RU2004125177A - Композиции, содержащие 25-гидроксивитамин d3 - Google Patents
Композиции, содержащие 25-гидроксивитамин d3 Download PDFInfo
- Publication number
- RU2004125177A RU2004125177A RU2004125177/13A RU2004125177A RU2004125177A RU 2004125177 A RU2004125177 A RU 2004125177A RU 2004125177/13 A RU2004125177/13 A RU 2004125177/13A RU 2004125177 A RU2004125177 A RU 2004125177A RU 2004125177 A RU2004125177 A RU 2004125177A
- Authority
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- Russia
- Prior art keywords
- oil
- composition
- oil composition
- vitamin
- hydroxyvitamin
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract 29
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 title claims abstract 11
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 title abstract 4
- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 title abstract 4
- 239000000839 emulsion Substances 0.000 claims abstract 3
- 239000003921 oil Substances 0.000 claims 29
- 235000019198 oils Nutrition 0.000 claims 29
- 239000008393 encapsulating agent Substances 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 229910052738 indium Inorganic materials 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 2
- 229930003270 Vitamin B Natural products 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 239000003240 coconut oil Substances 0.000 claims 2
- 235000019864 coconut oil Nutrition 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 claims 2
- 239000003346 palm kernel oil Substances 0.000 claims 2
- 235000019865 palm kernel oil Nutrition 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019156 vitamin B Nutrition 0.000 claims 2
- 239000011720 vitamin B Substances 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 1
- 235000019743 Choline chloride Nutrition 0.000 claims 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims 1
- 239000005751 Copper oxide Substances 0.000 claims 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 1
- 229960002079 calcium pantothenate Drugs 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 1
- 229960003178 choline chloride Drugs 0.000 claims 1
- 239000004927 clay Substances 0.000 claims 1
- 229910000361 cobalt sulfate Inorganic materials 0.000 claims 1
- 229940044175 cobalt sulfate Drugs 0.000 claims 1
- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 claims 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 1
- 229910000431 copper oxide Inorganic materials 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 239000010903 husk Substances 0.000 claims 1
- 229910000358 iron sulfate Inorganic materials 0.000 claims 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0053—Compositions other than spreads
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0056—Spread compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Edible Oils And Fats (AREA)
- General Preparation And Processing Of Foods (AREA)
Claims (10)
1. Масляная композиция, содержащая масло и 25-гидроксивитамин D3, в которой 25-гидроксивитамин D3 растворен в масле в количестве от примерно 12,5 до 50 мас.% в пересчете на общую массу масляной композиции.
2. Масляная композиция по п.1, дополнительно содержащая антиоксидант.
3. Эмульсия, содержащая масляную композицию, которая включает масло и 25-гидроксивитамин D3, где 25-гидроксивитамин D3 растворен в масле в количестве от примерно 12,5 до 50 мас.% в пересчете на общую массу масляной композиции; и водную композицию.
4. Эмульсия по п.3, в которой масляная композиция диспергирована в виде капель в водной композиции.
5. Микроинкапсулированное масло, содержащее масляную композицию, которая включает 25-гидроксивитамин D3, который растворен в масле в количестве от примерно 12,5 до 50 мас.% в пересчете на общую массу масляной композиции; и инкапсулирующий агент, который инкапсулирует масляную композицию.
6. Микроинкапсулированная масляная композиция по п.5, в которой инкапсулирующий агент представляет собой крахмал и масло представляет собой кокосовое масло или пальмоядровое масло.
7. Композиция кормового премикса, содержащая Микроинкапсулированное масло, включающее масляную композицию, которая содержит 25-гидроксивитамин D3, растворенный в масле в количестве от примерно 12,5 до 50 мас.% в пересчете на общую массу масляной композиции; и инкапсулирующий агент, который инкапсулирует масляную композицию; и по меньшей мере одну пищевую добавку.
8. Композиция кормового премикса по п.7, в которой инкапсулирующий агент представляет собой крахмал и масло представляет собой кокосовое масло или пальмоядровое масло.
9. Композиция кормового премикса по п.7, в которой пищевые добавки представляют собой витамин D3, витамин А, витамин Е, витамин В12, витамин В3, ниацин, пантотенат кальция, витамин К3, фолиевую кислоту, витамин В6, витамин В1, глину и рисовую шелуху; или витамин Е, витамин В3, каротиноиды, холинхлорид, оксид марганца, оксид цинка, сульфат железа, оксид меди, сульфат кобальта и пшеничный кормовой продукт.
