ATE177082T1 - N-heteroarylamidederivate als inhibitoren von acyl-coenzym a: cholesterol-acyl-transferase - Google Patents
N-heteroarylamidederivate als inhibitoren von acyl-coenzym a: cholesterol-acyl-transferaseInfo
- Publication number
- ATE177082T1 ATE177082T1 AT94200437T AT94200437T ATE177082T1 AT E177082 T1 ATE177082 T1 AT E177082T1 AT 94200437 T AT94200437 T AT 94200437T AT 94200437 T AT94200437 T AT 94200437T AT E177082 T1 ATE177082 T1 AT E177082T1
- Authority
- AT
- Austria
- Prior art keywords
- acyl
- inhibitors
- coenzyme
- cholesterol
- transferase
- Prior art date
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/004033 WO1991004027A1 (en) | 1989-09-15 | 1989-09-15 | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
EP90310009A EP0418071B1 (de) | 1989-09-15 | 1990-09-13 | N-aryl und N-Heteroarylamide und Harnstoffderivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE177082T1 true ATE177082T1 (de) | 1999-03-15 |
Family
ID=22215232
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90310009T ATE121730T1 (de) | 1989-09-15 | 1990-09-13 | N-aryl und n-heteroarylamide und harnstoffderivate als inhibitoren von acyl- coenzym a: cholesterol-acyl-transferase. |
AT94200437T ATE177082T1 (de) | 1989-09-15 | 1990-09-13 | N-heteroarylamidederivate als inhibitoren von acyl-coenzym a: cholesterol-acyl-transferase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90310009T ATE121730T1 (de) | 1989-09-15 | 1990-09-13 | N-aryl und n-heteroarylamide und harnstoffderivate als inhibitoren von acyl- coenzym a: cholesterol-acyl-transferase. |
Country Status (24)
Country | Link |
---|---|
EP (2) | EP0609960B1 (de) |
JP (1) | JPH0825974B2 (de) |
KR (1) | KR930011303B1 (de) |
CN (1) | CN1050183A (de) |
AT (2) | ATE121730T1 (de) |
AU (1) | AU652345B2 (de) |
CA (1) | CA2025301C (de) |
DD (1) | DD298092A5 (de) |
DE (2) | DE69018908T2 (de) |
DK (2) | DK0418071T3 (de) |
EG (1) | EG19358A (de) |
ES (2) | ES2127878T3 (de) |
FI (1) | FI111362B (de) |
GR (1) | GR3029826T3 (de) |
HU (1) | HUT70027A (de) |
IE (1) | IE66324B1 (de) |
IL (3) | IL95610A (de) |
MX (1) | MX22406A (de) |
NO (1) | NO904022L (de) |
NZ (1) | NZ235323A (de) |
PL (4) | PL291471A1 (de) |
PT (1) | PT95310B (de) |
WO (1) | WO1991004027A1 (de) |
ZA (1) | ZA907346B (de) |
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JP4960355B2 (ja) | 2005-07-14 | 2012-06-27 | ノボ・ノルデイスク・エー/エス | ウレア型グルコキナーゼ活性化剤 |
ES2341489T3 (es) | 2005-07-27 | 2010-06-21 | F.Hoffmann-La Roche Ag | Derivados de 4-ariloxi quinolina como moduladores de 5-ht6. |
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US8138185B2 (en) | 2007-01-09 | 2012-03-20 | Novo Nordisk A/S | Urea glucokinase activators |
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EA019970B8 (ru) | 2009-12-11 | 2014-11-28 | Отифони Терапеутикс Лимитед | Производные имидазолидиндиона |
BR112013013914B1 (pt) | 2010-12-06 | 2021-10-26 | Autifony Therapeutics Limited | Compostos derivados de hidantoína úteis como inibidores de kv3, usos dos referidos compostos e composição farmacêutica compreendendo os mesmos |
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EP2852589B1 (de) | 2012-05-22 | 2021-04-28 | Autifony Therapeutics Limited | Triazole als kv3 inhibitoren |
BR112014028718A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
MX2020008905A (es) | 2018-06-12 | 2020-12-03 | Vtv Therapeutics Llc | Usos terapeuticos de activadores de glucoquinasa en combinacion con insulina o analogos de insulinas. |
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CH500980A (de) * | 1966-01-28 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren |
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US4716175A (en) * | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
US5238908A (en) * | 1989-08-31 | 1993-08-24 | Rohm And Haas Company | Herbicidal glutaramic acids and derivatives |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
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-
1989
- 1989-09-15 MX MX2240690A patent/MX22406A/es unknown
- 1989-09-15 WO PCT/US1989/004033 patent/WO1991004027A1/en unknown
-
1990
- 1990-09-07 IL IL9561090A patent/IL95610A/en not_active IP Right Cessation
- 1990-09-13 ES ES94200437T patent/ES2127878T3/es not_active Expired - Lifetime
- 1990-09-13 EG EG54590A patent/EG19358A/xx active
- 1990-09-13 EP EP94200437A patent/EP0609960B1/de not_active Expired - Lifetime
- 1990-09-13 PT PT95310A patent/PT95310B/pt not_active IP Right Cessation
- 1990-09-13 ES ES90310009T patent/ES2071033T3/es not_active Expired - Lifetime
- 1990-09-13 AT AT90310009T patent/ATE121730T1/de not_active IP Right Cessation
- 1990-09-13 AT AT94200437T patent/ATE177082T1/de not_active IP Right Cessation
- 1990-09-13 DE DE69018908T patent/DE69018908T2/de not_active Expired - Fee Related
- 1990-09-13 DE DE69032981T patent/DE69032981T2/de not_active Expired - Fee Related
- 1990-09-13 DK DK90310009.7T patent/DK0418071T3/da active
- 1990-09-13 EP EP90310009A patent/EP0418071B1/de not_active Expired - Lifetime
- 1990-09-13 DK DK94200437T patent/DK0609960T3/da active
- 1990-09-13 CA CA002025301A patent/CA2025301C/en not_active Expired - Fee Related
- 1990-09-14 KR KR1019900014554A patent/KR930011303B1/ko not_active IP Right Cessation
- 1990-09-14 PL PL29147190A patent/PL291471A1/xx unknown
- 1990-09-14 PL PL90291470A patent/PL165357B1/pl unknown
- 1990-09-14 JP JP2245969A patent/JPH0825974B2/ja not_active Expired - Fee Related
- 1990-09-14 IE IE333690A patent/IE66324B1/en not_active IP Right Cessation
- 1990-09-14 CN CN90108294A patent/CN1050183A/zh active Pending
- 1990-09-14 PL PL29147290A patent/PL291472A1/xx unknown
- 1990-09-14 HU HU9302945A patent/HUT70027A/hu unknown
- 1990-09-14 FI FI904537A patent/FI111362B/fi active IP Right Grant
- 1990-09-14 NO NO90904022A patent/NO904022L/no unknown
- 1990-09-14 AU AU62553/90A patent/AU652345B2/en not_active Ceased
- 1990-09-14 PL PL90286899A patent/PL165370B1/pl unknown
- 1990-09-14 ZA ZA907346A patent/ZA907346B/xx unknown
- 1990-09-14 NZ NZ235323A patent/NZ235323A/xx unknown
- 1990-09-27 DD DD90343971A patent/DD298092A5/de not_active IP Right Cessation
-
1994
- 1994-07-14 IL IL11032494A patent/IL110324A0/xx unknown
- 1994-07-14 IL IL11032194A patent/IL110321A0/xx unknown
-
1999
- 1999-03-30 GR GR990400917T patent/GR3029826T3/el unknown
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