-27 2018-04-26 2-氨基-喹啉衍生物
MX2019012676A MX2019012676A (es) 2017-04-27 2018-04-26 Derivados de 2-aminoquinolina.
RU2019138177A RU2019138177A (ru) 2017-04-27 2018-04-26 Производные 2-аминохинолина
SG11201909325R SG11201909325RA (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
PCT/CN2018/084674 WO2018196823A1 (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
AU2018259831A AU2018259831B2 (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
CA3061187A CA3061187A1 (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
EP18792253.9A EP3615539B1 (en) 2017-04-27 2018-04-26 2-amino-quinoline derivatives
BR112019022246-4A BR112019022246A2 (pt) 2017-04-27 2018-04-26 compostos derivados de 2-amino-quinolina e uso dos mesmos
IL270219A IL270219B (en) 2017-04-27 2018-04-26 Substances with a 2-aminoquinoline skeleton and their uses
JP2019558496A JP7179357B2 (ja) 2017-04-27 2018-04-26 ２－アミノ－キノリン誘導体
US17/315,156 US11834448B2 (en) 2017-04-27 2021-05-07 2-amino-quinoline derivatives
US17/315,162 US20210261549A1 (en) 2017-04-27 2021-05-07 2-amino-quinoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710287322.2A CN108794467A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202410623331.4A Division CN118515666A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物

Publications (1)

Publication Number Publication Date
CN108794467A true CN108794467A (zh) 2018-11-13

Family

ID=63918846

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201710287322.2A Pending CN108794467A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物
CN202410623331.4A Pending CN118515666A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物
CN201880014574.0A Active CN110637018B (zh) 2017-04-27 2018-04-26 2-氨基-喹啉衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202410623331.4A Pending CN118515666A (zh) 2017-04-27 2017-04-27 2-氨基-喹啉衍生物
CN201880014574.0A Active CN110637018B (zh) 2017-04-27 2018-04-26 2-氨基-喹啉衍生物

Country Status (13)

Country Link
US (3) US11053240B2 (https=)
EP (1) EP3615539B1 (https=)
JP (1) JP7179357B2 (https=)
KR (1) KR102541238B1 (https=)
CN (3) CN108794467A (https=)
AU (1) AU2018259831B2 (https=)
BR (1) BR112019022246A2 (https=)
CA (1) CA3061187A1 (https=)
IL (1) IL270219B (https=)
MX (1) MX2019012676A (https=)
RU (1) RU2019138177A (https=)
SG (1) SG11201909325RA (https=)
WO (1) WO2018196823A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN112587672A (zh) 2014-09-01 2021-04-02 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN106943597A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-egfr组合
CN115350279A (zh) 2016-01-07 2022-11-18 博笛生物科技有限公司 用于治疗肿瘤的抗-her2组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-cd20组合
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
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