IL83235A - N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof - Google Patents

N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Info

Publication number
IL83235A
IL83235A IL83235A IL8323587A IL83235A IL 83235 A IL83235 A IL 83235A IL 83235 A IL83235 A IL 83235A IL 8323587 A IL8323587 A IL 8323587A IL 83235 A IL83235 A IL 83235A
Authority
IL
Israel
Prior art keywords
phosphonylmethoxyalkyl
purines
pyrimidines
therapeutic application
derivatives
Prior art date
Application number
IL83235A
Other languages
English (en)
Other versions
IL83235A0 (en
Original Assignee
Stichting Rega V Z W
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W, Ceskoslovenska Akademie Ved filed Critical Stichting Rega V Z W
Publication of IL83235A0 publication Critical patent/IL83235A0/xx
Publication of IL83235A publication Critical patent/IL83235A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL83235A 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof IL83235A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Publications (2)

Publication Number Publication Date
IL83235A0 IL83235A0 (en) 1987-12-31
IL83235A true IL83235A (en) 1992-11-15

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83235A IL83235A (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Country Status (21)

Country Link
US (3) US5142051A (pt)
EP (1) EP0253412B1 (pt)
JP (1) JPH0822866B2 (pt)
KR (1) KR950004179B1 (pt)
AT (1) ATE57932T1 (pt)
AU (1) AU600002B2 (pt)
CA (1) CA1340856C (pt)
CS (1) CS264222B1 (pt)
DE (2) DE19775085I2 (pt)
DK (1) DK170646B1 (pt)
EG (1) EG18273A (pt)
ES (1) ES2036194T3 (pt)
FI (1) FI86856C (pt)
GR (1) GR3002534T3 (pt)
IE (1) IE60117B1 (pt)
IL (1) IL83235A (pt)
LU (1) LU90155I2 (pt)
NL (1) NL970036I2 (pt)
NZ (1) NZ221100A (pt)
PT (1) PT85354B (pt)
ZA (1) ZA875283B (pt)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
ATE124050T1 (de) * 1990-04-20 1995-07-15 Acad Of Science Czech Republic Chirale 2-(phosphonomethoxy)propyl-guanine als antivirale agentien.
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
DE69132276T2 (de) * 1990-08-10 2001-03-01 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha Verfahren zur herstellung von nukleotiden
DE69129650T2 (de) * 1990-09-14 1999-03-25 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
KR0184530B1 (ko) * 1991-10-11 1999-05-15 카렐 마르티넥 항비루스 비고리 포스포노메톡시알킬치환, 알켄일 및 알킨일 퓨린 및 피리미딘 유도체
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
JPH09506333A (ja) * 1993-09-17 1997-06-24 ギリアード サイエンシーズ，インコーポレイテッド 治療化合物の投薬方法
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5468752A (en) * 1994-04-04 1995-11-21 Freeman; William R. Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines
JPH09511507A (ja) * 1994-04-04 1997-11-18 フリーマン，ウイリアム・アール 上昇した眼圧を治療するためのホスホニルメトキシアルキルヌクレオシドの使用
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5717095A (en) * 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
DK1256584T3 (da) * 1997-07-25 2004-12-06 Gilead Sciences Inc Fremgangsmåde til fremstilling af adefovir-dipivoxil
EP1380303B1 (en) 1998-11-02 2008-09-17 Gilead Sciences, Inc. Combination therapy to treat hepatitis B virus
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ATE322494T1 (de) * 2000-01-07 2006-04-15 Universitaire Instelling Antwe Purin derivate, ihre herstellung und verwendung
AUPQ806700A0 (en) * 2000-06-08 2000-07-06 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
EP2682397B1 (en) 2000-07-21 2017-04-19 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
CA2439831C (en) * 2001-03-01 2010-01-12 Triangle Pharmaceuticals, Inc. Polymorphic and other crystalline forms of cis-ftc
ES2564144T3 (es) * 2001-06-29 2016-03-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Derivados de 6-[2-(fosfonometoxi)alcoxi] pirimidina que tienen actividad antivírica
US7247621B2 (en) * 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
EP1532157A4 (en) 2002-05-13 2009-02-25 Metabasis Therapeutics Inc NEW PRODRUGS FROM PMEA TO PHOSPHONIC ACID BASE AND ITS ANALOG
US7193081B2 (en) * 2002-05-13 2007-03-20 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of PMEA and PMPA
AP2089A (en) 2003-01-14 2010-01-11 Gilead Sciences Inc Compositions and methods for combination antiviraltherapy
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20050080053A1 (en) * 2003-08-29 2005-04-14 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
US20070269420A1 (en) * 2003-11-24 2007-11-22 Chunduru Srinivas K Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
