FI873165A - N-fosfonylmetoxialkylpyrimidiner och -puriner. - Google Patents

N-fosfonylmetoxialkylpyrimidiner och -puriner. Download PDF

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Publication number
FI873165A
FI873165A FI873165A FI873165A FI873165A FI 873165 A FI873165 A FI 873165A FI 873165 A FI873165 A FI 873165A FI 873165 A FI873165 A FI 873165A FI 873165 A FI873165 A FI 873165A
Authority
FI
Finland
Prior art keywords
puriner
phosphonylmetoxykylpyrimidiner
och
derivatives
compounds
Prior art date
Application number
FI873165A
Other languages
English (en)
Other versions
FI873165A0 (fi
FI86856C (fi
FI86856B (fi
Inventor
Clercq Erik De
Antonin Holy
Ivan Rosenberg
Original Assignee
Stichting Rega V Z W
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W, Ceskoslovenska Akademie Ved filed Critical Stichting Rega V Z W
Publication of FI873165A0 publication Critical patent/FI873165A0/fi
Publication of FI873165A publication Critical patent/FI873165A/fi
Application granted granted Critical
Publication of FI86856B publication Critical patent/FI86856B/fi
Publication of FI86856C publication Critical patent/FI86856C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI873165A 1986-07-18 1987-07-17 Foerfarande foer framstaellning av n-fosfonylmetoxialkylpyrimidiner och -puriner FI86856C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
CS546986 1986-07-18

Publications (4)

Publication Number Publication Date
FI873165A0 FI873165A0 (fi) 1987-07-17
FI873165A true FI873165A (fi) 1988-01-19
FI86856B FI86856B (fi) 1992-07-15
FI86856C FI86856C (fi) 1992-10-26

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873165A FI86856C (fi) 1986-07-18 1987-07-17 Foerfarande foer framstaellning av n-fosfonylmetoxialkylpyrimidiner och -puriner

Country Status (21)

Country Link
US (3) US5142051A (fi)
EP (1) EP0253412B1 (fi)
JP (1) JPH0822866B2 (fi)
KR (1) KR950004179B1 (fi)
AT (1) ATE57932T1 (fi)
AU (1) AU600002B2 (fi)
CA (1) CA1340856C (fi)
CS (1) CS264222B1 (fi)
DE (2) DE19775085I2 (fi)
DK (1) DK170646B1 (fi)
EG (1) EG18273A (fi)
ES (1) ES2036194T3 (fi)
FI (1) FI86856C (fi)
GR (1) GR3002534T3 (fi)
IE (1) IE60117B1 (fi)
IL (1) IL83235A (fi)
LU (1) LU90155I2 (fi)
NL (1) NL970036I2 (fi)
NZ (1) NZ221100A (fi)
PT (1) PT85354B (fi)
ZA (1) ZA875283B (fi)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
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CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc 2’−デオキシ−β−アデノシンの製造方法
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
DE69110528T2 (de) * 1990-04-20 1996-03-14 Inst Of Organic Chemistry And Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien.
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
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US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ287745B6 (cs) * 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
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Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
DE2909709A1 (de) * 1979-03-12 1980-09-25 Kailash Kumar Dr Gauri Verfahren zur herstellung von nucleotidderivaten, neue nucleotidderivate und daraus hergestellte arzneimittel
NZ205802A (en) * 1982-09-30 1986-10-08 Syntex Inc Phosphate ester derivatives of guanine as antiviral agents
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
PT78769A (en) * 1983-06-24 1984-07-01 Merck & Co Inc Process for preparing (s)-9-(2,3-dihydroxy-1-propoxymethyl)guanine and derivatives thereof useful as antiviral agents
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US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
ES2036194T3 (es) 1993-05-16
NL970036I1 (nl) 1997-12-01
AU600002B2 (en) 1990-08-02
NL970036I2 (nl) 1998-03-02
KR880001688A (ko) 1988-04-26
DE19775085I2 (de) 2004-01-15
US5142051A (en) 1992-08-25
DK373487A (da) 1988-01-19
IE60117B1 (en) 1994-06-01
AU7575987A (en) 1988-01-21
ATE57932T1 (de) 1990-11-15
GR3002534T3 (en) 1993-01-25
NZ221100A (en) 1991-09-25
DK373487D0 (da) 1987-07-17
EP0253412A2 (en) 1988-01-20
CS264222B1 (en) 1989-06-13
LU90155I2 (fr) 1997-12-22
EG18273A (en) 1992-12-30
JPH0822866B2 (ja) 1996-03-06
FI873165A0 (fi) 1987-07-17
EP0253412A3 (en) 1989-04-26
JPS6345289A (ja) 1988-02-26
IL83235A0 (en) 1987-12-31
IL83235A (en) 1992-11-15
CS546986A1 (en) 1988-08-16
KR950004179B1 (en) 1995-04-27
FI86856C (fi) 1992-10-26
EP0253412B1 (en) 1990-10-31
US5869467A (en) 1999-02-09
IE871944L (en) 1988-01-18
CA1340856C (en) 1999-12-21
DE3765864D1 (de) 1990-12-06
PT85354A (en) 1987-08-01
PT85354B (pt) 1990-04-30
FI86856B (fi) 1992-07-15
DK170646B1 (da) 1995-11-20
US5641763A (en) 1997-06-24
ZA875283B (en) 1988-03-30

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