RO85271B - Procedeu pentru prepararea unor derivati de indolizina - Google Patents

Procedeu pentru prepararea unor derivati de indolizina

Info

Publication number
RO85271B
RO85271B RO108949A RO10894980A RO85271B RO 85271 B RO85271 B RO 85271B RO 108949 A RO108949 A RO 108949A RO 10894980 A RO10894980 A RO 10894980A RO 85271 B RO85271 B RO 85271B
Authority
RO
Romania
Prior art keywords
bromine
iodine
chlorine
methyl
fluorine
Prior art date
Application number
RO108949A
Other languages
English (en)
Other versions
RO85271A (ro
Inventor
Gilbert Rosseels
Henri Inion
Original Assignee
S.A. Labaz N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.A. Labaz N.V. filed Critical S.A. Labaz N.V.
Publication of RO85271A publication Critical patent/RO85271A/ro
Publication of RO85271B publication Critical patent/RO85271B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de indolizina cu formula generala I: (vezi formula) în care R reprezinta un radical alchil cu catena liniara sau ramificata cu 1...8 atomi de carbon, un radical fenil eventual monosubstituit cu fluor, clor, brom, metil sau metoxi, sau disubstituit cu fluor, brom sau clor, sau un radical metilfenil substituit în nucleul aromatic cu un atom de fluor, clor, brom, X1 reprezinta clor, brom sau iod, A este o grupa aleasa dintre (vezi formula) în care X2 reprezinta clor, brom, iod, metil sau metoxi, X3 reprezinta clor, brom, iod sau metil R1 reprezinta metil, etil, n-propil, sau n-butil, n este un numar întreg cuprins între 2 si 6, caracterizat prin aceea ca un derivat de indolizina cu formula II: (vezi formula) în care R, A, R1 si n au semnificatiile de mai sus se supune reactiei cu N-clorsuccinimida, brom sau iod, ractia avînd loc în mediu de dicloretan sau dioxan, între 0 degree C si temperatura camerei, eventual în prezenta de acetat de metil alcalin cînd se lucreaza cu brom sau iod, obtinîndu-se derivatul de indolizina ca baza libera care eventual reactioneaza cu un acid anorganic sau organic pentru a da o sare de aditie netoxica.
RO108949A 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina RO85271B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7942146 1979-12-06

Publications (2)

Publication Number Publication Date
RO85271A RO85271A (ro) 1984-09-29
RO85271B true RO85271B (ro) 1984-10-30

Family

ID=10509659

Family Applications (3)

Application Number Title Priority Date Filing Date
RO102781A RO81452B (ro) 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina
RO108949A RO85271B (ro) 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina
RO108948A RO84707B (ro) 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO102781A RO81452B (ro) 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO108948A RO84707B (ro) 1979-12-06 1980-12-05 Procedeu pentru prepararea unor derivati de indolizina

Country Status (40)

Country Link
JP (1) JPS56103181A (ro)
AR (4) AR227036A1 (ro)
AT (1) AT376438B (ro)
AU (1) AU536320B2 (ro)
BE (1) BE886511A (ro)
BG (2) BG37379A3 (ro)
BR (1) BR8007691A (ro)
CA (1) CA1152077A (ro)
CH (1) CH651041A5 (ro)
CS (3) CS222692B2 (ro)
DD (1) DD155069A5 (ro)
DE (1) DE3046017C2 (ro)
DK (1) DK146977C (ro)
ES (4) ES8205798A1 (ro)
FI (1) FI67846C (ro)
GR (1) GR70224B (ro)
HK (1) HK65884A (ro)
HU (1) HU185019B (ro)
IE (1) IE50519B1 (ro)
IL (1) IL61385A (ro)
IN (1) IN151241B (ro)
IS (1) IS1209B6 (ro)
IT (1) IT1218424B (ro)
KE (1) KE3438A (ro)
LU (1) LU82983A1 (ro)
MA (1) MA19007A1 (ro)
NL (1) NL184683C (ro)
NO (1) NO157019C (ro)
NZ (1) NZ195754A (ro)
OA (1) OA06711A (ro)
PH (1) PH17028A (ro)
PL (3) PL129365B1 (ro)
PT (1) PT72151B (ro)
RO (3) RO81452B (ro)
SE (1) SE441926B (ro)
SG (1) SG33384G (ro)
SU (3) SU1058505A3 (ro)
YU (3) YU42366B (ro)
ZA (1) ZA806831B (ro)
ZW (1) ZW28580A1 (ro)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10065955B2 (en) * 2014-12-10 2018-09-04 Ono Pharmaceutical Co., Ltd. Dihydroindolizinone derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1518443A (en) 1976-02-19 1978-07-19 Labaz Indolizine derivatives and process for preparing the same

