NO157019B - ANALOGICAL PROCEDURE FOR PREPARATION OF THERAPEUTICALLY ACTIVE INDOLIZINE DERIVATIVES. - Google Patents
ANALOGICAL PROCEDURE FOR PREPARATION OF THERAPEUTICALLY ACTIVE INDOLIZINE DERIVATIVES. Download PDFInfo
- Publication number
- NO157019B NO157019B NO803681A NO803681A NO157019B NO 157019 B NO157019 B NO 157019B NO 803681 A NO803681 A NO 803681A NO 803681 A NO803681 A NO 803681A NO 157019 B NO157019 B NO 157019B
- Authority
- NO
- Norway
- Prior art keywords
- window
- preparation
- therapeutically active
- methyl
- hook
- Prior art date
Links
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical class C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000003406 indolizinyl group Chemical class C=1(C=CN2C=CC=CC12)* 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
pNye, terapeutisk aktive, særlig for behandling av angina pectoris og hjertearytmi, indolizin-derivater med den generelle formel:. hvor Xbetyr hydrogen, klor, brom, jod, metyl eller metoksy, og Xbetyr hydrogen, klor, brom, jod eller metyl, Rbetyr et metyl-, etyl-, n-propyl- eller n-buty1-radikal, og n betyr et helt tall fra 2 til 6,. med det forbehold at når bådeog Xbetyr hydrogen eller metyl, er Xforskjellig fra hydrogen.Fremstilling av forbindelsene er beskrevet.New, therapeutically active, in particular for the treatment of angina pectoris and cardiac arrhythmia, indolizine derivatives of the general formula :. wherein X represents hydrogen, chlorine, bromine, iodine, methyl or methoxy, and X represents hydrogen, chlorine, bromine, iodine or methyl, R represents a methyl, ethyl, n-propyl or n-butyl radical, and n represents a whole numbers from 2 to 6,. with the proviso that when both X represents hydrogen or methyl, X is different from hydrogen. Preparation of the compounds is described.
Description
Foreliggende oppfinnelse angår en The present invention relates to a
stengeanordning for vinduslemmer som er hengslet ved siden av vinduene og som er beregnet til gjenstengning av vinduene, eventuelt dører på en effektiv måte slik at det skal bli vanskeligere for tyver å gjøre innbrudd. closing device for window sashes which are hinged next to the windows and which are intended to re-close the windows, possibly doors in an effective way so that it will be more difficult for thieves to break in.
Den vanlige måten å stenge slike vinduslemmer er at et svingbart jern eller lignende settes foran vinduslemmen etter-at denne er lukket, og at jernet blir festet ved sin frie ende ved en bolt som stikkes tvers gjennom hytteveggen og låses på innsiden med en vingemutter eller lignende. The usual way to close such window sashes is for a pivoting iron or similar to be placed in front of the window sash after it has been closed, and for the iron to be fixed at its free end by a bolt that is inserted across the cabin wall and locked on the inside with a wing nut or similar .
