PT3021859T - Adenovírus oncolíticos munidos de genes heterólogos - Google Patents
Adenovírus oncolíticos munidos de genes heterólogosInfo
- Publication number
- PT3021859T PT3021859T PT147991178T PT14799117T PT3021859T PT 3021859 T PT3021859 T PT 3021859T PT 147991178 T PT147991178 T PT 147991178T PT 14799117 T PT14799117 T PT 14799117T PT 3021859 T PT3021859 T PT 3021859T
- Authority
- PT
- Portugal
- Prior art keywords
- heterologous genes
- oncolytic adenoviruses
- armed
- adenoviruses armed
- oncolytic
- Prior art date
Links
- 230000000174 oncolytic effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1318880.0A GB201318880D0 (en) | 2013-10-25 | 2013-10-25 | Adenovirus |
| GB201318885A GB201318885D0 (en) | 2013-10-25 | 2013-10-25 | Adenovirus |
| GBGB1322851.5A GB201322851D0 (en) | 2013-12-23 | 2013-12-23 | Method |
| GB201401159A GB201401159D0 (en) | 2014-01-23 | 2014-01-23 | Adenovirus |
| GB201406470A GB201406470D0 (en) | 2014-04-10 | 2014-04-10 | Virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3021859T true PT3021859T (pt) | 2018-03-09 |
Family
ID=51900851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147991178T PT3021859T (pt) | 2013-10-25 | 2014-10-24 | Adenovírus oncolíticos munidos de genes heterólogos |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US9987314B2 (pt) |
| EP (3) | EP3831398A1 (pt) |
| KR (1) | KR102272932B1 (pt) |
| CN (2) | CN114457044A (pt) |
| AU (1) | AU2014338864C1 (pt) |
| CA (2) | CA3183645A1 (pt) |
| CL (1) | CL2016000959A1 (pt) |
| CY (1) | CY1119955T1 (pt) |
| DK (1) | DK3021859T3 (pt) |
| EA (1) | EA036414B1 (pt) |
| ES (1) | ES2661132T3 (pt) |
| HR (1) | HRP20180317T1 (pt) |
| HU (1) | HUE035875T2 (pt) |
| IL (2) | IL244944B (pt) |
| LT (1) | LT3021859T (pt) |
| MX (1) | MX2016005170A (pt) |
| MY (1) | MY175614A (pt) |
| NO (1) | NO3021859T3 (pt) |
| NZ (1) | NZ718931A (pt) |
| PE (1) | PE20160951A1 (pt) |
| PH (1) | PH12016500759A1 (pt) |
| PL (1) | PL3021859T3 (pt) |
| PT (1) | PT3021859T (pt) |
| RS (1) | RS57043B1 (pt) |
| SA (1) | SA516371011B1 (pt) |
| SG (2) | SG11201602887QA (pt) |
| SI (1) | SI3021859T1 (pt) |
| TR (1) | TR201802728T4 (pt) |
| WO (1) | WO2015059303A1 (pt) |
| ZA (1) | ZA201603646B (pt) |
Families Citing this family (38)
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| BR112015030881A2 (pt) | 2013-06-14 | 2017-10-24 | Psioxus Theraupeutics Ltd | regime de dosagem e formulações para adenovírus de tipo b |
| HUE035875T2 (hu) | 2013-10-25 | 2018-06-28 | Psioxus Therapeutics Ltd | Heterológ géneket tartalmazó onkolitikus adenovírusok |
| GB201406608D0 (en) | 2014-04-12 | 2014-05-28 | Psioxus Therapeutics Ltd | Virus |
| GB201510197D0 (en) | 2014-06-12 | 2015-07-29 | Psioxus Therapeutics Ltd | Method of treating ovarian cancer |
| SG11201701502VA (en) | 2014-08-27 | 2017-03-30 | Psioxus Therapeutics Ltd | A process for the production of adenovirus |
| AU2016219785B2 (en) | 2015-02-20 | 2021-10-28 | Ohio State Innovation Foundation | Bivalent antibody directed against NKG2D and tumor associated antigens |
| WO2016164370A1 (en) | 2015-04-06 | 2016-10-13 | Ohio State Innovation Foundation | Egfr-directed car therapy for glioblastoma |
| CN107690479B (zh) | 2015-04-30 | 2022-02-18 | 皮斯奥克斯治疗公司 | 编码b7蛋白质的溶瘤腺病毒 |