WO2005107742A1 (en) 2004-05-05 2005-11-17 Yale University Novel antiviral helioxanthin analogs
CA2565966A1 (en) * 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
EP1831235B1 (en) * 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
WO2006110656A2 (en) * 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN100526315C (zh) 2005-06-16 2009-08-12 浙江医药股份有限公司新昌制药厂 N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途
EP2305697A3 (en) 2005-07-25 2011-07-27 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
JP2009511595A (ja) 2005-10-11 2009-03-19 インターミューン・インコーポレーテッド Ｃ型肝炎ウイルスの複製を阻害する化合物および方法
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
GB0709408D0 (en) * 2007-05-16 2007-06-27 Katholleke Universiteit Leuven Anti-col herpes virus compounds
US20090181931A1 (en) * 2008-01-16 2009-07-16 Oncolys Biopharma, Inc. Antiviral activity of cidofovir against oncolytic viruses
WO2009094190A2 (en) 2008-01-25 2009-07-30 Chimerix, Inc. Methods of treating viral infections
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
MX2010011306A (es) * 2008-04-15 2010-11-09 Intermune Inc Nuevos inhibidores macrociclicos de la replicacion del virus de la hepatitis c.
EP2358736A1 (en) * 2008-10-15 2011-08-24 Intermune, Inc. Therapeutic antiviral peptides
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
BR112012002551A2 (pt) 2009-08-03 2017-06-13 Chimerix Inc composição e métodos de tratamento de infecções virais e tumores induzidos por vírus
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
DK2534150T3 (en) 2010-02-12 2017-06-12 Chimerix Inc METHODS OF TREATING VIRUS INFECTION
EP2371369A1 (en) 2010-04-01 2011-10-05 Institut Gustave Roussy (IGR) EGFR inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
BR112013014485B1 (pt) 2010-12-10 2021-03-30 Sigmapharm Laboratories, Llc Composições farmacêuticas compreendendo pró-fármacos análogos de nucleotídeos de fosfonato ativos por via oral e sistema de embalagem de recipiente/fechamento contendo as ditas composições
JP2014505076A (ja) * 2011-01-27 2014-02-27 ザ トラスティーズ オブ プリンストン ユニバーシティ 抗ウイルス剤としてのｍＴＯＲキナーゼの阻害剤
WO2012138954A1 (en) 2011-04-07 2012-10-11 Johnson Matthey Public Limited Company Forms of cidofovir
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
EP2846788A1 (en) 2012-05-11 2015-03-18 Akron Molecules AG Use of compounds for the treatment of pain
AU2013340559B2 (en) 2012-10-29 2018-03-15 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
RS57796B1 (sr) 2013-03-15 2018-12-31 Univ California Diestri acikličnog nukleozid fosfonata
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
US9493493B2 (en) 2014-09-15 2016-11-15 The Regents Of The University Of California Nucleotide analogs
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
US10745427B2 (en) 2016-03-09 2020-08-18 Janssen Biopharma, Inc. Acyclic antivirals
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
DE2909709A1 (de) * 1979-03-12 1980-09-25 Kailash Kumar Dr Gauri Verfahren zur herstellung von nucleotidderivaten, neue nucleotidderivate und daraus hergestellte arzneimittel
EP0105486A3 (en) * 1982-09-30 1984-05-16 Syntex (U.S.A.) Inc. 1-monophosphate esters, 1,3-bisphosphate esters and cyclic phosphate esters of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agents
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
US4670424A (en) * 1983-09-19 1987-06-02 Merck & Co., Inc. Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
US4590269A (en) * 1984-03-29 1986-05-20 Syntex (U.S.A.) Inc. Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
IL83235A0 (en) 1987-12-31
JPS6345289A (ja) 1988-02-26
EP0253412A2 (en) 1988-01-20
EG18273A (en) 1992-12-30
CS546986A1 (en) 1988-08-16
IE871944L (en) 1988-01-18
FI86856C (fi) 1992-10-26
AU7575987A (en) 1988-01-21
DK373487D0 (da) 1987-07-17
NZ221100A (en) 1991-09-25
FI86856B (fi) 1992-07-15
LU90155I2 (fr) 1997-12-22
ZA875283B (en) 1988-03-30
KR950004179B1 (en) 1995-04-27
DK170646B1 (da) 1995-11-20
KR880001688A (ko) 1988-04-26
JPH0822866B2 (ja) 1996-03-06
NL970036I2 (nl) 1998-03-02
DE3765864D1 (de) 1990-12-06
NL970036I1 (nl) 1997-12-01
EP0253412A3 (en) 1989-04-26
FI873165A0 (fi) 1987-07-17
GR3002534T3 (en) 1993-01-25
US5142051A (en) 1992-08-25
PT85354A (en) 1987-08-01
ATE57932T1 (de) 1990-11-15
US5641763A (en) 1997-06-24
AU600002B2 (en) 1990-08-02
CA1340856C (en) 1999-12-21
DE19775085I2 (de) 2004-01-15
PT85354B (pt) 1990-04-30
IE60117B1 (en) 1994-06-01
EP0253412B1 (en) 1990-10-31
ES2036194T3 (es) 1993-05-16
CS264222B1 (en) 1989-06-13
US5869467A (en) 1999-02-09
DK373487A (da) 1988-01-19
FI873165A (fi) 1988-01-19

