PT85354A - N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof - Google Patents

N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Info

Publication number
PT85354A
PT85354A PT85354A PT8535487A PT85354A PT 85354 A PT85354 A PT 85354A PT 85354 A PT85354 A PT 85354A PT 8535487 A PT8535487 A PT 8535487A PT 85354 A PT85354 A PT 85354A
Authority
PT
Portugal
Prior art keywords
phosphonylmethoxyalkyl
purines
pyrimidines
therapeutic application
derivatives
Prior art date
Application number
PT85354A
Other languages
English (en)
Other versions
PT85354B (pt
Inventor
Erik De Clercq
Antonin Holy
Ivan Rosenberg
Original Assignee
Stichting Rega V Z W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W filed Critical Stichting Rega V Z W
Publication of PT85354A publication Critical patent/PT85354A/pt
Publication of PT85354B publication Critical patent/PT85354B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT85354A 1986-07-18 1987-07-20 Processo de preparacao de derivados n-fosfonilmetoxialquilo de bases pirimidina e purina e de composicoes farmaceuticas que os contem PT85354B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Publications (2)

Publication Number Publication Date
PT85354A true PT85354A (en) 1987-08-01
PT85354B PT85354B (pt) 1990-04-30

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
PT85354A PT85354B (pt) 1986-07-18 1987-07-20 Processo de preparacao de derivados n-fosfonilmetoxialquilo de bases pirimidina e purina e de composicoes farmaceuticas que os contem

Country Status (21)

Country Link
US (3) US5142051A (pt)
EP (1) EP0253412B1 (pt)
JP (1) JPH0822866B2 (pt)
KR (1) KR950004179B1 (pt)
AT (1) ATE57932T1 (pt)
AU (1) AU600002B2 (pt)
CA (1) CA1340856C (pt)
CS (1) CS264222B1 (pt)
DE (2) DE3765864D1 (pt)
DK (1) DK170646B1 (pt)
EG (1) EG18273A (pt)
ES (1) ES2036194T3 (pt)
FI (1) FI86856C (pt)
GR (1) GR3002534T3 (pt)
IE (1) IE60117B1 (pt)
IL (1) IL83235A (pt)
LU (1) LU90155I2 (pt)
NL (1) NL970036I2 (pt)
NZ (1) NZ221100A (pt)
PT (1) PT85354B (pt)
ZA (1) ZA875283B (pt)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
FI911875A (fi) * 1990-04-20 1991-10-21 Bristol Myers Squibb Co Kirala 2-(fosfonometoxi) propylguaniner som antivirala aemnen.
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
SK280313B6 (sk) * 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
ATE194142T1 (de) * 1990-08-10 2000-07-15 Acad Of Science Czech Republic Verfahren zur herstellung von nukleotiden
DE10399025I2 (de) * 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
HU225970B1 (en) * 1991-10-11 2008-01-28 Acad Of Science Czech Republic Antiviral acyclic phosphonomethoxyalkyl-substituted alkenyl purine and pyrimidine derivatives, and pharmaceutical preparations containing them
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
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US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
DE2909709A1 (de) * 1979-03-12 1980-09-25 Kailash Kumar Dr Gauri Verfahren zur herstellung von nucleotidderivaten, neue nucleotidderivate und daraus hergestellte arzneimittel
FI833504A (fi) * 1982-09-30 1984-03-31 Syntex Inc 1-monofosfatestrar, 1,3-bisfosfatestrar och cykliska fosfatestrar av 9-(1,3-dihydroxi-2-propoximetyl)-guanin saosom antivirala aemnen
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
PT78769A (en) * 1983-06-24 1984-07-01 Merck & Co Inc Process for preparing (s)-9-(2,3-dihydroxy-1-propoxymethyl)guanine and derivatives thereof useful as antiviral agents
US4670424A (en) * 1983-09-19 1987-06-02 Merck & Co., Inc. Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
US4590269A (en) * 1984-03-29 1986-05-20 Syntex (U.S.A.) Inc. Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
GR3002534T3 (en) 1993-01-25
KR950004179B1 (en) 1995-04-27
NL970036I2 (nl) 1998-03-02
ZA875283B (en) 1988-03-30
IL83235A (en) 1992-11-15
ES2036194T3 (es) 1993-05-16
PT85354B (pt) 1990-04-30
IE60117B1 (en) 1994-06-01
DE3765864D1 (de) 1990-12-06
CA1340856C (en) 1999-12-21
US5142051A (en) 1992-08-25
US5641763A (en) 1997-06-24
IL83235A0 (en) 1987-12-31
LU90155I2 (fr) 1997-12-22
DK373487D0 (da) 1987-07-17
AU600002B2 (en) 1990-08-02
AU7575987A (en) 1988-01-21
DK373487A (da) 1988-01-19
KR880001688A (ko) 1988-04-26
EG18273A (en) 1992-12-30
FI873165A0 (fi) 1987-07-17
DK170646B1 (da) 1995-11-20
EP0253412A3 (en) 1989-04-26
FI86856B (fi) 1992-07-15
JPS6345289A (ja) 1988-02-26
ATE57932T1 (de) 1990-11-15
US5869467A (en) 1999-02-09
IE871944L (en) 1988-01-18
NL970036I1 (nl) 1997-12-01
EP0253412A2 (en) 1988-01-20
DE19775085I2 (de) 2004-01-15
FI873165A (fi) 1988-01-19
CS264222B1 (en) 1989-06-13
NZ221100A (en) 1991-09-25
CS546986A1 (en) 1988-08-16
FI86856C (fi) 1992-10-26
EP0253412B1 (en) 1990-10-31
JPH0822866B2 (ja) 1996-03-06

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