RU2015114767A - Способы лечения рака - Google Patents
Способы лечения рака Download PDFInfo
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- RU2015114767A RU2015114767A RU2015114767A RU2015114767A RU2015114767A RU 2015114767 A RU2015114767 A RU 2015114767A RU 2015114767 A RU2015114767 A RU 2015114767A RU 2015114767 A RU2015114767 A RU 2015114767A RU 2015114767 A RU2015114767 A RU 2015114767A
- Authority
- RU
- Russia
- Prior art keywords
- acid
- agent
- therapeutic agent
- intracellular penetration
- oxo
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract 37
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Abstract
1. Способ лечения рака у субъекта, который нуждается в лечении, включающий интратуморальное введение терапевтически эффективного количества терапевтического средства и средства, усиливающего внутриклеточное проникновение, при этом терапевтическое средство не связано ковалентно со средством, усиливающим внутриклеточное проникновение.2. Способ по п. 1, в котором введение средства для усиления внутриклеточного проникновения повышает терапевтическую эффективность терапевтического средства и субъект является млекопитающим, выбранным из группы, состоящей из собаки, кошки, лошади, коровы, овцы, козы, свиньи, мыши, крысы, морской свинки, обезьяны или человека.3. Способ по п. 1, в котором рак представляет собой одну или более опухолей, выбранных из группы, состоящей из солидной опухоли, карциномы и саркомы.4. Способ по п. 3, в котором солидная опухоль, карцинома или саркома представляют собой опухоль кожи, кости, мышцы, молочной железы, ротовой полости, толстой кишки, органа, почки, печени, легкого, желчного пузыря, поджелудочной железы, головного мозга, пищевода, мочевого пузыря, толстого кишечника, тонкого кишечника, селезенки, желудка, предстательной железы, яичек, яичников, шейки матки, прямой кишки или матки.5. Способ по п. 3, в котором одна или более опухолей образовали метастазы.6. Способ по п. 3, приводящий к замедлению роста одной или более опухолей, уменьшению одной или более опухолей, ликвидации одной или более опухолей или предотвращению образования новых опухолей.7. Способ по п. 3, предотвращающий метастазирование опухоли.8. Способ по п. 1, в котором терапевтически эффективное количество терапевтического средства и/или средства, усиливающего
Claims (28)
1. Способ лечения рака у субъекта, который нуждается в лечении, включающий интратуморальное введение терапевтически эффективного количества терапевтического средства и средства, усиливающего внутриклеточное проникновение, при этом терапевтическое средство не связано ковалентно со средством, усиливающим внутриклеточное проникновение.
2. Способ по п. 1, в котором введение средства для усиления внутриклеточного проникновения повышает терапевтическую эффективность терапевтического средства и субъект является млекопитающим, выбранным из группы, состоящей из собаки, кошки, лошади, коровы, овцы, козы, свиньи, мыши, крысы, морской свинки, обезьяны или человека.
3. Способ по п. 1, в котором рак представляет собой одну или более опухолей, выбранных из группы, состоящей из солидной опухоли, карциномы и саркомы.
4. Способ по п. 3, в котором солидная опухоль, карцинома или саркома представляют собой опухоль кожи, кости, мышцы, молочной железы, ротовой полости, толстой кишки, органа, почки, печени, легкого, желчного пузыря, поджелудочной железы, головного мозга, пищевода, мочевого пузыря, толстого кишечника, тонкого кишечника, селезенки, желудка, предстательной железы, яичек, яичников, шейки матки, прямой кишки или матки.
5. Способ по п. 3, в котором одна или более опухолей образовали метастазы.
6. Способ по п. 3, приводящий к замедлению роста одной или более опухолей, уменьшению одной или более опухолей, ликвидации одной или более опухолей или предотвращению образования новых опухолей.
7. Способ по п. 3, предотвращающий метастазирование опухоли.
8. Способ по п. 1, в котором терапевтически эффективное количество терапевтического средства и/или средства, усиливающего внутриклеточное проникновение, выбирают, исходя из объема и типа опухоли.
9. Способ по п. 1, в котором терапевтическое средство и/или средство, усиливающее внутриклеточное проникновение, вводят в первый день и повторно вводят в один или более последующих дней.
10. Способ по п. 9, в котором первый день и один или более последующих дней разделены интервалом от примерно 1 дня до примерно 3 недель.
11. Способ по п. 9, в котором терапевтическое средство и средство, усиливающее внутриклеточное проникновение, совместно вводят в соотношении примерно 1:2, 1:4, 1:10, 1:20, 1:25, 1:50, 1:100 или 1:200 (массовое соотношение терапевтическое средство:средство, усиливающее внутриклеточное проникновение).
12. Способ по п. 9, в котором средство, усиливающее внутриклеточное проникновение, вводят в концентрации от примерно 0,5 до примерно 50 мг/мл раствора для дозирования.
