BR112015030881A2 - regime de dosagem e formulações para adenovírus de tipo b - Google Patents
regime de dosagem e formulações para adenovírus de tipo bInfo
- Publication number
- BR112015030881A2 BR112015030881A2 BR112015030881A BR112015030881A BR112015030881A2 BR 112015030881 A2 BR112015030881 A2 BR 112015030881A2 BR 112015030881 A BR112015030881 A BR 112015030881A BR 112015030881 A BR112015030881 A BR 112015030881A BR 112015030881 A2 BR112015030881 A2 BR 112015030881A2
- Authority
- BR
- Brazil
- Prior art keywords
- formulations
- dose
- adenovirus
- per minute
- range
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 241000701161 unidentified adenovirus Species 0.000 title abstract 3
- 239000002245 particle Substances 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 230000000174 oncolytic effect Effects 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
trata-se de um método de tratamento de um paciente humano que compreende as etapas de: administrar sistemicamente múltiplas doses de uma formulação parenteral de um adenovírus oncolítico com capacidade de replicação de subgrupo b em um ciclo de tratamento único, em que a dose total dada em cada dose está na faixa de 1x1010 a 1x1014 partículas virais e em que cada dose de vírus é administrada por um período de 1 a 90 minutos, por exemplo, em uma taxa de liberação de partícula viral na faixa de 2x1010 partículas por minuto a 2x1012 partículas por minuto. a revelação se estende, adicionalmente, às formulações dos ditos adenovírus oncolíticos e terapias de combinação dos vírus e formulações com outros agentes terapêuticos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201310698A GB201310698D0 (en) | 2013-06-14 | 2013-06-14 | Method |
GB201405140A GB201405140D0 (en) | 2014-03-22 | 2014-03-22 | Method |
GB201406509A GB201406509D0 (en) | 2014-04-10 | 2014-04-10 | Method |
PCT/EP2014/062284 WO2014198852A2 (en) | 2013-06-14 | 2014-06-12 | A dosing regime and formulations for type b adenoviruses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015030881A2 true BR112015030881A2 (pt) | 2017-10-24 |
Family
ID=51162703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015030881A BR112015030881A2 (pt) | 2013-06-14 | 2014-06-12 | regime de dosagem e formulações para adenovírus de tipo b |
Country Status (13)
Country | Link |
---|---|
US (2) | US11173186B2 (pt) |
EP (2) | EP3007711B1 (pt) |
JP (2) | JP6797680B2 (pt) |
KR (3) | KR20210054067A (pt) |
CN (2) | CN105431157A (pt) |
AU (2) | AU2014280123B2 (pt) |
BR (1) | BR112015030881A2 (pt) |
CA (2) | CA3176971A1 (pt) |
HK (1) | HK1223564A1 (pt) |
IL (1) | IL243071B (pt) |
RU (1) | RU2671558C2 (pt) |
SG (1) | SG11201510064WA (pt) |
WO (1) | WO2014198852A2 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201510197D0 (en) | 2014-06-12 | 2015-07-29 | Psioxus Therapeutics Ltd | Method of treating ovarian cancer |
CN110461323A (zh) * | 2017-03-31 | 2019-11-15 | 绪方久修 | 溶瘤病毒的增殖方法和抗肿瘤剂 |
GB201801614D0 (en) * | 2018-01-31 | 2018-03-14 | Psioxus Therapeutics Ltd | Formulation |
CA3095427A1 (en) * | 2018-03-30 | 2019-10-03 | Tomoki Todo | Swelling-suppressive oncolytic virus |
WO2021067310A1 (en) * | 2019-09-30 | 2021-04-08 | Candel Therapeutics, Inc. | Combination gmci and atri cancer treatment |
CN114469938A (zh) * | 2020-10-27 | 2022-05-13 | 中国医学科学院药物研究所 | 化合物bix02189在制备抗流感病毒药物中的应用 |
CN114601838B (zh) * | 2022-04-29 | 2023-10-27 | 广东龙帆生物科技有限公司 | 一种azd8055在制备用于抗腺病毒感染的药物中的用途 |
WO2024042231A1 (en) * | 2022-08-26 | 2024-02-29 | Universite De Namur | Adenovirus-based adjuvants for cancer treatment |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
ATE371372T1 (de) * | 1997-10-09 | 2007-09-15 | Wellstat Biologics Corp | Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren |
US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
WO2000034494A1 (en) | 1998-12-09 | 2000-06-15 | The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | A recombinant vector expressing multiple costimulatory molecules and uses thereof |
US7279318B1 (en) | 1999-06-09 | 2007-10-09 | Hybrid Systems Limited | Modification of biological elements |
EP1327688A1 (en) | 2002-01-14 | 2003-07-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Adenoviruses with enhanced lytic potency |
US20040167088A1 (en) * | 2003-02-25 | 2004-08-26 | Genvec, Inc. | Method of using adenoviral vectors with increased persistence in vivo |
US20050036989A1 (en) | 2003-07-18 | 2005-02-17 | Onyx Pharmaceuticals, Inc. | Subgroup B adenoviral vectors for treating disease |
ATE493441T1 (de) | 2003-10-16 | 2011-01-15 | Micromet Ag | Multispezifische deimmunisierte cd3-bindende moleküle |
CA2567094C (en) * | 2004-05-26 | 2014-11-25 | Schering Aktiengesellschaft | Chimeric adenoviruses for use in cancer treatment |
GB0416487D0 (en) | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
EP1819823A2 (en) | 2004-12-01 | 2007-08-22 | Bayer Schering Pharma Aktiengesellschaft | Generation of replication competent viruses for therapeutic use |
EP1929021A2 (en) | 2005-08-31 | 2008-06-11 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
RU2382884C2 (ru) | 2006-07-10 | 2010-02-27 | Александр Владимирович Дидин | Сферическая объемная роторная машина и способ работы сферической объемной роторной машины |
WO2008080003A2 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Generation of oncolytic adenoviruses and uses thereof |
AU2009253682B2 (en) * | 2008-05-27 | 2015-09-17 | Oncolytics Biotech Inc. | Modulating interstitial pressure and oncolytic viral delivery and distribution |
MX2011003553A (es) | 2008-10-02 | 2011-05-25 | Respivert Ltd | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38. |
CN101381742A (zh) | 2008-10-23 | 2009-03-11 | 浙江理工大学 | 晚期启动子靶向性调控溶瘤腺病毒pCN305载体及其构建方法与应用 |
CA2744959A1 (en) | 2008-12-11 | 2010-06-17 | Psioxus Therapeutics Limited | Modification of nucleic acid vectors with polymers comprising charged quaternary amino groups |
GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
JP2015507604A (ja) * | 2011-11-14 | 2015-03-12 | リジェネレイティブ サイエンシーズ, エルエルシー | 懸濁粒子送達システムおよび方法 |
CA3183645A1 (en) | 2013-10-25 | 2015-04-30 | Psioxus Therapeutics Limited | Oncolytic adenoviruses armed with heterologous genes |
SG11201701502VA (en) | 2014-08-27 | 2017-03-30 | Psioxus Therapeutics Ltd | A process for the production of adenovirus |
-
2014
- 2014-06-12 AU AU2014280123A patent/AU2014280123B2/en active Active
- 2014-06-12 CA CA3176971A patent/CA3176971A1/en active Pending
- 2014-06-12 BR BR112015030881A patent/BR112015030881A2/pt not_active Application Discontinuation
- 2014-06-12 RU RU2015152860A patent/RU2671558C2/ru active
- 2014-06-12 EP EP14736650.4A patent/EP3007711B1/en active Active
- 2014-06-12 CN CN201480033427.XA patent/CN105431157A/zh active Pending
- 2014-06-12 CA CA2914790A patent/CA2914790C/en active Active
- 2014-06-12 US US14/896,294 patent/US11173186B2/en active Active
- 2014-06-12 WO PCT/EP2014/062284 patent/WO2014198852A2/en active Application Filing
- 2014-06-12 CN CN202011432713.7A patent/CN112516179A/zh active Pending
- 2014-06-12 JP JP2016518498A patent/JP6797680B2/ja active Active
- 2014-06-12 KR KR1020217013679A patent/KR20210054067A/ko not_active Application Discontinuation
- 2014-06-12 KR KR1020217041147A patent/KR20210156857A/ko not_active Application Discontinuation
- 2014-06-12 KR KR1020167000214A patent/KR20160026970A/ko active Application Filing
- 2014-06-12 SG SG11201510064WA patent/SG11201510064WA/en unknown
- 2014-06-12 EP EP20198714.6A patent/EP3777870A1/en active Pending
-
2015
- 2015-12-09 IL IL24307115A patent/IL243071B/en active IP Right Revival
-
2016
- 2016-10-17 HK HK16111964.1A patent/HK1223564A1/zh unknown
-
2020
- 2020-02-14 AU AU2020201101A patent/AU2020201101B2/en active Active
- 2020-09-09 JP JP2020151615A patent/JP2020203932A/ja active Pending
-
2021
- 2021-09-23 US US17/448,549 patent/US20220054563A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SG11201510064WA (en) | 2016-01-28 |
RU2015152860A (ru) | 2017-07-19 |
KR20210156857A (ko) | 2021-12-27 |
KR20210054067A (ko) | 2021-05-12 |
