PT2785359T - Células estromais mesenquimatosas e usos relacionados com as mesmas - Google Patents
Células estromais mesenquimatosas e usos relacionados com as mesmasInfo
- Publication number
- PT2785359T PT2785359T PT12854438T PT12854438T PT2785359T PT 2785359 T PT2785359 T PT 2785359T PT 12854438 T PT12854438 T PT 12854438T PT 12854438 T PT12854438 T PT 12854438T PT 2785359 T PT2785359 T PT 2785359T
- Authority
- PT
- Portugal
- Prior art keywords
- stromal cells
- mesenchymal stromal
- related uses
- mesenchymal
- cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/141—Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F9/00—Arrangements for program control, e.g. control units
- G06F9/06—Arrangements for program control, e.g. control units using stored programs, i.e. using an internal store of processing equipment to receive or retain programs
- G06F9/46—Multiprogramming arrangements
- G06F9/54—Interprogram communication
- G06F9/542—Event management; Broadcasting; Multicasting; Notifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1171—Haematopoietic stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161565358P | 2011-11-30 | 2011-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2785359T true PT2785359T (pt) | 2018-11-06 |
Family
ID=48536141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT12854438T PT2785359T (pt) | 2011-11-30 | 2012-11-30 | Células estromais mesenquimatosas e usos relacionados com as mesmas |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US8962321B2 (enExample) |
| EP (2) | EP2785359B1 (enExample) |
| JP (5) | JP2015500810A (enExample) |
| KR (4) | KR102246369B1 (enExample) |
| CN (2) | CN108478599B (enExample) |
| AU (4) | AU2012345630A1 (enExample) |
| CA (1) | CA2857545A1 (enExample) |
| CY (1) | CY1122275T1 (enExample) |
| DK (1) | DK2785359T3 (enExample) |
| ES (1) | ES2690212T3 (enExample) |
| HR (1) | HRP20181515T1 (enExample) |
| HU (1) | HUE040566T2 (enExample) |
| LT (1) | LT2785359T (enExample) |
| PL (1) | PL2785359T3 (enExample) |
| PT (1) | PT2785359T (enExample) |
| RS (1) | RS57886B1 (enExample) |
| SI (1) | SI2785359T1 (enExample) |
| TW (4) | TW202344258A (enExample) |
| WO (1) | WO2013082543A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102230288B1 (ko) | 2006-04-14 | 2021-03-22 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| WO2009137629A2 (en) | 2008-05-06 | 2009-11-12 | Advanced Cell Technology, Inc. | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| HRP20181515T1 (hr) | 2011-11-30 | 2018-11-16 | Astellas Institute For Regenerative Medicine | Mezenhimne stromalne stanice i upotreba povezana s njima |
| WO2014011881A2 (en) | 2012-07-11 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| WO2014011407A2 (en) | 2012-07-12 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| KR101669124B1 (ko) * | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
| ES2615396T3 (es) | 2013-08-22 | 2017-06-07 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | Método para producir músculo cardiaco por ingeniería (EHM) |
| WO2015074057A1 (en) * | 2013-11-18 | 2015-05-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies |
| KR102865313B1 (ko) * | 2014-06-10 | 2025-09-29 | 메조블라스트 인터내셔널 에스에이알엘 | 면역 장애의 치료 |
| JP6452107B2 (ja) * | 2014-09-05 | 2019-01-16 | 国立大学法人 東京大学 | 糖尿病性皮膚潰瘍治療のための多能性幹細胞 |
| CN104232573B (zh) * | 2014-09-11 | 2017-01-11 | 安沂华 | 一种生长培养基及其用途和培养脐带间充质干细胞的方法 |
| US20160095885A1 (en) * | 2014-10-01 | 2016-04-07 | WibiWorks Therapeutics, Inc. | Induction Medium & Methods for Stem Cell Culture & Therapy |
| CN104531613B (zh) * | 2014-11-17 | 2017-12-19 | 中国农业科学院北京畜牧兽医研究所 | Wip1敲除在促进小鼠骨髓间充质干细胞迁移中的应用 |
| ES2956655T3 (es) * | 2014-12-23 | 2023-12-26 | Mesoblast Int Sarl | Método para el tratamiento de la insuficiencia cardíaca |
| CN107889507B (zh) | 2015-03-23 | 2021-11-26 | 安斯泰来再生医药协会 | 改进的人视网膜色素(rpe)细胞和感光祖细胞的效能测定 |
| EA201890424A1 (ru) | 2015-08-05 | 2018-06-29 | Селл Кьюр Нейросайансес Лтд. | Получение клеток пигментного эпителия сетчатки |
| TW202417023A (zh) | 2015-08-18 | 2024-05-01 | 美商安斯泰來再生醫藥協會 | 臨床調配物 |
| MX2018004005A (es) * | 2015-09-29 | 2018-06-12 | Celularity Inc | Ensayo de potencia celular. |
| WO2017060240A1 (en) * | 2015-10-05 | 2017-04-13 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and culture medium for ex vivo culturing of epidermis-derived stem cells |
