RS53420B - Kombinacije makrocikličnog jedinjenja hinoksalina koje je inhibitor hcv ns3 proteaze sa drugim hcv sredstvima - Google Patents

Kombinacije makrocikličnog jedinjenja hinoksalina koje je inhibitor hcv ns3 proteaze sa drugim hcv sredstvima

Info

Publication number
RS53420B
RS53420B RS20140375A RSP20140375A RS53420B RS 53420 B RS53420 B RS 53420B RS 20140375 A RS20140375 A RS 20140375A RS P20140375 A RSP20140375 A RS P20140375A RS 53420 B RS53420 B RS 53420B
Authority
RS
Serbia
Prior art keywords
hcv
compound
methyl
combination
compounds
Prior art date
Application number
RS20140375A
Other languages
English (en)
Serbian (sr)
Inventor
Steven Harper
Vincenzo Summa
Nigel J. Liverton
John A. Mccauley
Original Assignee
Msd Italia S.R.L.
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS53420(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Msd Italia S.R.L., Merck Sharp & Dohme Corp. filed Critical Msd Italia S.R.L.
Publication of RS53420B publication Critical patent/RS53420B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RS20140375A 2008-07-22 2009-07-17 Kombinacije makrocikličnog jedinjenja hinoksalina koje je inhibitor hcv ns3 proteaze sa drugim hcv sredstvima RS53420B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22

Publications (1)

Publication Number Publication Date
RS53420B true RS53420B (sr) 2014-12-31

Family

ID=41130248

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20140375A RS53420B (sr) 2008-07-22 2009-07-17 Kombinacije makrocikličnog jedinjenja hinoksalina koje je inhibitor hcv ns3 proteaze sa drugim hcv sredstvima
RS20120463A RS52534B (sr) 2008-07-22 2009-07-17 Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20120463A RS52534B (sr) 2008-07-22 2009-07-17 Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze

Country Status (43)

Country Link
US (2) US7973040B2 (enExample)
EP (3) EP2540349B1 (enExample)
JP (1) JP4920797B2 (enExample)
KR (1) KR101313675B1 (enExample)
CN (1) CN102159285B (enExample)
AR (1) AR072588A1 (enExample)
AU (1) AU2009274190B2 (enExample)
BR (1) BRPI0916235B8 (enExample)
CA (1) CA2731177C (enExample)
CL (1) CL2011000145A1 (enExample)
CO (1) CO6351757A2 (enExample)
CR (1) CR20110089A (enExample)
CY (3) CY1113752T1 (enExample)
DK (2) DK2540350T3 (enExample)
DO (1) DOP2011000023A (enExample)
EA (1) EA019327B1 (enExample)
EC (1) ECSP11010777A (enExample)
ES (2) ES2491090T3 (enExample)
FR (1) FR16C1027I2 (enExample)
HN (1) HN2011000209A (enExample)
HR (2) HRP20120866T1 (enExample)
HU (1) HUS1700001I1 (enExample)
IL (1) IL210580A (enExample)
LT (1) LTC2310095I2 (enExample)
LU (1) LUC00002I2 (enExample)
MA (1) MA32502B1 (enExample)
ME (2) ME02132B (enExample)
MX (1) MX2011000826A (enExample)
MY (1) MY152070A (enExample)
NI (1) NI201100023A (enExample)
NL (1) NL300857I2 (enExample)
NO (1) NO2017004I2 (enExample)
NZ (1) NZ590638A (enExample)
PE (1) PE20110212A1 (enExample)
PL (2) PL2310095T3 (enExample)
PT (2) PT2540350E (enExample)
RS (2) RS53420B (enExample)
SI (2) SI2540350T1 (enExample)
SV (1) SV2011003813A (enExample)
TN (1) TN2011000014A1 (enExample)
TW (1) TWI441638B (enExample)
UA (1) UA100436C2 (enExample)
WO (1) WO2010011566A1 (enExample)

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