CL2011000145A1 - Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv. - Google Patents

Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv.

Info

Publication number
CL2011000145A1
CL2011000145A1 CL2011000145A CL2011000145A CL2011000145A1 CL 2011000145 A1 CL2011000145 A1 CL 2011000145A1 CL 2011000145 A CL2011000145 A CL 2011000145A CL 2011000145 A CL2011000145 A CL 2011000145A CL 2011000145 A1 CL2011000145 A1 CL 2011000145A1
Authority
CL
Chile
Prior art keywords
hcv
hepatitis
virus
prevention
treatment
Prior art date
Application number
CL2011000145A
Other languages
English (en)
Inventor
Steven Summa Vincenzo Liverton Nigel J Maccauley John A Harper
Original Assignee
Merck Sharp & Dohme
Msd Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011000145(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Msd Italia Srl filed Critical Merck Sharp & Dohme
Publication of CL2011000145A1 publication Critical patent/CL2011000145A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO MACROCÍCLICO CON LA FORMULA (I) Y A SU USO COMO INHIBIDOR DE LA PROTEASA NS3 DEL VIRUS DE LA HEPATITIS C (HCV), COMPOSICIÓN FARMACÉUTICA QUE LO COMPRENDE Y EN EL TRATAMIENTO O PREVENCIÓN DE INFECCIONES POR HCV
CL2011000145A 2008-07-22 2011-01-21 Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv. CL2011000145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22

Publications (1)

Publication Number Publication Date
CL2011000145A1 true CL2011000145A1 (es) 2011-05-06

Family

ID=41130248

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000145A CL2011000145A1 (es) 2008-07-22 2011-01-21 Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv.

Country Status (44)