| US11802272B2 (en) * | 2015-11-04 | 2023-10-31 | The Board Of Regents Of The University Of Texas System | Enrich and amplify highly potent human mesenchymal stem cells from elderly cell populations |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| CN105326864A (zh) * | 2015-11-30 | 2016-02-17 | 奥思达干细胞有限公司 | 一种治疗系统性红斑狼疮的干细胞制剂及其制备方法 |
| US10383895B2 (en) * | 2016-02-18 | 2019-08-20 | Viera Bioscience, Inc. | Stimulation of therapeutic angiogenesis by T regulatory cells |
| CN105671000A (zh) * | 2016-03-02 | 2016-06-15 | 深圳爱生再生医学科技有限公司 | 重组间充质干细胞及其制备方法和应用 |
| US10758574B2 (en) | 2016-04-28 | 2020-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Cartilage cells with a high regenerative potential and low immune response for use in cellular therapy |
| AU2017296175B2 (en) * | 2016-07-11 | 2023-11-02 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
| CN106267161A (zh) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞制剂及其制备方法和应用 |
| CN106265899A (zh) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种组合物及其在制备改善慢性鼻炎的产品中的应用 |
| CN106479968A (zh) * | 2016-10-11 | 2017-03-08 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脐带间充质干细胞的培养方法 |
| CN106520686A (zh) * | 2016-10-11 | 2017-03-22 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脂肪间充质干细胞的培养方法 |
| KR101971322B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | Socs의 발현 또는 활성 억제를 이용한 고효능 줄기세포 선별방법 |
| WO2018083700A1 (en) * | 2016-11-03 | 2018-05-11 | Exostem Biotec Ltd. | Mesenchymal stem cells populations, their products, and use thereof |
| CN106563161A (zh) * | 2016-11-08 | 2017-04-19 | 华南生物医药研究院 | 可用于美容的新型药物组合剂 |
| CN106581760A (zh) * | 2016-11-08 | 2017-04-26 | 华南生物医药研究院 | 增强细胞活性的特殊处理方法 |
| CN106619721A (zh) * | 2016-11-08 | 2017-05-10 | 中国人民解放军军事医学科学院野战输血研究所 | 一种增强细胞活性的新方法 |
| KR102390909B1 (ko) * | 2016-12-19 | 2022-04-26 | 주식회사 파이안바이오테크놀로지 | 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물 |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201703058D0 (en) * | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| JP7102397B2 (ja) * | 2017-04-03 | 2022-07-19 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| JPWO2018207918A1 (ja) * | 2017-05-12 | 2020-03-26 | 国立大学法人 東京医科歯科大学 | 移植効率を向上させる間葉系幹細胞の純化方法 |
| CA3067963A1 (en) * | 2017-06-19 | 2018-12-27 | National University Corporation Hokkaido University | Treatment agent for epidermolysis bullosa |
| CN107490701B (zh) * | 2017-08-17 | 2021-09-14 | 上海集技生物技术有限公司 | 一种基于局部照射的全身性骨损伤模型的建立及病理机制分析的方法 |
| CN107714726A (zh) | 2017-10-16 | 2018-02-23 | 中国科学院广州生物医药与健康研究院 | 一种重塑骨髓微环境的方法 |
| CN109069543B (zh) * | 2017-10-16 | 2020-02-18 | 中国科学院广州生物医药与健康研究院 | 一种重塑骨髓微环境的方法 |
| WO2019086912A1 (en) * | 2017-11-06 | 2019-05-09 | King's College London | Therapeutic substances, their preparation and diagnostic procedure |
| KR102095628B1 (ko) | 2018-01-05 | 2020-04-01 | 재단법인 아산사회복지재단 | 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물 |
| CN111712565A (zh) * | 2018-02-16 | 2020-09-25 | 奈科斯特细胞制药有限公司 | 同种异体组合物 |
| WO2019171386A1 (en) * | 2018-03-07 | 2019-09-12 | The Medical Research Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center | Compositions and methods for treating age-related macular degeneration |
| MA52883A (fr) * | 2018-06-15 | 2021-05-26 | Prieto Manuel Hermida | Composition pharmaceutique pour dermatologie et ses utilisations |
| KR102337954B1 (ko) * | 2018-08-16 | 2021-12-10 | 차의과학대학교 산학협력단 | 뇌졸중 치료용 조성물 및 이를 스크리닝하는 방법 |
| CN109082409A (zh) * | 2018-09-14 | 2018-12-25 | 四川新生命干细胞科技股份有限公司 | 一种组织修复能力强的脂肪干细胞分离培养及筛选方法 |
| CN109182262A (zh) * | 2018-09-25 | 2019-01-11 | 深圳市五零生命科技有限公司 | 一种间充质干细胞无血清培养基 |
| US12409249B2 (en) | 2018-11-26 | 2025-09-09 | Massachusetts Institute Of Technology | Compositions and methods for immune tolerance |
| CN109342739A (zh) * | 2018-11-27 | 2019-02-15 | 上海科医联创生物科技有限公司 | 一种鉴定间充质干细胞纯度的方法 |
| CN109609584A (zh) * | 2018-12-10 | 2019-04-12 | 天津长和生物技术有限公司 | 间充质干细胞免疫调节能力的检测方法 |
| US20220202868A1 (en) * | 2019-02-27 | 2022-06-30 | Tigenix S.A.U. | Improved stem cell populations for allogeneic therapy |
| CA3132414A1 (en) * | 2019-03-12 | 2020-09-17 | Global Stem Cell Technology | Immunomodulating mesenchymal stem cells |
| JP7541699B2 (ja) | 2019-03-14 | 2024-08-29 | 北海道公立大学法人 札幌医科大学 | 筋萎縮性側索硬化症の治療用医薬組成物 |
