PT95310B - Processo para a preparacao de novos derivados n-aril e n-heteroarilamida e ureia uteis como inibidores de acil coenzima a:aciltransferase do colesterol - Google Patents
Processo para a preparacao de novos derivados n-aril e n-heteroarilamida e ureia uteis como inibidores de acil coenzima a:aciltransferase do colesterol Download PDFInfo
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- PT95310B PT95310B PT95310A PT9531090A PT95310B PT 95310 B PT95310 B PT 95310B PT 95310 A PT95310 A PT 95310A PT 9531090 A PT9531090 A PT 9531090A PT 95310 B PT95310 B PT 95310B
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- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/004033 WO1991004027A1 (en) | 1989-09-15 | 1989-09-15 | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
Publications (2)
Publication Number | Publication Date |
---|---|
PT95310A PT95310A (pt) | 1991-05-22 |
PT95310B true PT95310B (pt) | 1997-06-30 |
Family
ID=22215232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95310A PT95310B (pt) | 1989-09-15 | 1990-09-13 | Processo para a preparacao de novos derivados n-aril e n-heteroarilamida e ureia uteis como inibidores de acil coenzima a:aciltransferase do colesterol |
Country Status (24)
Country | Link |
---|---|
EP (2) | EP0418071B1 (hu) |
JP (1) | JPH0825974B2 (hu) |
KR (1) | KR930011303B1 (hu) |
CN (1) | CN1050183A (hu) |
AT (2) | ATE177082T1 (hu) |
AU (1) | AU652345B2 (hu) |
CA (1) | CA2025301C (hu) |
DD (1) | DD298092A5 (hu) |
DE (2) | DE69032981T2 (hu) |
DK (2) | DK0418071T3 (hu) |
EG (1) | EG19358A (hu) |
ES (2) | ES2071033T3 (hu) |
FI (1) | FI111362B (hu) |
GR (1) | GR3029826T3 (hu) |
HU (1) | HUT70027A (hu) |
IE (1) | IE66324B1 (hu) |
IL (3) | IL95610A (hu) |
MX (1) | MX22406A (hu) |
NO (1) | NO904022L (hu) |
NZ (1) | NZ235323A (hu) |
PL (4) | PL291471A1 (hu) |
PT (1) | PT95310B (hu) |
WO (1) | WO1991004027A1 (hu) |
ZA (1) | ZA907346B (hu) |
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FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
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US5124337A (en) * | 1991-05-20 | 1992-06-23 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase |
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JPH05320143A (ja) * | 1992-03-18 | 1993-12-03 | Mochida Pharmaceut Co Ltd | 新規ピリミジン誘導体 |
US6001860A (en) * | 1992-05-28 | 1999-12-14 | Pfizer Inc. | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) |
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US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
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US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
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JP4191269B2 (ja) * | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
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DE10050663A1 (de) † | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
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US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
ATE420644T1 (de) * | 2002-02-20 | 2009-01-15 | Abbott Lab | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) |
ES2299689T3 (es) | 2002-02-25 | 2008-06-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas. |
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AU2003251828A1 (en) * | 2002-07-12 | 2004-02-02 | Janssen Pharmaceutica N.V. | Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
KR20070001922A (ko) | 2003-12-12 | 2007-01-04 | 와이어쓰 | 심장혈관질환 치료에 유용한 퀴놀린 |
PT1723128E (pt) | 2004-01-06 | 2013-02-27 | Novo Nordisk As | Heteroaril-ureias e o seu uso como activadores da glicoquinase |
PT1746999E (pt) | 2004-05-06 | 2012-01-11 | Warner Lambert Co | 4-fenilamino-quinazolin-6-il-amidas |
EP1767527A4 (en) | 2004-06-30 | 2009-11-11 | Kowa Co | PROCESS FOR PRODUCING CYCLIC DIAMINE DERIVATIVE |
US7999114B2 (en) | 2005-07-08 | 2011-08-16 | Novo Nordisk A/S | Dicycloalkylcarbamoyl ureas as glucokinase activators |
WO2007006760A1 (en) | 2005-07-08 | 2007-01-18 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
US7884210B2 (en) | 2005-07-14 | 2011-02-08 | Novo Nordisk A/S | Ureido-thiazole glucokinase activators |
CA2616473A1 (en) | 2005-07-27 | 2007-03-08 | F. Hoffmann-La Roche Ag | 4-aryloxy quinoline derivatives as 5-ht6 modulators |
US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
CN101541758A (zh) | 2006-08-25 | 2009-09-23 | 艾博特公司 | 抑制trpv1的吲唑衍生物及其用途 |
BRPI0718515A2 (pt) * | 2006-09-25 | 2013-11-19 | Boehringer Ingelheim Int | Compostos que modulam o receptor cb2 |
MX2009006730A (es) | 2006-12-20 | 2009-06-30 | Abbott Lab | Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor. |
WO2008084043A1 (en) | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
AU2008204530B2 (en) | 2007-01-11 | 2013-08-01 | Vtv Therapeutics Llc | Urea glucokinase activators |
JP2011515414A (ja) | 2008-03-20 | 2011-05-19 | アボット・ラボラトリーズ | Trpv1アンタゴニストである中枢神経系薬剤を作製する方法 |
CA2781685C (en) | 2009-12-11 | 2018-09-04 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
PL2649066T3 (pl) | 2010-12-06 | 2017-04-28 | Autifony Therapeutics Limited | Pochodne hydantoiny przydatne jako inhibitory KV3 |
CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
WO2013175215A1 (en) | 2012-05-22 | 2013-11-28 | Autifony Therapeutics Limited | Triazoles as kv3 inhibitors |
BR112014028718A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
CA3093025A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
CN109553591B (zh) * | 2019-01-15 | 2020-12-15 | 山东安信制药有限公司 | 一种富马酸喹硫平中间体的制备方法 |
GB201919213D0 (en) * | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
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NL125255C (hu) * | 1964-07-31 | |||
US3555035A (en) * | 1966-01-28 | 1971-01-12 | Geigy Chem Corp | N-(substituted pyridyl) linolamides and -linolenamides |
CH484906A (de) * | 1966-01-28 | 1970-01-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren |
CH500980A (de) * | 1966-01-28 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4722927A (en) * | 1986-04-28 | 1988-02-02 | Warner-Lambert Company | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
US4716175A (en) * | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
US5238908A (en) * | 1989-08-31 | 1993-08-24 | Rohm And Haas Company | Herbicidal glutaramic acids and derivatives |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
-
1989
- 1989-09-15 MX MX2240690A patent/MX22406A/es unknown
- 1989-09-15 WO PCT/US1989/004033 patent/WO1991004027A1/en unknown
-
1990
- 1990-09-07 IL IL9561090A patent/IL95610A/en not_active IP Right Cessation
- 1990-09-13 ES ES90310009T patent/ES2071033T3/es not_active Expired - Lifetime
- 1990-09-13 ES ES94200437T patent/ES2127878T3/es not_active Expired - Lifetime
- 1990-09-13 DK DK90310009.7T patent/DK0418071T3/da active
- 1990-09-13 EG EG54590A patent/EG19358A/xx active
- 1990-09-13 CA CA002025301A patent/CA2025301C/en not_active Expired - Fee Related
- 1990-09-13 DE DE69032981T patent/DE69032981T2/de not_active Expired - Fee Related
- 1990-09-13 DK DK94200437T patent/DK0609960T3/da active
- 1990-09-13 EP EP90310009A patent/EP0418071B1/en not_active Expired - Lifetime
- 1990-09-13 PT PT95310A patent/PT95310B/pt not_active IP Right Cessation
- 1990-09-13 AT AT94200437T patent/ATE177082T1/de not_active IP Right Cessation
- 1990-09-13 EP EP94200437A patent/EP0609960B1/en not_active Expired - Lifetime
- 1990-09-13 AT AT90310009T patent/ATE121730T1/de not_active IP Right Cessation
- 1990-09-13 DE DE69018908T patent/DE69018908T2/de not_active Expired - Fee Related
- 1990-09-14 IE IE333690A patent/IE66324B1/en not_active IP Right Cessation
- 1990-09-14 PL PL29147190A patent/PL291471A1/xx unknown
- 1990-09-14 PL PL29147290A patent/PL291472A1/xx unknown
- 1990-09-14 PL PL90286899A patent/PL165370B1/pl unknown
- 1990-09-14 PL PL90291470A patent/PL165357B1/pl unknown
- 1990-09-14 KR KR1019900014554A patent/KR930011303B1/ko not_active IP Right Cessation
- 1990-09-14 ZA ZA907346A patent/ZA907346B/xx unknown
- 1990-09-14 JP JP2245969A patent/JPH0825974B2/ja not_active Expired - Fee Related
- 1990-09-14 HU HU9302945A patent/HUT70027A/hu unknown
- 1990-09-14 FI FI904537A patent/FI111362B/fi active IP Right Grant
- 1990-09-14 CN CN90108294A patent/CN1050183A/zh active Pending
- 1990-09-14 NZ NZ235323A patent/NZ235323A/xx unknown
- 1990-09-14 AU AU62553/90A patent/AU652345B2/en not_active Ceased
- 1990-09-14 NO NO90904022A patent/NO904022L/no unknown
- 1990-09-27 DD DD90343971A patent/DD298092A5/de not_active IP Right Cessation
-
1994
- 1994-07-14 IL IL11032194A patent/IL110321A0/xx unknown
- 1994-07-14 IL IL11032494A patent/IL110324A0/xx unknown
-
1999
- 1999-03-30 GR GR990400917T patent/GR3029826T3/el unknown
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