Country Link
US (2) US7973040B2 (es)
EP (3) EP2540349B1 (es)
JP (1) JP4920797B2 (es)
KR (1) KR101313675B1 (es)
CN (1) CN102159285B (es)
AR (1) AR072588A1 (es)
AU (1) AU2009274190B2 (es)
BR (1) BRPI0916235B8 (es)
CA (1) CA2731177C (es)
CL (1) CL2011000145A1 (es)
CO (1) CO6351757A2 (es)
CR (1) CR20110089A (es)
CY (3) CY1113752T1 (es)
DK (2) DK2310095T3 (es)
DO (1) DOP2011000023A (es)
EA (1) EA019327B1 (es)
EC (1) ECSP11010777A (es)
ES (2) ES2392611T3 (es)
FR (1) FR16C1027I2 (es)
HK (2) HK1173402A1 (es)
HN (1) HN2011000209A (es)
HR (2) HRP20120866T1 (es)
HU (1) HUS1700001I1 (es)
IL (1) IL210580A (es)
LT (1) LTC2310095I2 (es)
LU (1) LUC00002I2 (es)
MA (1) MA32502B1 (es)
ME (2) ME02024B (es)
MX (1) MX2011000826A (es)
MY (1) MY152070A (es)
NI (1) NI201100023A (es)
NL (1) NL300857I2 (es)
NO (1) NO2017004I2 (es)
NZ (1) NZ590638A (es)
PE (1) PE20110212A1 (es)
PL (2) PL2540350T3 (es)
PT (2) PT2540350E (es)
RS (2) RS53420B (es)
SI (2) SI2540350T1 (es)
SV (1) SV2011003813A (es)
TN (1) TN2011000014A1 (es)
TW (1) TWI441638B (es)
UA (1) UA100436C2 (es)
WO (1) WO2010011566A1 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
AU2007318165B2 (en) * 2006-10-27 2011-11-17 Msd Italia S.R.L. HCV NS3 protease inhibitors
EP2271345B1 (en) * 2008-04-28 2015-05-20 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
CA2731177C (en) 2008-07-22 2013-10-29 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors
US20190127365A1 (en) 2017-11-01 2019-05-02 Merck Sharp & Dohme Corp. Inhibitors of hepatitis c virus replication
CN102427729B (zh) 2009-03-27 2014-09-03 默沙东公司 丙型肝炎病毒复制的抑制剂
CA2761650C (en) * 2009-05-13 2015-05-26 Enanta Pharmaceuticals, Inc. Macrocyclic compounds as hepatitis c virus inhibitors
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
RS53856B1 (en) * 2009-06-11 2015-08-31 Abbvie Bahamas Ltd. HETEROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
EP2459582B1 (en) 2009-07-30 2015-05-27 Merck Sharp & Dohme Corp. Hepatitis c virus ns3 protease inhibitors
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
AU2011305695B2 (en) * 2010-09-21 2016-05-19 Enanta Pharmaceuticals, Inc. Macrocyclic proline derived HCV serine protease inhibitors
US9254292B2 (en) 2010-09-29 2016-02-09 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
KR20130120469A (ko) * 2010-09-29 2013-11-04 머크 샤프 앤드 돔 코포레이션 폴리시클릭 헤테로사이클 유도체 및 바이러스성 질환의 치료를 위한 그의 사용 방법
JP6034802B2 (ja) 2010-12-14 2016-11-30 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 大環状ラクタムの調製のための方法および中間体
WO2012122716A1 (en) 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US9249204B2 (en) * 2011-06-01 2016-02-02 Jyant Technologies, Inc. Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
AU2012299218A1 (en) 2011-08-19 2014-02-20 Merck Sharp & Dohme Corp. Crystal forms of a HCV protease inhibitor
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
GB2506086A (en) 2011-10-21 2014-03-19 Abbvie Inc Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon
ES2527544T1 (es) 2011-10-21 2015-01-26 Abbvie Inc. Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC
RU2014122154A (ru) * 2011-10-31 2015-12-10 Мерк Шарп И Доум Корп. Композиции, пригодные для лечения вирусных заболеваний
EP2780026B1 (en) * 2011-11-15 2019-10-23 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
MA37992B1 (fr) 2012-10-19 2018-09-28 Bristol Myers Squibb Co Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c.
EP2914613B1 (en) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014110687A1 (en) 2013-01-16 2014-07-24 Merck Sharp & Dohme Corp. Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US9617310B2 (en) * 2013-03-15 2017-04-11 Gilead Sciences, Inc. Inhibitors of hepatitis C virus
WO2015057611A1 (en) * 2013-10-18 2015-04-23 Merck Sharp & Dohme Corp. Methods and intermediates for preparing macrolactams
WO2015095430A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Methods and intermediates for the preparation of macrolactams
CN111320610B (zh) 2013-12-23 2023-06-06 吉利德科学公司 大环hcv ns3抑制三肽的合成
JP6568541B2 (ja) * 2013-12-23 2019-08-28 ギリアド ファーマセット エルエルシー 大環状ｈｃｖ ｎｓ３阻害トリペプチドの結晶形態
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2015119924A2 (en) * 2014-02-05 2015-08-13 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
WO2015119919A1 (en) * 2014-02-05 2015-08-13 Merck Sharp & Dohme Corp. Pharmaceutical composition of selective hcv ns3/4a inhibitors
JP2017518319A (ja) * 2014-06-06 2017-07-06 アッヴィ・インコーポレイテッド 結晶形
WO2017023716A1 (en) * 2015-08-04 2017-02-09 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
US20180228826A1 (en) * 2015-08-04 2018-08-16 Merck Sharp & Dohme Corp. Fixed-dose combinations of antiviral compounds
CN105753806B (zh) * 2016-02-02 2018-06-05 厦门市蔚嘉化学科技有限公司 一种利托那韦中间体的非均相合成方法及其应用
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
