DE60024830T2 - Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen - Google Patents

Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen Download PDF

Info

Publication number
DE60024830T2
DE60024830T2 DE60024830T DE60024830T DE60024830T2 DE 60024830 T2 DE60024830 T2 DE 60024830T2 DE 60024830 T DE60024830 T DE 60024830T DE 60024830 T DE60024830 T DE 60024830T DE 60024830 T2 DE60024830 T2 DE 60024830T2
Authority
DE
Germany
Prior art keywords
sub
substituted urea
heteroaryl substituted
urea bonding
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024830T
Other languages
English (en)
Other versions
DE60024830D1 (de
Inventor
Lin-Hua Zhang
Lei Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Publication of DE60024830D1 publication Critical patent/DE60024830D1/de
Application granted granted Critical
Publication of DE60024830T2 publication Critical patent/DE60024830T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DE60024830T 1999-07-09 2000-06-27 Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen Expired - Lifetime DE60024830T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14309499P 1999-07-09 1999-07-09
PCT/US2000/017655 WO2001004115A2 (en) 1999-07-09 2000-06-27 Novel process for synthesis of heteroaryl-substituted urea compounds

Publications (2)

Publication Number Publication Date
DE60024830D1 DE60024830D1 (de) 2006-01-19
DE60024830T2 true DE60024830T2 (de) 2006-06-14

Family

ID=22502581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024830T Expired - Lifetime DE60024830T2 (de) 1999-07-09 2000-06-27 Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen

Country Status (9)

