IE802520L - Indolizine derivatives. - Google Patents
Indolizine derivatives.Info
- Publication number
- IE802520L IE802520L IE802520A IE252080A IE802520L IE 802520 L IE802520 L IE 802520L IE 802520 A IE802520 A IE 802520A IE 252080 A IE252080 A IE 252080A IE 802520 L IE802520 L IE 802520L
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- bromine
- iodine
- chlorine
- represents hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
The invention relates to new indolizine derivatives of the general formula <IMAGE> and to their non-toxic addition salts in which: R represents C1 to C8 alkyl, phenyl or phenyl substituted by one or two substituents selected from halogen atoms and from lower alkyl or lower alkoxy groups, X1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy, A represents a group selected from: <IMAGE> in which X2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X3 represents hydrogen, chlorine, bromine, iodine or methyl, R1 represents methyl, ethyl, n-propyl or n-butyl, n represents an integer from 2 to 6 inclusive provided that, if X2 and X3 each represent H or CH3, X1 is other than H. The derivatives in question can be used in the treatment of certain pathological heart syndromes, in particular in the treatment of angina pectoris and of cardiac arrhythmias.
[DE3046017A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942146 | 1979-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE802520L true IE802520L (en) | 1981-06-06 |
| IE50519B1 IE50519B1 (en) | 1986-04-30 |
Family
ID=10509659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2520/80A IE50519B1 (en) | 1979-12-06 | 1980-12-03 | Indolizine derivatives and their manufacture |
Country Status (40)
| Country | Link |
|---|---|
| JP (1) | JPS56103181A (en) |
| AR (4) | AR227036A1 (en) |
| AT (1) | AT376438B (en) |
| AU (1) | AU536320B2 (en) |
| BE (1) | BE886511A (en) |
| BG (2) | BG35598A3 (en) |
| BR (1) | BR8007691A (en) |
| CA (1) | CA1152077A (en) |
| CH (1) | CH651041A5 (en) |
| CS (3) | CS222692B2 (en) |
| DD (1) | DD155069A5 (en) |
| DE (1) | DE3046017C2 (en) |
| DK (1) | DK146977C (en) |
| ES (4) | ES8205798A1 (en) |
| FI (1) | FI67846C (en) |
| GR (1) | GR70224B (en) |
| HK (1) | HK65884A (en) |
| HU (1) | HU185019B (en) |
| IE (1) | IE50519B1 (en) |
| IL (1) | IL61385A (en) |
| IN (1) | IN151241B (en) |
| IS (1) | IS1209B6 (en) |
| IT (1) | IT1218424B (en) |
| KE (1) | KE3438A (en) |
| LU (1) | LU82983A1 (en) |
| MA (1) | MA19007A1 (en) |
| NL (1) | NL184683C (en) |
| NO (1) | NO157019C (en) |
| NZ (1) | NZ195754A (en) |
| OA (1) | OA06711A (en) |
| PH (1) | PH17028A (en) |
| PL (3) | PL127865B1 (en) |
| PT (1) | PT72151B (en) |
| RO (3) | RO85271B (en) |
| SE (1) | SE441926B (en) |
| SG (1) | SG33384G (en) |
| SU (3) | SU1058505A3 (en) |
| YU (3) | YU42366B (en) |
| ZA (1) | ZA806831B (en) |
| ZW (1) | ZW28580A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2814098T3 (en) * | 2014-12-10 | 2021-03-26 | Ono Pharmaceutical Co | Dihydroindolizinone derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1518443A (en) | 1976-02-19 | 1978-07-19 | Labaz | Indolizine derivatives and process for preparing the same |
-
1980
- 1980-10-31 IL IL61385A patent/IL61385A/en unknown
- 1980-11-04 GR GR63275A patent/GR70224B/el unknown
- 1980-11-05 ZA ZA00806831A patent/ZA806831B/en unknown