CN112661775A (zh) * 2016-05-16 2021-04-16 深圳市塔吉瑞生物医药有限公司 一种取代的大环喹喔啉化合物及其药物组合物及应用
RU2650610C1 (ru) 2017-02-28 2018-04-16 Васильевич Иващенко Александр Противовирусная композиция и способ ее применения
US20220227806A1 (en) * 2019-06-07 2022-07-21 University Of Massachusetts Hepatitis c virus ns3/4a protease inhibitors
CN111057045A (zh) * 2019-12-18 2020-04-24 安徽红杉生物医药科技有限公司 Hcv ns3/4a蛋白酶抑制剂中间体及其合成方法、应用
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US6128582A (en) 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
IL134232A0 (en) 1997-08-11 2001-04-30 Boehringer Ingelheim Ca Ltd Hepatitis c inhibitor peptides
HUP0100100A3 (en) 1997-08-11 2001-12-28 Boehringer Ingelheim Ca Ltd Hepatitis c inhibitor peptide analogues, pharmaceutical compositions comprising thereof and their use
IT1299134B1 (it) 1998-02-02 2000-02-29 Angeletti P Ist Richerche Bio Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
CA2322008C (en) 1998-02-25 2011-06-28 Emory University 2'-fluoronucleosides
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
EP1066247B1 (en) 1998-03-31 2006-11-22 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
EP1106626B1 (en) 1998-08-10 2003-05-28 Hokkaido Electric Power Company, Incorporated Process for the preparation of regular glycopeptides
AU764479B2 (en) 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
US6395763B1 (en) 1999-06-25 2002-05-28 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of IMPDH
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6455508B1 (en) 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
EA200200778A1 (ru) * 2000-02-18 2003-06-26 Шайре Байокем Инк. СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИИ ГЕПАТИТА С В ОРГАНИЗМЕ ХОЗЯИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ПРОТИВ ФЛАВИВИРУСА, СОЕДИНЕНИЕ ФОРМУЛЫ Ib - АКТИВНЫЙ АГЕНТ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИИ ГЕПАТИТА С ИЛИ ФЛАВИВИРУСА (ВАРИАНТЫ)
JP4748911B2 (ja) 2000-04-05 2011-08-17 シェーリング コーポレイション Ｎ−環状ｐ２部分を含むｃ型肝炎ウイルスの大環状ｎｓ３‐セリンプロテアーゼ阻害剤
WO2001077091A2 (en) 2000-04-05 2001-10-18 Tularik Inc. Ns5b hcv polymerase inhibitors
DE60136620D1 (de) 2000-04-13 2009-01-02 Pharmasset Inc 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1736478B1 (en) 2000-05-26 2015-07-22 IDENIX Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CA2419485C (en) 2000-08-10 2007-10-30 The Trustees Of Boston College Recyclable metathesis catalysts
US6955174B2 (en) * 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
US6809101B2 (en) 2000-09-01 2004-10-26 Shionogi & Co., Ltd. Compounds having anti-hepatitis C virus effect
CN101862345B (zh) 2000-10-18 2014-06-04 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
AU2002236591B2 (en) 2000-12-12 2005-07-14 Schering Corporation Diaryl peptides as NS3-serine protease inhibitors of hepatits C virus
AU2002230763A1 (en) 2000-12-13 2008-01-03 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
EP1366055A2 (en) 2000-12-15 2003-12-03 Pharmasset Limited Antiviral agents for treatment of flaviviridae infections
WO2002051425A1 (fr) 2000-12-26 2002-07-04 Mitsubishi Pharma Corporation Remedes pour l'hepatite c
WO2002057287A2 (en) 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
CA2456966A1 (en) 2001-08-14 2003-02-27 Tel Aviv University Future Technology Development Lp Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
US20040006002A1 (en) 2001-09-28 2004-01-08 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
EP1465862A1 (en) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
GB0201179D0 (en) 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
CA2369711A1 (en) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
WO2003068244A1 (en) 2002-02-13 2003-08-21 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
DE60202603T2 (de) 2002-03-28 2005-12-29 Council Of Scientific And Industrial Research 8-(c-beta-d-glucopyranosyl)-7,3',4'-trihydroxyflavone, verfahren zur isolation aus pterocarpus marsupium und pharmazeutische zusammensetzung zur behandlung von diabetes
EP1501850A2 (en) 2002-05-06 2005-02-02 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US20070004669A1 (en) 2002-06-21 2007-01-04 Carroll Steven S Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
EP1572945A2 (en) 2002-06-27 2005-09-14 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2003263412A1 (en) 2002-06-28 2004-01-19 Centre National De La Recherche Scientifique (Cnrs) 1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
PT1523489E (pt) 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
AP2005003213A0 (en) 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
US20060264389A1 (en) 2002-07-16 2006-11-23 Balkrishen Bhat Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
CN1671727A (zh) 2002-07-25 2005-09-21 麦克洛基克斯生物技术有限公司 抗病毒7－脱氮－d－核苷及其用途
