SG10202011046RA - Method of treating cancer - Google Patents

Method of treating cancer

Info

Publication number
SG10202011046RA
SG10202011046RA SG10202011046RA SG10202011046RA SG10202011046RA SG 10202011046R A SG10202011046R A SG 10202011046RA SG 10202011046R A SG10202011046R A SG 10202011046RA SG 10202011046R A SG10202011046R A SG 10202011046RA SG 10202011046R A SG10202011046R A SG 10202011046RA
Authority
SG
Singapore
Prior art keywords
treating cancer
cancer
treating
Prior art date
Application number
SG10202011046RA
Inventor
Lewis Bender
Original Assignee
Intensity Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50341876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10202011046R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intensity Therapeutics Inc filed Critical Intensity Therapeutics Inc
Publication of SG10202011046RA publication Critical patent/SG10202011046RA/en

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SG10202011046RA 2012-09-21 2013-09-15 Method of treating cancer SG10202011046RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703890P 2012-09-21 2012-09-21
US201261707733P 2012-09-28 2012-09-28
US201361779509P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
SG10202011046RA true SG10202011046RA (en) 2020-12-30

Family

ID=50341876

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202011046RA SG10202011046RA (en) 2012-09-21 2013-09-15 Method of treating cancer
SG11201501850VA SG11201501850VA (en) 2012-09-21 2013-09-15 Method of treating cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201501850VA SG11201501850VA (en) 2012-09-21 2013-09-15 Method of treating cancer

Country Status (19)