| EP4004191A4 (en) | 2019-07-26 | 2022-10-12 | Brexogen Inc. | Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same |
| CN110305839A (zh) * | 2019-08-02 | 2019-10-08 | 陕西佰傲干细胞再生医学有限公司 | 间充质干细胞无血清培养基 |
| TW202122573A (zh) | 2019-08-28 | 2021-06-16 | 安斯泰來再生醫藥協會 | 治療血管疾病之組成物及方法 |
| JP2022547832A (ja) | 2019-08-28 | 2022-11-16 | アステラス インスティテュート フォー リジェネラティブ メディシン | 血管疾患の処置方法 |
| CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
| WO2021072595A1 (zh) * | 2019-10-14 | 2021-04-22 | 玛旺干细胞医学生物科技股份有限公司 | 间充质干细胞在治疗听力障碍上的医药用途 |
| RU2740152C1 (ru) * | 2020-01-09 | 2021-01-13 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" (ФИЦ КНЦ СО РАН) | Способ активации пролиферативного ответа фибробластоподобных клеток стромально-васкулярной фракции жировой ткани |
| WO2021169017A1 (zh) * | 2020-02-25 | 2021-09-02 | 上海大学 | 间充质干细胞在治疗重症covid19肺炎中的用途 |
| WO2021210515A1 (ja) * | 2020-04-13 | 2021-10-21 | 国立大学法人東海国立大学機構 | 腎臓中のcd25陽性の制御性t細胞増加剤 |
| WO2021222389A1 (en) * | 2020-04-28 | 2021-11-04 | Factor Bioscience Inc. | Mesenchymal stem cell therapies |
| EP3909594A1 (en) * | 2020-05-14 | 2021-11-17 | Bernat Soria Escoms | Mesenchymal stromal cells for the treatment of covid-19 and other inflammatory, autoimmune and degenerative diseases |
| CN111518761B (zh) * | 2020-05-25 | 2022-04-29 | 青岛瑞思德生物科技有限公司 | 一种间充质干细胞体外筛选、激活、扩增、冻存及其细胞库建立的方法 |
| WO2022004938A1 (ko) * | 2020-06-30 | 2022-01-06 | 주식회사 미래셀바이오 | 유사 중간엽 줄기세포의 제조방법 |
| EP3945133A1 (en) * | 2020-07-29 | 2022-02-02 | Georg-August-Universität Göttingen | Mass production of human pluripotent stem cell derived cardiac stromal cell |
| CN112826833A (zh) * | 2020-07-30 | 2021-05-25 | 中国人民解放军总医院第五医学中心 | 间充质干细胞在制备新冠肺炎引起的肺损伤修复药物中的应用 |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| WO2022086276A1 (ko) * | 2020-10-22 | 2022-04-28 | 가톨릭대학교 산학협력단 | 특정 유전자의 발현이 증가 또는 감소된 줄기세포를 유효성분으로 포함하는 류마티스 관절염 예방 또는 치료용 약학적 조성물 |
| US20240366676A1 (en) * | 2021-05-07 | 2024-11-07 | Sungkwang Medical Foundation | Mesenchymal stem cells having enhanced osteogenic differentiation capacity, and use thereof |
| TW202320819A (zh) * | 2021-07-08 | 2023-06-01 | 比利時商比利時百靈佳殷格翰動物醫藥公司 | 用於治療慢性齦口炎之間葉幹細胞 |
| CN113717972B (zh) * | 2021-08-16 | 2022-07-01 | 南通市肿瘤医院 | MYADM靶向的siRNA及其应用 |
| CA3234969A1 (en) * | 2021-10-12 | 2023-04-20 | Makoto Funaki | Anti-aging composition using mesenchymal stem cells and methods thereof |
| IL314150A (en) * | 2022-02-07 | 2024-09-01 | Smartcella Solutions Ab | Methods and preparations for the production of human-derived mesenchymal stem cells |
| CN114984051A (zh) * | 2022-06-27 | 2022-09-02 | 广州惠善医疗技术有限公司 | 间充质干细胞在制备治疗炎症及免疫相关疾病的药物中的应用 |
| WO2024007038A2 (en) * | 2022-07-01 | 2024-01-04 | Northwestern University | Compositions and methods for the treatment of intestinal inflammation |
| US20250257321A1 (en) | 2022-07-18 | 2025-08-14 | Astellas Institute For Regenerative Medicine | Methods of treating brain injury |
| CN115305234B (zh) * | 2022-09-28 | 2023-01-17 | 呈诺再生医学科技(北京)有限公司 | 一种制备间充质干细胞的方法、间充质干细胞和应用 |
| WO2024158058A1 (ja) * | 2023-01-27 | 2024-08-02 | 株式会社Rainbow | 自動培養装置における細胞増殖制御方法 |
| TW202434721A (zh) * | 2023-02-14 | 2024-09-01 | 國立大學法人山口大學 | 細胞群、三維細胞培養體、醫藥組成物、胞泌體及製作此細胞群的方法 |
| CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
| CN117210528B (zh) * | 2023-09-12 | 2024-08-20 | 长沙干细胞与再生医学工业技术研究院有限公司 | 一种综合评估间充质干细胞免疫调控能力的方法 |
| WO2025084581A1 (ko) * | 2023-10-18 | 2025-04-24 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포를 포함하는 복막 섬유증의 개선, 예방 또는 치료용 조성물 |
Family Cites Families (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6416581A (en) * | 1987-07-09 | 1989-01-20 | Rikagaku Kenkyusho | Frozen animal cell and production thereof |
| US5128259A (en) | 1989-10-27 | 1992-07-07 | Hahnemann University | Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5599705A (en) | 1993-11-16 | 1997-02-04 | Cameron; Robert B. | In vitro method for producing differentiated universally compatible mature human blood cells |
| EP0739412B1 (en) | 1993-12-23 | 2002-02-27 | Infigen, Inc. | ungulate EMBRYONIC STEM CELLS AS NUCLEAR DONORS AND NUCLEAR TRANSFER TECHNIQUES TO PRODUCE CHIMERIC AND TRANSGENIC ANIMALS |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| WO1998033891A1 (en) | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| WO1998053048A1 (en) | 1997-05-21 | 1998-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells |
| US6429012B1 (en) | 1997-10-06 | 2002-08-06 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
| JP4526186B2 (ja) | 1998-06-08 | 2010-08-18 | オシリス セラピューティクス,インコーポレイテッド | 造血幹細胞を試験管内で維持する方法と組成物 |
| US6361998B1 (en) | 1998-06-25 | 2002-03-26 | Hemosol Inc. | Efficient culture of stem cells for the production of hemoglobin |
| EP1270719A3 (en) | 1998-08-24 | 2003-06-25 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
| US20110171185A1 (en) | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| CA2388497A1 (en) | 1999-10-15 | 2001-04-26 | Advanced Cell Technology, Inc. | Method of producing differentiated progenitor cells by culturing morula or inner cell mass cells |
| WO2001036589A2 (en) | 1999-11-17 | 2001-05-25 | University Of Rochester | Human ex vivo immune system |
| AU2927501A (en) | 2000-01-07 | 2001-07-24 | Oregon Health And Science University | Clonal propagation of primate offspring by embryo splitting |
| US7795026B2 (en) | 2000-01-21 | 2010-09-14 | The Johns Hopkins University School Of Medicine | Methods for obtaining human embryoid body-derived cells |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| JP2004504834A (ja) | 2000-08-01 | 2004-02-19 | イスム リサーチ ディベロップメント カンパニー | 胚性細胞の定方向分化 |
| MXPA03002414A (es) | 2000-09-18 | 2004-07-08 | Organogenesis Inc | Protesis con injerto de hoja plana tratada por bioingenieria y su uso. |
| AU2002335610C1 (en) | 2001-01-29 | 2008-09-25 | Hemogenix, Inc. | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation |
| US20030027330A1 (en) | 2001-04-02 | 2003-02-06 | Robert Lanza | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| KR20020083634A (ko) | 2001-04-27 | 2002-11-04 | 크레아젠 주식회사 | 수지상 세포를 포함하는 자가면역 질환의 치료용 약제학적조성물 및 이를 이용한 치료방법 |
| EP1393066A4 (en) | 2001-05-15 | 2006-01-25 | Rappaport Family Inst For Res | INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
| EP1470217A1 (en) | 2001-10-31 | 2004-10-27 | Université Libre de Bruxelles | Generation and use of dendritic cells |
| AU2002356896B2 (en) | 2001-11-02 | 2007-11-01 | Wisconsin Alumni Research Foundation | Endothelial cells derived from primate embryonic stem cells |
| AU2002363659B2 (en) * | 2001-11-15 | 2008-09-25 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| AU2002360424A1 (en) | 2001-11-26 | 2003-06-10 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| CN1630716A (zh) | 2001-12-07 | 2005-06-22 | 杰龙公司 | 人胚胎干细胞衍生的造血细胞 |
| US7491389B2 (en) * | 2002-03-21 | 2009-02-17 | University Of Florida Reasearch Foundation, Inc. | Modulating angiogenesis |
| EP1563058A4 (en) | 2002-07-12 | 2005-12-28 | Univ Singapore | Haemangioblasts-Progenitor Cells |
| US20040052771A1 (en) | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
| AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
| US7427603B2 (en) | 2002-09-26 | 2008-09-23 | The Children's Medical Center Corporation | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells |
| AU2002348947A1 (en) | 2002-09-26 | 2004-04-19 | Institut National De La Sante Et De La Recherche Medicale | Compositions and methods for amplification of human stem cells |
| US20050054096A1 (en) | 2002-11-06 | 2005-03-10 | Piniella Carlos J. | Pluripotent cells from monocytes, and methods of making and using pluripotent cells |
| US20040156878A1 (en) | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
| US20050032210A1 (en) | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
| CA2524929C (en) | 2003-05-08 | 2015-01-13 | Cellartis Ab | Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| WO2005040391A1 (en) | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
| US20070141703A1 (en) | 2003-11-19 | 2007-06-21 | Stanley Edouard G | Methods for producing blood products from pluripotent cells in cell culture |
| WO2005063303A1 (en) | 2003-12-19 | 2005-07-14 | Viacell, Inc. | Use of human cord blood-derived pluripotent cells for the treatment of disease |
| CN1286970C (zh) | 2003-12-30 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 由脐血cd34+细胞体外诱导生成巨核细胞的方法 |
| US20060112438A1 (en) | 2004-01-02 | 2006-05-25 | West Michael D | Novel culture systems for ex vivo development |
| KR100535326B1 (ko) | 2004-01-20 | 2005-12-09 | 한국생명공학연구원 | 줄기 세포로부터 자연살해 세포로의 분화 조절용 유전자를유효성분으로 포함하는 분화 조절제 |