10. Способ получения кормового премикса, заключающийся в том, что получают микроинкапсулированную масляную композицию, которая содержит масляную композицию, включающую 25-гидроксивитамин D3, который растворен в масле в количестве от примерно 12,5 до 50 мас.% в пересчете на общую массу масляной композиции; и инкапсулирующий агент, который инкапсулирует масляную композицию; и смешивают композицию микроинкапсулированного масла с по меньшей мере одной пищевой добавкой.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35030102P | 2002-01-15 | 2002-01-15 | |
| US60/350,301 | 2002-01-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004125177A true RU2004125177A (ru) | 2005-06-10 |
| RU2322083C2 RU2322083C2 (ru) | 2008-04-20 |
Family
ID=23376109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004125177/13A RU2322083C2 (ru) | 2002-01-15 | 2003-01-14 | Композиции, содержащие 25-гидроксивитамин d3 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7632518B2 (ru) |
| EP (1) | EP1465637B1 (ru) |
| JP (1) | JP4456871B2 (ru) |
| CN (1) | CN1278690C (ru) |
| AT (1) | ATE493990T1 (ru) |
| AU (2) | AU2003235715B2 (ru) |
| BR (1) | BR0306874A (ru) |
| CA (1) | CA2471745C (ru) |
| DE (1) | DE60335605D1 (ru) |
| DK (1) | DK1465637T3 (ru) |
| ES (1) | ES2359138T3 (ru) |
| MX (1) | MXPA04006432A (ru) |
| NZ (1) | NZ533745A (ru) |
| PT (1) | PT1465637E (ru) |
| RU (1) | RU2322083C2 (ru) |
| WO (1) | WO2003059358A1 (ru) |
| ZA (1) | ZA200404969B (ru) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082398A1 (en) * | 2003-03-17 | 2004-09-30 | Dsm Ip Assets B.V. | Fat soluble vitamin feed supplements and processes for delivering same |
| EP1662896B1 (en) * | 2003-09-22 | 2012-10-24 | DSM IP Assets B.V. | Vitamin containing pet food compositions |
| PL1516540T3 (pl) * | 2003-09-22 | 2013-02-28 | Dsm Ip Assets Bv | Zastosowanie związków z grupy witaminy D |
| JP4921794B2 (ja) * | 2004-02-06 | 2012-04-25 | 中外製薬株式会社 | Ｅｄ−７１製剤 |
| US20050186307A1 (en) * | 2004-02-20 | 2005-08-25 | Axelrod Glen S. | Pet food with enhanced nutritional value |
| US20060029641A1 (en) * | 2004-08-05 | 2006-02-09 | Keller Nathan I | Calcium and magnesium nutritional supplement |
| WO2006133828A1 (en) * | 2005-06-17 | 2006-12-21 | Dsm Ip Assets B.V. | Novel use 25-hydroxycholecalciferol in combination with uv-b screening agents |
| WO2007020042A1 (en) * | 2005-08-18 | 2007-02-22 | Dsm Ip Assets B.V. | Use of 25-hydroxy vitamin d3 to improve male animal fertility |
| ES2352101T3 (es) * | 2005-11-25 | 2011-02-15 | Dsm Ip Assets B.V. | Uso de 25-hidroxi-vitamina a d3, para mejorar la vitalidad de los animales. |
| EP1962614B1 (en) * | 2005-11-25 | 2010-08-04 | DSM IP Assets B.V. | Use of 25-hydroxy vitamin d3 to improve vitality of animals |
| HUE029572T2 (en) | 2006-02-03 | 2017-03-28 | Opko Renal Llc | Treatment of Vitamin D Insufficiency and Deficiency with 25-Hydroxy-D2 and 25-Hydroxy-D3 |
| US8329677B2 (en) | 2006-06-21 | 2012-12-11 | Cytochroma, Inc. | Method of treating and preventing secondary hyperparathyroidism |
| US20100087405A1 (en) * | 2006-09-14 | 2010-04-08 | Robert Elliott | Food supplementation composition containing one or more vitamin d3 compounds and one or more magnesium salts |
| WO2008134523A1 (en) | 2007-04-25 | 2008-11-06 | Proventiv Therapeutics, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
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2003
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- 2003-01-14 BR BR0306874-9A patent/BR0306874A/pt active IP Right Grant
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- 2003-01-14 JP JP2003559520A patent/JP4456871B2/ja not_active Expired - Lifetime
- 2003-01-14 CA CA2471745A patent/CA2471745C/en not_active Expired - Lifetime
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- 2003-01-14 DE DE60335605T patent/DE60335605D1/de not_active Expired - Lifetime
- 2003-01-14 PT PT03729446T patent/PT1465637E/pt unknown
- 2003-01-14 RU RU2004125177/13A patent/RU2322083C2/ru active
- 2003-01-14 DK DK03729446.9T patent/DK1465637T3/da active
- 2003-01-14 EP EP03729446A patent/EP1465637B1/en not_active Expired - Lifetime
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| EP1465637A1 (en) | 2004-10-13 |
| ES2359138T3 (es) | 2011-05-18 |
| CN1615139A (zh) | 2005-05-11 |
| WO2003059358A1 (en) | 2003-07-24 |
| US20030170324A1 (en) | 2003-09-11 |
| AU2003235715B2 (en) | 2008-04-10 |
| JP4456871B2 (ja) | 2010-04-28 |
| US7632518B2 (en) | 2009-12-15 |
| US20100112162A1 (en) | 2010-05-06 |
| NZ533745A (en) | 2005-03-24 |
| DE60335605D1 (de) | 2011-02-17 |
| US8088410B2 (en) | 2012-01-03 |
| CA2471745C (en) | 2010-08-10 |
| DK1465637T3 (da) | 2011-04-18 |
| AU2003235715A1 (en) | 2003-07-30 |
| CN1278690C (zh) | 2006-10-11 |
| ZA200404969B (en) | 2005-12-28 |
| MXPA04006432A (es) | 2004-10-04 |
| BR0306874A (pt) | 2004-11-03 |
| ATE493990T1 (de) | 2011-01-15 |
| PT1465637E (pt) | 2011-04-04 |
| AU2008203063A1 (en) | 2008-07-31 |
| EP1465637B1 (en) | 2011-01-05 |
| JP2005519894A (ja) | 2005-07-07 |
| RU2322083C2 (ru) | 2008-04-20 |
| CA2471745A1 (en) | 2003-07-24 |
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