RU2017118935A3 - - Google Patents
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- RU2017118935A3 RU2017118935A3 RU2017118935A RU2017118935A RU2017118935A3 RU 2017118935 A3 RU2017118935 A3 RU 2017118935A3 RU 2017118935 A RU2017118935 A RU 2017118935A RU 2017118935 A RU2017118935 A RU 2017118935A RU 2017118935 A3 RU2017118935 A3 RU 2017118935A3
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Sustainable Development (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Plant Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Mechanical Engineering (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073548P | 2014-10-31 | 2014-10-31 | |
| US62/073,548 | 2014-10-31 | ||
| PCT/US2015/058489 WO2016070136A1 (en) | 2014-10-31 | 2015-10-30 | Delivery of biomolecules to immune cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020139190A Division RU2020139190A (ru) | 2014-10-31 | 2015-10-30 | Доставка биомолекул в клетки иммунной системы |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017118935A RU2017118935A (ru) | 2018-12-03 |
| RU2017118935A3 true RU2017118935A3 (OSRAM) | 2019-10-01 |
| RU2739794C2 RU2739794C2 (ru) | 2020-12-28 |
Family
ID=55858434
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017118935A RU2739794C2 (ru) | 2014-10-31 | 2015-10-30 | Доставка биомолекул в клетки иммунной системы |
| RU2020139190A RU2020139190A (ru) | 2014-10-31 | 2015-10-30 | Доставка биомолекул в клетки иммунной системы |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020139190A RU2020139190A (ru) | 2014-10-31 | 2015-10-30 | Доставка биомолекул в клетки иммунной системы |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11111472B2 (OSRAM) |
| EP (1) | EP3212772A4 (OSRAM) |
| JP (2) | JP7523203B2 (OSRAM) |
| KR (2) | KR20170074235A (OSRAM) |
| CN (1) | CN107109362A (OSRAM) |
| AU (2) | AU2015338893A1 (OSRAM) |
| BR (1) | BR112017009050A2 (OSRAM) |
| CA (1) | CA2964392A1 (OSRAM) |
| IL (1) | IL252005B (OSRAM) |
| RU (2) | RU2739794C2 (OSRAM) |
| SG (2) | SG10201903912XA (OSRAM) |
| WO (1) | WO2016070136A1 (OSRAM) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0611766A2 (pt) * | 2005-06-08 | 2011-12-20 | Dana Farber Cancer Inst Inc | métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada |
| BR112014009346B1 (pt) * | 2011-10-17 | 2020-09-15 | Massachusetts Institute Of Technology | Entrega intracelular |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| CN107109362A (zh) | 2014-10-31 | 2017-08-29 | 麻省理工学院 | 递送生物分子至免疫细胞 |
| CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
| WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| US20180133327A1 (en) | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| WO2016168680A1 (en) * | 2015-04-17 | 2016-10-20 | Exocyte Therapeutics Pte Ltd. | Method for developing exosome-based vaccines |
| WO2017008063A1 (en) | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| WO2017015245A1 (en) * | 2015-07-20 | 2017-01-26 | Angiocrine Bioscience, Inc. | Methods and compositions for stem cell transplantation |
| US11613759B2 (en) | 2015-09-04 | 2023-03-28 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| JP7033535B2 (ja) * | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | 複合体の細胞内送達 |
| LT3429618T (lt) | 2016-03-16 | 2024-05-10 | Amal Therapeutics Sa | Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| AU2017259987B2 (en) | 2016-05-03 | 2023-10-19 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| US20210138050A1 (en) * | 2016-05-03 | 2021-05-13 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| EP3463398A4 (en) * | 2016-05-25 | 2020-03-11 | The Council of the Queensland Institute of Medical Research | IMMUNE CONTROL POINT INHIBITORS AND CYTOTOXIC T-LYMPHOCYTES FOR THE TREATMENT OF CANCER |