13. Способ по п. 9, в котором средство, усиливающее внутриклеточное проникновение, вводят в концентрации от примерно 10 до примерно 30 мг/мл раствора для дозирования.
14. Способ по п. 1, в котором терапевтическое средство и средство, усиливающее внутриклеточное проникновение, доставляют одновременно в одном составе или одновременно в отдельных составах.
15. Способ по п. 1, в котором средство, усиливающее внутриклеточное проникновение, вводят перед терапевтическим средством.
16. Способ по п. 1, в котором терапевтическое средство представляет собой противораковое средство, выбранное из группы, состоящей из абиратерона ацетата, афатиниба, альдеслейкина, алемтузумаба, алитретиноина, алтретамина, амифостина, аминоглутетимида, анагрелида, анастрозола, триоксида мышьяка, аспарагиназы, азацитидина, азатиоприна, бендамустина, бевацизумаба, бексаротина, бикалутамида, блеомицина, бортезомиба, бусульфана, капецитабина, карбоплатина, кармустина, цетуксимаба, хлорамбуцила, цисплатина, кладрибина, кризотиниба, циклофосфамида, цитарабина, дакарбазина, дактиномицина, дазатиниба, даунорубицина, денилейкина дифлитокса, децитабина, доцетаксела, дексаметазона, доксифлуридина, доксорубицина, эпирубицина, эпоэтина альфа, эпотилона, эрлотиниба, эстрамустина, энтиностата, этопозида, эверолимуса, экземестана, филграстима, флоксуридина, флударабина, фторурацила, флуоксиместерона, флутамида, связанных с фолатом алкалоидов, гефитиниба, гемцитабина, гемтузумаб озогамицина, GM-CT-01, гозерелина, гексаметилмеламина, гидроксимочевин, ибритумомаба, идарубицина, ифосфамида, иматиниба, интерферона альфа, интерферона бета, иринотекана, иксабепилона, лапатиниба, лейковорина, леупролида, леналидомида, летрозола, ломустина, мехлорэтамина, мегестрола, мелфалана, меркаптопурина, метотрексата, митомицина, митоксантрона, неларабина, нилотиниба, нилутамида, октреотида, офатумумаба, опрелвекина, оксалиплатина, паклитаксела, панитумумаба, пеметрекседа, пентостатина, полисахаридных ингибиторов галектина, прокарбазина, ралоксифена, ретиноевых кислот, ритуксимаба, ромиплостима, сарграмостима, сорафениба, стрептозоцина, сунитиниба, тамоксифена, темсиролимуса, темозоламида, тенипозида, талидомида, тиогуанина, тиотепы, тиогуанина, топотекана, торемифена, тозитумомаба, траметиниба, трастузумаба, третиноина, валрубицина, ингибиторов и уловителей VEGF, винбластина, винкристина, виндезина, винорелбина, винтафолида (EC145), вориностата, а также их солей, и любого их сочетания.
17. Способ по п. 1, в котором терапевтическое средство представляет собой терапевтическое антитело или сочетание двух или более терапевтических антител, выбранных из группы, состоящей из абаговомаба, алацизумаба пегола, алемтузумаба, алтумомаба пентетата (Hybri-ceaker), аматуксимаба, анатумомаба мафенатокса, анти-PD-1 антител, аполизумаба, арцитумомаба (CEA-Scan), белимумаба, бевацизумаба, биватузумаба мертанзина, блинатумомаба, брентуксимаба ведотина, кантузумаба мертанзина, кантузумаба равтанзина, капромаба пендетида (Prostascint), катумаксомаба (Removab), цетуксимаба (Erbitux), цитатузумаба богатокса, циксутумумаба, кливатузумаба тетраксетана (hPAM4-Cide), конатумумаба, далотузумаба, деносумаба, дрозитумаба, эдреколомаба (Panorex), энаватузумаба, гемтузумаба, ибритумомаба тиуксетана, ипилимумаба (MDX-101), офатумумаба, панитумумаба, ритуксимаба, тозитумомаба, трастузумаба или любого их сочетания.
18. Способ по п. 1, в котором терапевтическое средство представляет собой молекулу нуклеиновой кислоты, выбранную из группы, состоящей из интерферирующей РНК, генно-терапевтического экспрессионного вектора или выключающего ген вектора.
19. Способ по п. 1, в котором терапевтическое средство представляет собой радиоизотоп, ингибитор тимидилатсинтазы или соединение платины, алкалоид барвинка или любое их сочетание.
20. Способ по п. 1, в котором средство, усиливающее внутриклеточное проникновение, представляет собой химическое соединение, которое усиливает пассивный транспорт терапевтического соединения в клетку.
