YU136390A - Postupak za dobijanje supstituisanih 2-imidazolina - Google Patents

Postupak za dobijanje supstituisanih 2-imidazolina

Info

Publication number
YU136390A
YU136390A YU136390A YU136390A YU136390A YU 136390 A YU136390 A YU 136390A YU 136390 A YU136390 A YU 136390A YU 136390 A YU136390 A YU 136390A YU 136390 A YU136390 A YU 136390A
Authority
YU
Yugoslavia
Prior art keywords
pct
imidazolines
procedure
obtaining substituted
sec
Prior art date
Application number
YU136390A
Other languages
English (en)
Inventor
P. Borrevang
H.S. Andersen
Original Assignee
Novo Nordisk A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S. filed Critical Novo Nordisk A/S.
Publication of YU136390A publication Critical patent/YU136390A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

POSTUPAK ZA DOBIJANJE SUPSTITUISANIH 2-IMIDAZOLINA, pronalazak se odnosi na postupak za dobijanje novih supstituisanih 2-imidazolina opšte formule (I): gde R i R nezavisno predstavljaju vodonik, halogeni element, alkil ili alkoksi; R1 je veza za bočni lanac koji nosi prsten imidazolina, a moguće je da R2 zajedno sa R3 predstavlja dodatnu vezu; R3, R4 i R5 nezavisno predstavljaju vodonik, halogeni element, alkil, alkoksi, fenil ili supstituisani fenil, a moguće je da R3 zajedno sa R2 predstavlja dodatnu vezu, a takodje je moguće da R5 predstavlja hidroksi, ili je R5 veza za bočni lanac koji nosi prsten imidazolina; R6 je supstituisani fenil, a može biti i piridil grupa; a R7 je vodonik, halogeni element, alkil, alkoksi, hidroksi, fenil ili supstituisani fenil ili R7 predstavlja vezu za bočni lanac koji nosi prsten imidazolina. Pronalazak se takodje odnosi i na jedinjenja supstituisanih 2-imidazolina, koja se dobijaju reagovanjem odgovarajućih medjuproizvoda, koji, umesto prstena imidazolina imaju alkilester grupu, fenilester grupu ili benzilester grupu, sa etilendiaminom ili njegovim aktiviranim derivatom.
YU136390A 1989-07-12 1990-07-12 Postupak za dobijanje supstituisanih 2-imidazolina YU136390A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK344489A DK344489D0 (da) 1989-07-12 1989-07-12 Substituerede 2-imidazoliner og fremstilling og anvendelse deraf

Publications (1)

Publication Number Publication Date
YU136390A true YU136390A (sh) 1993-10-20

Family

ID=8122944

Family Applications (1)

Application Number Title Priority Date Filing Date
YU136390A YU136390A (sh) 1989-07-12 1990-07-12 Postupak za dobijanje supstituisanih 2-imidazolina

Country Status (22)

Country Link
US (1) US5262430A (sh)
EP (1) EP0482108B1 (sh)
JP (1) JPH04506968A (sh)
KR (1) KR927003578A (sh)
CN (1) CN1049343A (sh)
AT (1) ATE135703T1 (sh)
AU (1) AU637393B2 (sh)
CA (1) CA2064095A1 (sh)
DD (1) DD296489A5 (sh)
DE (1) DE69026087T2 (sh)
DK (2) DK344489D0 (sh)
ES (1) ES2086409T3 (sh)
FI (1) FI920118A0 (sh)
GR (1) GR1000716B (sh)
IE (1) IE74210B1 (sh)
IL (1) IL95046A (sh)
NO (1) NO920143L (sh)
NZ (1) NZ234451A (sh)
PT (1) PT94685B (sh)
WO (1) WO1991000862A1 (sh)
YU (1) YU136390A (sh)
ZA (1) ZA905422B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4201709A1 (de) * 1992-01-23 1993-07-29 Bayer Ag (alpha)-aryl-(alpha)-hydroxy-ss-imidazolinyl-propionsaeureamide
US5750543A (en) * 1996-02-01 1998-05-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US6410562B1 (en) 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
US20090162342A1 (en) * 2001-06-07 2009-06-25 Sanomune Inc. Therapeutic uses of glandular kallikrein
ES2340180T3 (es) * 2004-06-01 2010-05-31 F.Hoffmann-La Roche Ag 3-amino-1-arilpropil-indoles como inhibidores de reabsorcion de monoaminas.
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
SI2854841T1 (sl) 2012-06-04 2017-06-30 Diamedica Inc. Glikozilacijske izooblike humanega tkivnega kalikreina-1
US11857608B2 (en) 2017-03-09 2024-01-02 Diamedica Inc. Dosage forms of tissue kallikrein 1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936885B2 (ja) * 1976-06-24 1984-09-06 第一製薬株式会社 糖尿病治療剤
ZW13782A1 (en) * 1981-07-28 1982-10-06 Reckitt & Colmann Prod Ltd Imidazoline derivatives
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use

Also Published As

Publication number Publication date
IL95046A (en) 1995-03-15
CA2064095A1 (en) 1991-01-13
CN1049343A (zh) 1991-02-20
ZA905422B (en) 1991-03-27
IE74210B1 (en) 1997-07-16
WO1991000862A1 (en) 1991-01-24
GR1000716B (el) 1992-11-23
NO920143D0 (no) 1992-01-10
IL95046A0 (en) 1991-06-10
FI920118A0 (fi) 1992-01-10
GR900100535A (en) 1991-12-10
DE69026087D1 (de) 1996-04-25
ATE135703T1 (de) 1996-04-15
AU6164490A (en) 1991-02-06
EP0482108B1 (en) 1996-03-20
DK0482108T3 (da) 1996-07-22
IE902546A1 (en) 1991-02-27
JPH04506968A (ja) 1992-12-03
NZ234451A (en) 1991-08-27
KR927003578A (ko) 1992-12-18
EP0482108A1 (en) 1992-04-29
DD296489A5 (de) 1991-12-05
DE69026087T2 (de) 1996-08-29
DK344489D0 (da) 1989-07-12
US5262430A (en) 1993-11-16
AU637393B2 (en) 1993-05-27
PT94685B (pt) 1997-04-30
NO920143L (no) 1992-03-04
PT94685A (pt) 1991-03-20
ES2086409T3 (es) 1996-07-01

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