RU2007126814A - Способ получения фторорганических соединений в спиртовых растворителях - Google Patents
Способ получения фторорганических соединений в спиртовых растворителях Download PDFInfo
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- RU2007126814A RU2007126814A RU2007126814/04A RU2007126814A RU2007126814A RU 2007126814 A RU2007126814 A RU 2007126814A RU 2007126814/04 A RU2007126814/04 A RU 2007126814/04A RU 2007126814 A RU2007126814 A RU 2007126814A RU 2007126814 A RU2007126814 A RU 2007126814A
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- fluoride
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- butanol
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
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- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Claims (22)
2. Способ по п. 1, в котором фторид содержит фтор-18 или фтор-19.
3. Способ по п. 1, в котором R1 представляет атом водорода или С1-С18 алкил; R2 является атомом водорода или С1-С18 алкилом; и R3 представляет атом водорода или С1-С18 алкил.
4. Способ по п. 1, в котором R1 представляет метил или этил; R2 представляет метил или этил; и R3 является метилом или этилом.
5. Способ по п. 1, в котором спирт формулы 1 выбран из группы, состоящей из первичных спиртов, таких как метанол, этанол, н-пропанол, н-бутанол, амиловый спирт, н-гексиловый спирт, н-гептанол или н-октанол; вторичных спиртов, таких как изопропанол, изобутанол, изоамиловый спирт и 3-пентанол; и третичных спиртов, таких как трет-бутанол, трет-амиловый спирт, 2,3-диметил-2-бутанол, 2-(трифторметил)-2-пропанол, 3-метил-3-пентанол, 3-этил-3-пентанол, 2-метил-2-пентанол, 2,3-диметил-3-пентанол, 2,4-диметил-2-пентанол, 2-метил-2-гексанол, 2-циклопропил-2-пропанол, 2-циклопропил-2-бутанол, 2-циклопропил-3-метил-2-бутанол, 1-метилциклопентанол, 1-этилциклопентанол, 1-пропилциклопентанол, 1-метилциклогексанол, 1-этилциклогексанол и 1-метилциклогептанол.
6. Способ по п.1, в котором спирт формулы 1 выбран из группы, состоящей из трет-бутанола, трет-амилового спирта, 2,3-диметил-2-бутанола и 2-(трифторметил)-2-пропанола.
7. Способ по п.1 или 2, в котором фторид представляет фторид цезия или фторид тетраалкиламмония, и спирт выбран из группы, состоящей из трет-бутанола, трет-амилового спирта, 2,3-диметил-2-бутанола и 2-(трифторметил)-2-пропанола.
8. Способ по пп.1 и 2, в котором фторид предпочтительно выбран из группы, состоящей из фторидов щелочных металлов, включающих щелочные металлы, выбранные из группы, состоящей из лития, натрия, калия, рубидия и цезия; фторидов щелочно-земельных металлов, включающих щелочно-земельные металлы, выбранные из группы, состоящей из магния, кальция, стронция и бария; и фторида аммония.
9. Способ по п.8, в котором фторид аммония предпочтительно выбран из группы, состоящей из фторидов четвертичного аммония, включая фторид тетрабутиламмония и фторид бензилтриметиламмония; фторидов третичного аммония, включая фторид триэтиламмония и фторид трибутиламмония; фторидов вторичного аммония, включая фторид дибутиламмония и фторид дигексиламмония; и фторидов первичного аммония, включая фторид бутиламмония и фторид гексиламмония.
10. Способ по пп.1 и 2, в котором фторид представляет фторид цезия или фторид тетраалкиламмония.
11. Способ по п.10, в котором фторид цезия или фторид тетраалкиламмония адсорбирован на подложках, выбранных из группы, состоящей из целита, молекулярного сита, оксида алюминия и силикагеля.
12. Способ по пп.1 и 2, в котором количество фторида составляет 1,0-10 экв к алкилгалогениду или алкилсульфонату в случае фтора-19, и количество фторида является следовым количеством [18F]фторида к алкилгалогениду или алкилсульфонату в случае фтора-18.
