BR112021016960A2 - Processo para a preparação de uma imidazoquinolina substituída - Google Patents
Processo para a preparação de uma imidazoquinolina substituídaInfo
- Publication number
- BR112021016960A2 BR112021016960A2 BR112021016960A BR112021016960A BR112021016960A2 BR 112021016960 A2 BR112021016960 A2 BR 112021016960A2 BR 112021016960 A BR112021016960 A BR 112021016960A BR 112021016960 A BR112021016960 A BR 112021016960A BR 112021016960 A2 BR112021016960 A2 BR 112021016960A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- substituted imidazoquinoline
- quinolin
- imidazo
- pyran
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical class OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 title abstract 2
- 229940124669 imidazoquinoline Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 229940124615 TLR 7 agonist Drugs 0.000 abstract 1
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 239000003970 toll like receptor agonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
processo para a preparação de uma imidazoquinolina substituída. a presente invenção se refere a um processo para sintetizar n-(4-(4-amino-2-(2 metoxietil)-1h-imidazo [4,5- c] quinolin-1-il)butil)-n-(tetrahidro-2h-piran-4-il) acetamida, um derivado de imidazoquinolina útil como agonista do receptor do tipo toll, em particular, como agonista de tlr7, que promove a indução de certas citocinas. além disso, a presente invenção também fornece intermediários úteis na síntese de n-(4-(4-amino-2-(2- metoxietil)-1h-imidazo[4,5-c]quinolin-1-il)butil)-n-(tetra hidro-2h-piran-4-il) acetamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2019055793 | 2019-03-07 | ||
| PCT/EP2020/056047 WO2020178434A1 (en) | 2019-03-07 | 2020-03-06 | Process for the preparation of a substituted imidazoquinoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021016960A2 true BR112021016960A2 (pt) | 2021-11-23 |
Family
ID=69723965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021016960A BR112021016960A2 (pt) | 2019-03-07 | 2020-03-06 | Processo para a preparação de uma imidazoquinolina substituída |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220144822A1 (pt) |
| EP (1) | EP3935047B1 (pt) |
| JP (1) | JP2022525023A (pt) |
| KR (1) | KR20210136033A (pt) |
| CN (1) | CN113518775A (pt) |
| AU (1) | AU2020231822A1 (pt) |
| BR (1) | BR112021016960A2 (pt) |
| CA (1) | CA3132229A1 (pt) |
| CL (1) | CL2021002322A1 (pt) |
| CO (1) | CO2021011258A2 (pt) |
| CU (1) | CU24679B1 (pt) |
| DK (1) | DK3935047T3 (pt) |
| IL (1) | IL286054A (pt) |
| MX (1) | MX2021010669A (pt) |
| SG (1) | SG11202108752YA (pt) |
| WO (1) | WO2020178434A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023083439A1 (en) * | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573273B1 (en) | 1999-06-10 | 2003-06-03 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6451810B1 (en) | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6756382B2 (en) | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6677349B1 (en) | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| EP1686992A4 (en) | 2003-11-25 | 2009-11-04 | 3M Innovative Properties Co | HYDROXYLAMINE, AND IMIDAZOQUINOLEINS, AND IMIDAZOPYRIDINES AND IMIDAZONAPHTYRIDINE SUBSTITUTED WITH OXIME |
| MX344330B (es) * | 2008-03-24 | 2016-12-13 | 4Sc Ag | Imidazoquinolinas substituidas novedosas. |
| US8735386B2 (en) * | 2010-07-23 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Aminopyrazoloquinazolines |
| UA113280C2 (xx) * | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
| AU2018329152B2 (en) * | 2017-09-06 | 2024-02-15 | BioNTech SE | Substituted imidazoquinolines as agonists of TLR7 |
| WO2019048036A1 (en) * | 2017-09-06 | 2019-03-14 | Biontech Ag | SUBSTITUTED IMIDAZOQUINOLINES |
-
2020
- 2020-03-06 CA CA3132229A patent/CA3132229A1/en active Pending
- 2020-03-06 US US17/432,017 patent/US20220144822A1/en active Pending
- 2020-03-06 CN CN202080018804.8A patent/CN113518775A/zh active Pending