- 1980-11-05 IS IS2594A patent/IS1209B6/en unknown
- 1980-11-07 CH CH8289/80A patent/CH651041A5/en not_active IP Right Cessation
- 1980-11-12 AU AU64292/80A patent/AU536320B2/en not_active Ceased
- 1980-11-13 PH PH24853A patent/PH17028A/en unknown
- 1980-11-19 NL NLAANVRAGE8006310,A patent/NL184683C/en not_active IP Right Cessation
- 1980-11-25 BR BR8007691A patent/BR8007691A/en unknown
- 1980-11-26 ZW ZW285/80A patent/ZW28580A1/en unknown
- 1980-12-01 CA CA000365859A patent/CA1152077A/en not_active Expired
- 1980-12-01 BG BG8049830A patent/BG35598A3/en unknown
- 1980-12-01 BG BG8362985A patent/BG37379A3/en unknown
- 1980-12-02 SE SE8008444A patent/SE441926B/en not_active IP Right Cessation
- 1980-12-02 YU YU3041/80A patent/YU42366B/en unknown
- 1980-12-03 MA MA19209A patent/MA19007A1/en unknown
- 1980-12-03 IE IE2520/80A patent/IE50519B1/en unknown
- 1980-12-04 PT PT72151A patent/PT72151B/en unknown
- 1980-12-04 CS CS808517A patent/CS222692B2/en unknown
- 1980-12-04 NZ NZ195754A patent/NZ195754A/en unknown
- 1980-12-04 PL PL1980231829A patent/PL127865B1/en unknown
- 1980-12-04 PL PL1980231828A patent/PL129365B1/en unknown
- 1980-12-04 CS CS808517A patent/CS222697B2/en unknown
- 1980-12-04 IN IN1344/CAL/80A patent/IN151241B/en unknown
- 1980-12-04 CS CS814016A patent/CS222698B2/en unknown
- 1980-12-04 PL PL1980228265A patent/PL127999B1/en unknown
- 1980-12-05 LU LU82983A patent/LU82983A1/en unknown
- 1980-12-05 RO RO108949A patent/RO85271B/en unknown
- 1980-12-05 HU HU802915A patent/HU185019B/en not_active IP Right Cessation
- 1980-12-05 NO NO803681A patent/NO157019C/en unknown
- 1980-12-05 SU SU803213301A patent/SU1058505A3/en active
- 1980-12-05 FI FI803792A patent/FI67846C/en not_active IP Right Cessation
- 1980-12-05 RO RO108948A patent/RO84707B/en unknown
- 1980-12-05 ES ES497504A patent/ES8205798A1/en not_active Expired
- 1980-12-05 RO RO102781A patent/RO81452B/en unknown
- 1980-12-05 BE BE0/203053A patent/BE886511A/en not_active IP Right Cessation
- 1980-12-05 AT AT0596780A patent/AT376438B/en not_active IP Right Cessation
- 1980-12-05 IT IT26463/80A patent/IT1218424B/en active
- 1980-12-05 DE DE3046017A patent/DE3046017C2/en not_active Expired
- 1980-12-05 JP JP17252180A patent/JPS56103181A/en active Granted
- 1980-12-05 DK DK521980A patent/DK146977C/en not_active IP Right Cessation
- 1980-12-06 OA OA57269A patent/OA06711A/en unknown
- 1980-12-06 AR AR283495A patent/AR227036A1/en active
- 1980-12-06 DD DD80225817A patent/DD155069A5/en unknown
-
1981
- 1981-12-16 ES ES508051A patent/ES508051A0/en active Granted
- 1981-12-16 ES ES508053A patent/ES8300110A1/en not_active Expired
- 1981-12-16 ES ES508052A patent/ES8300109A1/en not_active Expired
- 1981-12-22 SU SU813367150A patent/SU1109051A3/en active
-
1982
- 1982-02-24 AR AR288535A patent/AR229692A1/en active
- 1982-02-24 AR AR288533A patent/AR227093A1/en active
- 1982-02-24 AR AR227094A patent/AR227094A1/en active
-
1983
- 1983-02-24 YU YU443/83A patent/YU42840B/en unknown
- 1983-02-24 YU YU444/83A patent/YU42127B/en unknown
-
1984
- 1984-04-25 SG SG33384A patent/SG33384G/en unknown
- 1984-08-13 KE KE3438A patent/KE3438A/en unknown
- 1984-08-23 HK HK658/84A patent/HK65884A/en unknown
- 1984-10-12 SU SU843801012A patent/SU1287751A3/en active
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