| MX2018007249A (es) * | 2015-12-17 | 2019-05-16 | Psioxus Therapeutics Ltd | Adenovirus del grupo b que codifica un anticuerpo contra el complejo tcr o fragmento de este. |
| WO2017118867A1 (en) | 2016-01-08 | 2017-07-13 | Replimune Limited | Use of an oncolytic virus for the treatment of cancer |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| WO2018041838A1 (en) * | 2016-08-29 | 2018-03-08 | Psioxus Therapeutics Limited | Adenovirus armed with bispecific t cell engager (bite) |
| GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
| WO2018083257A1 (en) * | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding transgenes |
| WO2018083259A1 (en) * | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding transgenes |
| WO2018083258A1 (en) * | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding at least three transgenes |
| GB201700350D0 (en) * | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| WO2018170763A1 (zh) * | 2017-03-22 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | ILA 基因的 RNAi 表达载体及其构建方法和应用 |
| TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗－ilt4抗體及抗原結合片段 |
| SI3630143T1 (sl) * | 2017-06-01 | 2023-11-30 | Akamis Bio Limited | Onkolitični virus in postopek |
| WO2019077113A1 (en) | 2017-10-20 | 2019-04-25 | F. Hoffmann-La Roche Ag | COPY PROTECTION FOR ANTIBODIES |
| CN112673093A (zh) * | 2018-07-04 | 2021-04-16 | 赛通免疫治疗公司 | 靶向flt3、pd-1和/或pd-l1的免疫疗法的组合物和方法 |
| CA3176812A1 (en) | 2018-07-11 | 2020-01-16 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| WO2020052551A1 (en) * | 2018-09-10 | 2020-03-19 | Genesail Biotech (Shanghai) Co. Ltd. | A modified oncolytic virus, composition and use thereof |
| EP3927833A4 (en) * | 2019-02-21 | 2022-11-30 | Unleash Immuno Oncolytics, Inc. | ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE |
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| GB201909081D0 (en) | 2019-06-25 | 2019-08-07 | Psioxus Therapeutics Ltd | Method |
| IL292836A (en) | 2019-11-12 | 2022-07-01 | Actym Therapeutics Inc | Platforms for administering bacteria that stimulate the immune system and their use for administering therapeutic products |
| KR20210118757A (ko) * | 2020-03-23 | 2021-10-01 | (주)큐리진 | STAT3 및 mTOR를 이중 특이적으로 표적하는 핵산서열을 포함한 항암 바이러스 |
| KR20210118760A (ko) * | 2020-03-23 | 2021-10-01 | (주)큐리진 | AR 및 mTOR를 이중 특이적으로 표적하는 핵산분자를 포함하는 항암바이러스 |
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| WO2022036159A2 (en) | 2020-08-12 | 2022-02-17 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| AU2021410765A1 (en) * | 2020-12-22 | 2023-07-13 | Ensoma, Inc. | Adenoviral gene therapy vectors |
| CN114717203B (zh) * | 2020-12-22 | 2023-06-27 | 广东东阳光药业有限公司 | 一种hIL7/hCCL19双基因重组溶瘤病毒及其制备方法和用途 |
| GB202102049D0 (en) | 2021-02-13 | 2021-03-31 | Psioxus Therapeutics Ltd | Viruses |
| WO2023086796A2 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| WO2023168436A1 (en) * | 2022-03-03 | 2023-09-07 | Board Of Regents, The University Of Texas System | Anti-cd19 and anti-cd79b chimeric antigen receptors and methods of use thereof |
| CN116836283B (zh) * | 2022-05-17 | 2024-05-07 | 苏州万灏生物科技有限公司 | 具有多种免疫调节因子的增强型溶瘤病毒及其制备方法和应用 |
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