- 2020-03-06 CU CU2021000071A patent/CU24679B1/es unknown
- 2020-03-06 SG SG11202108752YA patent/SG11202108752YA/en unknown
- 2020-03-06 AU AU2020231822A patent/AU2020231822A1/en active Pending
- 2020-03-06 BR BR112021016960A patent/BR112021016960A2/pt unknown
- 2020-03-06 WO PCT/EP2020/056047 patent/WO2020178434A1/en active Application Filing
- 2020-03-06 EP EP20707669.6A patent/EP3935047B1/en active Active
- 2020-03-06 KR KR1020217029506A patent/KR20210136033A/ko unknown
- 2020-03-06 JP JP2021552887A patent/JP2022525023A/ja active Pending
- 2020-03-06 DK DK20707669.6T patent/DK3935047T3/da active
- 2020-03-06 MX MX2021010669A patent/MX2021010669A/es unknown
-
2021
- 2021-08-26 CO CONC2021/0011258A patent/CO2021011258A2/es unknown
- 2021-09-01 IL IL286054A patent/IL286054A/en unknown
- 2021-09-06 CL CL2021002322A patent/CL2021002322A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3935047T3 (da) | 2024-09-09 |
| CU24679B1 (es) | 2023-09-07 |
| SG11202108752YA (en) | 2021-09-29 |
| EP3935047A1 (en) | 2022-01-12 |
| US20220144822A1 (en) | 2022-05-12 |
| EP3935047B1 (en) | 2024-08-07 |
| WO2020178434A1 (en) | 2020-09-10 |
| JP2022525023A (ja) | 2022-05-11 |
| CL2021002322A1 (es) | 2022-05-13 |
| IL286054A (en) | 2021-10-31 |
| CO2021011258A2 (es) | 2021-09-09 |
| KR20210136033A (ko) | 2021-11-16 |
| CU20210071A7 (es) | 2022-04-07 |
| AU2020231822A1 (en) | 2021-08-26 |
| MX2021010669A (es) | 2021-09-28 |
| CN113518775A (zh) | 2021-10-19 |
| CA3132229A1 (en) | 2020-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2014003181A1 (es) | Compuestos derivados de benzamidas n- sustituidas o piridinamidas n-sustituidas; composicion farmaceutica que los comprende; metodo de tratamiento; y su uso para el tratamiento de enfermedades o trastornos seleccionados de dolor, depresion y enfermedades cardiovasculares, respiratorias o psiquiatricas o combinaciones de estas. | |
| AR081577A1 (es) | Derivados de aminopirimidina como moduladores de la lrrk2 | |
| AR085149A1 (es) | Moduladores del receptor de glucagon | |
| IN2014CN00961A (pt) | ||
| PE20151981A1 (es) | Pontenciador de inhibidores del homologo de zeste | |
| DOP2011000076A (es) | Derivados de heteroaril amidas y su uso como activadores de glucoquinasa | |
| CR20110028A (es) | Derivados de pirimidina como inhibidores de cinasa | |
| CO6290683A2 (es) | Compuestos de pirido imidazolinas heterociclicas y sus composiciones como inhibidores de c-met | |
| ECSP13012958A (es) | Inhibidores de benzodioxano de la producción de leucotrieno. | |
| UY32863A (es) | COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR | |
| BR112017017349A2 (pt) | composto, composição, método para tratar um distúrbio | |
| SV2010003677A (es) | Inhibidores de desacetilasas b a base de hidroxamato | |
| AR082111A1 (es) | Furopiridinas o tienopiridinas condensadas, composiciones farmaceuticas que las contienen utiles para tratar trastornos psicoticos y del sistema nervioso central, y metodo de preparacion de las mismas | |
| CR20140553A (es) | Compuestos de fenoxietil piperidina | |
| CU24365B1 (es) | Derivados de oxazolidin-2-ona-pirimidina | |
| BR112021016960A2 (pt) | Processo para a preparação de uma imidazoquinolina substituída | |
| PH12015500795B1 (en) | N-(2-(cyclic amine)ethyl)benzamide derivatives as p2x7 inhibitors | |
| ECSP11010807A (es) | Sales de los compuestos del inhibidor de vih | |
| BR112015028801A2 (pt) | copolímero por blocos e processo para a preparação do mesmo | |
| UY32744A (es) | Derivados de 2-carboxamida-7-piperazinil-benzofurano 774 | |
| BR112013003121A2 (pt) | moduladores de trpv3 | |
| CY1115983T1 (el) | Συνθεση toy aliskiren | |
| BR112016018418A2 (pt) | Composto, uso do mesmo, e composição farmacêutica | |
| BR112013031334A2 (pt) | método para preparar zeólitos do tipo lta utilizando um agente de dirigir estrutura novo | |
| MX2022007916A (es) | Conjugados que experimentan rearreglos intramoleculares. |