GB8513754D0
(en)
*
|
1985-05-31 |
1985-07-03 |
Jones T R |
Anti-cancer quinazoline derivatives
|
GB8625019D0
(en)
*
|
1986-10-18 |
1986-11-19 |
Wellcome Found |
Compounds
|
GB8707053D0
(en)
*
|
1987-03-25 |
1987-04-29 |
Ici Plc |
Anti-tumour agents
|
US4857530A
(en)
*
|
1987-11-03 |
1989-08-15 |
Warner-Lambert Company |
Substituted quinazolinones as anticancer agents
|
GB8727737D0
(en)
*
|
1987-11-26 |
1987-12-31 |
Ici Plc |
Antitumour agents
|
US5019577A
(en)
*
|
1988-04-15 |
1991-05-28 |
Burroughs Welcome Co. |
Novel compounds and use
|
US4940713A
(en)
*
|
1988-04-15 |
1990-07-10 |
Burroughs Wellcome Co. |
Substituted glutamic acids
|
GB8809978D0
(en)
*
|
1988-04-27 |
1988-06-02 |
Ici Plc |
Anti-tumour agents
|
EP0365763A1
(en)
*
|
1988-09-30 |
1990-05-02 |
Agouron Pharmaceuticals, Inc. |
Antiproliferative cyclic compounds
|
GB8829296D0
(en)
*
|
1988-12-15 |
1989-01-25 |
Ici Plc |
Anti-tumour compounds
|
US5252573A
(en)
*
|
1988-12-15 |
1993-10-12 |
Imperial Chemical Industries Plc |
Anti-tumor agents
|
US5286726A
(en)
*
|
1990-04-12 |
1994-02-15 |
The Regents Of The University Of Michigan |
Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
|
ZA913730B
(en)
*
|
1990-05-30 |
1992-02-26 |
Ici Plc |
Anti-tumor compounds
|
GB9013615D0
(en)
*
|
1990-06-19 |
1990-08-08 |
Wellcome Found |
Pharmaceutical compounds
|
US5290780A
(en)
*
|
1991-01-30 |
1994-03-01 |
American Cyanamid Co. |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
GB9105771D0
(en)
*
|
1991-03-19 |
1991-05-01 |
Cancer Res Inst Royal |
Anti-cancer compounds
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
US5403843A
(en)
*
|
1991-08-12 |
1995-04-04 |
Takeda Chemical Industries, Ltd. |
Pyrrolopyrimidinyalglutaminate derivatives and their use
|
US5145854A
(en)
*
|
1991-11-27 |
1992-09-08 |
Nair Madhavan G |
1-formyl-5,8,10-trideazafolates
|
GB9205320D0
(en)
*
|
1992-03-11 |
1992-04-22 |
Ici Plc |
Anti-tumour compounds
|
GB9205907D0
(en)
*
|
1992-03-18 |
1992-04-29 |
Cancer Res Inst Royal |
Anti-cancer compounds
|
ES2049659B1
(es)
*
|
1992-10-08 |
1994-10-16 |
Ici Plc |
Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
|
GB9223352D0
(en)
*
|
1992-11-06 |
1992-12-23 |
Ici Plc |
Tricyclic compounds
|
GB9323290D0
(en)
|
1992-12-10 |
1994-01-05 |
Zeneca Ltd |
Quinazoline derivatives
|
US7910624B1
(en)
|
1995-03-03 |
2011-03-22 |
The Trustees Of Boston University |
Compositions for the treatment of blood disorders
|
JP3971454B2
(ja)
*
|
1993-10-29 |
2007-09-05 |
ザ トラスティーズ オブ ボストン ユニバーシティ |
抗新生物剤としての酪酸、酪酸塩、および誘導体の生理学的に安定な組成物
|
US6011000A
(en)
*
|
1995-03-03 |
2000-01-04 |
Perrine; Susan P. |
Compositions for the treatment of blood disorders
|
GB9508565D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
US5593999A
(en)
*
|
1995-06-07 |
1997-01-14 |
Nair; Madhavan G. |
Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
|
US6420427B1
(en)
*
|
1997-10-09 |
2002-07-16 |
Ono Pharmaceutical Co., Ltd. |
Aminobutyric acid derivatives
|
US5912251A
(en)
*
|
1998-01-17 |
1999-06-15 |
Nair; Madhavan G. |
Metabolically inert anti-inflammatory and anti-tumor antifolates
|
AU774861B2
(en)
*
|
1998-02-11 |