13. Способ по п.12, в котором используют 1 пкг-100 нг [18F]фторида на 1 мг алкилгалогенида или алкилсульфоната соли фторида в случае фтора-18.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20040106553 | 2004-12-15 | ||
KR10-2004-0106553 | 2004-12-15 | ||
KR1020050084411A KR100789847B1 (ko) | 2004-12-15 | 2005-09-10 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
KR10-2005-0084411 | 2005-09-10 |
Publications (2)
Publication Number | Publication Date |
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RU2007126814A true RU2007126814A (ru) | 2009-01-27 |
RU2357947C2 RU2357947C2 (ru) | 2009-06-10 |
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Application Number | Title | Priority Date | Filing Date |
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RU2007126814/04A RU2357947C2 (ru) | 2004-12-15 | 2005-12-09 | Способ получения [18f]фторорганических соединений в спиртовых растворителях |
Country Status (14)
Country | Link |
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US (2) | US7847092B2 (ru) |
EP (1) | EP1824805B1 (ru) |
JP (1) | JP4981683B2 (ru) |
KR (1) | KR100789847B1 (ru) |
CN (1) | CN101094824B (ru) |
AU (1) | AU2005317370B8 (ru) |
CA (1) | CA2590014C (ru) |
HK (1) | HK1108683A1 (ru) |
IL (1) | IL183548A (ru) |
NO (1) | NO345018B1 (ru) |
NZ (1) | NZ555538A (ru) |
RU (1) | RU2357947C2 (ru) |
UA (1) | UA83324C2 (ru) |
WO (1) | WO2006065038A1 (ru) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
SI2213652T1 (sl) * | 2004-12-17 | 2015-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov |
EP2017359A3 (en) | 2007-06-11 | 2009-08-05 | Trasis S.A. | Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step |
KR101009712B1 (ko) * | 2007-02-22 | 2011-01-19 | 재단법인 아산사회복지재단 | 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법 |
EP2062630A1 (en) | 2007-11-20 | 2009-05-27 | Trasis S.A. | Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium by the use of strong organic bases |
CA2967254C (en) | 2008-02-29 | 2019-03-26 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including imaging cancer |
KR100891700B1 (ko) * | 2008-04-22 | 2009-04-03 | 한국원자력연구원 | 방사선을 이용한 플루오로알킬 화합물의 제조방법 |
GB0812923D0 (en) * | 2008-07-15 | 2008-08-20 | Isis Innovation | Preparation of flourine-labelled compounds |
EP2419096B1 (en) | 2009-04-15 | 2019-11-13 | Lantheus Medical Imaging, Inc. | Stabilization of radiopharmaceutical compositions using ascorbic acid |
WO2011003591A1 (en) * | 2009-07-10 | 2011-01-13 | Bayer Schering Pharma Aktiengesellschaft | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers |
EP2821395B1 (en) * | 2009-08-07 | 2017-06-21 | Wako Pure Chemical Industries, Ltd. | Novel disulfonic acid ester as an additive for an electrolyte for a lithium secondary battery |
GB0922023D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Preparation of n-monofluoroalkyl compounds |
JP6092628B2 (ja) | 2010-02-08 | 2017-03-08 | ランセウス メディカル イメージング, インコーポレイテッド | 造影剤およびその中間体を合成するための方法および装置 |
BR112012030935B1 (pt) * | 2010-04-06 | 2020-11-17 | Life Molecular Imaging Sa | método para a produção de ligantes de beta-amiloide marcados com f-18 |