Country Link
US (5) US9351997B2 (en)
EP (1) EP2897620B1 (en)
JP (2) JP6374388B2 (en)
KR (1) KR101839864B1 (en)
CN (1) CN104884065B (en)
AU (2) AU2013318338B2 (en)
BR (1) BR112015006176B1 (en)
CA (1) CA2884707C (en)
CL (1) CL2015000699A1 (en)
CY (1) CY1123258T1 (en)
DK (1) DK2897620T3 (en)
ES (1) ES2813340T3 (en)
IL (1) IL237791B (en)
MX (1) MX2015003643A (en)
PL (1) PL2897620T3 (en)
PT (1) PT2897620T (en)
RU (1) RU2657749C2 (en)
SG (2) SG10202011046RA (en)
WO (1) WO2014046983A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2897620T3 (en) 2012-09-21 2020-08-17 Intensity Therapeutics Inc CANCER TREATMENT PROCEDURE
BR112015009134A2 (en) * 2012-10-25 2017-07-04 Glaxosmithkline Llc combination
JP6720075B2 (en) * 2013-05-31 2020-07-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Combination therapy for cancer
ES2808076T3 (en) 2013-06-21 2021-02-25 Gemvax & Kael Co Ltd Regulator of hormonal secretion, composition that contains it and procedure to control hormonal secretion through its use
RS59480B1 (en) 2013-12-12 2019-12-31 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
JP6367950B2 (en) 2013-12-17 2018-08-01 ジェムバックス アンド カエル カンパニー，リミティド Prostate cancer treatment composition
ES2954860T3 (en) * 2014-10-24 2023-11-27 Launx Biomedical Co Ltd Use of azelnidipine in the preparation of a medicinal composition for the treatment of cancers
US20160166679A1 (en) * 2014-12-12 2016-06-16 Purdue Research Foundation Method of treatment using folate conjugates and tyrosine kinase inhibitors
KR102413243B1 (en) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 Peptides for treating ophthalmopathy and the Composition Comprising the Same
CN105983097B (en) * 2015-01-28 2021-06-08 华中科技大学同济医学院附属协和医院 Anti-tumor preparation and preparation method thereof
WO2016137162A1 (en) * 2015-02-27 2016-09-01 주식회사 젬백스앤카엘 Peptide for preventing hearing loss, and composition comprising same
JP2018512396A (en) * 2015-03-09 2018-05-17 キングス・カレッジ・ロンドン Combination therapy with RAR alpha agonists to enhance TH1 response
WO2016162229A1 (en) 2015-04-10 2016-10-13 Capsugel Belgium N.V. Abiraterone acetate lipid formulations
RU2750163C2 (en) 2015-06-04 2021-06-22 Крититек, Инк. Taxan particles and their application
EP3310379B1 (en) * 2015-06-18 2019-11-06 Vaximm AG Vegfr-2 targeting dna vaccine for combination therapy
ES2886946T3 (en) 2015-07-02 2021-12-21 Gemvax & Kael Co Ltd Peptide with antiviral effect and composition containing it
WO2017019526A2 (en) * 2015-07-24 2017-02-02 Kimberly-Clark Worldwide, Inc. Methods for better delivery of active agents to tumors
CN105241872B (en) * 2015-09-01 2018-09-25 中国科学院深圳先进技术研究院 Detect the method and agents useful for same of half lactadherin -1 in blood
EP3388084A4 (en) * 2015-12-07 2019-11-13 Kyoto University Pd-1 signal inhibitor combination therapy
TWI733719B (en) * 2015-12-07 2021-07-21 美商河谷控股Ｉｐ有限責任公司 Improved compositions and methods for viral delivery of neoepitopes and uses thereof
RU2737934C2 (en) 2016-04-04 2020-12-07 Крититек, Инк. Methods of treating solid tumors
US10898540B2 (en) 2016-04-07 2021-01-26 Gem Vax & KAEL Co., Ltd. Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same
MX2018012913A (en) 2016-04-22 2019-01-30 Receptor Life Sciences Inc Fast-acting plant-based medicinal compounds and nutritional supplements.
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
WO2017214974A1 (en) * 2016-06-17 2017-12-21 Johnpro Biotech Inc. Method for treating tumor
MX2019002947A (en) * 2016-09-14 2019-07-22 Abivax Combinations including abx196 for the treatment of cancer.
EA201892396A1 (en) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. QUICKLY PRODUCTIVE PLANT MEDICINES AND BIOLOGICALLY ACTIVE ADDITIVES
CA3063436A1 (en) 2017-06-14 2018-12-20 Crititech, Inc. Methods for treating lung disorders
WO2019042247A1 (en) * 2017-08-28 2019-03-07 江苏恒瑞医药股份有限公司 Pharmaceutical composition of cyp17 inhibitor and preparation method therefor
CN107475181B (en) * 2017-09-30 2021-03-02 中国农业大学 In-vitro maturation culture solution for immature oocyte and application thereof
CN111278436A (en) 2017-10-03 2020-06-12 克里蒂泰克公司 Local delivery of anti-tumor particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
JP2020536858A (en) * 2017-10-05 2020-12-17 レセプター・ホールディングス・インコーポレイテッド Herbal composition with improved bioavailability
CA3078549A1 (en) * 2017-10-05 2019-04-11 Receptor Holdings, Inc. Rapid onset and extended action plant-based and synthetic cannabinoid formulations
CN112804936A (en) * 2018-06-14 2021-05-14 梅塔博洛米克斯股份有限公司 Metabolic signatures for prediction, diagnosis and prognosis of various diseases including cancer
RU2704020C1 (en) * 2018-06-22 2019-10-23 Общество с ограниченной ответственностью "ПеритонТрит" Combination of dehydroxymethyl epoxyquinomycin (dhmeq) and cytostatics for treating ovarian cancer
BR112021005104A2 (en) 2018-10-16 2021-06-08 US Nano Food & Drug INC intratumoral injection formulation
WO2020204605A1 (en) * 2019-04-01 2020-10-08 한양대학교 산학협력단 Cp2c-targeting peptide-based anticancer agent
AU2021257738A1 (en) 2020-04-13 2022-05-19 US Nano Food & Drug INC Basic chemotherapeutic intratumour injection formulation
CR20230308A (en) * 2020-12-11 2023-09-08 Civi Biopharma Inc ORAL DELIVERY OF ANTISENSE CONJUGATES TARGETTING PCSK9
WO2022197743A1 (en) * 2021-03-16 2022-09-22 Multiple Energy Technologies Llc Bioceramic compositions for cancer recovery
US11541134B1 (en) 2021-08-02 2023-01-03 Rayzebio, Inc. Stabilized compositions of radionuclides and uses thereof

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35748E (en) * 1984-05-29 1998-03-17 Matrix Pharmaceutical, Inc. Treatments employing drug containing matrices for introduction into cellular lesion areas
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
US4983396A (en) 1985-12-06 1991-01-08 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
US4764381A (en) 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US5118845A (en) 1986-09-29 1992-06-02 Whitby Research, Inc. Penetration enhancer for transdermal delivery of systemic agents
US4783450A (en) 1987-04-13 1988-11-08 Warner-Lambert Company Use of commercial lecithin as skin penetration enhancer
US5045553A (en) 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
US4978332A (en) * 1987-09-28 1990-12-18 Matrix Pharmaceutical, Inc. Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas
US5162115A (en) * 1989-05-09 1992-11-10 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
US5219877A (en) 1989-09-25 1993-06-15 Bristol-Myers Squibb Company Lauryl alcohol as skin penetration enhancer for topical imidazole agents
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6344213B1 (en) 1996-03-29 2002-02-05 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5451410A (en) 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
WO1992020369A1 (en) * 1991-05-14 1992-11-26 Dana Farber Cancer Institute Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents
US5627270A (en) 1991-12-13 1997-05-06 Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US5693769A (en) 1991-12-13 1997-12-02 Transcell Technologies, Inc. Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US6916489B2 (en) 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
EP1025840B1 (en) 1993-04-22 2005-06-29 Emisphere Technologies, Inc. Oral drug compositions
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US20010003001A1 (en) 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5908635A (en) 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (en) 1995-03-31 1998-05-19 Emisphere Tech Inc Compound composition dosage unit form methods for administering a biologically active agent for preparing a composition for administering an active agent and for preparing a compound and pharmacological composition
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5601839A (en) 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5756122A (en) 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
IL115199A (en) 1995-09-07 2005-05-17 Opperbas Holding Bv Composition comprising a polynucleic acid molecule in a liposome and method using said composition
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
JP2000507215A (en) * 1996-02-21 2000-06-13 マトリックス ファーマシューティカルズ インコーポレイテッド Use of cell membrane penetrants in the treatment of cell proliferative disorders
DE69727384T2 (en) 1996-05-24 2004-11-04 IC-VEC Ltd. POLYCATONIC STERIN DERIVATIVES FOR TRANSFECTION
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5773647A (en) 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5776888A (en) 1997-02-07 1998-07-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051561A (en) 1997-02-07 2000-04-18 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US20030229040A1 (en) 1997-03-21 2003-12-11 Georgetown University Cationic liposomal delivery system and therapeutic use thereof
US6126965A (en) 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE69841002D1 (en) 1997-05-14 2009-09-03 Univ British Columbia Highly effective encapsulation of nucleic acids in lipid vesicles
US6110492A (en) * 1997-05-28 2000-08-29 Jenner Biotherapies, Inc. Immunogenic compositions
AU731909B2 (en) 1997-07-01 2001-04-05 Isis Pharmaceuticals, Inc. Compositions and methods for the delivery of oligonucleotides via the alimentary canal
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
CA2301166A1 (en) 1997-07-24 1999-02-04 Yuan-Peng Zhang Liposomal compositions for the delivery of nucleic acid catalysts
US6225118B1 (en) 1997-10-01 2001-05-01 Biocure Limited Multicellular in vitro assay of angiogenesis
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JPH11246439A (en) 1998-03-02 1999-09-14 Hisamitsu Pharmaceut Co Inc Transmucosal absorption accelerator