2004-07-08 |
Douglas V Faller |
Compositions and methods for the treatment of cystic fibrosis
|
GB9904275D0
(en)
|
1999-02-24 |
1999-04-21 |
Cancer Res Campaign Tech |
Anti-cancer compounds
|
US7671200B2
(en)
*
|
1999-10-27 |
2010-03-02 |
Cytokinetics, Inc. |
Quinazolinone KSP inhibitors
|
US7230000B1
(en)
|
1999-10-27 |
2007-06-12 |
Cytokinetics, Incorporated |
Methods and compositions utilizing quinazolinones
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
US6143776A
(en)
*
|
2000-02-02 |
2000-11-07 |
Sunesis Pharmaceuticals, Inc. |
Tosylproline analogs as thymidylate synthase inhibitors
|
AU2002345792A1
(en)
|
2001-06-21 |
2003-01-08 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
MXPA04001905A
(es)
|
2001-08-31 |
2005-04-19 |
Btg Int Ltd |
Compuestos anti-cancer de ciclopenta[g]quinazolina.
|
US7528141B2
(en)
|
2001-08-31 |
2009-05-05 |
Btg International Limited |
Use of cyclopenta[g]quinazoline derivatives for treating cancer
|
US6753428B2
(en)
*
|
2001-11-20 |
2004-06-22 |
Cytokinetics, Inc. |
Process for the racemization of chiral quinazolinones
|
US7009049B2
(en)
*
|
2002-02-15 |
2006-03-07 |
Cytokinetics, Inc. |
Syntheses of quinazolinones
|
CN101486682B
(zh)
|
2002-03-13 |
2013-08-14 |
阵列生物制药公司 |
作为mek抑制剂的n3烷基化苯并咪唑衍生物
|
AU2003223786A1
(en)
*
|
2002-05-09 |
2003-11-11 |
Cytokinetics, Inc. |
Compounds, methods and compositions
|
US7214800B2
(en)
*
|
2002-05-09 |
2007-05-08 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
US7038048B2
(en)
*
|
2002-05-23 |
2006-05-02 |
Cytokinetics, Inc. |
3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
|
US7041676B2
(en)
*
|
2002-06-14 |
2006-05-09 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
WO2004009036A2
(en)
*
|
2002-07-23 |
2004-01-29 |
Cytokinetics, Inc. |
Compounds compositions and methods
|
JP2005536553A
(ja)
*
|
2002-08-21 |
2005-12-02 |
サイトキネティクス・インコーポレーテッド |
化合物、組成物および方法
|
PA8580301A1
(es)
|
2002-08-28 |
2005-05-24 |
Pfizer Prod Inc |
Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
|
EP1558083A4
(en)
*
|
2002-09-30 |
2008-04-16 |
Cytokinetics Inc |
COMPOUNDS, COMPOSITIONS AND METHODS
|
DE60331479D1
(de)
|
2002-12-20 |
2010-04-08 |
Pfizer Prod Inc |
Pyrimidin-derivate zur behandlung von anormalem zellwachstum
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
WO2005041888A2
(en)
*
|
2003-11-03 |
2005-05-12 |
Cytokinetics, Inc. |
Pyrimidin-4-one compounds, compositions and methods
|
WO2005046588A2
(en)
*
|
2003-11-07 |
2005-05-26 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
PT1682138E
(pt)
|
2003-11-19 |
2011-02-28 |
Array Biopharma Inc |
Inibidores heterocíclicos de mek
|
WO2005061460A1
(en)
*
|
2003-12-08 |
2005-07-07 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
BRPI0511512A
(pt)
|
2004-05-27 |
2007-12-26 |
Pfizer Prod Inc |
derivados pirrolpirimidina úteis no tratamento do cáncer
|
EP1791544A4
(en)
|
2004-09-08 |
2007-09-12 |
Chelsea Therapeutics Inc |
DERIVATIVES OF QUINAZOLIN AS METABOLICALLY INERT ANTIFOLIC
|
US7429667B2
(en)
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
MX2007013304A
(es)
|
2005-04-26 |
2007-12-13 |
Pfizer |
Anticuerpos de p-caderina.
|
RS52243B
(en)
|
2005-05-18 |
2012-10-31 |
Astrazeneca Ab |
HETEROCYCLIC MELT INHIBITORS AND PROCEDURES FOR THEIR USE
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
TWI453218B
(zh)
|
2005-09-07 |
2014-09-21 |
Amgen Fremont Inc |
針對類活化素受體激酶-1之人類單株抗體
|
US7842836B2
(en)
|
2006-04-11 |
2010-11-30 |
Ardea Biosciences |
N-aryl-N'alkyl sulfamides as MEK inhibitors
|
ES2354182T3
(es)
|
2006-04-18 |
2011-03-10 |
Ardea Biosciences, Inc. |
Piridona sulfonamidas y piridona sulfamidas como inhibidores de mek.
|
MX2008013990A
(es)
|
2006-05-09 |
2009-01-29 |
Pfizer Prod Inc |
Derivados de cicloalquilamino acidos.
|
WO2008089390A1
(en)
|
2007-01-19 |
2008-07-24 |
Chelsea Therapeutics, Inc. |
New classical antifolates
|
WO2010105112A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Hemaquest Pharmaceuticals, Inc. |
Detection of short-chain fatty acids in biological samples
|
CN102448938A
(zh)
|
2009-03-27 |
2012-05-09 |
阿迪生物科学公司 |
作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺
|
NZ597107A
(en)
|
2009-06-25 |
2013-12-20 |
Alkermes Pharma Ireland Ltd |
Heterocyclic compounds for the treatment of neurological and psychological disorders
|
EP2473500A2
(en)
|
2009-09-01 |
2012-07-11 |
Pfizer Inc. |
Benzimidazole derivatives
|
US20110086869A1
(en)
|
2009-09-24 |
2011-04-14 |
The Trustees Of Boston University |
Methods for treating viral disorders
|
AU2010315152A1
(en)
|
2009-11-06 |
2012-06-14 |
Chelsea Therapeutics, Inc. |
Enzyme inhibiting compounds
|
WO2011068403A2
(en)
|
2009-12-02 |
2011-06-09 |
Ultimorphix Technologies B.V. |
Novel n-{3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamjne salts
|
EP2509418A4
(en)
|
2009-12-08 |
2013-03-20 |
Hemaquest Pharmaceuticals Inc |
METHODS AND REGIMES AT LOW DOSE FOR TREATING RED GLOBULAR DISORDERS
|
CA2798172C
(en)
*
|
2010-01-07 |
2017-11-21 |
Alkermes Pharma Ireland Limited |
Quaternary ammonium salt prodrugs
|
KR20120127495A
(ko)
|
2010-02-12 |
2012-11-21 |
화이자 인코포레이티드 |
8-플루오로-2-{4-[(메틸아미노)메틸]페닐}-1,3,4,5-테트라하이드로-6h-아제피노[5,4,3-cd]인돌-6-온의 염 및 다형체
|
WO2011113013A2
(en)
|
2010-03-11 |
2011-09-15 |
Hemaquest Pharmaceuticals, Inc. |
Methods and compositions for treating viral or virally-induced conditions
|
NZ604423A
(en)
|
2010-06-24 |
2015-01-30 |
Alkermes Pharma Ireland Ltd |
Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
|
RU2013114710A
(ru)
|
2010-09-03 |
2014-10-10 |
Байер Интеллектуэль Проперти Гмбх |
Замещенные конденсированные пиримидиноны и дигидропиримидиноны
|
JP5802756B2
(ja)
|
2010-10-20 |
2015-11-04 |
ファイザー・インク |
スムーズンド受容体モジュレーターとしてのピリジン−2−誘導体
|
WO2012078708A1
(en)
|
2010-12-07 |
2012-06-14 |
Chelsea Therapeutics, Inc. |
Combination comprising methotrexate and an antifolate compound
|
GB201103578D0
(en)
|
2011-03-02 |