Also Published As

Publication number Publication date
IT1218424B (it) 1990-04-19
HU185019B (en) 1984-11-28
PL228265A1 (ro) 1981-11-13
YU42840B (en) 1988-12-31
DE3046017A1 (de) 1981-09-03
CS222697B2 (en) 1983-07-29
DK146977C (da) 1984-08-13
NL184683C (nl) 1989-10-02
AU536320B2 (en) 1984-05-03
RO81452A (ro) 1983-04-29
PL127865B1 (en) 1983-12-31
BR8007691A (pt) 1981-06-09
SE441926B (sv) 1985-11-18
NO157019C (no) 1988-01-06
DE3046017C2 (de) 1986-09-25
SU1058505A3 (ru) 1983-11-30
LU82983A1 (fr) 1981-03-26
IL61385A (en) 1984-11-30
IE802520L (en) 1981-06-06
YU42366B (en) 1988-08-31
AR229692A1 (es) 1983-10-31
BE886511A (fr) 1981-06-05
NL184683B (nl) 1989-05-01
ES497504A0 (es) 1982-06-16
ES8300110A1 (es) 1982-10-01
DK146977B (da) 1984-03-05
AR227093A1 (es) 1982-09-15
YU304180A (en) 1983-10-31
FI67846C (fi) 1985-06-10
NZ195754A (en) 1984-03-16
ES8300108A1 (es) 1982-10-01
MA19007A1 (fr) 1981-07-01
ES508051A0 (es) 1982-10-01
BG37379A3 (en) 1985-05-15
IE50519B1 (en) 1986-04-30
IT8026463A0 (it) 1980-12-05
PL129365B1 (en) 1984-05-31
NL8006310A (nl) 1981-07-01
HK65884A (en) 1984-08-31
IS2594A7 (is) 1981-06-07
PH17028A (en) 1984-05-17
DK521980A (da) 1981-06-07
DD155069A5 (de) 1982-05-12
JPS6325591B2 (ro) 1988-05-26
PL231829A1 (ro) 1982-03-15
ES8205798A1 (es) 1982-06-16
SU1109051A3 (ru) 1984-08-15
ZA806831B (en) 1981-10-28
AR227036A1 (es) 1982-09-15
AT376438B (de) 1984-11-26
ES8300109A1 (es) 1982-10-01
RO85271A (ro) 1984-09-29
RO84707B (ro) 1984-09-30
OA06711A (fr) 1982-06-30
CA1152077A (en) 1983-08-16
IN151241B (ro) 1983-03-12
YU44483A (en) 1983-10-31
PT72151B (en) 1981-10-28
JPS56103181A (en) 1981-08-18
GR70224B (ro) 1982-08-31
AR227094A1 (es) 1982-09-15
SG33384G (en) 1985-02-08
CH651041A5 (en) 1985-08-30
IS1209B6 (is) 1986-03-24
PL127999B1 (en) 1983-12-31
RO81452B (ro) 1983-04-30
AU6429280A (en) 1981-06-11
IL61385A0 (en) 1980-12-31
FI67846B (fi) 1985-02-28
CS222698B2 (en) 1983-07-29
ES508052A0 (es) 1982-10-01
SU1287751A3 (ru) 1987-01-30
BG35598A3 (en) 1984-05-15
CS222692B2 (en) 1983-07-29
YU44383A (en) 1983-10-31
SE8008444L (sv) 1981-06-07
ES508053A0 (es) 1982-10-01
ATA596780A (de) 1984-04-15
YU42127B (en) 1988-04-30
RO84707A (ro) 1984-07-17
KE3438A (en) 1984-08-24
PL231828A1 (ro) 1982-03-15
ZW28580A1 (en) 1981-08-26
FI803792L (fi) 1981-06-07
NO157019B (no) 1987-09-28
NO803681L (no) 1981-06-09
PT72151A (en) 1981-01-01

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