KR880001688A - 피리미딘과 푸린염기의 n-포스포닐메톡시 알킬유도체와 그의 제조 방법 - Google Patents

피리미딘과 푸린염기의 n-포스포닐메톡시 알킬유도체와 그의 제조 방법 Download PDF

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KR880001688A
KR880001688A KR1019870007844A KR870007844A KR880001688A KR 880001688 A KR880001688 A KR 880001688A KR 1019870007844 A KR1019870007844 A KR 1019870007844A KR 870007844 A KR870007844 A KR 870007844A KR 880001688 A KR880001688 A KR 880001688A
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pyrimidine
purine base
following general
general formula
residue
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KR1019870007844A
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KR950004179B1 (en
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드 클렉 에릭
홀리 앤토닌
로젠버그 이반
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원본미기재
스티칭 레가 브이젯트더블유
쎄스코슬로벤스카 아카데미 브이이디
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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Abstract

내용 없음

Description

피리미딘과 푸린염기의 N-포스포닐메톡시 알킬유도체와 그의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(I)로 표시되는 피리미딘과 푸린염기의 N-포스포닐메톡시알킬유도체.
    (윗식에서, R은 수소원자 또느 하이드록시메틸기이며, B는 피리미딘 또는 푸린염기의 잔기 (비치환 아데닌잔기는 제외), 알칼리금속, 암모니아 또는 아민염이다.)
  2. 다음 일반식(II)로 표시되는 화합물과 R-톨루엔설포닐메탄포스핀산의 디에스테르를 먼저 반응시키고, 이어서 트리메틸할로게노실란과 반응시키거나 또는,
    B-CH2CH2OH..............................(II)
    (윗식에서, B는 피리미딘 또는 푸린 염기의 잔기이다.)
    피리미딘이나 푸린염기의 알카리금속염과 다음 일반식(III)으로 표시되는 2-브로모에톡시메탄포스핀산의 디에스테르를 반응시켜서
    BrCH2CH2OCH2P(O)(OC2H5)2...................(III)
    다음 일반식(IV)로 표시된느 중간체화합물을 생성시킨 다음,
    B-CH2CH2OCH2P(O)(OC2H5)2..........................(IV)
    (윗식에서, B는 피리미딘 또는 푸린염기의 잔기이다.)
    이를 트리메틸할로게노실란으로 처리시켜서 되어짐을 특징으로 하는 다음 일반식(I)로 표시되는 피리미딘과 푸린염기의 N-포스포닐메톡시알킬유도체의 제조 방법.
    (윗식에서, R은 수소원자이고, B는 피리미딘 또는 푸린염기의 잔기이다.)
  3. 다음 일반식(V)로 표시되는 화합물과,
    B-CH2CH(OH)CH2OH..................................(V)
    (윗식에서, B는 피리미딘 또는 푸린염기의 잔기이다.)
    다음 일반식(VI)로 표시되는 크로로메탄 포스포닐 디클로라이드와 반응시켜서 얻어진 에스테르화합물을,
    CICH2P(O)Cl2.............................(VI)
    다음 일반식(VII)로 표시되는 에스테르화합물로
    이성질체화시킨 다음에 이들을 수용성알카리 금속수산화물로 처리시켜서 되어짐을 특징으로 하는 다음식(I)로 표시되는 피리미딘과 푸린염기의 N-포스포닐메톡시 알킬유도체의 제조 방법.
    (윗식에서, R은 히드록시메틸기이고, B는 피리미딘 또는 푸린염기의 잔기이다.)
  4. 항바이러스활성을 가지며 다음 일반식(I)로 표시되는 화합물을 함유하고 있는 것을 특징으로 하는 치료학적 조성물
    (윗식에서, R은 수소원자 또는 히드록시메틸기이고, B는 활성성분인 피리미딘 또는 푸린염기의 유기잔기이거나 알카리금속, 암모니아 또는 아민염이다)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR87007844A 1986-07-18 1987-07-18 N-phosphonylmethoxyalkye derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity KR950004179B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV5469-86 1986-07-18
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

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KR880001688A true KR880001688A (ko) 1988-04-26
KR950004179B1 KR950004179B1 (en) 1995-04-27

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US (3) US5142051A (ko)
EP (1) EP0253412B1 (ko)
JP (1) JPH0822866B2 (ko)
KR (1) KR950004179B1 (ko)
AT (1) ATE57932T1 (ko)
AU (1) AU600002B2 (ko)
CA (1) CA1340856C (ko)
CS (1) CS264222B1 (ko)
DE (2) DE19775085I2 (ko)
DK (1) DK170646B1 (ko)
EG (1) EG18273A (ko)
ES (1) ES2036194T3 (ko)
FI (1) FI86856C (ko)
GR (1) GR3002534T3 (ko)
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IL (1) IL83235A (ko)
LU (1) LU90155I2 (ko)
NL (1) NL970036I2 (ko)
NZ (1) NZ221100A (ko)
PT (1) PT85354B (ko)
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PT85354A (en) 1987-08-01
US5641763A (en) 1997-06-24
ATE57932T1 (de) 1990-11-15
US5142051A (en) 1992-08-25
FI873165A (fi) 1988-01-19
IL83235A (en) 1992-11-15
FI86856B (fi) 1992-07-15
JPS6345289A (ja) 1988-02-26
IE60117B1 (en) 1994-06-01
ES2036194T3 (es) 1993-05-16
DE3765864D1 (de) 1990-12-06
DK373487A (da) 1988-01-19
NZ221100A (en) 1991-09-25
NL970036I1 (nl) 1997-12-01
IE871944L (en) 1988-01-18
US5869467A (en) 1999-02-09
JPH0822866B2 (ja) 1996-03-06
CS264222B1 (en) 1989-06-13
CS546986A1 (en) 1988-08-16
IL83235A0 (en) 1987-12-31
LU90155I2 (fr) 1997-12-22
CA1340856C (en) 1999-12-21
AU600002B2 (en) 1990-08-02
ZA875283B (en) 1988-03-30
AU7575987A (en) 1988-01-21
PT85354B (pt) 1990-04-30
EP0253412A2 (en) 1988-01-20
FI86856C (fi) 1992-10-26
FI873165A0 (fi) 1987-07-17
KR950004179B1 (en) 1995-04-27
GR3002534T3 (en) 1993-01-25
EP0253412B1 (en) 1990-10-31
NL970036I2 (nl) 1998-03-02
EP0253412A3 (en) 1989-04-26
EG18273A (en) 1992-12-30
DK170646B1 (da) 1995-11-20
DK373487D0 (da) 1987-07-17
DE19775085I2 (de) 2004-01-15

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