AU2020201101B2 (en) | 2021-10-21 |
AU2020201101A1 (en) | 2020-03-05 |
AU2014280123A1 (en) | 2016-01-28 |
RU2015152860A3 (pt) | 2018-05-04 |
JP6797680B2 (ja) | 2020-12-16 |
IL243071B (en) | 2019-10-31 |
JP2020203932A (ja) | 2020-12-24 |
EP3007711A2 (en) | 2016-04-20 |
WO2014198852A2 (en) | 2014-12-18 |
CA3176971A1 (en) | 2014-12-18 |
EP3007711B1 (en) | 2020-10-21 |
US11173186B2 (en) | 2021-11-16 |
RU2671558C2 (ru) | 2018-11-02 |
CN112516179A (zh) | 2021-03-19 |
CA2914790A1 (en) | 2014-12-18 |
CN105431157A (zh) | 2016-03-23 |
US20220054563A1 (en) | 2022-02-24 |
EP3777870A1 (en) | 2021-02-17 |
HK1223564A1 (zh) | 2017-08-04 |
US20160120922A1 (en) | 2016-05-05 |
JP2016526531A (ja) | 2016-09-05 |
KR20160026970A (ko) | 2016-03-09 |
AU2014280123B2 (en) | 2019-11-14 |
CA2914790C (en) | 2024-02-27 |
WO2014198852A3 (en) | 2015-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015030881A2 (pt) | regime de dosagem e formulações para adenovírus de tipo b | |
MX2022006107A (es) | Metodos y composiciones para dosificacion en terapia celular adoptiva. | |
CO7101246A2 (es) | Compuesto de carbamato y preparación y uso de los mismos | |
BR112015025464A2 (pt) | coagonistas do receptor de glp-1/glucagon estáveis, prolongados para uso médico | |
BR112015027282A2 (pt) | fenfluramina para uso no tratamento de síndrome de dravet | |
BR112014028633A8 (pt) | tratamento de amd usando sflt-1 de aav | |
BR212016030926U2 (pt) | conjugados de alvo e partículas e formulações dos mesmos | |
BR112015003590A8 (pt) | Métodos para tratamento ou prevenção da asma por administração de um antagonista de il-4r | |
MX2023012450A (es) | Esketamina para el tratamiento de la depresion. | |
BR112016003229A8 (pt) | composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica | |
BR112014015955A2 (pt) | uso terapêutico subcutâneo de inibidor de dpp-4 | |
PE20170302A1 (es) | Uso de pridopidina en dosis altas para el tratamiento de enfermedad de huntington | |
WO2011146777A3 (en) | Device and method for providing a synergistic combination of phototherapy and a non-light energy modality to the brain | |
BR112015010477A2 (pt) | combinação farmacêutica que compreende um inibidor b-raf e um inibidor de histona desacetilase e o uso dos mesmos no tratamento de doenças proliferativas | |
IN2015DN03219A (pt) | ||
BR112015018252A2 (pt) | composição farmacêutica aquosa de dose fixa estável para administração nasal para um ser humano, composição de suspensão aquosa farmacêutica de dose fixa estável para administração nasal para um ser humano, suspensão estável adequada para administração nasal a um ser humano, método para tratar rinite em um ser humano necessitando do mesmo, uso da composição farmacêutica para administração nasal, método para liberar uma composição farmacêutica e kit | |
AR104771A1 (es) | Inhalador de polvo seco | |
BR112014029735A2 (pt) | forma de dosagem e formulação de abediterol | |
MX2020011107A (es) | Regimen de glicosidasa para el tratamiento de enfermedades infecciosas. | |
SG11202103097QA (en) | Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy | |
BR112015018120A2 (pt) | partículas cristalinas multicomponentes para terapia por inalação, composição farmacêutica, inalador de pó seco, inalador pressurizado dosimetrado, métodos de tratamento de uma doença ou distúrbio respiratório ou uma doença ou distúrbio pulmonar em um paciente, e, de preparação das partículas | |
MX2015009891A (es) | Composiciones farmaceuticas que comprenden particulas cristalinas de multicomponentes adecuadas para usar en terapia de inhalacion. | |
BR112017009193A2 (pt) | método de tratamento de uma doença infecciosa, câncer, ou doença mieloproliferativa em um indivíduo; método de tratamento de uma doença mieloproliferativa em um indivíduo; e; interferon tipo i | |
MX2015011347A (es) | Tratamiento sistemico y topico combinado de tejidos con trastorno. | |
BR112017014847A2 (pt) | "método para tratar anemia com o uso de formulação de epo de atuação prolongada" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |