RU2007126814A - Способ получения фторорганических соединений в спиртовых растворителях - Google Patents
Способ получения фторорганических соединений в спиртовых растворителях Download PDFInfo
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- RU2007126814A RU2007126814A RU2007126814/04A RU2007126814A RU2007126814A RU 2007126814 A RU2007126814 A RU 2007126814A RU 2007126814/04 A RU2007126814/04 A RU 2007126814/04A RU 2007126814 A RU2007126814 A RU 2007126814A RU 2007126814 A RU2007126814 A RU 2007126814A
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- fluoride
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- butanol
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Claims (22)
2. Способ по п. 1, в котором фторид содержит фтор-18 или фтор-19.
3. Способ по п. 1, в котором R1 представляет атом водорода или С1-С18 алкил; R2 является атомом водорода или С1-С18 алкилом; и R3 представляет атом водорода или С1-С18 алкил.
4. Способ по п. 1, в котором R1 представляет метил или этил; R2 представляет метил или этил; и R3 является метилом или этилом.
5. Способ по п. 1, в котором спирт формулы 1 выбран из группы, состоящей из первичных спиртов, таких как метанол, этанол, н-пропанол, н-бутанол, амиловый спирт, н-гексиловый спирт, н-гептанол или н-октанол; вторичных спиртов, таких как изопропанол, изобутанол, изоамиловый спирт и 3-пентанол; и третичных спиртов, таких как трет-бутанол, трет-амиловый спирт, 2,3-диметил-2-бутанол, 2-(трифторметил)-2-пропанол, 3-метил-3-пентанол, 3-этил-3-пентанол, 2-метил-2-пентанол, 2,3-диметил-3-пентанол, 2,4-диметил-2-пентанол, 2-метил-2-гексанол, 2-циклопропил-2-пропанол, 2-циклопропил-2-бутанол, 2-циклопропил-3-метил-2-бутанол, 1-метилциклопентанол, 1-этилциклопентанол, 1-пропилциклопентанол, 1-метилциклогексанол, 1-этилциклогексанол и 1-метилциклогептанол.
6. Способ по п.1, в котором спирт формулы 1 выбран из группы, состоящей из трет-бутанола, трет-амилового спирта, 2,3-диметил-2-бутанола и 2-(трифторметил)-2-пропанола.
7. Способ по п.1 или 2, в котором фторид представляет фторид цезия или фторид тетраалкиламмония, и спирт выбран из группы, состоящей из трет-бутанола, трет-амилового спирта, 2,3-диметил-2-бутанола и 2-(трифторметил)-2-пропанола.
8. Способ по пп.1 и 2, в котором фторид предпочтительно выбран из группы, состоящей из фторидов щелочных металлов, включающих щелочные металлы, выбранные из группы, состоящей из лития, натрия, калия, рубидия и цезия; фторидов щелочно-земельных металлов, включающих щелочно-земельные металлы, выбранные из группы, состоящей из магния, кальция, стронция и бария; и фторида аммония.
9. Способ по п.8, в котором фторид аммония предпочтительно выбран из группы, состоящей из фторидов четвертичного аммония, включая фторид тетрабутиламмония и фторид бензилтриметиламмония; фторидов третичного аммония, включая фторид триэтиламмония и фторид трибутиламмония; фторидов вторичного аммония, включая фторид дибутиламмония и фторид дигексиламмония; и фторидов первичного аммония, включая фторид бутиламмония и фторид гексиламмония.
10. Способ по пп.1 и 2, в котором фторид представляет фторид цезия или фторид тетраалкиламмония.
11. Способ по п.10, в котором фторид цезия или фторид тетраалкиламмония адсорбирован на подложках, выбранных из группы, состоящей из целита, молекулярного сита, оксида алюминия и силикагеля.
12. Способ по пп.1 и 2, в котором количество фторида составляет 1,0-10 экв к алкилгалогениду или алкилсульфонату в случае фтора-19, и количество фторида является следовым количеством [18F]фторида к алкилгалогениду или алкилсульфонату в случае фтора-18.
13. Способ по п.12, в котором используют 1 пкг-100 нг [18F]фторида на 1 мг алкилгалогенида или алкилсульфоната соли фторида в случае фтора-18.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20040106553 | 2004-12-15 | ||
KR10-2004-0106553 | 2004-12-15 | ||
KR1020050084411A KR100789847B1 (ko) | 2004-12-15 | 2005-09-10 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
KR10-2005-0084411 | 2005-09-10 |
Publications (2)
Publication Number | Publication Date |
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RU2007126814A true RU2007126814A (ru) | 2009-01-27 |
RU2357947C2 RU2357947C2 (ru) | 2009-06-10 |
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Application Number | Title | Priority Date | Filing Date |
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RU2007126814/04A RU2357947C2 (ru) | 2004-12-15 | 2005-12-09 | Способ получения [18f]фторорганических соединений в спиртовых растворителях |
Country Status (14)
Country | Link |
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US (2) | US7847092B2 (ru) |
EP (1) | EP1824805B1 (ru) |
JP (1) | JP4981683B2 (ru) |
KR (1) | KR100789847B1 (ru) |
CN (1) | CN101094824B (ru) |
AU (1) | AU2005317370B8 (ru) |
CA (1) | CA2590014C (ru) |
HK (1) | HK1108683A1 (ru) |
IL (1) | IL183548A (ru) |
NO (1) | NO345018B1 (ru) |
NZ (1) | NZ555538A (ru) |
RU (1) | RU2357947C2 (ru) |
UA (1) | UA83324C2 (ru) |
WO (1) | WO2006065038A1 (ru) |
Families Citing this family (42)
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US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
SI2213652T1 (sl) * | 2004-12-17 | 2015-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov |
EP2017359A3 (en) | 2007-06-11 | 2009-08-05 | Trasis S.A. | Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step |
KR101009712B1 (ko) * | 2007-02-22 | 2011-01-19 | 재단법인 아산사회복지재단 | 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법 |
EP2062630A1 (en) | 2007-11-20 | 2009-05-27 | Trasis S.A. | Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium by the use of strong organic bases |
CA2967254C (en) | 2008-02-29 | 2019-03-26 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including imaging cancer |
KR100891700B1 (ko) * | 2008-04-22 | 2009-04-03 | 한국원자력연구원 | 방사선을 이용한 플루오로알킬 화합물의 제조방법 |
GB0812923D0 (en) * | 2008-07-15 | 2008-08-20 | Isis Innovation | Preparation of flourine-labelled compounds |
DK2419096T3 (da) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre |
JP2012532164A (ja) | 2009-07-10 | 2012-12-13 | バイエル ファーマ アクチエンゲゼルシャフト | 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用 |
EP2821395B1 (en) * | 2009-08-07 | 2017-06-21 | Wako Pure Chemical Industries, Ltd. | Novel disulfonic acid ester as an additive for an electrolyte for a lithium secondary battery |
GB0922023D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Preparation of n-monofluoroalkyl compounds |
CN113058046A (zh) * | 2010-02-08 | 2021-07-02 | 兰休斯医疗成像公司 | 用于合成显像剂和其中间体的方法和装置 |
JP6245981B2 (ja) | 2010-04-08 | 2017-12-13 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドSiemens Medical Solutions USA,Inc. | 含水有機溶媒中の18f−標識化トレーサーの合成 |
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TWI504414B (zh) * | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產F-18標記之Aβ配位體之方法 |
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-
2005
- 2005-09-10 KR KR1020050084411A patent/KR100789847B1/ko active IP Right Grant
- 2005-12-09 RU RU2007126814/04A patent/RU2357947C2/ru active
- 2005-12-09 WO PCT/KR2005/004228 patent/WO2006065038A1/en active Application Filing
- 2005-12-09 AU AU2005317370A patent/AU2005317370B8/en not_active Ceased
- 2005-12-09 NZ NZ555538A patent/NZ555538A/en unknown
- 2005-12-09 UA UAA200707903A patent/UA83324C2/ru unknown
- 2005-12-09 US US11/720,393 patent/US7847092B2/en active Active
- 2005-12-09 CN CN2005800431302A patent/CN101094824B/zh active Active
- 2005-12-09 EP EP05821819.9A patent/EP1824805B1/en active Active
- 2005-12-09 JP JP2007546555A patent/JP4981683B2/ja active Active
- 2005-12-09 CA CA2590014A patent/CA2590014C/en active Active
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2007
- 2007-05-21 NO NO20072570A patent/NO345018B1/no unknown
- 2007-05-30 IL IL183548A patent/IL183548A/en active IP Right Grant
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2008
- 2008-03-08 HK HK08102723.2A patent/HK1108683A1/xx unknown
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2009
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Also Published As
Publication number | Publication date |
---|---|
KR20060067808A (ko) | 2006-06-20 |
RU2357947C2 (ru) | 2009-06-10 |
CN101094824B (zh) | 2011-07-27 |
KR100789847B1 (ko) | 2007-12-28 |
NO345018B1 (no) | 2020-08-24 |
UA83324C2 (ru) | 2008-06-25 |
AU2005317370B2 (en) | 2006-06-22 |
CN101094824A (zh) | 2007-12-26 |
IL183548A0 (en) | 2007-09-20 |
CA2590014C (en) | 2010-05-25 |
EP1824805B1 (en) | 2020-02-12 |
CA2590014A1 (en) | 2006-06-22 |
US20100113763A1 (en) | 2010-05-06 |
US7847092B2 (en) | 2010-12-07 |
EP1824805A1 (en) | 2007-08-29 |
AU2005317370A1 (en) | 2007-06-14 |
HK1108683A1 (en) | 2008-05-16 |
NZ555538A (en) | 2010-10-29 |
WO2006065038A1 (en) | 2006-06-22 |
US20080171863A1 (en) | 2008-07-17 |
JP2008524205A (ja) | 2008-07-10 |
AU2005317370B8 (en) | 2008-12-11 |
IL183548A (en) | 2011-04-28 |
JP4981683B2 (ja) | 2012-07-25 |
NO20072570L (no) | 2007-09-04 |
EP1824805A4 (en) | 2010-01-06 |
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