2011-04-13 |
Sabrepharm Ltd |
Dipyridinium derivatives
|
CN107252414B
(zh)
|
2011-03-18 |
2020-11-24 |
奥克梅斯制药爱尔兰有限公司 |
包含脱水山梨糖醇酯的药物组合物
|
JP5914667B2
(ja)
|
2011-09-22 |
2016-05-11 |
ファイザー・インク |
ピロロピリミジンおよびプリン誘導体
|
CN102424679B
(zh)
*
|
2011-11-15 |
2014-07-30 |
扬子江药业集团有限公司 |
一种雷替曲塞的制备方法
|
EP2827867B1
(en)
|
2012-03-19 |
2019-11-06 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions comprising glycerol esters
|
CA2867121C
(en)
|
2012-03-19 |
2021-05-25 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions comprising fatty acid esters
|
NZ630428A
(en)
|
2012-03-19 |
2017-02-24 |
Alkermes Pharma Ireland Ltd |
Pharmaceutical compositions comprising benzyl alcohol
|
CA2885196C
(en)
|
2012-09-19 |
2021-06-22 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions having improved storage stability
|
CN105764511B
(zh)
|
2013-10-04 |
2019-01-11 |
艾普托斯生物科学公司 |
用于治疗癌症的组合物和方法
|
UA115388C2
(uk)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
RU2688233C2
(ru)
|
2014-03-20 |
2019-05-21 |
Алкермес Фарма Айэленд Лимитед |
Препараты арипипразола, имеющие повышенные скорости впрыска
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
HUE046518T2
(hu)
|
2014-04-30 |
2020-03-30 |
Pfizer |
Cikloalkilcsoporthoz kapcsolt diheterociklusos származékok
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
US9776992B2
(en)
|
2014-12-02 |
2017-10-03 |
Eli Lilly And Company |
1-oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors in the treatment of cancers
|
ES2746839T3
(es)
|
2014-12-18 |
2020-03-09 |
Pfizer |
Derivados de pirimidina y triazina y su uso como inhibidores de AXL
|
CN104447724B
(zh)
*
|
2014-12-31 |
2017-11-10 |
四川峨嵋山药业有限公司 |
一种雷替曲塞的精制方法
|
WO2017004192A1
(en)
|
2015-06-29 |
2017-01-05 |
Verastem, Inc. |
Therapeutic compositions, combinations, and methods of use
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
GB2543550A
(en)
|
2015-10-21 |
2017-04-26 |
Hox Therapeutics Ltd |
Peptides
|
HUE052893T2
(hu)
|
2016-01-13 |
2021-05-28 |
Acerta Pharma Bv |
Antifolát és BTK-gátló terápiás kombinációi
|
CN106957311B
(zh)
*
|
2016-12-29 |
2020-03-31 |
南京正大天晴制药有限公司 |
雷替曲塞的溶剂化物及其制备方法
|
CN106957312B
(zh)
*
|
2016-12-29 |
2019-11-01 |
南京正大天晴制药有限公司 |
雷替曲塞水合物晶型及其制备方法
|
WO2019173230A1
(en)
|
2018-03-05 |
2019-09-12 |
Alkermes Pharma Ireland Limited |
Aripiprazole dosing strategy
|
CN109734698B
(zh)
*
|
2019-01-25 |
2020-07-17 |
宏冠生物药业有限公司 |
一种雷替曲塞关键中间体的合成工艺
|
KR20220034736A
(ko)
|
2019-05-31 |
2022-03-18 |
비락타 서브시디어리 인크. |
히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법
|
EP3986890B1
(en)
|
2019-06-18 |
2023-11-15 |
Pfizer Inc. |
Benzisoxazole sulfonamide derivatives
|
AU2020295006B2
(en)
|
2019-06-19 |
2023-11-09 |
Ctxt Pty Ltd |
Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives
|