Country Link
US (5) US6583282B1 (de)
EP (1) EP1200411B1 (de)
JP (1) JP4162406B2 (de)
AT (1) ATE312823T1 (de)
CA (1) CA2374737C (de)
DE (1) DE60024830T2 (de)
ES (1) ES2253233T3 (de)
MX (1) MXPA02000314A (de)
WO (1) WO2001004115A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
EP1140840B1 (de) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US7351834B1 (en) * 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DE60024830T2 (de) * 1999-07-09 2006-06-14 Boehringer Ingelheim Pharma Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
WO2001036403A1 (en) * 1999-11-16 2001-05-25 Boehringer Ingelheim Pharmaceuticals, Inc. Urea derivatives as anti-inflammatory agents
JP2004504360A (ja) * 2000-07-24 2004-02-12 ベーリンガー　インゲルハイム　ファーマシューティカルズ　インコーポレイテッド １−（５−ｔｅｒｔ−ブチル−２−Ｐ−トリル−２Ｈ−ピラゾール−３−イル）−３−［４−（２−モルホリン−４−イル−エトキシ）−ナフタレン−１−イル］−ウレアの改良された経口製剤
WO2002066442A1 (en) 2001-02-15 2002-08-29 Boehringer Ingelheim Pharmaceuticals, Inc. Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
CA2490819A1 (en) * 2001-04-13 2002-10-24 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
EP1709965A3 (de) 2001-07-11 2006-12-27 Boehringer Ingelheim Pharmaceuticals, Inc. Methode zur Behandlung von zytokinvermittelten Erkrankungen
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
EP2324825A1 (de) 2002-02-11 2011-05-25 Bayer Healthcare LLC Arylharnstoffe mit Angiogenese hemmender Aktivität
ATE386030T1 (de) * 2002-02-25 2008-03-15 Boehringer Ingelheim Pharma 1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
US7056925B2 (en) 2002-08-13 2006-06-06 Abbott Laboratories Urea kinase inhibitors
US20040138216A1 (en) * 2002-12-23 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea
JP4613157B2 (ja) * 2003-01-14 2011-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
ATE366108T1 (de) 2003-05-20 2007-07-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
WO2004113352A1 (en) * 2003-06-19 2004-12-29 Amedis Pharmaceuticals Ltd. Silylated heterocyclylurea derivatives as cytokine-inhibitors
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
KR101024904B1 (ko) * 2003-08-14 2011-03-31 엘지전자 주식회사 기록매체, 기록방법, 기록장치 및 기록재생시스템
AU2004270733B2 (en) * 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
WO2005063715A1 (en) * 2003-12-18 2005-07-14 Boehringer Ingelheim Pharmaceuticals, Inc. Polymorph of birb 796, a p38map kinase inhibitor
JP2007535565A (ja) 2004-04-30 2007-12-06 バイエル ファーマシューティカルス コーポレーション 癌の治療に有用な置換ピラゾリル尿素誘導体
PL1765327T3 (pl) 2004-06-17 2015-01-30 Cytokinetics Inc Związki, kompozycje i sposoby
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
DE102005048390A1 (de) * 2005-10-10 2007-04-19 Siemens Ag Verfahren und Einrichtung zur Bewegungsführung eines bewegbaren Maschinenelementes einer Maschine
EP1947682B1 (de) 2005-10-11 2012-01-18 Nikon Corporation Mehrschichtiger reflektierender spiegel, verfahren zur herstellung eines mehrschichtigen reflektierenden spiegels, optisches system, belichtungsvorrichtung und vorrichtungsherstellungsverfahren
WO2007070683A2 (en) * 2005-12-15 2007-06-21 Cytokinetics, Inc. Certain chemical entities, compositions and methods
EP1959947A2 (de) * 2005-12-15 2008-08-27 Cytokinetics, Inc. Bestimmte chemische stoffe, zusammensetzungen und verfahren
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
EP1959962A2 (de) * 2005-12-16 2008-08-27 Cytokinetics, Inc. Bestimmte chemische stoffe, zusammensetzungen und verfahren
US7989455B2 (en) * 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
JP5131990B2 (ja) * 2006-01-31 2013-01-30 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害剤およびその使用方法
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
PE20110598A1 (es) 2008-10-02 2011-08-31 Respivert Ltd Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38
US8299073B2 (en) 2008-12-11 2012-10-30 Respivert Ltd. P38 MAP kinase inhibitors
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
BRPI1004176A2 (pt) * 2010-10-25 2015-08-11 Univ Rio De Janeiro Compostos aril e/ou hetero aril uréias funcionalizados; processo de síntese desses composto; composição farmacêutica contendo tais compostos e usos
BR112014007694B1 (pt) 2011-10-03 2022-09-27 Respivert Limited Compostos de 1-(3-(tert-butil)-1-(p-tolil)-1h-pirazol-5-il)-3-(4-((2-(fenilamino) pirimidin-4-il)óxi) naftalen-1-il)ureia, seus usos, composição e formulação farmacêutica compreendendo os mesmos
EP2578582A1 (de) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) Harnstoffe als p38 MAP Kinasehemmer
CA2860479A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Kinase inhibitors
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
US20150210722A1 (en) 2012-08-29 2015-07-30 Respivert Limited Kinase inhibitors
US9783556B2 (en) 2012-08-29 2017-10-10 Respivert Limited Kinase inhibitors
EP2890695A2 (de) 2012-08-29 2015-07-08 Respivert Limited Kinaseinhibitoren
GB201215357D0 (en) 2012-08-29 2012-10-10 Respivert Ltd Compounds
WO2014076484A1 (en) 2012-11-16 2014-05-22 Respivert Limited Kinase inhibitors
WO2014140582A1 (en) 2013-03-14 2014-09-18 Respivert Limited Kinase inhibitors
EP2981535B8 (de) 2013-04-02 2021-03-10 Oxular Acquisitions Limited Als kinaseinhibitoren nützliche harnstoffderivate
US9771353B2 (en) 2013-04-02 2017-09-26 Topivert Pharma Limited Kinase inhibitors based upon N-alkyl pyrazoles
CN106029651A (zh) 2013-12-20 2016-10-12 瑞斯比维特有限公司 用作激酶抑制剂的脲衍生物
EA034927B1 (ru) 2014-02-14 2020-04-07 Респайверт Лимитед Ароматические гетероциклические соединения как противовоспалительные соединения
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