Denne metode er meget tungvint idet This method is very cumbersome
man må på utsiden av hytten for å stikke boltene gjennom de resp. hull, og så inn igjen i hytten for å skru på mutterene. En ytterligere ulempe er at de løse boltene og muttere lett blir borte. Videre har det lett for å oppstå trekk i hullet for boltene. Foreliggende oppfinnelse tar sikte på en lett-vint og effektiv stengeanordning for oven-for beskrevne vinduslemmer hvis svinge-punkter ligger utenfor vinduenes svinge-punkter som; tidligere kjent fra koblede vinduer, og er karakterisert ved korresponderende krokorgan på innsiden (i lukket tilstand) av vinduslemmen, og på vindus-rammens ytterside, idet krokorganene er montert slik at deres frie ender peker i motsatt retning, slik at ved hel eller delvis åpning av vinduet vil den fri ende på krokorganet på dette kunne passere forbi den frie ende på lemmens krokorgan, og ved lukking av vinduet vil de fri ender you have to be on the outside of the cabin to put the bolts through the resp. hole, and then back into the cabin to tighten the nuts. A further disadvantage is that the loose bolts and nuts are easily lost. Furthermore, it is easy for drafts to occur in the hole for the bolts. The present invention aims at an easy-to-use and effective closing device for the above-described window members whose pivot points lie outside the windows' pivot points such as; previously known from linked windows, and is characterized by corresponding hooking means on the inside (in closed state) of the window sash, and on the outside of the window frame, the hooking means being mounted so that their free ends point in the opposite direction, so that in full or partial opening of the window, the free end of the hook member on this will be able to pass past the free end of the limb's hook member, and when closing the window, the free ends will
gripe inn under hverandre. Et annet ka-rakteristisk trekk er at festemidlene for krokorganene sitter skjult når lemmen er lukket. intervene under each other. Another characteristic feature is that the fastening means for the hook organs are hidden when the limb is closed.
For å forklare oppfinnelsen nærmere skal det i det følgende forklares et utfø-relseseksempel av oppfinnelsen ved hjelp av tegningen, der In order to explain the invention in more detail, an embodiment of the invention will be explained in the following with the help of the drawing, where
fig. 1 viser et vindu med lem sett for-fra og fig. 1 shows a window with a member seen from the front
fig. 2 viser i noe større målestokk et snitt gjennom fig. 1 efter linjen II—II, og med lemmen lukket. 1 betegner et vindu utstyrt med normale stengeanordninger 2 og hengsel 3. Vinduet sitter montert i vinduskarmen 4 hvori det er festet et hengsel 5 for en vinduslem 6. Nær sin frie ende er vinduslemmen forsynt med et krokorgan 7, hvis frie del peker inni mot midten av vinduslemmen. Vindusrammen på vinduet 1 er på tilsvarende måte utstyrt med et krokorgan, hvis frie ende peker motsatt vel av det som er tilfelle på vinduslemmen. Krokorganene på vinduslem resp. vindu, er festet ved hjelp av skruer 9 som med vinduslemmen i stengt tilstand vil være skjult og utilgjengelig. Hengslets 3 svingepunkt ligger omtrent i plan med ytterkant av vindu og kran, mens svingepunktet for lemmen er trukket vesentlig ut fra dette plan. Når derfor vinduet åpnes og svinges utover vil ytterkant av vindu og vinduslem, svinge efter forskjellige buer som vil diver-gere og krokorganene 7 og 8 vil derfor gå ut av inngrep med hverandre efterat vindu og lem er svingt ut et stykke. fig. 2 shows on a slightly larger scale a section through fig. 1 along the line II—II, and with the limb closed. 1 denotes a window equipped with normal closing devices 2 and hinge 3. The window is mounted in the window frame 4 in which is attached a hinge 5 for a window leaf 6. Near its free end, the window leaf is provided with a hook member 7, the free part of which points inside towards the center of the window sash. The window frame on window 1 is similarly equipped with a hook member, the free end of which points oppositely to what is the case on the window sash. The hook members on the window frame or window, is fixed by means of screws 9 which, with the window leaf in the closed state, will be hidden and inaccessible. The hinge's 3 pivot point is roughly in line with the outer edge of the window and crane, while the pivot point for the limb is significantly pulled out from this plane. Therefore, when the window is opened and swung outwards, the outer edge of the window and window frame will swing in different arcs that will diverge and the hook members 7 and 8 will therefore come out of engagement with each other after the window and frame have been swung out a bit.
Stengeanordning for hengslede vinduslemmer. Closing device for hinged window sashes.