IL166640A0 (en) 2002-08-01 2006-01-15 Pharmasset Ltd Compounds with the bicyclo Ä4.2.1Ü nonane system for the treatment of flaviviridae infections
JP2006505537A (ja) 2002-09-30 2006-02-16 ジェネラブス テクノロジーズ，インコーポレイテッド Ｃ型肝炎ウイルスの感染を治療するためのヌクレオシド誘導体
UA79834C2 (en) 2002-11-01 2007-07-25 Viropharma Inc Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
US20040254159A1 (en) * 2003-02-27 2004-12-16 Hasvold Lisa A. Heterocyclic kinase inhibitors
CA2516016C (en) * 2003-03-05 2012-05-29 Boehringer Ingelheim International Gmbh Hepatitis c inhibiting compounds
KR20050108420A (ko) 2003-04-02 2005-11-16 베링거 인겔하임 인터내셔날 게엠베하 Ｃ형 간염 바이러스 프로테아제 억제제를 위한 약제학적조성물
GB0307891D0 (en) 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
ES2320771T3 (es) * 2003-04-16 2009-05-28 Bristol-Myers Squibb Company Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c.
US7176208B2 (en) * 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
BRPI0410456B8 (pt) * 2003-05-21 2021-05-25 Boehringer Ingelheim Int compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação
CN100503628C (zh) 2003-05-30 2009-06-24 法莫赛特股份有限公司 修饰的氟化核苷类似物
GB0313250D0 (en) 2003-06-09 2003-07-16 Angeletti P Ist Richerche Bio Therapeutic agents
ES2276311T3 (es) 2003-06-19 2007-06-16 F. Hoffmann-La Roche Ag Proceso para praderar derivados de 4' -azidonucleosido.
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
GB0321003D0 (en) 2003-09-09 2003-10-08 Angeletti P Ist Richerche Bio Compounds, compositions and uses
GB0323845D0 (en) 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP1730167B1 (en) 2004-01-21 2011-01-12 Boehringer Ingelheim International GmbH Macrocyclic peptides active against the hepatitis c virus
PL1719773T3 (pl) 2004-02-24 2009-08-31 Japan Tobacco Inc Skondensowane związki heterotetracykliczne i ich zastosowanie jako inhibitora polimerazy HCV
GB0413087D0 (en) 2004-06-11 2004-07-14 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0416396D0 (en) 2004-07-22 2004-08-25 Angeletti P Ist Richerche Bio Therapeutic agents
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
GB0419850D0 (en) 2004-09-07 2004-10-13 Angeletti P Ist Richerche Bio Therapeutic agents
CA2585113A1 (en) 2004-10-26 2006-05-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Tetracyclic indole derivatives as antiviral agents
WO2006102087A2 (en) 2005-03-22 2006-09-28 Merck & Co., Inc. Hcv protease substrates
CA2606195C (en) 2005-05-02 2015-03-31 Merck And Co., Inc. Hcv ns3 protease inhibitors
GB0509326D0 (en) 2005-05-09 2005-06-15 Angeletti P Ist Richerche Bio Therapeutic compounds
TWI387603B (zh) * 2005-07-20 2013-03-01 Merck Sharp & Dohme Ｈｃｖ ｎｓ３蛋白酶抑制劑
US7462035B2 (en) 2005-07-27 2008-12-09 Physical Optics Corporation Electrical connector configured as a fastening element
BRPI0614205A2 (pt) 2005-08-01 2016-11-22 Merck & Co Inc composto, composição farmacêutica, e, uso de composto
WO2007028789A1 (en) 2005-09-07 2007-03-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Quinazoline derivatives as antiviral agents
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0519797D0 (en) 2005-09-29 2005-11-09 Istituto Di Ricerche D Biolog Therapeutic agents
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
EP2029741A4 (en) 2006-06-08 2011-03-16 Merck Sharp & Dohme QUICK PROCEDURE FOR DETERMINING THE HEMMERSENSITIVITY OF NS3 / 4A PROTEASE SEQUENCES CLONED FROM CLINICAL SAMPLES
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
AR061629A1 (es) * 2006-06-26 2008-09-10 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c. proceso de obtencion y composiciones farmaceuticas
EP2076278B1 (en) 2006-10-24 2015-05-06 Merck Sharp & Dohme Corp. Macrocyclic HCV NS3 protease inhibitors
JP5345541B2 (ja) 2006-10-24 2013-11-20 メルク・シャープ・アンド・ドーム・コーポレーション Ｈｃｖｎｓ３プロテアーゼ阻害剤
CN101583372A (zh) * 2006-10-24 2009-11-18 默克公司 Hcv ns3蛋白酶抑制剂
AU2007318165B2 (en) * 2006-10-27 2011-11-17 Msd Italia S.R.L. HCV NS3 protease inhibitors
EP2083844B1 (en) * 2006-10-27 2013-11-27 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
CA2705449C (en) 2006-11-09 2017-01-10 Twinblade Technologies Holding Sweden Ab Hub device
WO2008112108A1 (en) 2007-03-09 2008-09-18 Merck & Co., Inc. In vivo hcv resistance to anti-viral inhibitors
EP2170888B1 (en) 2007-06-29 2015-04-22 Gilead Sciences, Inc. Purine derivatives and their use as modulators of toll-like receptor 7
JP5433573B2 (ja) 2007-07-19 2014-03-05 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ 抗ウイルス剤としての大環状化合物
CL2008003384A1 (es) 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
CN102026544A (zh) 2007-11-14 2011-04-20 益安药业 大环四唑基丙型肝炎病毒丝氨酸蛋白酶抑制剂
EP2271345B1 (en) * 2008-04-28 2015-05-20 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
CA2731177C (en) 2008-07-22 2013-10-29 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors

Also Published As

Publication number Publication date
RS52534B (en) 2013-04-30
LUC00002I2 (es) 2017-04-04
HK1173403A1 (en) 2013-05-16
CY2017005I2 (el) 2017-06-28
DOP2011000023A (es) 2011-03-31
CN102159285B (zh) 2014-05-14
EA019327B1 (ru) 2014-02-28
TWI441638B (zh) 2014-06-21
JP4920797B2 (ja) 2012-04-18
ECSP11010777A (es) 2011-02-28
EA201170241A1 (ru) 2011-10-31
HRP20140693T1 (hr) 2014-11-21
US7973040B2 (en) 2011-07-05
NZ590638A (en) 2012-06-29
AU2009274190B2 (en) 2012-07-05
NI201100023A (es) 2011-09-20
PL2310095T3 (pl) 2013-03-29
EP2310095B1 (en) 2012-08-29
CO6351757A2 (es) 2011-12-20
US8080654B2 (en) 2011-12-20
BRPI0916235B1 (pt) 2020-09-29
PT2540350E (pt) 2014-08-27
SI2310095T1 (sl) 2013-01-31
CR20110089A (es) 2011-04-27
CA2731177A1 (en) 2010-01-28
EP2540349B1 (en) 2014-02-12
BRPI0916235B8 (pt) 2021-05-25
AR072588A1 (es) 2010-09-08
CY1115503T1 (el) 2017-01-04
IL210580A (en) 2014-08-31
LTPA2016049I1 (lt) 2017-01-25
ME02132B (me) 2014-08-22
IL210580A0 (en) 2011-03-31
CN102159285A (zh) 2011-08-17
PL2540350T3 (pl) 2014-10-31
ES2392611T3 (es) 2012-12-12
TN2011000014A1 (en) 2012-09-05
AU2009274190A1 (en) 2010-01-28
RS53420B (en) 2014-12-31
MA32502B1 (fr) 2011-07-03
MY152070A (en) 2014-08-15
EP2540350B1 (en) 2014-05-21
CY2017005I1 (el) 2017-06-28
EP2540350A1 (en) 2013-01-02
HUS1700001I1 (hu) 2017-02-28
MX2011000826A (es) 2011-02-23
HK1173402A1 (en) 2013-05-16
LTC2310095I2 (lt) 2018-11-12
UA100436C2 (en) 2012-12-25
BRPI0916235A8 (pt) 2018-06-12
NL300857I2 (es) 2017-04-25
NO2017004I1 (no) 2017-01-20
FR16C1027I1 (fr) 2017-02-03
US20110224134A1 (en) 2011-09-15
DK2540350T3 (da) 2014-08-04
CY1113752T1 (el) 2016-07-27
ES2491090T3 (es) 2014-09-05
CA2731177C (en) 2013-10-29
TW201023860A (en) 2010-07-01
PE20110212A1 (es) 2011-04-10
BRPI0916235A2 (pt) 2018-03-13
KR20110036627A (ko) 2011-04-07
WO2010011566A1 (en) 2010-01-28
NO2017004I2 (no) 2017-01-20
DK2310095T3 (da) 2012-12-10
JP2011528713A (ja) 2011-11-24
EP2540349A1 (en) 2013-01-02
SV2011003813A (es) 2011-05-25
SI2540350T1 (sl) 2015-01-30
HN2011000209A (es) 2013-04-22
ME02024B (me) 2015-05-20
US20100029666A1 (en) 2010-02-04
LUC00002I1 (es) 2017-01-19
FR16C1027I2 (fr) 2017-12-08
KR101313675B1 (ko) 2013-10-02
PT2310095E (pt) 2012-11-16
EP2310095A1 (en) 2011-04-20
HRP20120866T1 (hr) 2013-01-31