| WO2005070011A2 (en) | 2004-01-23 | 2005-08-04 | Advanced Cell Technology, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| US20050266556A1 (en) | 2004-02-09 | 2005-12-01 | Yoder Mervin C | Isolation, expansion and use of clonogenic endothelial progenitor cells |
| US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| EP2298862B1 (en) | 2004-03-22 | 2017-08-30 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| EP1735429A4 (en) | 2004-03-31 | 2008-06-11 | Newlink Genetics Corp | METHOD AND COMPOSITIONS FOR OBTAINING EMBRYONAL STEM CELLS OF ABSTINENT HEMATOPOETIC STEM CELLS AND USES THEREOF |
| AU2005243158B2 (en) | 2004-05-07 | 2010-03-25 | Wisconsin Alumni Research Foundation | Method of forming mesenchymal stem cells from embryonic stem cells |
| JP4980211B2 (ja) * | 2004-05-12 | 2012-07-18 | ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ | 細胞単離方法 |
| JP5139799B2 (ja) | 2004-06-04 | 2013-02-06 | ユニベルシテ ピエール エ マリー キュリー(パリ シズエム) | 赤血球細胞の生産方法 |
| AU2005257105A1 (en) | 2004-06-24 | 2006-01-05 | Dnavec Research Inc. | Anticancer agent containing minus-strand RNA virus |
| KR101441026B1 (ko) | 2004-09-24 | 2014-10-01 | 메소블라스트, 아이엔씨. | 증폭된 다능성 간엽 전구세포 자손 및 이의 용도 |
| MX2007005200A (es) | 2004-11-01 | 2007-05-11 | Wisconsin Alumni Res Found | Plaquetas a partir de celulas germinales. |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| JP4964121B2 (ja) | 2005-02-23 | 2012-06-27 | 財団法人先端医療振興財団 | 血管内皮前駆細胞の生体外増幅方法 |
| US20080166751A1 (en) | 2005-02-23 | 2008-07-10 | Takayuki Asahara | Method of Analyzing Dynamics in the Differentiation of Vascular Endothelial Progenitor Cells |
| JP2006230316A (ja) * | 2005-02-25 | 2006-09-07 | Japan Health Science Foundation | 瘢痕のない創傷治癒能を有する細胞およびその調製方法 |
| AU2006224313B2 (en) | 2005-03-17 | 2011-08-11 | Ucl Biomedica Plc | Method for actvating Natural Killer cells by tumor cell preparation in vitro |
| JP5020935B2 (ja) | 2005-04-08 | 2012-09-05 | アルゴス セラピューティクス,インコーポレイティド | 樹状細胞組成物および方法 |
| WO2006130504A2 (en) | 2005-05-27 | 2006-12-07 | Advanced Cell Technology, Inc. | Methods for identifying ligands for stem cells and cells derived therefrom |
| GB2440494B (en) | 2005-06-01 | 2010-07-28 | Wisconsin Alumni Res Found | Method of forming dendritic from embryonic stem cells |
| WO2007005595A1 (en) | 2005-07-05 | 2007-01-11 | The New England Medical Center Hospitals, Inc. | Pregnancy-associated progenitor cells |
| US8198085B2 (en) | 2005-08-03 | 2012-06-12 | Core Dynamics Limited | Somatic cells for use in cell therapy |
| EP1984487B1 (en) | 2005-08-03 | 2022-10-12 | Astellas Institute for Regenerative Medicine | Improved methods of reprogramming animal somatic cells |
| US9121008B2 (en) | 2005-08-31 | 2015-09-01 | University Of Utah Research Foundation | Development of natural killer cells and functional natural killer cell lines |
| WO2007032634A1 (en) | 2005-09-12 | 2007-03-22 | Industry Foundation Of Chonnam National University | A method for production of mature natural killer cell |
| JP2007089432A (ja) | 2005-09-27 | 2007-04-12 | Reprocell Inc | 幹細胞由来血小板産生増加法 |
| WO2007037682A1 (en) | 2005-09-28 | 2007-04-05 | Ipd-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics. |
| US20090271335A1 (en) | 2005-10-20 | 2009-10-29 | Advanced Cell Technology, Inc. | Totipotent, Nearly Totipotent or Pluripotent Mammalian Cells Homozygous or Hemizygous for One or More Histocompatibility Antigent Genes |
| US8460928B2 (en) | 2005-10-24 | 2013-06-11 | Agency For Science, Technology And Research | Methods of specifying mesodermal, endodermal and mesoendodermal cell fates |
| WO2007062198A1 (en) | 2005-11-21 | 2007-05-31 | Advanced Cell Technology, Inc. | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| BRPI0706529A2 (pt) | 2006-01-13 | 2011-03-29 | Osiris Therapeutics Inc | células-tronco mesenquimais que expressam receptores de tnf-alfa |
| EP1989296A2 (en) | 2006-02-09 | 2008-11-12 | Wisconsin Alumni Research Foundation | Erythroid cells producing adult-type -hemoglobin generated from human embryonic stem cells |
| WO2007093412A2 (en) | 2006-02-16 | 2007-08-23 | Fondazione Centro San Raffaele Del Monte Tabor | Skeletal muscle periangioblasts and cardiac mesoangioblasts, method for isolation and uses thereof |
| WO2007099337A1 (en) * | 2006-03-01 | 2007-09-07 | Cartela R&D Ab | Expansion and differentiation of mesenchymal stem cells |
| CN101045914A (zh) | 2006-03-29 | 2007-10-03 | 中国人民解放军军事医学科学院野战输血研究所 | 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用 |
| CN101045915A (zh) | 2006-03-29 | 2007-10-03 | 旭日干 | 一种卵母细胞生发泡移植技术 |
| AU2013201444B2 (en) | 2006-04-14 | 2015-01-22 | Astellas Institute For Regenerative Medicine | Hemangio-colony forming cells |
| NZ572842A (en) | 2006-04-14 | 2012-01-12 | Advanced Cell Tech Inc | Hemangio-colony forming cells |
| KR102230288B1 (ko) | 2006-04-14 | 2021-03-22 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| KR100791487B1 (ko) * | 2006-05-29 | 2008-01-03 | 연세대학교 산학협력단 | 제대혈로부터 간엽줄기세포의 분리 및 배양 방법 |
| US20070298496A1 (en) | 2006-06-23 | 2007-12-27 | Hung-Chih Kuo | Method of deriving pluripotent stem cells from a single blastomere |
| JP2010500047A (ja) | 2006-08-15 | 2010-01-07 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 間葉系幹細胞馴化培地 |
| PL2578081T4 (pl) | 2006-10-11 | 2016-09-30 | Kompozycje, sposoby i urządzenia do leczenia chorób wątroby | |
| WO2008067142A2 (en) | 2006-11-08 | 2008-06-05 | Wisconsin Alumni Research Foundation | In vitro differentiation of hematopoietic cells from primate embryonic stem cells |
| US20110151554A1 (en) | 2006-11-09 | 2011-06-23 | Akira Yuo | Method for culturing and subculturing primate embryonic stem cell, as well as method for inducing differentiation thereof |
| DE102006054041B3 (de) | 2006-11-16 | 2008-05-08 | Pierburg Gmbh | Regelvorrichtung für eine Verbrennungskraftmaschine |
| CN101679942A (zh) | 2007-02-23 | 2010-03-24 | 先进细胞技术公司 | 重编程分化细胞和从重编程的细胞产生动物和胚胎干细胞的高效方法 |
| CN103263439B (zh) | 2007-05-24 | 2015-04-22 | 埃普塞斯有限责任两合公司 | Cd34干细胞相关方法和组合物 |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| WO2008151386A1 (en) | 2007-06-15 | 2008-12-18 | Australian Stem Cell Centre Ltd | Megakaryocyte differentiation |
| US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
| EP3424514B1 (en) | 2007-08-06 | 2022-05-11 | Mesoblast, Inc. | Tnap+ mesenchymal precursor cells for use in treating connective tissue diseases |
| KR101039235B1 (ko) * | 2007-08-29 | 2011-06-07 | 메디포스트(주) | 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물 |
| US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
| RS53841B1 (sr) | 2007-09-28 | 2015-06-30 | Anthrogenesis Corporation | Supresija tumora korišćenjem humanog placentalnog perfuzata i intermedijernih ćelija ubica poreklom iz humane placente |
| IL292561A (en) | 2007-10-12 | 2022-06-01 | Astellas Inst For Regenerative Medicine | Improved methods of rpe cell production and rpe cell preparations |
| US20100304480A1 (en) | 2007-10-19 | 2010-12-02 | Goodell Margaret A | Hematopoietic Fingerprints: Methods of Use |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| US8685728B2 (en) | 2008-01-31 | 2014-04-01 | Rutgers The State University Of New Jersey | Kit containing stem cells and cytokines for use in attenuating immune responses |
| US10046011B2 (en) | 2008-01-31 | 2018-08-14 | Rutgers, The State University Of New Jersey | Compositions for inducing or suppressing an immune response |
| JP5728234B2 (ja) | 2008-02-15 | 2015-06-03 | ボーン・セラピューティクス | 骨関節疾患の治療又は予防において使用するための医薬組成物 |
| WO2009104825A1 (en) * | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
| WO2009137629A2 (en) | 2008-05-06 | 2009-11-12 | Advanced Cell Technology, Inc. | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| CN102083963A (zh) | 2008-05-06 | 2011-06-01 | 先进细胞技术公司 | 血管瘤集落形成细胞和非移植血管瘤细胞 |
| KR20110013450A (ko) * | 2008-05-07 | 2011-02-09 | 본 테라퓨틱스 소시에테아노님 | 간엽 줄기 세포 및 골-형성 세포 |
| US20110293576A1 (en) * | 2008-08-04 | 2011-12-01 | Allocure Inc. | Mesenchymal stromal cell populations and methods of isolating and using same |
| JP5639058B2 (ja) | 2008-09-03 | 2014-12-10 | メソブラスト,インコーポレーテッド | 造血前駆細胞の増殖 |
| FR2938947B1 (fr) | 2008-11-25 | 2012-08-17 | A Volute | Procede de traitement du signal, notamment audionumerique. |
| EP2221362A1 (en) | 2009-02-19 | 2010-08-25 | Naturin GmbH & Co | Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| CN102439136A (zh) | 2009-03-26 | 2012-05-02 | 加州大学校董 | 产生用于疾病修饰的抑制性rna的间充质干细胞 |
| JP2010252778A (ja) * | 2009-04-02 | 2010-11-11 | Shizui Bank Kk | 歯髄由来間葉系幹細胞の分離方法及び分離した幹細胞並びにそれらを用いた肝細胞系譜への分化 |
| US8679834B2 (en) | 2009-07-09 | 2014-03-25 | TiGenix S.A.U | Methods and compositions for use in cellular therapies |
| EP2485741A4 (en) * | 2009-10-06 | 2013-07-24 | Cohen Mcniece Foundation | PREPARATION AND USE OF STROMAL CELLS FOR THE TREATMENT OF CARDIAC DISORDERS |
| US20120201791A1 (en) | 2009-10-15 | 2012-08-09 | Tai June Yoo | Methods of treating diseases or conditions using mesenchymal stem cells |
| WO2011053860A2 (en) * | 2009-10-30 | 2011-05-05 | Allocure, Inc. | Mesenchymal stromal cell populations and methods of using same |
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| US8900860B2 (en) * | 2009-11-30 | 2014-12-02 | National Yang-Ming University | Method for expanding mesenchymal stem cells in low-density and hypoxic culture |
| CA2782013C (en) | 2009-12-04 | 2021-06-08 | Stem Cell & Regenerative Medicine International, Inc. | Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions |
| CA3095576A1 (en) | 2009-12-04 | 2011-06-09 | Astellas Institute For Regenerative Medicine | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| EP2531593A4 (en) * | 2010-02-02 | 2013-08-28 | Univ Rochester | PROCESS FOR THE ISOLATION AND CULTIVATION OF MESENCHYMAL STEM CELLS |
| EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
| CA2792802C (en) | 2010-03-10 | 2017-10-31 | Two Cells Co., Ltd. | Cell preparation containing mesenchymal stem cells, and method for producing same |
| WO2011124741A1 (es) | 2010-04-08 | 2011-10-13 | Fundación Progreso Y Salud | Uso de un medio de cultivo condicionado por células madre mesenquimales para la diferenciación de células madre pluripotentes humanas |
| KR101330327B1 (ko) | 2010-05-07 | 2013-11-14 | 한국생명공학연구원 | 줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법 |
| US9408873B2 (en) | 2010-08-23 | 2016-08-09 | Kang Stem Biotech Co., Ltd. | Pharmaceutical composition comprising stem cells treated with NOD2 agonist or culture thereof for prevention and treatment of immune disorders and inflammatory diseases |
| WO2012048099A2 (en) | 2010-10-08 | 2012-04-12 | Osiris Therapeutics, Inc. | Nanoparticle-loaded cells |
| KR20120095022A (ko) | 2011-02-18 | 2012-08-28 | 가톨릭대학교 산학협력단 | 간엽줄기세포 및 면역조절 t 세포를 유효성분으로 포함하는 이식편대숙주질환 예방 또는 치료용 세포치료제 조성물 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| HRP20181515T1 (hr) | 2011-11-30 | 2018-11-16 | Astellas Institute For Regenerative Medicine | Mezenhimne stromalne stanice i upotreba povezana s njima |
| KR101477016B1 (ko) | 2012-01-19 | 2014-12-29 | (주)차바이오텍 | 인간 배아줄기세포 유래 혈관주위 전구세포의 제조방법 및 이를 포함하는 세포치료 조성물 |
| WO2014011407A2 (en) | 2012-07-12 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| KR102188605B1 (ko) | 2012-12-14 | 2020-12-08 | 럿거스, 더 스테이트 유니버시티 오브 뉴저지 | 줄기세포의 면역조절성 효과의 조절 방법 |
| WO2014131877A1 (en) | 2013-03-01 | 2014-09-04 | Apceth Gmbh & Co. Kg | Protection of the vascular endothelium from immunologically mediated cytotoxic reactions with human cd34-negative progenitor cells |
| KR101669124B1 (ko) | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
| US20160245825A1 (en) | 2013-10-04 | 2016-08-25 | Cell Ideas Pty Ltd | Biomarkers for Cell Therapy |
| WO2015126528A1 (en) | 2014-02-18 | 2015-08-27 | Massachusetts Institute Of Technology | Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) |
| KR102865313B1 (ko) | 2014-06-10 | 2025-09-29 | 메조블라스트 인터내셔널 에스에이알엘 | 면역 장애의 치료 |
| JP6459257B2 (ja) | 2014-07-08 | 2019-01-30 | 富士ゼロックス株式会社 | 画像形成装置 |
| US20170204151A1 (en) | 2014-07-28 | 2017-07-20 | Darwin J. Prockop | Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for Treating Diseases and Disorders |
| JP6998768B2 (ja) | 2015-08-28 | 2022-02-10 | ロート製薬株式会社 | Ror1陽性の間葉系幹細胞及びその調製方法、ror1陽性の間葉系幹細胞を含む医薬組成物及びその調製方法、並びにror1陽性の間葉系幹細胞を用いる疾患の予防又は治療方法 |
| WO2017073656A1 (ja) | 2015-10-27 | 2017-05-04 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団の製造方法、間葉系幹細胞、細胞集団、並びに医薬組成物 |
| WO2017094879A1 (ja) | 2015-12-03 | 2017-06-08 | タカラバイオ株式会社 | 間葉系幹細胞の製造方法 |
| RU2756561C2 (ru) | 2016-03-16 | 2021-10-01 | Сината Терапьютикс Лимитед | Среда для формирования колоний и её применение |
| CN109104869B (zh) | 2016-04-27 | 2022-07-01 | 日本乐敦制药株式会社 | 表达细胞表面标记物的间充质干细胞、包含该间充质干细胞的药物组合物及其制备方法 |
| KR101816246B1 (ko) | 2016-09-07 | 2018-01-08 | 에스씨엠생명과학 주식회사 | 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물 |
| CA3042031A1 (en) | 2016-10-27 | 2018-05-03 | The Trustees Of Columbia University In The City Of New York | Immunosuppressive mesenchymal cells and methods for forming same |
