ES2690212T3 - Células estromales mesenquimales y usos relacionados con las mismas - Google Patents
Células estromales mesenquimales y usos relacionados con las mismas Download PDFInfo
- Publication number
- ES2690212T3 ES2690212T3 ES12854438T ES12854438T ES2690212T3 ES 2690212 T3 ES2690212 T3 ES 2690212T3 ES 12854438 T ES12854438 T ES 12854438T ES 12854438 T ES12854438 T ES 12854438T ES 2690212 T3 ES2690212 T3 ES 2690212T3
- Authority
- ES
- Spain
- Prior art keywords
- stromal cells
- mesenchymal stromal
- related uses
- cells
- under conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/141—Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F9/00—Arrangements for program control, e.g. control units
- G06F9/06—Arrangements for program control, e.g. control units using stored programs, i.e. using an internal store of processing equipment to receive or retain programs
- G06F9/46—Multiprogramming arrangements
- G06F9/54—Interprogram communication
- G06F9/542—Event management; Broadcasting; Multicasting; Notifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1171—Haematopoietic stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
Abstract
Un método para generar células estromales mesenquimales que comprende cultivar hemangioblastos en condiciones en las que las células se diferencian para producir células estromales mesenquimales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161565358P | 2011-11-30 | 2011-11-30 | |
PCT/US2012/067464 WO2013082543A1 (en) | 2011-11-30 | 2012-11-30 | Mesenchymal stromal cells and uses related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2690212T3 true ES2690212T3 (es) | 2018-11-19 |
Family
ID=48536141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12854438T Active ES2690212T3 (es) | 2011-11-30 | 2012-11-30 | Células estromales mesenquimales y usos relacionados con las mismas |
Country Status (20)
Country | Link |
---|---|
US (4) | US8962321B2 (es) |
EP (2) | EP2785359B1 (es) |
JP (5) | JP2015500810A (es) |
KR (4) | KR102108245B1 (es) |
CN (2) | CN104136034B (es) |
AU (4) | AU2012345630A1 (es) |
CA (1) | CA2857545A1 (es) |
CY (1) | CY1122275T1 (es) |
DK (1) | DK2785359T3 (es) |
ES (1) | ES2690212T3 (es) |
HK (1) | HK1202798A1 (es) |
HR (1) | HRP20181515T1 (es) |
HU (1) | HUE040566T2 (es) |
LT (1) | LT2785359T (es) |
PL (1) | PL2785359T3 (es) |
PT (1) | PT2785359T (es) |
RS (1) | RS57886B1 (es) |
SI (1) | SI2785359T1 (es) |
TW (4) | TW202344258A (es) |
WO (1) | WO2013082543A1 (es) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2377923A1 (en) | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Hemangio-colony forming cells |
CN102083960B (zh) | 2008-05-06 | 2014-12-03 | 先进细胞技术公司 | 用于制备衍生自多能干细胞的去核类红细胞的方法 |
US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
CA2857545A1 (en) | 2011-11-30 | 2013-06-06 | Advanced Cell Technology, Inc. | Mesenchymal stromal cells and uses related thereto |
EP2872619B1 (en) | 2012-07-11 | 2018-02-14 | Imstem Biotechnology Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
KR101669124B1 (ko) * | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
DK2840132T3 (en) | 2013-08-22 | 2017-02-20 | Georg-August-Universität Göttingen Stiftung Öffenlichen Rechts Universitätsmedizin | Method of Manufacturing Constructed Heart Muscle (EHM) |
CA2929310A1 (en) * | 2013-11-18 | 2015-05-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies |
EP4137146A1 (en) * | 2014-06-10 | 2023-02-22 | Mesoblast International Sàrl | Treatment of immune disorders |
JP6452107B2 (ja) * | 2014-09-05 | 2019-01-16 | 国立大学法人 東京大学 | 糖尿病性皮膚潰瘍治療のための多能性幹細胞 |
CN104232573B (zh) * | 2014-09-11 | 2017-01-11 | 安沂华 | 一种生长培养基及其用途和培养脐带间充质干细胞的方法 |
US20160095885A1 (en) * | 2014-10-01 | 2016-04-07 | WibiWorks Therapeutics, Inc. | Induction Medium & Methods for Stem Cell Culture & Therapy |
CN104531613B (zh) * | 2014-11-17 | 2017-12-19 | 中国农业科学院北京畜牧兽医研究所 | Wip1敲除在促进小鼠骨髓间充质干细胞迁移中的应用 |
BR112017012911B1 (pt) * | 2014-12-23 | 2021-10-05 | Mesoblast International Sàrl | Método para tratamento de insuficiência cardíaca |
MX2017012259A (es) | 2015-03-23 | 2018-05-17 | Astellas Inst For Regenerative Medicine | Ensayos mejorados para la potencia de células epiteliales pigmentarias de retina humana (rpe) y progenitores de fotorreceptores. |
EP3331994B1 (en) | 2015-08-05 | 2022-09-14 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
IL299326A (en) | 2015-08-18 | 2023-02-01 | Astellas Inst For Regenerative Medicine | Clinical formulations |
WO2017058838A1 (en) * | 2015-09-29 | 2017-04-06 | Anthrogenesis Corporation | Cell potency assay |
SG11201804307WA (en) * | 2015-11-24 | 2018-06-28 | Rohto Pharmaceutical Co Ltd | Therapeutic agent for liver disease containing stromal cells derived from adipose tissue and method for producing the same |
CN105326864A (zh) * | 2015-11-30 | 2016-02-17 | 奥思达干细胞有限公司 | 一种治疗系统性红斑狼疮的干细胞制剂及其制备方法 |
WO2017143219A2 (en) * | 2016-02-18 | 2017-08-24 | Viera Bioscience, Inc. | Stimulation of therapeutic angiogenesis by t regulatory cells |
CN105671000A (zh) * | 2016-03-02 | 2016-06-15 | 深圳爱生再生医学科技有限公司 | 重组间充质干细胞及其制备方法和应用 |
US10758574B2 (en) | 2016-04-28 | 2020-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Cartilage cells with a high regenerative potential and low immune response for use in cellular therapy |
US20190224244A1 (en) * | 2016-07-11 | 2019-07-25 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
CN106267161A (zh) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞制剂及其制备方法和应用 |
CN106265899A (zh) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种组合物及其在制备改善慢性鼻炎的产品中的应用 |
CN106520686A (zh) * | 2016-10-11 | 2017-03-22 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脂肪间充质干细胞的培养方法 |
CN106479968A (zh) * | 2016-10-11 | 2017-03-08 | 海南博鳌龄迈迪精准医学研究院有限公司 | 脐带间充质干细胞的培养方法 |
KR101971322B1 (ko) * | 2016-10-17 | 2019-04-23 | 사회복지법인 삼성생명공익재단 | Socs의 발현 또는 활성 억제를 이용한 고효능 줄기세포 선별방법 |
SG11201903928WA (en) * | 2016-11-03 | 2019-05-30 | Exostem Biotec Ltd | Mesenchymal stem cells populations, their products, and use thereof |
CN106581760A (zh) * | 2016-11-08 | 2017-04-26 | 华南生物医药研究院 | 增强细胞活性的特殊处理方法 |
CN106563161A (zh) * | 2016-11-08 | 2017-04-19 | 华南生物医药研究院 | 可用于美容的新型药物组合剂 |
CN106619721A (zh) * | 2016-11-08 | 2017-05-10 | 中国人民解放军军事医学科学院野战输血研究所 | 一种增强细胞活性的新方法 |
KR102390909B1 (ko) * | 2016-12-19 | 2022-04-26 | 주식회사 파이안바이오테크놀로지 | 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물 |
EP3608400A4 (en) | 2017-04-03 | 2021-01-06 | Kaneka Corporation | CELL POPULATION WITH MESENCHYMAL STEM CELLS, METHOD OF MANUFACTURING THEREFORE AND PHARMACEUTICAL COMPOSITION |
EP3739038A4 (en) * | 2017-05-12 | 2021-03-31 | National University Corporation Tokyo Medical and Dental University | MESENCHYMATIC STEM CELL PURIFICATION METHOD TO IMPROVE TRANSPLANT EFFICIENCY |
CA3067963A1 (en) * | 2017-06-19 | 2018-12-27 | National University Corporation Hokkaido University | Treatment agent for epidermolysis bullosa |
CN107490701B (zh) * | 2017-08-17 | 2021-09-14 | 上海集技生物技术有限公司 | 一种基于局部照射的全身性骨损伤模型的建立及病理机制分析的方法 |
CN109069543B (zh) * | 2017-10-16 | 2020-02-18 | 中国科学院广州生物医药与健康研究院 | 一种重塑骨髓微环境的方法 |
CN107714726A (zh) * | 2017-10-16 | 2018-02-23 | 中国科学院广州生物医药与健康研究院 | 一种重塑骨髓微环境的方法 |
JP2021510805A (ja) * | 2017-11-06 | 2021-04-30 | キングス カレッジ ロンドンKings College London | 治療物質、それらの調製物及び診断手順 |
KR102095628B1 (ko) * | 2018-01-05 | 2020-04-01 | 재단법인 아산사회복지재단 | 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물 |
HUE060984T2 (hu) * | 2018-02-16 | 2023-04-28 | Nextcell Pharma Ab | Allogén készítmény |