21. Способ по п. 1, в котором средство, усиливающее внутриклеточное проникновение, выбирают из группы, состоящей из функционализированных кетокислот, 6-оксо-6-фенилгексановой кислоты, 8-оксо-8-фенилоктановой кислоты, 8-(2,5-дихлорфенил)-8-оксооктановой кислоты, функционализированных кетоэфиров или альдегидов, модифицированных аминокислот, N-[8-(2-гидроксибензоил)аминооктановой кислоты, N-[8-(2-гидроксибензоил)аминодекановой кислоты, N-(5-хлорсалицилоил)-8-аминокаприловой кислоты, N-[4-(4-хлор-2-гидроксибензоил)аминобутановой кислоты, 2-этилгексил-2-гидроксибензоата, 5-циклогексил-5-оксовалериановой кислоты, 6-циклогексил-6-оксогексановой кислоты, 7-циклогексил-7-оксогептановой кислоты, 8-циклогексил-8-оксооктановой кислоты, 4-циклопентил-4-оксомасляной кислоты, 5-циклопентил-5-оксовалериановой кислоты, 6-циклопентил-6-оксогексановой кислоты, 7-циклопентил-7-оксогептановой кислоты, 8-циклопентил-8-оксооктановой кислоты, 4-циклобутил-4-оксомасляной кислоты, 5-циклобутил-5-оксовалериановой кислоты, 6-циклобутил-6-оксогексановой кислоты, 7-циклобутил-7-оксогептановой кислоты, 8-циклобутил-8-оксооктановой кислоты, 4-циклопропил-4-оксомасляной кислоты, 5-циклопропил-5-оксовалериановой кислоты, 6-циклопропил-6-оксогексановой кислоты, 7-циклопропил-7-оксогептановой кислоты, 8-циклопропил-8-оксооктановой кислоты, 8-[(3-метилциклогексил)окси]октановой кислоты, 7-[(3-метилциклогексил)окси]гептановой кислоты, 6-[(3-метилциклогексил)окси]гексановой кислоты, 5-[(3-метилциклогексил)окси]пентановой кислоты, 4-[(3-метилциклогексил)окси]бутановой кислоты, 3-[(3-метилциклогексил)окси]пропановой кислоты, октисалата, дикетопиперазинов, сапонина, ацилкарнитинов, алканоилхолинов, тауродигидрофузидата, сульфоксидов, оксазолидинонов, пирролидонов, спиртов или алканолов, бензойной кислоты, гликолей, поверхностно-активных веществ, терпенов, функционально эффективных солей любого из вышеперечисленных, производных любого из вышеперечисленных или любых их сочетаний.
22. Способ по п. 21, в котором средство, усиливающее внутриклеточное проникновение, выбирают из группы, состоящей из 6-оксо-6-фенилгексановой кислоты, 8-циклогексил-8-оксооктановой кислоты, N-[8-(2-гидроксибензоил)аминооктановой кислоты, функционально эффективной соли любого из вышеперечисленных, производного любого из вышеперечисленных или любого их сочетания.
23. Способ по п. 22, в котором терапевтическое средство представляет собой цисплатин или другое средство на основе платины, и в котором средство, усиливающее внутриклеточное проникновение, представляет собой 6-оксо-6-фенилгексановую кислоту, N-[8-(2-гидроксибензоил)аминооктановую кислоту или ее соль, или ее производное, и другое средство на основе платины представляет собой сатраплатин, пикоплатин, недаплатин, триплатин, карбоплатин или оксаплатин.
24. Способ по п. 1, дополнительно включающий: введение терапевтически эффективного количества иммунотерапевтического средства.
25. Способ по п. 24, в котором иммунотерапевтическое средство представляет собой противораковую вакцину, гормон, эпитоп, цитокин, опухолевый антиген, стимулятор CD4-клеток, агонист NKT клеток, ингибитор белка программируемой клеточной гибели-1, ингибитор CTLA-4 или адъювант.
26. Способ по п. 25, в котором иммунотерапевтическое средство представляет собой β-ManCer, содержащий фрагмент сфингозина и фрагмент жирной кислоты, содержащий линейную или разветвленную, насыщенную или ненасыщенную алифатическую углеводородную группу, имеющую от примерно 8 до примерно 49 атомов углерода.
27. Способ лечения рака у субъекта, который нуждается в лечении, включающий: интратуморальное введение водного состава, содержащего терапевтически эффективное количество терапевтического средства и средства, усиливающего внутриклеточное проникновение, при этом состав вводят в дозе от примерно 0,1 мл на см3 объема опухоли до 1 мл на см3 объема опухоли и он содержит 0,5 мг/мл цисплатина и 10 мг/мл N-(8[2-гидроксибензоил]амино)октановой кислоты или 0,1 мг/мл винбластина и 10 мг/мл N-(8[2-гидроксибензоил]амино)октановой кислоты.
28. Способ по п. 1, в котором терапевтическое средство и средство, усиливающее внутриклеточное проникновение, стимулируют иммунный ответ против рака.
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Publication number | Priority date | Publication date | Assignee | Title |
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RU2778812C2 (ru) * | 2017-09-13 | 2022-08-25 | Абивакс | Abx196 для применения при лечении рака мочевого пузыря |
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