MA33899B1 - Procedes et regimes a faible dose pour des troubles des globules rouges - Google Patents
Procedes et regimes a faible dose pour des troubles des globules rougesInfo
- Publication number
- MA33899B1 MA33899B1 MA35032A MA35032A MA33899B1 MA 33899 B1 MA33899 B1 MA 33899B1 MA 35032 A MA35032 A MA 35032A MA 35032 A MA35032 A MA 35032A MA 33899 B1 MA33899 B1 MA 33899B1
- Authority
- MA
- Morocco
- Prior art keywords
- disorders
- regimes
- low dose
- dose methods
- fstale
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
L'invention porte sur des procédés et des régimes à faibles doses pour augmenter les taux d'hémoglobine fstale dans des patients présentant des troubles des globules rouges, tels que la bêta-thalassémie, l'anémie falciforme, d'autres anémies, ou une perte de sang. Les taux d'hémoglobine fstale et totale et les comptages des globules rouges sont augmentés par l'administration de 2,2-diméthylbutyrate (dmb) seul ou en combinaison avec de l'hydroxyurée, de la décitabine ou un inhibiteur de hdac. Le traitement peut être poursuivi pendant au moins deux semaines.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26772709P | 2009-12-08 | 2009-12-08 | |
US29565010P | 2010-01-15 | 2010-01-15 | |
US30637610P | 2010-02-19 | 2010-02-19 | |
US31209010P | 2010-03-09 | 2010-03-09 | |
US36732610P | 2010-07-23 | 2010-07-23 | |
US41136910P | 2010-11-08 | 2010-11-08 | |
PCT/US2010/059584 WO2011072086A1 (fr) | 2009-12-08 | 2010-12-08 | Procédés et régimes à faible dose pour traiter des troubles des globules rouges |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33899B1 true MA33899B1 (fr) | 2013-01-02 |
Family
ID=44145905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35032A MA33899B1 (fr) | 2009-12-08 | 2010-12-08 | Procedes et regimes a faible dose pour des troubles des globules rouges |
Country Status (7)
Country | Link |
---|---|
US (1) | US8618068B2 (fr) |
EP (1) | EP2509418A4 (fr) |
CN (1) | CN102802412A (fr) |
IL (1) | IL220040A0 (fr) |
MA (1) | MA33899B1 (fr) |
TN (1) | TN2012000270A1 (fr) |
WO (1) | WO2011072086A1 (fr) |
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US6030961A (en) | 1997-03-11 | 2000-02-29 | Bar-Ilan Research & Development Co., Ltd. | Oxyalkylene phosphate compounds and uses thereof |
US6043389A (en) | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
US5939455A (en) | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
US5932545A (en) | 1997-03-17 | 1999-08-03 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
JP2002506436A (ja) | 1997-06-13 | 2002-02-26 | ザ ジョンズ ホプキンス ユニバーシティー | 治療用ナノスフェア |
AU774861B2 (en) | 1998-02-11 | 2004-07-08 | Douglas V Faller | Compositions and methods for the treatment of cystic fibrosis |
US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
DK1591109T3 (da) * | 2004-04-30 | 2008-10-06 | Topotarget Germany Ag | Formulering, der omfatter histondeacetylaseinhibitorer, der udviser tofaset frigivelse |
US20060069060A1 (en) | 2004-09-27 | 2006-03-30 | Sanjeev Redkar | Salts of decitabine |
FR2881746B1 (fr) | 2005-02-07 | 2007-04-13 | Centre Nat Rech Scient | Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications |
US20080075692A1 (en) * | 2006-05-09 | 2008-03-27 | Perrine Susan P | Methods for treating blood disorders |
WO2008028193A2 (fr) | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Formulations orales d'analogues de cytidine administrées dans le côlon |
US20110086869A1 (en) | 2009-09-24 | 2011-04-14 | The Trustees Of Boston University | Methods for treating viral disorders |
WO2011113013A2 (fr) | 2010-03-11 | 2011-09-15 | Hemaquest Pharmaceuticals, Inc. | Procédés et compositions pour le traitement d'états viraux ou induits par des virus |
-
2010
- 2010-12-08 MA MA35032A patent/MA33899B1/fr unknown
- 2010-12-08 WO PCT/US2010/059584 patent/WO2011072086A1/fr active Application Filing
- 2010-12-08 EP EP10836658A patent/EP2509418A4/fr not_active Withdrawn
- 2010-12-08 US US12/963,490 patent/US8618068B2/en active Active
- 2010-12-08 CN CN2010800630167A patent/CN102802412A/zh active Pending
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2012
- 2012-05-29 TN TNP2012000270A patent/TN2012000270A1/en unknown
- 2012-05-29 IL IL220040A patent/IL220040A0/en unknown
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IL220040A0 (en) | 2012-07-31 |
CN102802412A (zh) | 2012-11-28 |
US20110251149A1 (en) | 2011-10-13 |
EP2509418A4 (fr) | 2013-03-20 |
EP2509418A1 (fr) | 2012-10-17 |
WO2011072086A1 (fr) | 2011-06-16 |
US8618068B2 (en) | 2013-12-31 |
WO2011072086A9 (fr) | 2012-09-27 |
TN2012000270A1 (en) | 2013-12-12 |
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