FR2620336B1 - Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments - Google Patents

Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments

Info

Publication number
FR2620336B1
FR2620336B1 FR888811953A FR8811953A FR2620336B1 FR 2620336 B1 FR2620336 B1 FR 2620336B1 FR 888811953 A FR888811953 A FR 888811953A FR 8811953 A FR8811953 A FR 8811953A FR 2620336 B1 FR2620336 B1 FR 2620336B1
Authority
FR
France
Prior art keywords
water
fatty acids
drug solubilizers
soluble monoesters
monoesters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR888811953A
Other languages
English (en)
Other versions
FR2620336A1 (fr
Inventor
Lorenz Hahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2620336A1 publication Critical patent/FR2620336A1/fr
Application granted granted Critical
Publication of FR2620336B1 publication Critical patent/FR2620336B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR888811953A 1987-09-15 1988-09-12 Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments Expired - Lifetime FR2620336B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (2)

Publication Number Publication Date
FR2620336A1 FR2620336A1 (fr) 1989-03-17
FR2620336B1 true FR2620336B1 (fr) 1991-10-25

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
FR888811953A Expired - Lifetime FR2620336B1 (fr) 1987-09-15 1988-09-12 Utilisation de monoesters solubles dans l'eau d'acides gras comme solubilisants de medicaments

Country Status (24)

Country Link
JP (1) JP3090666B2 (fr)
KR (1) KR0131084B1 (fr)
AT (1) AT395819B (fr)
AU (1) AU628787B2 (fr)
BE (1) BE1001204A5 (fr)
CA (1) CA1338775C (fr)
CH (1) CH683672A5 (fr)
DK (1) DK175132B1 (fr)
ES (1) ES2012118A6 (fr)
FI (1) FI94837C (fr)
FR (1) FR2620336B1 (fr)
GB (1) GB2209671B (fr)
GR (1) GR1002243B (fr)
HU (1) HU205010B (fr)
IE (1) IE61195B1 (fr)
IL (1) IL87746A (fr)
IT (1) IT1224886B (fr)
LU (1) LU87335A1 (fr)
MY (1) MY103769A (fr)
NL (1) NL195094C (fr)
NO (1) NO179434C (fr)
NZ (1) NZ226163A (fr)
PT (1) PT88492B (fr)
SE (1) SE503279C2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ATE147619T1 (de) 1992-05-13 1997-02-15 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
SI1033128T2 (sl) * 1993-09-28 2012-02-29 Scherer Gmbh R P Izdelava mehke Ĺľelatinaste kapsule
ATE218359T1 (de) 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
TR199901686T2 (xx) 1997-01-30 1999-09-21 Norvartis Ag Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1558215A4 (fr) * 2003-10-14 2007-09-12 Wockhardt Ltd Agents gelifiants steriles
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624258A (fr) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (fr) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (fr) * 1984-10-04 1986-04-30 Merck & Co. Inc. Système pour augmenter la vitesse de dissolution dans l'eau et la solubilité de médicaments peu solubles
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Also Published As

Publication number Publication date
GR1002243B (en) 1996-04-22
FI884192A (fi) 1989-03-16
HU205010B (en) 1992-03-30
GB2209671A (en) 1989-05-24
NO179434C (no) 1996-10-09
FI94837B (fi) 1995-07-31
PT88492B (pt) 1993-03-31
BE1001204A5 (fr) 1989-08-16
GR880100602A (el) 1989-06-22
SE503279C2 (sv) 1996-05-13
GB2209671B (en) 1991-11-13
JPH01151526A (ja) 1989-06-14
AU628787B2 (en) 1992-09-24
DK511188D0 (da) 1988-09-14
KR890004694A (ko) 1989-05-09
IE61195B1 (en) 1994-10-19
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
KR0131084B1 (ko) 1998-04-17
ATA224988A (de) 1992-08-15
IL87746A0 (en) 1989-02-28
MY103769A (en) 1993-09-30
DK175132B1 (da) 2004-06-14
ES2012118A6 (es) 1990-03-01
AU2217288A (en) 1989-04-27
NL8802275A (nl) 1989-04-03
HUT49494A (en) 1989-10-30
FR2620336A1 (fr) 1989-03-17
NO179434B (no) 1996-07-01
AT395819B (de) 1993-03-25
IL87746A (en) 1992-07-15
LU87335A1 (fr) 1989-04-06
IT1224886B (it) 1990-10-24
NZ226163A (en) 1991-08-27
IT8848349A0 (it) 1988-09-14
NO884052L (no) 1989-03-16
PT88492A (pt) 1988-10-01
CH683672A5 (de) 1994-04-29
FI94837C (fi) 1995-11-10
JP3090666B2 (ja) 2000-09-25
SE8803221L (sv) 1989-03-16
GB8821443D0 (en) 1988-10-12
CA1338775C (fr) 1996-12-10
DK511188A (da) 1989-03-16
NO884052D0 (no) 1988-09-13
FI884192A0 (fi) 1988-09-13
IE882772L (en) 1989-03-15

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Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)

Free format text: 11/89

TP Transmission of property