KR101430422B1 (ko) | 2010-04-08 | 2014-08-14 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | 함수 유기 용매에서 18f-표지된 트레이서의 합성 |
EP2569071B1 (en) | 2010-05-10 | 2015-07-08 | Technische Universität München | Method for the direct elution of reactive [18f]fluoride from an anion exchange resin in an organic medium suitable for radiolabelling without any evaporation step by the use of alkalimetal and alkaline earth metal cryptates |
JP2013532136A (ja) * | 2010-06-04 | 2013-08-15 | ピラマル イメージング ソシエテ アノニム | F−18標識アミロイド・ベータ・リガンドの製造方法 |
KR20130088118A (ko) * | 2010-06-04 | 2013-08-07 | 피라말 이미징 에스에이 | F-18 표지된 아밀로이드 베타 리간드의 제조 방법 |
TWI504414B (zh) * | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產F-18標記之Aβ配位體之方法 |
DE102010036356A1 (de) * | 2010-07-12 | 2012-01-12 | Abx Advanced Biochemical Compounds Gmbh | Vorrichtung zur Synthese radioaktiv markierter Verbindungen |
US20140039074A1 (en) | 2010-09-09 | 2014-02-06 | Piramal Imaging Sa | Method for rapid preparation of suitable [18f]fluoride for nucleophilic [18f]fluorination |
KR101269588B1 (ko) * | 2010-10-13 | 2013-06-05 | (주)퓨쳐켐 | Fp―cit 전구체로서의 아제티디늄 염, 이의 선택적 제조방법 및 fp―cit의 합성 |
KR101351878B1 (ko) | 2010-12-14 | 2014-02-06 | 서강대학교산학협력단 | 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용 |
WO2012157900A2 (ko) * | 2011-05-13 | 2012-11-22 | 서강대학교산학협력단 | 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법 |
GB201117786D0 (en) * | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Eluent vial |
GB201117785D0 (en) | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Improved radiosynthesis method |
IN2014MN00875A (ru) | 2011-10-19 | 2015-04-17 | Piramal Imaging Sa | |
GB201120586D0 (en) * | 2011-11-30 | 2012-01-11 | Ge Healthcare Ltd | Solid phase extraction neutralisation |
KR101326000B1 (ko) * | 2012-01-30 | 2013-11-07 | 재단법인 아산사회복지재단 | 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법 |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
CN104109111B (zh) * | 2013-04-22 | 2019-02-12 | 江苏豪森药业集团有限公司 | 托西酸贝格列汀及其中间体的制备方法 |
AU2014326601B2 (en) * | 2013-09-25 | 2018-01-18 | SpecGx LLC | Preparation of radioiodinated 3-fluoropropyl-nor-beta-CIT |
KR20160078965A (ko) * | 2013-10-31 | 2016-07-05 | 사빅 글로벌 테크놀러지스 비.브이. | 축방향으로 불소화된―프탈로시아닌들의 제조방법 및 광전지 기기들에서 그 용도 |
CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
US10525151B2 (en) | 2014-11-07 | 2020-01-07 | The Asan Foundation | Method for preparing organic fluoride-aliphatic compound and method for purifying organic fluoride-aliphatic compound |
BE1023674B1 (fr) * | 2015-12-11 | 2017-06-12 | Out And Out Chemistry Sprl | Actionneur rotatif a positionnement multiple controle par un fluide |
KR20170076933A (ko) * | 2015-12-24 | 2017-07-05 | (의료)길의료재단 | 불소-18 동위원소를 함유하는 방사성 화합물의 제조방법 |
WO2018089491A1 (en) * | 2016-11-08 | 2018-05-17 | The Regents Of The University Of California | Methods for multi-dose synthesis of [f-18]fddnp for clinical settings |
KR101842989B1 (ko) * | 2018-01-02 | 2018-03-28 | (주)퓨쳐켐 | 카보닐기를 갖는 알코올 용매를 이용한 플루오르화 화합물의 제조방법 |
KR102063498B1 (ko) | 2019-06-25 | 2020-01-08 | (주)퓨쳐켐 | 불포화 탄화수소기를 갖는 알코올 용매를 이용한 플루오로 화합물의 제조방법 |