Similar Documents

Publication Publication Date Title
CL2011000145A1 (es) Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv.
CL2012000919A1 (es) Composicion que comprende un compuesto derivado de metoxicarbonil-amino-metilbutanoil-pirrolidinil-imidazol de formula i, inhibidor especifico de ns5a de hcv, y un compuesto derivado de oxo-pirrolidin-quinoleina de formula ii, inhibidor de proteasa ns3 de hcv; y uso en el tratamiento de la hepatitis c.
SV2009003239A (es) Inhibidores de la proteasa ns3 del hcv.
CL2012000573A1 (es) Compuestos derivados de bifenil-pirrolidinil-imidazol; composicion farmaceutica que los comprende; su uso en el tratamiento de una infeccion viral por hcv.
GT200600317A (es) Inhibidores de la proteasa ns3 del vhc
CL2009000305A1 (es) Compuestos derivados de 2-aril-sustituido-1-benzofurano-3-carboxamida, inhibidores de la polimerasa ns5b; composicion farmaceutica; y su uso en el tratamiento de una enfermedad causada por el virus de la hepatitis c (hcv).
CO6561788A2 (es) Inhibidores del virus de la hepatitis c
EA201071315A1 (ru) Ингибиторы протеазы вируса гепатита с
EA200901101A1 (ru) Макроциклические соединения в качестве ингибиторов протеазы ns3 вгс
CL2012001176A1 (es) Compuestos derivados de bencimidazol-imidazol, inhibidores del virus de la hepatitis c (hcv); composición farmacéutica que los comprende; combinación farmacéutica; uso en la prevención o tratamiento de infección de hcv.
PE20090228A1 (es) Compuestos de azufre como inhibidores de la serina proteasa ns3 del virus de la hepatitis c
EA201270423A1 (ru) Ингибиторы протеазы hcv
PE20150202A1 (es) Compuestos antivirales
CO6400192A2 (es) Inhibidores del virus de la hepatitis c
CL2011002830A1 (es) Compuestos derivados de haloalquil heteroaril benzamidas; composicion farmaceutica uso de la composicion en el tratamiento de una infeccion viral, tal como el virus de la hepatitis b y c.
EA200970805A1 (ru) Ингибиторы серинпротеаз для лечения hcv инфекций
MX2011006631A (es) Inhibidores de proteasa ns3 del virus hcv.
CL2013003171A1 (es) Compuesto macrociclico derivado de prolina inhibidor de la proteasa serina ns3; su composicion farmaceutica; y su uso en el tratamiento de una infeccion viral, en particular una infeccion causada por el virus de la hepatitis c (vhc).
CL2011002453A1 (es) Compuestos derivados de diazol u oxazol-pirrol o pirrolciclopropil condensados sustituidos, inhibidores de la función de la proteína ns5a codificada por el virus de la hepatitis c (vhc); composición farmacéutica; y su uso para el tratamiento de una infección por vhc.
ECSP10010210A (es) Compuestos nucleósidos antivirales
UY32332A (es) Compuestos macrocíclicos sus prodrogas, n-óxidos, sales de adición, aminas cuaternarias, complejos de metales y formas estereoquímicamente isoméricas puras.
CL2013000670A1 (es) Metodo para tratar una infeccion por virus de la hepatitis c (hcv) que comprende admninistrar un inhibidor de la serina proteasa ns3 del hvc, un inhibidor de la arn polimerasa dependiente de arn ns5b de hcv y opcionalmente ribavirina; composicion farmaceutica; estuche; y su uso de para el tratamiento de una infeccion por hcv.
PE20091164A1 (es) Inhibidores macrociclicos de la ns3 serina proteasa del virus de la hepatitis c
CO6290680A2 (es) Inhibidores de virus de la hepatitis c
TH124148B (th) สารประกอบมาโครไซคลิก ควินอกซาลีนในฐานะสารยับยั้งโปรตีเอส ns3 ของ hcv