WO2019171386A1 (en) * | 2018-03-07 | 2019-09-12 | The Medical Research Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center | Compositions and methods for treating age-related macular degeneration |
CN112584846A (zh) * | 2018-06-15 | 2021-03-30 | 路易斯·马里纳斯·帕尔多 | 用于皮肤病的药物组合物及其用途 |
KR102337954B1 (ko) * | 2018-08-16 | 2021-12-10 | 차의과학대학교 산학협력단 | 뇌졸중 치료용 조성물 및 이를 스크리닝하는 방법 |
CN109082409A (zh) * | 2018-09-14 | 2018-12-25 | 四川新生命干细胞科技股份有限公司 | 一种组织修复能力强的脂肪干细胞分离培养及筛选方法 |
CN109182262A (zh) * | 2018-09-25 | 2019-01-11 | 深圳市五零生命科技有限公司 | 一种间充质干细胞无血清培养基 |
WO2020112904A1 (en) * | 2018-11-26 | 2020-06-04 | Massachusetts Institute Of Technology | Compositions and methods for immune tolerance |
CN109342739A (zh) * | 2018-11-27 | 2019-02-15 | 上海科医联创生物科技有限公司 | 一种鉴定间充质干细胞纯度的方法 |
CN109609584A (zh) * | 2018-12-10 | 2019-04-12 | 天津长和生物技术有限公司 | 间充质干细胞免疫调节能力的检测方法 |
BR112021016316A8 (pt) * | 2019-02-27 | 2023-04-11 | Tigenix S A U | Método in vitro para selecionar uma população de células-tronco (sc), composição farmacêutica, método para preparar uma composição farmacêutica, uso da composição farmacêutica e uso da população de sc |
EP3939660A4 (en) | 2019-03-14 | 2022-12-28 | Sapporo Medical University | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS |
CN110305839A (zh) * | 2019-08-02 | 2019-10-08 | 陕西佰傲干细胞再生医学有限公司 | 间充质干细胞无血清培养基 |
BR112022003659A2 (pt) | 2019-08-28 | 2022-05-24 | Astellas Inst For Regenerative Medicine | Composições e métodos de tratamento de doenças vasculares |
KR20220054359A (ko) | 2019-08-28 | 2022-05-02 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 질병을 치료하는 방법 |
CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
WO2021072595A1 (zh) * | 2019-10-14 | 2021-04-22 | 玛旺干细胞医学生物科技股份有限公司 | 间充质干细胞在治疗听力障碍上的医药用途 |
RU2740152C1 (ru) * | 2020-01-09 | 2021-01-13 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" (ФИЦ КНЦ СО РАН) | Способ активации пролиферативного ответа фибробластоподобных клеток стромально-васкулярной фракции жировой ткани |
WO2021169017A1 (zh) * | 2020-02-25 | 2021-09-02 | 上海大学 | 间充质干细胞在治疗重症covid19肺炎中的用途 |
JPWO2021210515A1 (es) * | 2020-04-13 | 2021-10-21 | ||
CN115701285A (zh) * | 2020-04-28 | 2023-02-07 | 菲克特生物科学股份有限公司 | 间充质干细胞疗法 |
EP3909594A1 (en) * | 2020-05-14 | 2021-11-17 | Bernat Soria Escoms | Mesenchymal stromal cells for the treatment of covid-19 and other inflammatory, autoimmune and degenerative diseases |
CN111518761B (zh) * | 2020-05-25 | 2022-04-29 | 青岛瑞思德生物科技有限公司 | 一种间充质干细胞体外筛选、激活、扩增、冻存及其细胞库建立的方法 |
WO2022004938A1 (ko) * | 2020-06-30 | 2022-01-06 | 주식회사 미래셀바이오 | 유사 중간엽 줄기세포의 제조방법 |
EP3945133A1 (en) * | 2020-07-29 | 2022-02-02 | Georg-August-Universität Göttingen | Mass production of human pluripotent stem cell derived cardiac stromal cell |
CN112826833A (zh) * | 2020-07-30 | 2021-05-25 | 中国人民解放军总医院第五医学中心 | 间充质干细胞在制备新冠肺炎引起的肺损伤修复药物中的应用 |
CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
US20230405051A1 (en) * | 2020-10-22 | 2023-12-21 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Pharmaceutical composition for prevention or treatment of rheumatoid arthritis, comprising, as active ingredient, stem cells having expression of specific genes increased or decreased therein |
JP2024515384A (ja) * | 2021-05-07 | 2024-04-09 | スンクワン メディカル ファウンデーション | 骨分化能機能強化の間葉系幹細胞、及びその用途 |
CN113717972B (zh) * | 2021-08-16 | 2022-07-01 | 南通市肿瘤医院 | MYADM靶向的siRNA及其应用 |
WO2023064404A1 (en) * | 2021-10-12 | 2023-04-20 | Mechanogenic K.K. | Anti-aging composition using mesenchymal stem cells and methods thereof |
WO2023148556A1 (en) * | 2022-02-07 | 2023-08-10 | Smartcella Solutions Ab | Methods and compositions for generating human induced mesenchymal stem cells |
CN114984051A (zh) * | 2022-06-27 | 2022-09-02 | 广州惠善医疗技术有限公司 | 间充质干细胞在制备治疗炎症及免疫相关疾病的药物中的应用 |
