PT88492B - Processo para a preparacao de excipientes farmaceuticos contendo monoesteres soluveis em agua e que solubilizam compostos farmacologicamente activos - Google Patents
Processo para a preparacao de excipientes farmaceuticos contendo monoesteres soluveis em agua e que solubilizam compostos farmacologicamente activos Download PDFInfo
- Publication number
- PT88492B PT88492B PT88492A PT8849288A PT88492B PT 88492 B PT88492 B PT 88492B PT 88492 A PT88492 A PT 88492A PT 8849288 A PT8849288 A PT 8849288A PT 88492 B PT88492 B PT 88492B
- Authority
- PT
- Portugal
- Prior art keywords
- solid solution
- preparation
- water
- component
- monoester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3730909 | 1987-09-15 | ||
| DE3802355 | 1988-01-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT88492A PT88492A (pt) | 1988-10-01 |
| PT88492B true PT88492B (pt) | 1993-03-31 |
Family
ID=25859774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT88492A PT88492B (pt) | 1987-09-15 | 1988-09-13 | Processo para a preparacao de excipientes farmaceuticos contendo monoesteres soluveis em agua e que solubilizam compostos farmacologicamente activos |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JP3090666B2 (de) |
| KR (1) | KR0131084B1 (de) |
| AT (1) | AT395819B (de) |
| AU (1) | AU628787B2 (de) |
| BE (1) | BE1001204A5 (de) |
| CA (1) | CA1338775C (de) |
| CH (1) | CH683672A5 (de) |
| DK (1) | DK175132B1 (de) |
| ES (1) | ES2012118A6 (de) |
| FI (1) | FI94837C (de) |
| FR (1) | FR2620336B1 (de) |
| GB (1) | GB2209671B (de) |
| GR (1) | GR1002243B (de) |
| HU (1) | HU205010B (de) |
| IE (1) | IE61195B1 (de) |
| IL (1) | IL87746A (de) |
| IT (1) | IT1224886B (de) |
| LU (1) | LU87335A1 (de) |
| MY (1) | MY103769A (de) |
| NL (1) | NL195094C (de) |
| NO (1) | NO179434C (de) |
| NZ (1) | NZ226163A (de) |
| PT (1) | PT88492B (de) |
| SE (1) | SE503279C2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| GR1000466B (el) * | 1989-01-28 | 1992-07-30 | Sandoz Ag | Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης. |
| BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
| GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| WO1993023010A1 (en) | 1992-05-13 | 1993-11-25 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| DK1033128T4 (da) | 1993-09-28 | 2012-03-19 | Scherer Gmbh R P | Blød gelatinekapselfremstilling |
| EP0789580B1 (de) | 1994-11-03 | 2002-06-05 | Novartis AG | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| TW414696B (en) * | 1996-07-01 | 2000-12-11 | Mitsubishi Kagaku Foods Kk | Anti-bacteria agent |
| ES2229473T3 (es) | 1997-01-30 | 2005-04-16 | Novartis Ag | Composiciones farmaceuticas sin aceite que contienen ciclosporina a. |
| GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| AU2003267747A1 (en) * | 2003-10-14 | 2005-05-05 | Ramesh Varada Bapat | Sterile gelling agents |
| JP5422871B2 (ja) * | 2006-10-24 | 2014-02-19 | 不二製油株式会社 | イソフラボン類組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL284933A (de) * | 1961-10-31 | |||
| GB1134878A (en) * | 1966-05-12 | 1968-11-27 | Suga Kazuo | Improvements in and relating to oryzanol solutions and compositions |
| FR5986M (de) * | 1966-11-22 | 1968-06-21 | ||
| BE787842A (fr) * | 1971-08-25 | 1972-12-18 | Sumito Chemical Cy Ltd | Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol |
| JPS53107408A (en) * | 1977-02-28 | 1978-09-19 | Yamanouchi Pharmaceut Co Ltd | Micellar preparation for rectal infusion |
| FI65914C (fi) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
| JPS57128634A (en) * | 1981-02-03 | 1982-08-10 | Eisai Co Ltd | Elastase-containing compound increasing absorption |
| EP0179583A1 (de) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | System zur Verbesserung der Auflösungsgeschwindigkeit in Wasser und der Löslichkeit von schwer löslichen Arzneimitteln |
| JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
-
1988
- 1988-09-01 HU HU884518A patent/HU205010B/hu unknown
- 1988-09-12 FR FR888811953A patent/FR2620336B1/fr not_active Expired - Lifetime
- 1988-09-12 CH CH3398/88A patent/CH683672A5/de not_active IP Right Cessation
- 1988-09-12 BE BE8801044A patent/BE1001204A5/fr not_active IP Right Cessation
- 1988-09-12 LU LU87335A patent/LU87335A1/xx unknown
- 1988-09-13 NO NO884052A patent/NO179434C/no not_active IP Right Cessation
- 1988-09-13 NZ NZ226163A patent/NZ226163A/xx unknown
- 1988-09-13 CA CA000577214A patent/CA1338775C/en not_active Expired - Lifetime
- 1988-09-13 AU AU22172/88A patent/AU628787B2/en not_active Expired
- 1988-09-13 PT PT88492A patent/PT88492B/pt not_active IP Right Cessation
- 1988-09-13 IE IE277288A patent/IE61195B1/en not_active IP Right Cessation
- 1988-09-13 FI FI884192A patent/FI94837C/fi not_active IP Right Cessation
- 1988-09-13 GB GB8821443A patent/GB2209671B/en not_active Expired - Lifetime
- 1988-09-13 SE SE8803221A patent/SE503279C2/sv not_active IP Right Cessation
- 1988-09-14 IT IT8848349A patent/IT1224886B/it active
- 1988-09-14 KR KR1019880011874A patent/KR0131084B1/ko not_active IP Right Cessation
- 1988-09-14 MY MYPI88001027A patent/MY103769A/en unknown
- 1988-09-14 AT AT0224988A patent/AT395819B/de not_active IP Right Cessation
- 1988-09-14 GR GR880100602A patent/GR1002243B/el not_active IP Right Cessation
- 1988-09-14 JP JP63231396A patent/JP3090666B2/ja not_active Expired - Lifetime
- 1988-09-14 IL IL87746A patent/IL87746A/xx active Protection Beyond IP Right Term
- 1988-09-14 DK DK198805111A patent/DK175132B1/da not_active IP Right Cessation
- 1988-09-15 ES ES8802831A patent/ES2012118A6/es not_active Expired - Lifetime
- 1988-09-15 NL NL8802275A patent/NL195094C/nl not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT88492B (pt) | Processo para a preparacao de excipientes farmaceuticos contendo monoesteres soluveis em agua e que solubilizam compostos farmacologicamente activos | |
| JP2577049B2 (ja) | シクロスポリン製剤 | |
| US5756450A (en) | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms | |
| ES2365734T3 (es) | Composiciones farmacéuticas que contienen derivados de rapamicina. | |
| ES2713326T3 (es) | Composición de gotas oftálmicas de nanoemulsión que contiene ciclosporina y método de preparación de la misma | |
| KR100188305B1 (ko) | 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도 | |
| JP2003534265A (ja) | 生物学的に活性な親水性化合物を非経口的に投与するための徐放性薬剤組成物 | |
| JP2006508104A (ja) | 難溶性風邪薬の経口投与用マイクロエマルション濃縮液及びその製造方法 | |
| ES2782106T3 (es) | Formulaciones mejoradas de levosimendán para administración intravenosa como infusión o inyección y como concentrado de infusión | |
| AU616049B2 (en) | Etoposide solutions | |
| WO2009118754A2 (en) | A process for preparing a stable lyophilized composition | |
| JPH0558906A (ja) | シクロスポリン点眼製剤 | |
| WO2005101982A2 (en) | A stable ophthalmic composition | |
| JP2002502384A (ja) | 生理学上の媒体中において低い溶解性を有するペプチドの薬剤組成物 | |
| KR20140091652A (ko) | 안정적이며 바로 사용 가능한 세트로레릭스 주사액 | |
| JP2942556B2 (ja) | シクロスポリンを含有する新規組成物 | |
| JP2002508330A (ja) | ダルホプリスチンおよびキヌプリスチンに基づく医薬組成物ならびに調製 | |
| JP2023541265A (ja) | カバジタキセル製剤 | |
| JP3917820B2 (ja) | オザグレルナトリウム含有注射液およびその安定化方法 | |
| DE3830494B4 (de) | Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe | |
| JP2005060377A (ja) | インターロイキン−１１含有凍結乾燥製剤 | |
| KR960004019B1 (ko) | 니모디핀의 가용화 방법 | |
| KR100299942B1 (ko) | 비페닐디메칠디카르복실레이트의액제 | |
| JPH0816058B2 (ja) | トルナフテ−ト含有マイクロエマルシヨン製剤 | |
| PT89279B (pt) | Processo para a preparacao de uma nova forma cristalina de ciclosporinas e de composicoes farmaceuticas que as contem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920914 |
|
| PC3A | Transfer or assignment |
Free format text: 971017 NOVARTIS AG CH |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20080914 |