RO81452B - Process for preparing indolizin derivatives - Google Patents

Process for preparing indolizin derivatives

Info

Publication number
RO81452B
RO81452B RO102781A RO10278180A RO81452B RO 81452 B RO81452 B RO 81452B RO 102781 A RO102781 A RO 102781A RO 10278180 A RO10278180 A RO 10278180A RO 81452 B RO81452 B RO 81452B
Authority
RO
Romania
Prior art keywords
methyl
mono
bromo
chloro
general formula
Prior art date
Application number
RO102781A
Other languages
Romanian (ro)
Other versions
RO81452A (en
Inventor
Rosseels Gilbert
Inion Henri
Original Assignee
S.A. Labaz N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.A. Labaz N.V. filed Critical S.A. Labaz N.V.
Publication of RO81452A publication Critical patent/RO81452A/en
Publication of RO81452B publication Critical patent/RO81452B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Procedeu pentru prepararea unor derivati de indolizina cu formula generala I:(vezi form. în desc.) în care R reprezinta un radical alchil cu catena dreapta sau ramificata avînd 1....8 atomi de carbon, un radical fenil, un radical mono-fluor, mono-clor, mono-brom, mono-metil sau monometoxifenil, sau un radical difluor, di-clor, di-brom-fenil sau un radical metil-fenil substituit în ciclu aromatic cu un atom de fluor, clor sau brom, X1 reprezinta hidrogen, clor, brom, iod metil sau metoxi, A reprezinta o grupa selectionata dintre: (vezi form. in desc.) în care X2 reprezinta hidrogen, clor, brom, iod, metil sau metoxi si X3 reprezinta hidrogen, clor, brom sau metil, R1 reprezinta metil, etil, n-propil sau n-butil; n reprezinta un numar întreg cuprins între 2 si 6 inclusiv, cu conditia ca daca X2si X3 reprezinta altceva decat hidrogen, consta în reactia de condensare dintre o bromoalcoxiindolizina cu formula generala II: (vezi form. in desc.)în care X1, R, A si n au semnificatiile de mai sus si o amina cu formula generala III în care R1 are semnificatiile de mai sus în mediu de toluen, drept solvent inert.Process for the preparation of indolizine derivatives of the general formula I: wherein R represents a straight or branched alkyl radical having 1 to 8 carbon atoms, a phenyl radical, a mono- -fluoro, mono-chloro, mono-bromo, mono-methyl or monomethoxyphenyl, or a difluoride, dichloro, dibromo-phenyl or a methyl-phenyl radical substituted in the aromatic ring by a fluorine, chlorine or bromine atom , X 1 represents hydrogen, chlorine, bromine, iodine methyl or methoxy, A represents a group selected from: wherein X 2 represents hydrogen, chloro, bromo, iodo, methyl or methoxy and X 3 represents hydrogen, chloro , bromo or methyl, R 1 represents methyl, ethyl, n-propyl or n-butyl; n represents an integer ranging from 2 to 6 inclusive, provided that if X 2 and X 3 are other than hydrogen, it consists of the condensation reaction of a bromoalkoxy indolizine of the general formula II wherein X 1, R 2, A and n are as defined above and an amine of general formula III wherein R1 has the above meaning in toluene as an inert solvent.

RO102781A 1979-12-06 1980-12-05 Process for preparing indolizin derivatives RO81452B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7942146 1979-12-06

Publications (2)

Publication Number Publication Date
RO81452A RO81452A (en) 1983-04-29
RO81452B true RO81452B (en) 1983-04-30

Family

ID=10509659

Family Applications (3)

Application Number Title Priority Date Filing Date
RO108949A RO85271B (en) 1979-12-06 1980-12-05 Process for preparing indolizine derivatives
RO108948A RO84707B (en) 1979-12-06 1980-12-05 Process for preparing some indolozine derivatives
RO102781A RO81452B (en) 1979-12-06 1980-12-05 Process for preparing indolizin derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO108949A RO85271B (en) 1979-12-06 1980-12-05 Process for preparing indolizine derivatives
RO108948A RO84707B (en) 1979-12-06 1980-12-05 Process for preparing some indolozine derivatives

Country Status (40)

Country Link
JP (1) JPS56103181A (en)
AR (4) AR227036A1 (en)
AT (1) AT376438B (en)
AU (1) AU536320B2 (en)
BE (1) BE886511A (en)
BG (2) BG35598A3 (en)
BR (1) BR8007691A (en)
CA (1) CA1152077A (en)
CH (1) CH651041A5 (en)
CS (3) CS222692B2 (en)
DD (1) DD155069A5 (en)
DE (1) DE3046017C2 (en)
DK (1) DK146977C (en)
ES (4) ES8205798A1 (en)
FI (1) FI67846C (en)
GR (1) GR70224B (en)
HK (1) HK65884A (en)
HU (1) HU185019B (en)
IE (1) IE50519B1 (en)
IL (1) IL61385A (en)
IN (1) IN151241B (en)
IS (1) IS1209B6 (en)
IT (1) IT1218424B (en)
KE (1) KE3438A (en)
LU (1) LU82983A1 (en)
MA (1) MA19007A1 (en)
NL (1) NL184683C (en)
NO (1) NO157019C (en)
NZ (1) NZ195754A (en)
OA (1) OA06711A (en)
PH (1) PH17028A (en)
PL (3) PL127865B1 (en)
PT (1) PT72151B (en)
RO (3) RO85271B (en)
SE (1) SE441926B (en)
SG (1) SG33384G (en)
SU (3) SU1058505A3 (en)
YU (3) YU42366B (en)
ZA (1) ZA806831B (en)
ZW (1) ZW28580A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2814098T3 (en) * 2014-12-10 2021-03-26 Ono Pharmaceutical Co Dihydroindolizinone derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1518443A (en) 1976-02-19 1978-07-19 Labaz Indolizine derivatives and process for preparing the same

Also Published As

Publication number Publication date
AU536320B2 (en) 1984-05-03
RO84707A (en) 1984-07-17
ZW28580A1 (en) 1981-08-26
AR227093A1 (en) 1982-09-15
IS1209B6 (en) 1986-03-24
IL61385A0 (en) 1980-12-31
IE802520L (en) 1981-06-06
AR227036A1 (en) 1982-09-15
SE441926B (en) 1985-11-18
JPS6325591B2 (en) 1988-05-26
NO157019B (en) 1987-09-28
YU42366B (en) 1988-08-31
RO85271B (en) 1984-10-30
IT1218424B (en) 1990-04-19
ZA806831B (en) 1981-10-28
YU44483A (en) 1983-10-31
CA1152077A (en) 1983-08-16
IN151241B (en) 1983-03-12
DE3046017A1 (en) 1981-09-03
NO157019C (en) 1988-01-06
HU185019B (en) 1984-11-28
DK521980A (en) 1981-06-07
ES508052A0 (en) 1982-10-01
MA19007A1 (en) 1981-07-01
IT8026463A0 (en) 1980-12-05
PL228265A1 (en) 1981-11-13
ES497504A0 (en) 1982-06-16
YU42127B (en) 1988-04-30
NL184683B (en) 1989-05-01
RO85271A (en) 1984-09-29
PH17028A (en) 1984-05-17
BR8007691A (en) 1981-06-09
SE8008444L (en) 1981-06-07
GR70224B (en) 1982-08-31
OA06711A (en) 1982-06-30
FI67846C (en) 1985-06-10
CS222692B2 (en) 1983-07-29
PL231829A1 (en) 1982-03-15
IL61385A (en) 1984-11-30
IS2594A7 (en) 1981-06-07
RO81452A (en) 1983-04-29
PL129365B1 (en) 1984-05-31
NZ195754A (en) 1984-03-16
CS222698B2 (en) 1983-07-29
ATA596780A (en) 1984-04-15
ES8300109A1 (en) 1982-10-01
ES8300108A1 (en) 1982-10-01
NO803681L (en) 1981-06-09
ES508051A0 (en) 1982-10-01
DD155069A5 (en) 1982-05-12
RO84707B (en) 1984-09-30
SU1058505A3 (en) 1983-11-30
AR227094A1 (en) 1982-09-15
NL184683C (en) 1989-10-02
PL231828A1 (en) 1982-03-15
LU82983A1 (en) 1981-03-26
PL127865B1 (en) 1983-12-31
ES508053A0 (en) 1982-10-01
IE50519B1 (en) 1986-04-30
PL127999B1 (en) 1983-12-31
KE3438A (en) 1984-08-24
FI67846B (en) 1985-02-28
DK146977B (en) 1984-03-05
AT376438B (en) 1984-11-26
AR229692A1 (en) 1983-10-31
SG33384G (en) 1985-02-08
PT72151B (en) 1981-10-28
YU44383A (en) 1983-10-31
ES8300110A1 (en) 1982-10-01
CH651041A5 (en) 1985-08-30
SU1109051A3 (en) 1984-08-15
ES8205798A1 (en) 1982-06-16
BG37379A3 (en) 1985-05-15
BE886511A (en) 1981-06-05
JPS56103181A (en) 1981-08-18
YU304180A (en) 1983-10-31
AU6429280A (en) 1981-06-11
YU42840B (en) 1988-12-31
DE3046017C2 (en) 1986-09-25
SU1287751A3 (en) 1987-01-30
NL8006310A (en) 1981-07-01
PT72151A (en) 1981-01-01
CS222697B2 (en) 1983-07-29
DK146977C (en) 1984-08-13
HK65884A (en) 1984-08-31
BG35598A3 (en) 1984-05-15
FI803792L (en) 1981-06-07

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