Similar Documents

Publication Publication Date Title
EG18273A (en) N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
HUT52769A (en) Process for producing pyrimidine derivatives and pharmaceutical compositions containing them
IL88755A (en) (1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same
IL109578A (en) Nor-bile acid derivatives processes for their preparation and the use of these compounds as medicaments
IL81002A (en) 3,4-diphenyl-pyrazoline-1-carboxamide derivatives,processes for the preparation thereof and insecticidal and acaricidal compositions containing the same
HUT61004A (en) Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
ZA887157B (en) Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
MD1007C2 (ro) 1,3-Oxatiolan,izomeri geometrici şi optici ai lui,amestecurile acestor izomeri, procedeu de obţinere a lor şi compoziţie farmaceutică care manifestă activitate antivirotică
IT1228288B (it) Composti ad attivita' antiserotoninica
PT85128A (en) Process for the preparation of pharmaceutical compounds containing as active ingredient 4-(1-methyl-4-piperydilidene)-4h-benzo-(4,5)-cyclohepta(1,2-b)thiophene-10(9h)-one
SE8404065D0 (sv) Novel biologically active compounds
CA2046755A1 (en) /2r/-2-[di/2-propyl/phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane, its preparation and use
EP0321968A3 (en) Compounds active on the cardiovascular system
NO162069C (no) Analogifremgangsmaate for fremstilling av 1h-indol-3-yl inneholdende 1,3-di-metyl-1h-purin-2,6-dioner.
ES2013379A6 (es) Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.
IT1216104B (it) Peptidi ad attivita' farmaceutica.
DE3778642D1 (de) Therapeutikum zur behandlung von magengeschwueren.
IT1223395B (it) Composti ad attivita' cardiovascolare
IL87197A0 (en) Leukotriene antagonists,precursors of same,processes for the preparation thereof and pharmaceutical compositions containing same
IT1142639B (it) Composizioni terapeutiche ad attivita' coleretica contenenti come principio attivo derivati dall'acido colanico
EP0321967A3 (en) Compounds active on the cardiovascular system
TW360630B (en) A secoaporphine compounds on arrhythmia

Legal Events

Date Code Title Description
HP Change in proprietorship
KB Patent renewed
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
EXP Patent expired