DE60024830D1 - Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen - Google Patents
Verfahren zur herstellung heteroarylsubstituierter ureaverbindungenInfo
- Publication number
- DE60024830D1 DE60024830D1 DE60024830T DE60024830T DE60024830D1 DE 60024830 D1 DE60024830 D1 DE 60024830D1 DE 60024830 T DE60024830 T DE 60024830T DE 60024830 T DE60024830 T DE 60024830T DE 60024830 D1 DE60024830 D1 DE 60024830D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- substituted urea
- heteroaryl substituted
- urea bonding
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14309499P | 1999-07-09 | 1999-07-09 | |
PCT/US2000/017655 WO2001004115A2 (en) | 1999-07-09 | 2000-06-27 | Novel process for synthesis of heteroaryl-substituted urea compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60024830D1 true DE60024830D1 (de) | 2006-01-19 |
DE60024830T2 DE60024830T2 (de) | 2006-06-14 |
Family
ID=22502581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60024830T Expired - Lifetime DE60024830T2 (de) | 1999-07-09 | 2000-06-27 | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
Country Status (9)
Country | Link |
---|---|
US (5) | US6583282B1 (de) |
EP (1) | EP1200411B1 (de) |
JP (1) | JP4162406B2 (de) |
AT (1) | ATE312823T1 (de) |
CA (1) | CA2374737C (de) |
DE (1) | DE60024830T2 (de) |
ES (1) | ES2253233T3 (de) |
MX (1) | MXPA02000314A (de) |
WO (1) | WO2001004115A2 (de) |
Families Citing this family (64)
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
RU2319693C9 (ru) * | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
CA2374737C (en) * | 1999-07-09 | 2008-02-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel process for synthesis of heteroaryl-substituted urea compounds |
US6492393B1 (en) * | 1999-11-16 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
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MXPA03009361A (es) * | 2001-04-13 | 2004-01-29 | Boehringer Ingelheim Pharma | Compuestos de urea utilies como agentes anti-inflamatorios. |
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WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
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ES2299689T3 (es) * | 2002-02-25 | 2008-06-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas. |
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US20070197505A1 (en) * | 2005-12-15 | 2007-08-23 | Morgan Bradley P | Certain chemical entities, compositions and methods |
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US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
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CN102256964A (zh) | 2008-10-02 | 2011-11-23 | 瑞斯比维特有限公司 | p38MAP激酶抑制剂 |
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BRPI1004176A2 (pt) * | 2010-10-25 | 2015-08-11 | Univ Rio De Janeiro | Compostos aril e/ou hetero aril uréias funcionalizados; processo de síntese desses composto; composição farmacêutica contendo tais compostos e usos |
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WO2014033446A1 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
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2000
- 2000-06-27 CA CA002374737A patent/CA2374737C/en not_active Expired - Lifetime
- 2000-06-27 EP EP00941745A patent/EP1200411B1/de not_active Expired - Lifetime
- 2000-06-27 AT AT00941745T patent/ATE312823T1/de active
- 2000-06-27 ES ES00941745T patent/ES2253233T3/es not_active Expired - Lifetime
- 2000-06-27 JP JP2001509725A patent/JP4162406B2/ja not_active Expired - Lifetime
- 2000-06-27 DE DE60024830T patent/DE60024830T2/de not_active Expired - Lifetime
- 2000-06-27 MX MXPA02000314A patent/MXPA02000314A/es active IP Right Grant
- 2000-06-27 WO PCT/US2000/017655 patent/WO2001004115A2/en active IP Right Grant
- 2000-07-06 US US09/611,109 patent/US6583282B1/en not_active Expired - Lifetime
-
2002
- 2002-11-20 US US10/300,448 patent/US6753426B2/en not_active Expired - Lifetime
-
2003
- 2003-02-10 US US10/361,440 patent/US6894173B2/en not_active Expired - Lifetime
- 2003-02-10 US US10/361,731 patent/US6835832B2/en not_active Expired - Lifetime
- 2003-02-10 US US10/361,719 patent/US6774233B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2374737C (en) | 2008-02-12 |
US20030181718A1 (en) | 2003-09-25 |
US6774233B2 (en) | 2004-08-10 |
WO2001004115A3 (en) | 2001-09-27 |
ATE312823T1 (de) | 2005-12-15 |
US6583282B1 (en) | 2003-06-24 |
US6835832B2 (en) | 2004-12-28 |
JP4162406B2 (ja) | 2008-10-08 |
JP2003504366A (ja) | 2003-02-04 |
EP1200411A2 (de) | 2002-05-02 |
US6753426B2 (en) | 2004-06-22 |
ES2253233T3 (es) | 2006-06-01 |
US20030109703A1 (en) | 2003-06-12 |
EP1200411B1 (de) | 2005-12-14 |
DE60024830T2 (de) | 2006-06-14 |
US6894173B2 (en) | 2005-05-17 |
US20030166930A1 (en) | 2003-09-04 |
US20030166931A1 (en) | 2003-09-04 |
CA2374737A1 (en) | 2001-01-18 |
WO2001004115A2 (en) | 2001-01-18 |
MXPA02000314A (es) | 2004-06-22 |
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