AU2017245888B2 (en) 2016-04-06 2021-05-13 Oxular Acquisitions Limited Kinase inhibitors
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN109053623B (zh) * 2018-08-27 2020-08-04 济南悟通生物科技有限公司 一种4-甲基-5-噻唑甲醛的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US447624A (en) * 1891-03-03 Corn-harvester
US3291808A (en) * 1961-08-14 1966-12-13 Parke Davis & Co Naphthalene diamine compounds and methods for their production
US4105766A (en) * 1977-08-19 1978-08-08 Sterling Drug Inc. 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
US4447624A (en) * 1980-08-27 1984-05-08 Eastman Kodak Company Preparation of thiophenes
HU185294B (en) 1980-12-29 1984-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted urea derivatives
US4436567A (en) * 1982-03-22 1984-03-13 Weikert Roy J Method for joining webs of aseptic pouches
JPS61228444A (ja) 1985-04-02 1986-10-11 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
EP0272866A1 (de) 1986-12-23 1988-06-29 Merck & Co. Inc. 1,4-Benzodiazepine mit 5-gliedrigen heterocyclischen Ringen
GB8908869D0 (en) 1989-04-19 1989-06-07 Shell Int Research A process for the preparation of aromatic ureas
MX22406A (es) 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
DD293352A5 (de) 1990-04-06 1991-08-29 Adw,Zi Fuer Organische Chemie,De Verfahren zur herstellung von 2,2-disubstituierten 1-acyl- und/oder 9-acyl-2,3-dihydro-imidazo/1,2-a/benzimidazol-3-onen
US5162360A (en) * 1991-06-24 1992-11-10 Warner-Lambert Company 2-heteroatom containing urea and thiourea ACAT inhibitors
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
CA2134359C (en) 1992-05-28 1997-07-01 Ernest S. Hamanaka New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
US5342942A (en) 1992-06-09 1994-08-30 Warner-Lambert Company Pyrazoloquinazolone derivatives as neurotrophic agents
GB9302275D0 (en) 1993-02-05 1993-03-24 Smithkline Beecham Plc Novel compounds
EP0692483A1 (de) 1993-03-30 1996-01-17 Yoshitomi Pharmaceutical Industries, Ltd. Zelladhäsionsinhibitor und thienotriazoldiazepin-derivat
US5783664A (en) * 1993-09-17 1998-07-21 Smithkline Beecham Corporation Cytokine suppressive anit-inflammatory drug binding proteins
US5869043A (en) * 1993-09-17 1999-02-09 Smithkline Beecham Corporation Drug binding protein
DE69421624T2 (de) * 1993-09-17 2000-07-20 Smithkline Beecham Corp Medikamente bindendes protein
EP0809492A4 (de) 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 rezeptor antagonisten
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US5658903A (en) 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
WO1997016442A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
US6074862A (en) 1995-12-20 2000-06-13 Signal Pharmaceuticals Inc. Mitogen-activated protein kinase kinase MEK6 and variants thereof
US6096748A (en) 1996-03-13 2000-08-01 Smithkline Beecham Corporation Pyrimidine compounds useful in treating cytokine mediated diseases
US6235760B1 (en) 1996-03-25 2001-05-22 Smithkline Beecham Corporation Treatment for CNS injuries
JP2000507558A (ja) 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
US5948885A (en) * 1996-05-20 1999-09-07 Signal Pharmaceuticals, Inc. Mitogen-activated protein kinase p38-2 and methods of use therefor
AU736316B2 (en) 1996-05-20 2001-07-26 Signal Pharmaceuticals, Inc. Mitogen-activated protein kinase p38-2 and methods of use therefor
WO1997047618A1 (en) 1996-06-10 1997-12-18 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
CA2258728C (en) 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
ATE284955T1 (de) 1996-10-09 2005-01-15 Medical Res Council Map-kinase: polypeptide, polynukleotide und ihre verwendung
EP0955293B1 (de) 1996-12-03 2003-03-19 Banyu Pharmaceutical Co., Ltd. Harnstoffderivate
US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6376214B1 (en) 1997-02-18 2002-04-23 Smithkline Beecham Corporation DNA encoding a novel homolog of CSBP/p38 MAP kinase
ATE399007T1 (de) 1997-05-23 2008-07-15 Bayer Pharmaceuticals Corp Raf kinase hemmer
WO1998052558A1 (en) 1997-05-23 1998-11-26 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US5851812A (en) * 1997-07-01 1998-12-22 Tularik Inc. IKK-β proteins, nucleic acids and methods
US5858041A (en) * 1997-08-22 1999-01-12 David Luetkemeyer Clean air system
CA2223075A1 (en) 1997-12-02 1999-06-02 Smithkline Beecham Corporation Drug binding protein
ATE297383T1 (de) 1997-12-22 2005-06-15 Bayer Pharmaceuticals Corp Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen
WO1999032111A1 (en) 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
CZ299156B6 (cs) 1997-12-22 2008-05-07 Bayer Corporation Substituované heterocyklické mocoviny, farmaceutické prípravky je obsahující a jejich použití
KR100622138B1 (ko) 1997-12-22 2006-09-13 바이엘 코포레이션 아릴 및 헤테로아릴 치환 헤테로고리형 우레아를 사용한라프 키나제의 저해
ES2155817T3 (es) 1997-12-22 2007-06-16 Bayer Pharmaceuticals Corp. Inhibicion de la actividad de la quinasa p38 utilizando ureas heterociclicas sustituidas con arilo y heteroarilo.
AU2713799A (en) 1998-03-12 1999-09-27 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
UA73492C2 (en) * 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
EP1157026A1 (de) * 1999-02-22 2001-11-28 Boehringer Ingelheim Pharmaceuticals Inc. Polyheterocyclische verbindungen mit entzündungshemmender wirkung
DE60014603T2 (de) 1999-03-12 2006-02-16 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel
DE60023853T2 (de) 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
DE60024830T2 (de) * 1999-07-09 2006-06-14 Boehringer Ingelheim Pharma Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen

Also Published As

Publication number Publication date
US6774233B2 (en) 2004-08-10
US20030166931A1 (en) 2003-09-04
US6894173B2 (en) 2005-05-17
JP4162406B2 (ja) 2008-10-08
US6753426B2 (en) 2004-06-22
CA2374737A1 (en) 2001-01-18
US6583282B1 (en) 2003-06-24
CA2374737C (en) 2008-02-12
ES2253233T3 (es) 2006-06-01
US20030166930A1 (en) 2003-09-04
DE60024830D1 (de) 2006-01-19
JP2003504366A (ja) 2003-02-04
EP1200411B1 (de) 2005-12-14
EP1200411A2 (de) 2002-05-02
US6835832B2 (en) 2004-12-28
ATE312823T1 (de) 2005-12-15
US20030181718A1 (en) 2003-09-25
US20030109703A1 (en) 2003-06-12
WO2001004115A2 (en) 2001-01-18
WO2001004115A3 (en) 2001-09-27
MXPA02000314A (es) 2004-06-22

Similar Documents

Publication Publication Date Title
DE60024830D1 (de) Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
CA2389360A1 (en) Urea derivatives as anti-inflammatory agents
MY128063A (en) Aromatic heterocyclic compound as antiinflammatory agents
ATE386030T1 (de) 1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
CA2361998A1 (en) Aromatic heterocyclic compounds as anti-inflammatory agents
WO2003097656A3 (en) Novel substituted sulfamate anticonvulsant derivatives
YU37904A (sh) Benzimidazoli kao korisni inhibitori proteinske kinaze
MXPA03011954A (es) Nuevos derivados de acido sulfonico.
TR28332A (tr) Arilasetik asit türevleri.
DE602004025344D1 (de) Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon
RS19504A (en) Novel compounds and compositions as cathepsin inhibitors
ATE329909T1 (de) 1,2,3-triazolamid-derivate als cytokininhibitoren
WO2003042169A3 (en) Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof
EA200300066A1 (ru) Производные аминоалкоксибензоил-бензофурана или бензотиофена, способ их получения и содержащие их композиции
WO2004033423A3 (en) Anticancer compounds
RS88704A (en) Acyl-3-carboxyphenylurea derivatives, method for production and use thereof
DE60318320D1 (de) Benzimidazolone und ihre verwendung als cytokininhibitoren
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
TR200000536A2 (tr) Büyüme hormonu sekretagogları hazırlamak için proses.
ATE446952T1 (de) Herstellungsverfahren von 2-cyanopyridinen
PT1373218E (pt) Derivados de imidazolilo úteis como ligandos do receptor h3 de histamina
WO2003070696A3 (de) Substituierte arylketone
BR9910370A (pt) Compostos de cefalosporina, processo para preparar compostos de cefalosporina, e, composições antimicrobianas
DE50107619D1 (de) Verfahren zur herstellung von 4-brom-anilin-derivaten
CA2168921A1 (en) 1,6-naphthyridonecarboxylic acid derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition