IL81924A - Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them - Google Patents

Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them

Info

Publication number
IL81924A
IL81924A IL81924A IL8192487A IL81924A IL 81924 A IL81924 A IL 81924A IL 81924 A IL81924 A IL 81924A IL 8192487 A IL8192487 A IL 8192487A IL 81924 A IL81924 A IL 81924A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
quinazolinone derivatives
antitumor pharmaceutical
Prior art date
Application number
IL81924A
Other languages
English (en)
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of IL81924A publication Critical patent/IL81924A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL81924A 1986-03-27 1987-03-18 Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them IL81924A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868607683A GB8607683D0 (en) 1986-03-27 1986-03-27 Anti-tumor agents

Publications (1)

Publication Number Publication Date
IL81924A true IL81924A (en) 1991-07-18

Family

ID=10595358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81924A IL81924A (en) 1986-03-27 1987-03-18 Quinazolinone derivatives,their preparation and antitumor pharmaceutical compositions containing them

Country Status (22)

Country Link
US (2) US4992550A (pt)
EP (1) EP0239362B1 (pt)
JP (1) JPH0657699B2 (pt)
AR (1) AR244213A1 (pt)
AT (1) ATE70057T1 (pt)
AU (1) AU592628B2 (pt)
CA (1) CA1285943C (pt)
DE (1) DE3774909D1 (pt)
DK (1) DK166621B1 (pt)
ES (1) ES2038170T3 (pt)
FI (1) FI89912C (pt)
GB (2) GB8607683D0 (pt)
GR (1) GR3003282T3 (pt)
HK (1) HK8594A (pt)
HU (1) HU197317B (pt)
IE (1) IE60302B1 (pt)
IL (1) IL81924A (pt)
LU (1) LU88797I2 (pt)
NL (1) NL970024I2 (pt)
NO (2) NO173545C (pt)
PT (1) PT84571B (pt)
ZA (1) ZA871998B (pt)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
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GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
GB8625019D0 (en) * 1986-10-18 1986-11-19 Wellcome Found Compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
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US4940713A (en) * 1988-04-15 1990-07-10 Burroughs Wellcome Co. Substituted glutamic acids
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (en) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Antiproliferative cyclic compounds
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
US5403843A (en) * 1991-08-12 1995-04-04 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinyalglutaminate derivatives and their use
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
ES2049659B1 (es) * 1992-10-08 1994-10-16 Ici Plc Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
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Also Published As

Publication number Publication date
JPH0657699B2 (ja) 1994-08-03
AU592628B2 (en) 1990-01-18
FI871139A0 (fi) 1987-03-16
LU88797I2 (fr) 1996-11-05
FI89912C (fi) 1993-12-10
PT84571B (pt) 1989-11-30
FI871139A (fi) 1987-09-28
NL970024I2 (nl) 1997-10-01
GB8706948D0 (en) 1987-04-29
EP0239362B1 (en) 1991-12-04
NO871266D0 (no) 1987-03-26
DK155087A (da) 1987-09-28
DK166621B1 (da) 1993-06-21
NL970024I1 (nl) 1997-09-01
IE870699L (en) 1987-09-27
IE60302B1 (en) 1994-06-29
GB2188319B (en) 1989-12-13
NO173545C (no) 1993-12-29
NO1998020I1 (no) 1998-09-28
GB8607683D0 (en) 1986-04-30
AU7047287A (en) 1987-10-01
ES2038170T3 (es) 1993-07-16
PT84571A (en) 1987-04-01
HU197317B (en) 1989-03-28
CA1285943C (en) 1991-07-09
EP0239362A2 (en) 1987-09-30
GB2188319A (en) 1987-09-30
NO871266L (no) 1987-09-28
US4992550A (en) 1991-02-12
JPH01125373A (ja) 1989-05-17
NO173545B (no) 1993-09-20
DK155087D0 (da) 1987-03-26
DE3774909D1 (de) 1992-01-16
GR3003282T3 (en) 1993-02-17
US5081124A (en) 1992-01-14
ZA871998B (en) 1987-11-25
FI89912B (fi) 1993-08-31
AR244213A1 (es) 1993-10-29
HUT43835A (en) 1987-12-28
HK8594A (en) 1994-02-04
ATE70057T1 (de) 1991-12-15
EP0239362A3 (en) 1989-07-05

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