ATE295347T1 (en) 1998-07-27 2005-05-15 Emisphere Tech Inc SUBSTANCES AND COMPOSITIONS FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES
US7648695B2 (en) 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
DE69931930T2 (en) 1998-08-07 2006-10-05 Emisphere Technologies, Inc. COMPOUNDS AND COMPOSITIONS FOR THE ADMINISTRATION OF ACTIVE SUBSTANCES
US6991798B1 (en) 1998-08-07 2006-01-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1131344B1 (en) 1998-11-19 2005-08-03 ELAN CORPORATION, Plc Retro-inversion peptides that target gastro-intestinal tract transport receptors and use thereof
CN1338924A (en) 1999-01-08 2002-03-06 艾米斯菲尔技术有限公司 Polymeric delivery agents and delivery agent compounds
US7084279B1 (en) 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
EP1811036B8 (en) 1999-02-22 2011-09-21 Georgetown University Antibody fragment-targeted immunoliposomes for systemic gene delivery
JP4637365B2 (en) 1999-02-26 2011-02-23 エミスフェアー・テクノロジーズ・インク Compounds and compositions for active agent delivery
US6537585B1 (en) * 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
CA2369591C (en) 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
US7112337B2 (en) 1999-04-23 2006-09-26 Alza Corporation Liposome composition for delivery of nucleic acid
US6780846B1 (en) 1999-09-27 2004-08-24 Elan Corporation, Plc Membrane translocating peptide drug delivery system
US20030181367A1 (en) 1999-09-27 2003-09-25 O'mahony Daniel Conjugates of membrane translocating agents and pharmaceutically active agents
US6200599B1 (en) 1999-10-07 2001-03-13 The Regents Of The University Of California Ortho ester lipids
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US20050037086A1 (en) 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
AU2274201A (en) 1999-12-16 2001-06-25 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP4879433B2 (en) 2000-01-13 2012-02-22 エミスフェアー・テクノロジーズ・インク Compounds and compositions for delivering active agents
US20020012998A1 (en) 2000-03-29 2002-01-31 Igor Gonda Cationic liposomes
US20030072794A1 (en) 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
BR0112311A (en) 2000-06-29 2003-09-02 Emisphere Tech Inc Active agent release compounds and compositions, unit dosage form, method for preparing said compositions and their use
WO2003057650A2 (en) 2002-01-09 2003-07-17 Emisphere Technologies, Inc. Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate
JP4707931B2 (en) 2000-08-18 2011-06-22 エミスフェアー・テクノロジーズ・インク Active agent delivery compounds and compositions
US7138546B2 (en) 2000-08-18 2006-11-21 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE60138468D1 (en) 2000-09-06 2009-06-04 Emisphere Tech Inc CYANOPHENOXY CARBOXYLIC ACIDS AND COMPOSITIONS FOR THE RELEASE OF ACTIVE SUBSTANCES
US7495030B2 (en) 2000-09-06 2009-02-24 Emisphere Technologies, Inc. (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
US6673574B2 (en) 2000-11-30 2004-01-06 Unigene Laboratories Inc. Oral delivery of peptides using enzyme-cleavable membrane translocators
TR200401292T3 (en) 2000-12-01 2004-07-21 Max@Planck@Gesellschaft�Zur�F�Rderung�Der�Wissenschaften the rnaágirişimineáyoláaçanáküçükárnaámolekül
EP2308479A3 (en) 2001-03-01 2012-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2002076427A2 (en) 2001-03-26 2002-10-03 Thomas Jefferson University Ph sensitive liposomal drug delivery
WO2002076428A1 (en) 2001-03-26 2002-10-03 Alza Corporation Liposome composition for improved intracellular delivery of a therapeutic agent
US20030026831A1 (en) 2001-04-20 2003-02-06 Aparna Lakkaraju Anionic liposomes for delivery of bioactive agents
US20030203865A1 (en) 2001-04-30 2003-10-30 Pierrot Harvie Lipid-comprising drug delivery complexes and methods for their production
EP1392272B1 (en) 2001-05-11 2014-08-06 Merrion Research III Limited Permeation enhancers
WO2003003999A2 (en) 2001-07-02 2003-01-16 Elan Corporation, Plc. Delivery of a bioactive material
US6916789B2 (en) 2001-07-02 2005-07-12 Merrion Research I Limited Peyer's patch and/or M-cell targeting ligands
BR0103887C1 (en) * 2001-07-17 2005-11-08 Univ Minas Gerais Immunogenic compositions containing biodegradable microspheres encapsulating antigens, gene vectors and adjuvants