Når vinduslemmen skal settes for åpnes vinduet 1 og vinduslemmen 6 svinges inntil vinduet. Når da vindu med lem svin-ger sammen innover mot lukket tilstand vil krokorganene 8 og 9 gripe inn i hverandre og når de normale stengeanordninger for vinduet fastgjøres er også vinduslemmen fastlåst. When the window leaf is to be fitted, the window 1 is opened and the window leaf 6 is swung up to the window. When the window with the sash swings together inwards towards the closed state, the hook members 8 and 9 will engage each other and when the normal closing devices for the window are attached, the window sash is also locked.
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942146 | 1979-12-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO803681L NO803681L (en) | 1981-06-09 |
| NO157019B true NO157019B (en) | 1987-09-28 |
| NO157019C NO157019C (en) | 1988-01-06 |
Family
ID=10509659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO803681A NO157019C (en) | 1979-12-06 | 1980-12-05 | ANALOGICAL PROCEDURE FOR PREPARATION OF THERAPEUTICALLY ACTIVE INDOLIZINE DERIVATIVES. |
Country Status (40)
| Country | Link |
|---|---|
| JP (1) | JPS56103181A (en) |
| AR (4) | AR227036A1 (en) |
| AT (1) | AT376438B (en) |
| AU (1) | AU536320B2 (en) |
| BE (1) | BE886511A (en) |
| BG (2) | BG35598A3 (en) |
| BR (1) | BR8007691A (en) |
| CA (1) | CA1152077A (en) |
| CH (1) | CH651041A5 (en) |
| CS (3) | CS222692B2 (en) |
| DD (1) | DD155069A5 (en) |
| DE (1) | DE3046017C2 (en) |
| DK (1) | DK146977C (en) |
| ES (4) | ES8205798A1 (en) |
| FI (1) | FI67846C (en) |
| GR (1) | GR70224B (en) |
| HK (1) | HK65884A (en) |
| HU (1) | HU185019B (en) |
| IE (1) | IE50519B1 (en) |
| IL (1) | IL61385A (en) |
| IN (1) | IN151241B (en) |
| IS (1) | IS1209B6 (en) |
| IT (1) | IT1218424B (en) |
| KE (1) | KE3438A (en) |
| LU (1) | LU82983A1 (en) |
| MA (1) | MA19007A1 (en) |
| NL (1) | NL184683C (en) |
| NO (1) | NO157019C (en) |
| NZ (1) | NZ195754A (en) |
| OA (1) | OA06711A (en) |
| PH (1) | PH17028A (en) |
| PL (3) | PL127865B1 (en) |
| PT (1) | PT72151B (en) |
| RO (3) | RO85271B (en) |
| SE (1) | SE441926B (en) |
| SG (1) | SG33384G (en) |
| SU (3) | SU1058505A3 (en) |
| YU (3) | YU42366B (en) |
| ZA (1) | ZA806831B (en) |
| ZW (1) | ZW28580A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2814098T3 (en) * | 2014-12-10 | 2021-03-26 | Ono Pharmaceutical Co | Dihydroindolizinone derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1518443A (en) | 1976-02-19 | 1978-07-19 | Labaz | Indolizine derivatives and process for preparing the same |
-
1980
- 1980-10-31 IL IL61385A patent/IL61385A/en unknown
- 1980-11-04 GR GR63275A patent/GR70224B/el unknown
- 1980-11-05 ZA ZA00806831A patent/ZA806831B/en unknown
- 1980-11-05 IS IS2594A patent/IS1209B6/en unknown
- 1980-11-07 CH CH8289/80A patent/CH651041A5/en not_active IP Right Cessation
- 1980-11-12 AU AU64292/80A patent/AU536320B2/en not_active Ceased
- 1980-11-13 PH PH24853A patent/PH17028A/en unknown
- 1980-11-19 NL NLAANVRAGE8006310,A patent/NL184683C/en not_active IP Right Cessation
- 1980-11-25 BR BR8007691A patent/BR8007691A/en unknown
- 1980-11-26 ZW ZW285/80A patent/ZW28580A1/en unknown
- 1980-12-01 CA CA000365859A patent/CA1152077A/en not_active Expired
- 1980-12-01 BG BG8049830A patent/BG35598A3/en unknown
- 1980-12-01 BG BG8362985A patent/BG37379A3/en unknown
- 1980-12-02 SE SE8008444A patent/SE441926B/en not_active IP Right Cessation
- 1980-12-02 YU YU3041/80A patent/YU42366B/en unknown
- 1980-12-03 MA MA19209A patent/MA19007A1/en unknown
- 1980-12-03 IE IE2520/80A patent/IE50519B1/en unknown
- 1980-12-04 PT PT72151A patent/PT72151B/en unknown
- 1980-12-04 CS CS808517A patent/CS222692B2/en unknown
- 1980-12-04 NZ NZ195754A patent/NZ195754A/en unknown
- 1980-12-04 PL PL1980231829A patent/PL127865B1/en unknown
- 1980-12-04 PL PL1980231828A patent/PL129365B1/en unknown
- 1980-12-04 CS CS808517A patent/CS222697B2/en unknown
- 1980-12-04 IN IN1344/CAL/80A patent/IN151241B/en unknown
- 1980-12-04 CS CS814016A patent/CS222698B2/en unknown
- 1980-12-04 PL PL1980228265A patent/PL127999B1/en unknown
- 1980-12-05 LU LU82983A patent/LU82983A1/en unknown
- 1980-12-05 RO RO108949A patent/RO85271B/en unknown
- 1980-12-05 HU HU802915A patent/HU185019B/en not_active IP Right Cessation
- 1980-12-05 NO NO803681A patent/NO157019C/en unknown
- 1980-12-05 SU SU803213301A patent/SU1058505A3/en active
- 1980-12-05 FI FI803792A patent/FI67846C/en not_active IP Right Cessation
- 1980-12-05 RO RO108948A patent/RO84707B/en unknown
- 1980-12-05 ES ES497504A patent/ES8205798A1/en not_active Expired
- 1980-12-05 RO RO102781A patent/RO81452B/en unknown
- 1980-12-05 BE BE0/203053A patent/BE886511A/en not_active IP Right Cessation
- 1980-12-05 AT AT0596780A patent/AT376438B/en not_active IP Right Cessation
- 1980-12-05 IT IT26463/80A patent/IT1218424B/en active
- 1980-12-05 DE DE3046017A patent/DE3046017C2/en not_active Expired
- 1980-12-05 JP JP17252180A patent/JPS56103181A/en active Granted
- 1980-12-05 DK DK521980A patent/DK146977C/en not_active IP Right Cessation
- 1980-12-06 OA OA57269A patent/OA06711A/en unknown
- 1980-12-06 AR AR283495A patent/AR227036A1/en active
- 1980-12-06 DD DD80225817A patent/DD155069A5/en unknown
-
1981
- 1981-12-16 ES ES508051A patent/ES508051A0/en active Granted
- 1981-12-16 ES ES508053A patent/ES8300110A1/en not_active Expired
- 1981-12-16 ES ES508052A patent/ES8300109A1/en not_active Expired
- 1981-12-22 SU SU813367150A patent/SU1109051A3/en active
-
1982
- 1982-02-24 AR AR288535A patent/AR229692A1/en active
- 1982-02-24 AR AR288533A patent/AR227093A1/en active
- 1982-02-24 AR AR227094A patent/AR227094A1/en active
-
1983
- 1983-02-24 YU YU443/83A patent/YU42840B/en unknown
- 1983-02-24 YU YU444/83A patent/YU42127B/en unknown
-
1984
- 1984-04-25 SG SG33384A patent/SG33384G/en unknown
- 1984-08-13 KE KE3438A patent/KE3438A/en unknown
- 1984-08-23 HK HK658/84A patent/HK65884A/en unknown
- 1984-10-12 SU SU843801012A patent/SU1287751A3/en active
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