CN115160308A (zh) * | 2022-08-08 | 2022-10-11 | 江苏华益科技有限公司 | 一种18f-fpcit的自动化合成方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE710129C (de) * | 1936-12-24 | 1941-09-04 | Dr Alfred Gnuechtel | Verfahren zur Herstellung fluorierter aliphatischer Kohlenwasserstoffe |
US2980670A (en) * | 1959-11-02 | 1961-04-18 | Pfizer & Co C | Fluorinated corticosteroids |
EP0355774B1 (en) * | 1988-08-26 | 1995-04-26 | Asahi Glass Company Ltd. | Nucleus-fluorinated aromatic carboxylates and processes for their production |
JPH05301844A (ja) * | 1992-04-22 | 1993-11-16 | Idemitsu Kosan Co Ltd | 2−フルオロイソ酪酸エステルの製造方法 |
WO1995009844A1 (en) * | 1993-10-04 | 1995-04-13 | Board Of Regents, The University Of Texas System | Rapid synthesis and use of 18f-fluoromisonidazole and analogs |
AU759945B2 (en) * | 1998-08-20 | 2003-05-01 | Regents Of The University Of California, The | Methods for labeling beta-amyloid plaques and neurofibrillary tangles |
DE10104250A1 (de) * | 2001-01-31 | 2002-08-14 | Deutsches Krebsforsch | Markierungsfähige Verbindungen zur einfachen Synthese von 3'-[18F]Fluor-3'-deoxythymidin und Verfahren zu deren Herstellung |
GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
KR100441153B1 (ko) * | 2002-03-14 | 2004-07-21 | 주식회사 씨트리 | 유기 불소화합물의 제조방법 |
US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
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2005
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- 2005-12-09 US US11/720,393 patent/US7847092B2/en active Active
- 2005-12-09 CN CN2005800431302A patent/CN101094824B/zh active Active
- 2005-12-09 EP EP05821819.9A patent/EP1824805B1/en active Active
- 2005-12-09 WO PCT/KR2005/004228 patent/WO2006065038A1/en active Application Filing
- 2005-12-09 JP JP2007546555A patent/JP4981683B2/ja active Active
- 2005-12-09 UA UAA200707903A patent/UA83324C2/ru unknown
- 2005-12-09 NZ NZ555538A patent/NZ555538A/en unknown
- 2005-12-09 RU RU2007126814/04A patent/RU2357947C2/ru active
- 2005-12-09 AU AU2005317370A patent/AU2005317370B8/en active Active
- 2005-12-09 CA CA2590014A patent/CA2590014C/en active Active
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2007
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2008
- 2008-03-08 HK HK08102723.2A patent/HK1108683A1/xx unknown
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JP2008524205A (ja) | 2008-07-10 |
HK1108683A1 (en) | 2008-05-16 |
NO20072570L (no) | 2007-09-04 |
US20100113763A1 (en) | 2010-05-06 |
AU2005317370B2 (en) | 2006-06-22 |
KR20060067808A (ko) | 2006-06-20 |
JP4981683B2 (ja) | 2012-07-25 |
CN101094824A (zh) | 2007-12-26 |
IL183548A0 (en) | 2007-09-20 |
AU2005317370A1 (en) | 2007-06-14 |
EP1824805B1 (en) | 2020-02-12 |
CA2590014A1 (en) | 2006-06-22 |
US7847092B2 (en) | 2010-12-07 |
EP1824805A1 (en) | 2007-08-29 |
UA83324C2 (ru) | 2008-06-25 |
CA2590014C (en) | 2010-05-25 |
WO2006065038A1 (en) | 2006-06-22 |
NZ555538A (en) | 2010-10-29 |
KR100789847B1 (ko) | 2007-12-28 |
IL183548A (en) | 2011-04-28 |
AU2005317370B8 (en) | 2008-12-11 |
NO345018B1 (no) | 2020-08-24 |
RU2357947C2 (ru) | 2009-06-10 |
US20080171863A1 (en) | 2008-07-17 |
CN101094824B (zh) | 2011-07-27 |
EP1824805A4 (en) | 2010-01-06 |
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