BRPI0916235A8 - Composto, composição farmacêutica, e, uso do composto ou da composição - Google Patents

Composto, composição farmacêutica, e, uso do composto ou da composição

Info

Publication number
BRPI0916235A8
BRPI0916235A8 BRPI0916235A BRPI0916235A BRPI0916235A8 BR PI0916235 A8 BRPI0916235 A8 BR PI0916235A8 BR PI0916235 A BRPI0916235 A BR PI0916235A BR PI0916235 A BRPI0916235 A BR PI0916235A BR PI0916235 A8 BRPI0916235 A8 BR PI0916235A8
Authority
BR
Brazil
Prior art keywords
compound
composition
compounds
pharmaceutical composition
diseases
Prior art date
Application number
BRPI0916235A
Other languages
English (en)
Inventor
Harper Steven
Summa Vincenzo
J Liverton Nigel
A Mccauley John
Original Assignee
Merck Sharp & Dohme
Msd Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0916235(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Msd Italia Srl filed Critical Merck Sharp & Dohme
Publication of BRPI0916235A2 publication Critical patent/BRPI0916235A2/pt
Publication of BRPI0916235A8 publication Critical patent/BRPI0916235A8/pt
Publication of BRPI0916235B1 publication Critical patent/BRPI0916235B1/pt
Publication of BRPI0916235B8 publication Critical patent/BRPI0916235B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, E, USO DE UM COMPOSTO A presente invenção diz respeito a compostos de tripiridil carboxamida que são antagonistas de receptores de orexina, e que são usados no tratamento ou prevenção de desordens e doenças neurológicas e psiquiátricas em que receptores de orexina estão envolvidos. A invenção também diz respeito a composições farmacêuticas compreendendo estes compostos e ao uso destes compostos e composições na prevenção ou tratamento de tais doenças em que receptores de orexina estão envolvidos (Formula).
BRPI0916235A 2008-07-22 2009-07-17 composto, composição farmacêutica, e, uso do composto ou da composição BRPI0916235B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22
US61/135559 2008-07-22
PCT/US2009/050915 WO2010011566A1 (en) 2008-07-22 2009-07-17 Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors

Publications (4)

Publication Number Publication Date
BRPI0916235A2 BRPI0916235A2 (pt) 2018-03-13
BRPI0916235A8 true BRPI0916235A8 (pt) 2018-06-12
BRPI0916235B1 BRPI0916235B1 (pt) 2020-09-29
BRPI0916235B8 BRPI0916235B8 (pt) 2021-05-25

Family

ID=41130248

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916235A BRPI0916235B8 (pt) 2008-07-22 2009-07-17 composto, composição farmacêutica, e, uso do composto ou da composição

Country Status (44)

Country Link
US (2) US7973040B2 (pt)
EP (3) EP2310095B1 (pt)
JP (1) JP4920797B2 (pt)
KR (1) KR101313675B1 (pt)
CN (1) CN102159285B (pt)
AR (1) AR072588A1 (pt)
AU (1) AU2009274190B2 (pt)
BR (1) BRPI0916235B8 (pt)
CA (1) CA2731177C (pt)
CL (1) CL2011000145A1 (pt)
CO (1) CO6351757A2 (pt)
CR (1) CR20110089A (pt)
CY (3) CY1113752T1 (pt)
DK (2) DK2310095T3 (pt)
DO (1) DOP2011000023A (pt)
EA (1) EA019327B1 (pt)
EC (1) ECSP11010777A (pt)
ES (2) ES2491090T3 (pt)
FR (1) FR16C1027I2 (pt)
HK (2) HK1173403A1 (pt)
HN (1) HN2011000209A (pt)
HR (2) HRP20120866T1 (pt)
HU (1) HUS1700001I1 (pt)
IL (1) IL210580A (pt)
LT (1) LTC2310095I2 (pt)
LU (1) LUC00002I2 (pt)
MA (1) MA32502B1 (pt)
ME (2) ME02132B (pt)
MX (1) MX2011000826A (pt)
MY (1) MY152070A (pt)
NI (1) NI201100023A (pt)
NL (1) NL300857I2 (pt)
NO (1) NO2017004I1 (pt)
NZ (1) NZ590638A (pt)
PE (1) PE20110212A1 (pt)
PL (2) PL2310095T3 (pt)
PT (2) PT2540350E (pt)
RS (2) RS52534B (pt)
SI (2) SI2310095T1 (pt)
SV (1) SV2011003813A (pt)
TN (1) TN2011000014A1 (pt)
TW (1) TWI441638B (pt)
UA (1) UA100436C2 (pt)
WO (1) WO2010011566A1 (pt)

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