| EP3471539A4 (en) | 2016-06-03 | 2020-02-26 | The Brigham and Women's Hospital | KLRG1 SIGNALING THERAPY |
| CN106047818A (zh) * | 2016-08-05 | 2016-10-26 | 武汉赛云博生物科技有限公司 | 癌胚抗原特异性tcr基因修饰的t细胞及其抑癌用途 |
| KR20190057345A (ko) | 2016-09-21 | 2019-05-28 | 아말 테라퓨틱스 에스에이 | 암 치료를 위한, 세포 투과 펩타이드, 멀티 에피토프 및 tlr 펩타이드 작용제를 포함하는 융합체 |
| US20190203230A1 (en) * | 2016-09-28 | 2019-07-04 | Novartis Ag | Porous membrane-based macromolecule delivery system |
| CN110088286B (zh) * | 2016-10-21 | 2024-01-02 | 新加坡科技研究局 | 用于细胞内递送物质的装置、系统和方法 |
| EP3538269A4 (en) * | 2016-11-08 | 2020-07-01 | Georgia Tech Research Corporation | METHODS OF INTRACELLULAR CONVECTION ADMINISTRATION |
| US11981915B2 (en) | 2016-12-22 | 2024-05-14 | Avectas Limited | Vector-free intracellular delivery by reversible permeabilization |
| EP3577132A4 (en) * | 2017-02-03 | 2021-03-10 | University of Pittsburgh - of The Commonwealth System of Higher Education | ONCOLYTIC VIRUS THERAPY |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| WO2019018497A1 (en) * | 2017-07-18 | 2019-01-24 | President And Fellows Of Harvard College | INTRACELLULAR DELIVERY USING MICROFLUIDIC ASSISTED CELLULAR SCREENING (MACS) |
| WO2019037055A1 (zh) * | 2017-08-24 | 2019-02-28 | 深圳市博奥康生物科技有限公司 | 人 GRD4 基因的 shRNA 及其应用 |
| US11052394B2 (en) * | 2017-11-02 | 2021-07-06 | Indee. Pty. Ltd. | Intracellular delivery method |
| EP3720878A1 (en) * | 2017-12-05 | 2020-10-14 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to modulate antibody production |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| CN120154716A (zh) | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| CR20200460A (es) * | 2018-03-12 | 2020-11-23 | Sqz Biotechnologies Co | Suministro intracelular de biomeléculas para modificar respuestas inmunes |
| WO2019178005A2 (en) * | 2018-03-12 | 2019-09-19 | Sqz Biotechnologies Company | Methods for treating hpv-associated diseases |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US20210388390A1 (en) * | 2018-10-04 | 2021-12-16 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to enhance antigen presenting cell function |
| WO2020101254A1 (ko) * | 2018-11-12 | 2020-05-22 | 주식회사 펨토바이오메드 | 세포 내 물질 전달을 제어하는 방법 및 장치 |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| WO2020154696A1 (en) | 2019-01-25 | 2020-07-30 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| WO2020172198A1 (en) * | 2019-02-18 | 2020-08-27 | Duke University | Prr-activating and microrna-inhibiting molecules and methods of using same |
| SG11202109333SA (en) | 2019-02-28 | 2021-09-29 | Sqz Biotechnologies Co | Delivery of biomolecules to pbmcs to modify an immune response |
| SG11202109514VA (en) * | 2019-03-08 | 2021-09-29 | Massachusetts Inst Technology | Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy |
| CN113840657B (zh) * | 2019-03-12 | 2023-04-14 | 明新特生物科技公司 | 用于材料的细胞内输送的微流体系统及其方法 |
| CN113613663B (zh) * | 2019-03-29 | 2024-09-03 | 雀巢产品有限公司 | 用于增加t细胞功能的组合物和方法 |
| KR20210149791A (ko) | 2019-04-08 | 2021-12-09 | 에스큐지 바이오테크놀로지스 컴퍼니 | 페이로드를 세포 내로 전달하기 위한 시스템에서 이용하기 위한 카트리지 |
| US12465912B2 (en) | 2019-04-11 | 2025-11-11 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| US11685891B2 (en) | 2019-05-17 | 2023-06-27 | Regents Of The University Of Colorado | Precise mechanical disruption for intracellular delivery to cells and small organisms |
| US12473522B2 (en) | 2019-06-12 | 2025-11-18 | Cellfe, Inc. | Methods and systems for cell labeling and imaging |
| GB2628935B (en) | 2019-09-03 | 2025-03-05 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
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| EP3212772A1 (en) | 2017-09-06 |
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