| ES2927461T3 (es) | 2016-12-12 | 2022-11-07 | Health And Biotech France H&B France | Células madre mesenquimatosas derivadas de tejido perinatal: método de preparación y utilizaciones de las mismas |
| JP7102397B2 (ja) | 2017-04-03 | 2022-07-19 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| WO2018186419A1 (ja) | 2017-04-03 | 2018-10-11 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| KR102660506B1 (ko) | 2017-05-04 | 2024-04-25 | 메조블라스트 인터내셔널 에스에이알엘 | 면역억제가 향상된 간충직 계통 전구체 또는 줄기 세포 |
-
2012
- 2012-11-30 HR HRP20181515TT patent/HRP20181515T1/hr unknown
- 2012-11-30 CN CN201810244786.XA patent/CN108478599B/zh active Active
- 2012-11-30 EP EP12854438.4A patent/EP2785359B1/en active Active
- 2012-11-30 WO PCT/US2012/067464 patent/WO2013082543A1/en not_active Ceased
- 2012-11-30 KR KR1020207012502A patent/KR102246369B1/ko active Active
- 2012-11-30 ES ES12854438T patent/ES2690212T3/es active Active
- 2012-11-30 KR KR1020237013378A patent/KR102811933B1/ko active Active
- 2012-11-30 PL PL12854438T patent/PL2785359T3/pl unknown
- 2012-11-30 TW TW112104480A patent/TW202344258A/zh unknown
- 2012-11-30 SI SI201231414T patent/SI2785359T1/sl unknown
- 2012-11-30 TW TW109121434A patent/TWI812867B/zh active
- 2012-11-30 CN CN201280067692.0A patent/CN104136034B/zh active Active
- 2012-11-30 TW TW106124778A patent/TWI698242B/zh active
- 2012-11-30 LT LTEP12854438.4T patent/LT2785359T/lt unknown
- 2012-11-30 EP EP18186151.9A patent/EP3449929B1/en active Active
- 2012-11-30 HU HUE12854438A patent/HUE040566T2/hu unknown
- 2012-11-30 KR KR1020147017312A patent/KR102108245B1/ko active Active
- 2012-11-30 RS RS20181203A patent/RS57886B1/sr unknown
- 2012-11-30 DK DK12854438.4T patent/DK2785359T3/en active
- 2012-11-30 PT PT12854438T patent/PT2785359T/pt unknown
- 2012-11-30 JP JP2014544956A patent/JP2015500810A/ja active Pending
- 2012-11-30 KR KR1020217010975A patent/KR102525175B1/ko active Active
- 2012-11-30 US US13/691,349 patent/US8962321B2/en active Active
- 2012-11-30 TW TW101145218A patent/TWI698527B/zh active
- 2012-11-30 AU AU2012345630A patent/AU2012345630A1/en not_active Abandoned
- 2012-11-30 CA CA2857545A patent/CA2857545A1/en active Pending
-
2014
- 2014-10-01 US US14/504,351 patent/US20160038543A1/en not_active Abandoned
-
2017
- 2017-03-23 US US15/467,201 patent/US20170252374A1/en not_active Abandoned
- 2017-09-08 JP JP2017172589A patent/JP6526130B2/ja active Active
- 2017-10-04 AU AU2017239526A patent/AU2017239526B2/en active Active
-
2018
- 2018-10-25 CY CY20181101104T patent/CY1122275T1/el unknown
-
2019
- 2019-05-07 JP JP2019087857A patent/JP6983195B2/ja active Active
- 2019-11-14 AU AU2019264631A patent/AU2019264631B2/en active Active
-
2020
- 2020-09-16 US US17/022,807 patent/US12097223B2/en active Active
-
2021
- 2021-11-22 JP JP2021189684A patent/JP7777430B2/ja active Active
-
2022
- 2022-04-20 AU AU2022202639A patent/AU2022202639B2/en active Active
-
2023
- 2023-12-14 JP JP2023211105A patent/JP2024067032A/ja active Pending
-
2024
- 2024-08-21 US US18/811,109 patent/US20250090590A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2785359T (pt) | Células estromais mesenquimatosas e usos relacionados com as mesmas | |
| DK3354728T3 (da) | Alpha-amylase-varianter | |
| DK4389885T3 (da) | Alfa-amylasevarianter | |
| IL229803B (en) | Mammalian cell culture | |
| DK2900806T3 (da) | Tredimensionel celledyrkning | |
| DK3401319T3 (da) | Celledyrkningsmedium | |
| EP2681306A4 (en) | CELL CULTURE SYSTEM | |
| DK3101127T3 (da) | Alfa-amylasevarianter med forbedret stabilitet | |
| DK2775557T3 (da) | Brændselscelle | |
| EP2850178A4 (en) | EXOSOMES OF MESHCHYMIC STROKE CELL OF UMBILICAL CORD | |
| CO6960510A2 (es) | Celdas fotocatalíticas mejoradas | |
| DK3421470T3 (da) | Substituerede 5-fluor-1h-pyrazolopyridiner i krytallinsk form | |
| EP3719852C0 (en) | SOLAR CELL | |
| EP2879794A4 (en) | CELL CULTURE | |
| DK3144319T3 (da) | Cellekultursammensætning indeholdende laminin-521 | |
| IL235125A0 (en) | Microbial fuel cell | |
| IL231640A (en) | Propulsion bay | |
| CL2014002030A1 (es) | Alfa-amilasa | |
| EP2786976A4 (en) | MONOLITHIC COMPOSITION | |
| DK2685554T3 (da) | Siliciumdioxid-solcelle | |
| EP2794841A4 (en) | BIOREACTOR | |
| EP2544283A4 (en) | Fuel cell | |
| EP2757623A4 (en) | FUEL CELL | |
| DE112011105455T8 (de) | Brennstoffzelle | |
| DE112011101133T8 (de) | Brennstoffzelle |