ES8300109A1 - Procedimiento para preparar derivados de indolizina. - Google Patents

Procedimiento para preparar derivados de indolizina.

Info

Publication number
ES8300109A1
ES8300109A1 ES508052A ES508052A ES8300109A1 ES 8300109 A1 ES8300109 A1 ES 8300109A1 ES 508052 A ES508052 A ES 508052A ES 508052 A ES508052 A ES 508052A ES 8300109 A1 ES8300109 A1 ES 8300109A1
Authority
ES
Spain
Prior art keywords
methyl
bromine
iodine
chlorine
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508052A
Other languages
English (en)
Other versions
ES508052A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz NV
Original Assignee
Labaz NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz NV filed Critical Labaz NV
Publication of ES8300109A1 publication Critical patent/ES8300109A1/es
Publication of ES508052A0 publication Critical patent/ES508052A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE INDOLIZINA. SE HACE REACCIONAR CON BROMO O IODO UN DERIVADO DE INDOLIZINA DE FORMULA GENERAL (I). LA REACCION TIENE LUGAR A TEMPERATURA AMBIENTE EN DIOXANO COMO DISOLVENTE Y EN PRESENCIA DE UN ACETATO DE METAL ALCALINO. SE OBTIENE UN DERIVADO DE INDOLIZINA EN FORMA DE BASE LIBRE, LA CUAL, OPCIONALMENTE SE HACE REACCIONAR CON UN ACIDO ORGANICO O INORGANICO PARA OBTENER LA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. SE OBTEIENE EL COMPUESTO (II). *FORMULA* C
ES508052A 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina. Granted ES508052A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7942146 1979-12-06

Publications (2)

Publication Number Publication Date
ES8300109A1 true ES8300109A1 (es) 1982-10-01
ES508052A0 ES508052A0 (es) 1982-10-01

Family

ID=10509659

Family Applications (4)

Application Number Title Priority Date Filing Date
ES497504A Expired ES8205798A1 (es) 1979-12-06 1980-12-05 Procedimiento para preparar derivados de indolizina
ES508051A Expired ES8300108A1 (es) 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina.
ES508052A Granted ES508052A0 (es) 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina.
ES508053A Expired ES8300110A1 (es) 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES497504A Expired ES8205798A1 (es) 1979-12-06 1980-12-05 Procedimiento para preparar derivados de indolizina
ES508051A Expired ES8300108A1 (es) 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES508053A Expired ES8300110A1 (es) 1979-12-06 1981-12-16 Procedimiento para preparar derivados de indolizina.

Country Status (40)

Country Link
JP (1) JPS56103181A (es)
AR (4) AR227036A1 (es)
AT (1) AT376438B (es)
AU (1) AU536320B2 (es)
BE (1) BE886511A (es)
BG (2) BG35598A3 (es)
BR (1) BR8007691A (es)
CA (1) CA1152077A (es)
CH (1) CH651041A5 (es)
CS (3) CS222692B2 (es)
DD (1) DD155069A5 (es)
DE (1) DE3046017C2 (es)
DK (1) DK146977C (es)
ES (4) ES8205798A1 (es)
FI (1) FI67846C (es)
GR (1) GR70224B (es)
HK (1) HK65884A (es)
HU (1) HU185019B (es)
IE (1) IE50519B1 (es)
IL (1) IL61385A (es)
IN (1) IN151241B (es)
IS (1) IS1209B6 (es)
IT (1) IT1218424B (es)
KE (1) KE3438A (es)
LU (1) LU82983A1 (es)
MA (1) MA19007A1 (es)
NL (1) NL184683C (es)
NO (1) NO157019C (es)
NZ (1) NZ195754A (es)
OA (1) OA06711A (es)
PH (1) PH17028A (es)
PL (3) PL127865B1 (es)
PT (1) PT72151B (es)
RO (3) RO85271B (es)
SE (1) SE441926B (es)
SG (1) SG33384G (es)
SU (3) SU1058505A3 (es)
YU (3) YU42366B (es)
ZA (1) ZA806831B (es)
ZW (1) ZW28580A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017012146B1 (pt) * 2014-12-10 2023-11-21 Ono Pharmaceutical Co., Ltd Composto derivado de di-hidroindolizinona, seu uso, composição farmacêutica e inibidor de fxia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1518443A (en) 1976-02-19 1978-07-19 Labaz Indolizine derivatives and process for preparing the same

Also Published As

Publication number Publication date
NL8006310A (nl) 1981-07-01
RO84707A (ro) 1984-07-17
HU185019B (en) 1984-11-28
AR227093A1 (es) 1982-09-15
IL61385A0 (en) 1980-12-31
PL228265A1 (es) 1981-11-13
YU42127B (en) 1988-04-30
YU44483A (en) 1983-10-31
PL231828A1 (es) 1982-03-15
NL184683B (nl) 1989-05-01
ES508051A0 (es) 1982-10-01
SE8008444L (sv) 1981-06-07
PH17028A (en) 1984-05-17
AU536320B2 (en) 1984-05-03
KE3438A (en) 1984-08-24
ES508053A0 (es) 1982-10-01
IE50519B1 (en) 1986-04-30
ZW28580A1 (en) 1981-08-26
CH651041A5 (en) 1985-08-30
CS222697B2 (en) 1983-07-29
DK146977C (da) 1984-08-13
IN151241B (es) 1983-03-12
RO85271B (ro) 1984-10-30
IT1218424B (it) 1990-04-19
IS2594A7 (is) 1981-06-07
PL129365B1 (en) 1984-05-31
BG37379A3 (en) 1985-05-15
ES8300108A1 (es) 1982-10-01
DK146977B (da) 1984-03-05
IL61385A (en) 1984-11-30
NO157019B (no) 1987-09-28
AR227094A1 (es) 1982-09-15
NZ195754A (en) 1984-03-16
PL127865B1 (en) 1983-12-31
NL184683C (nl) 1989-10-02
FI803792L (fi) 1981-06-07
OA06711A (fr) 1982-06-30
YU42840B (en) 1988-12-31
AT376438B (de) 1984-11-26
BR8007691A (pt) 1981-06-09
YU304180A (en) 1983-10-31
MA19007A1 (fr) 1981-07-01
IS1209B6 (is) 1986-03-24
SG33384G (en) 1985-02-08
RO81452B (ro) 1983-04-30
BG35598A3 (en) 1984-05-15
AU6429280A (en) 1981-06-11
IT8026463A0 (it) 1980-12-05
SE441926B (sv) 1985-11-18
ES8300110A1 (es) 1982-10-01
CS222692B2 (en) 1983-07-29
PL127999B1 (en) 1983-12-31
BE886511A (fr) 1981-06-05
LU82983A1 (fr) 1981-03-26
SU1058505A3 (ru) 1983-11-30
PT72151A (en) 1981-01-01
JPS56103181A (en) 1981-08-18
FI67846C (fi) 1985-06-10
GR70224B (es) 1982-08-31
CS222698B2 (en) 1983-07-29
NO157019C (no) 1988-01-06
FI67846B (fi) 1985-02-28
AR229692A1 (es) 1983-10-31
JPS6325591B2 (es) 1988-05-26
DK521980A (da) 1981-06-07
RO81452A (ro) 1983-04-29
DE3046017A1 (de) 1981-09-03
HK65884A (en) 1984-08-31
RO85271A (ro) 1984-09-29
ES508052A0 (es) 1982-10-01
PT72151B (en) 1981-10-28
ATA596780A (de) 1984-04-15
ES497504A0 (es) 1982-06-16
NO803681L (no) 1981-06-09
SU1109051A3 (ru) 1984-08-15
ZA806831B (en) 1981-10-28
PL231829A1 (es) 1982-03-15
AR227036A1 (es) 1982-09-15
ES8205798A1 (es) 1982-06-16
IE802520L (en) 1981-06-06
DD155069A5 (de) 1982-05-12
SU1287751A3 (ru) 1987-01-30
YU42366B (en) 1988-08-31
RO84707B (ro) 1984-09-30
DE3046017C2 (de) 1986-09-25
CA1152077A (en) 1983-08-16
YU44383A (en) 1983-10-31

Similar Documents

Publication Publication Date Title
ES479021A1 (es) Procedimiento para preparar composiones insecticidas y aca- ricidas a base de derivados sustituidos de fenoxibenciloxi- carbonilo.
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
SE7602144L (sv) Kvaternera imidazoliumforeningar
SE7601143L (sv) Nytt oxadiazolinonderivat
GB1069797A (en) ª‡-aminoketone derivatives
ES8300109A1 (es) Procedimiento para preparar derivados de indolizina.
ES447646A1 (es) Procedimiento para la preparacion de nuevas tiazolinas.
ES451934A1 (es) Procedimiento para la preparacion de n-derivados de anilinasde actividad microbicida.
FR2361352A1 (fr) Derives acylamino (alkyl)-benzeniques, leur procede de preparation et leur application
JPS57126441A (en) Novel cinnamoylcinnamic acid derivative, manufacture and therapeutical composition containing same
IL81933A0 (en) Asymmetrical ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them
ES423232A1 (es) Procedimiento para la preparacion de nuevas 2-fenilamino-i-midazolinas-(2) sustituidas.
DE3269349D1 (en) Dioxybenzene ether derivatives, pharmaceutical compositions containing them, process for the preparation thereof and their use
ES399003A1 (es) Procedimiento para la preparacion de 2-arilamino-imidazoli-nas-(2) sustituidas.
JO1162B1 (en) New endolysin derivatives and method of preparation
ES8103077A1 (es) Procedimiento de preparacion de nuevos derivados fenotiazi- nos o de sus sales de adicion acidas
GB845486A (en) Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines
SE7901034L (sv) Nya anilider med antitussiv verkan och forfarande for framstellning derav
SE7710933L (sv) 5-alkoxi-pikolinsyror
ATE17851T1 (de) Imidazolylkarbonsaeure, deren derivate und herstellung.
ZA792678B (en) A new drug containing a cyclopentylaldehyde derivative and composition containing same
ES8105291A1 (es) Procedimiento para la obtencion de derivados del decahidro- quinolinol
ES433957A1 (es) Un procedimiento de preparacion de nuevas fenotiazinas.
ATE113941T1 (de) Substituierte n-(phenyl-(thioxomethyl)>- morpholinderivate, verfahren zu ihrer herstellung, diese enthaltende zusammensetzung und ihre verwendung.