US7063860B2 (en) 2001-08-13 2006-06-20 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
DE10152145A1 (en) 2001-10-19 2003-05-22 Novosom Ag Stabilization of liposomes and emulsions
CN1596248B (en) 2001-11-13 2012-05-09 艾米斯菲尔技术有限公司 Phenoxy amine compounds and compositions for delivering active agents
WO2003047633A2 (en) 2001-12-04 2003-06-12 Nanospectra Biosciences, Inc. Treatment of angiogenesis disorders using targeted nanoparticles
WO2003057190A1 (en) 2001-12-31 2003-07-17 Elan Pharmaceuticals, Inc. Efficient nucleic acid encapsulation into medium sized liposomes
EP1478341A4 (en) 2002-01-09 2009-05-20 Transave Inc Efficient nucleic acid encapsulation into medium sized liposomes
DE10207177A1 (en) 2002-02-19 2003-09-04 Novosom Ag Optionally cationic lipids
US7037520B2 (en) 2002-03-22 2006-05-02 Baylor College Of Medicine Reversible masking of liposomal complexes for targeted delivery
US20030198664A1 (en) 2002-03-29 2003-10-23 Sullivan Sean Michael Lipid mediated screening of drug candidates for identification of active compounds
AU2003237686A1 (en) 2002-05-24 2003-12-12 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. Rna interference mediating small rna molecules
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US20070071677A1 (en) * 2003-03-10 2007-03-29 Park Yoon J Non-toxic membrane-translocating peptides
WO2004081196A2 (en) * 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
EP1742958B1 (en) 2004-03-15 2017-05-17 City of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
CA2563335A1 (en) 2004-04-16 2005-12-08 Emisphere Technologies, Inc. 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents
JP4903690B2 (en) * 2004-05-06 2012-03-28 エミスフェアー・テクノロジーズ・インク Crystalline polymorph of monosodium N- [8- (2-hydroxybenzoyl) amino] caprylate
CA2566161C (en) * 2004-05-14 2013-10-01 Emisphere Technologies, Inc. Aryl ketone compounds and compositions for delivering active agents
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
WO2006085987A2 (en) 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
CA2591515C (en) * 2004-12-29 2010-06-22 Emisphere Technologies, Inc. Pharmaceutical formulations of gallium salts
US7820628B2 (en) 2005-02-22 2010-10-26 University Of Massachusetts Medical School Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding
US20070049557A1 (en) 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
AR058053A1 (en) 2005-09-19 2008-01-23 Toole Doris C O CRYSTALLINE FORMS POLYMORPHICS OF ACID DIODIUM SALT N- (5-CHLOROSALICILOIL) -8- AMINOCAPRILICO
CA2633063A1 (en) * 2005-12-16 2007-06-21 Diatos Cell penetrating peptide conjugates for delivering of nucleic acids intocells
US20070196277A1 (en) 2006-01-20 2007-08-23 Levin Victor A Compositions and Methods for the Direct Therapy of Tumors
AU2008210329B2 (en) * 2007-01-31 2013-11-28 Rutgers, The State University Of New Jersey Controlled release of actives in skin
EP2262837A4 (en) * 2008-03-12 2011-04-06 Merck Sharp & Dohme Pd-1 binding proteins
US20090275654A1 (en) 2008-04-30 2009-11-05 Genta Incorporated Pharmaceutical Gallium Compositions and Methods
US20110077297A1 (en) * 2008-05-30 2011-03-31 Novelix Pharmaceuticals, Inc. Compositions and methods for treatment of inflammation and hyperkeratotic lesions
PT2402032T (en) * 2009-02-27 2019-11-19 Toray Industries Immunogenic composition
WO2011084061A1 (en) * 2010-01-08 2011-07-14 Universitair Medisch Centrum St. Radboud Cpp (cell penetrating peptide) and its uses
CN101928234B (en) 2010-01-15 2012-12-12 北京欧凯纳斯科技有限公司 6/7-(hetero)aryl-N-hydroxyl hexanamide/heptamide compounds and method for preparing same
US8835613B2 (en) * 2010-03-12 2014-09-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-mannosylceramide and stimulation of NKT cell anti-tumor immunity
KR101843385B1 (en) * 2010-08-26 2018-03-29 도레이 카부시키가이샤 Immunogenic composition
CA2880236C (en) 2012-07-27 2022-09-13 Antonius Martinus Gustave Bunt Efflux inhibitor compositions and methods of treatment using the same
DK2897620T3 (en) 2012-09-21 2020-08-17 Intensity Therapeutics Inc CANCER TREATMENT PROCEDURE

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