WO2024007038A2 (en) * | 2022-07-01 | 2024-01-04 | Northwestern University | Compositions and methods for the treatment of intestinal inflammation |
WO2024019962A1 (en) | 2022-07-18 | 2024-01-25 | Astellas Institute For Regenerative Medicine | Methods of treating brain injury |
CN115305234B (zh) * | 2022-09-28 | 2023-01-17 | 呈诺再生医学科技(北京)有限公司 | 一种制备间充质干细胞的方法、间充质干细胞和应用 |
WO2024158058A1 (ja) * | 2023-01-27 | 2024-08-02 | 株式会社Rainbow | 自動培養装置における細胞増殖制御方法 |
WO2024172009A1 (ja) * | 2023-02-14 | 2024-08-22 | 国立大学法人山口大学 | 間葉系細胞を含む細胞集団、細胞集団を含む医薬組成物、細胞集団から得られたエクソソーム及び細胞集団を作製する方法 |
CN116836920B (zh) * | 2023-08-21 | 2024-05-24 | 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 | 一种无血清培养基及其制备间充质干细胞的方法 |
CN117210528B (zh) * | 2023-09-12 | 2024-08-20 | 长沙干细胞与再生医学工业技术研究院有限公司 | 一种综合评估间充质干细胞免疫调控能力的方法 |
Family Cites Families (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6416581A (en) * | 1987-07-09 | 1989-01-20 | Rikagaku Kenkyusho | Frozen animal cell and production thereof |
US5128259A (en) | 1989-10-27 | 1992-07-07 | Hahnemann University | Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation |
US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
US5599705A (en) | 1993-11-16 | 1997-02-04 | Cameron; Robert B. | In vitro method for producing differentiated universally compatible mature human blood cells |
EP1149898A2 (en) | 1993-12-23 | 2001-10-31 | Infigen, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
US6194207B1 (en) | 1997-01-31 | 2001-02-27 | Hemosol Inc. | Methods for the selective expansion of lymphocytes by in vitro cultivation |
WO1998053048A1 (en) | 1997-05-21 | 1998-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells |
US6429012B1 (en) | 1997-10-06 | 2002-08-06 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
AU4336599A (en) | 1998-06-08 | 1999-12-30 | Osiris Therapeutics, Inc. | (in vitro) maintenance of hematopoietic stem cells |
US6361998B1 (en) | 1998-06-25 | 2002-03-26 | Hemosol Inc. | Efficient culture of stem cells for the production of hemoglobin |
EP1105463A1 (en) | 1998-08-24 | 2001-06-13 | t. Breeders, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
US20110171185A1 (en) | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
MXPA02003733A (es) | 1999-10-15 | 2003-10-14 | Advanced Cell Tech Inc | Metodos para producir celulas progenitoras diferenciadas y celulas troncales embrionicas de lineas de descendencia defectivas. |
CN1423523A (zh) | 1999-11-17 | 2003-06-11 | 罗切斯特大学 | 来自人体内的免疫系统 |
EP1248517A2 (en) | 2000-01-07 | 2002-10-16 | Oregon Health and Science University | Clonal propagation of primate offspring by embryo splitting |
US7795026B2 (en) | 2000-01-21 | 2010-09-14 | The Johns Hopkins University School Of Medicine | Methods for obtaining human embryoid body-derived cells |
US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
IL154159A0 (en) | 2000-08-01 | 2003-07-31 | Yissum Res Dev Co | Directed differentiation of ebryonic cells |
WO2002022184A2 (en) | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Bioengineered flat sheet graft prosthesis and its use |
CA2437084C (en) | 2001-01-29 | 2010-12-21 | Ivan N. Rich | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation |
WO2002078449A2 (en) | 2001-04-02 | 2002-10-10 | Advanced Cell Technology, Inc. | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
KR20020083634A (ko) | 2001-04-27 | 2002-11-04 | 크레아젠 주식회사 | 수지상 세포를 포함하는 자가면역 질환의 치료용 약제학적조성물 및 이를 이용한 치료방법 |
EP1393066A4 (en) | 2001-05-15 | 2006-01-25 | Rappaport Family Inst For Res | INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONAL STEM CELLS |
WO2003038072A1 (en) | 2001-10-31 | 2003-05-08 | Universite Libre De Bruxelles | Generation and use of new types of dendritic cells |
NZ532170A (en) | 2001-11-02 | 2008-05-30 | Wisconsin Alumni Res Found | Endothelial cells derived from primate embryonic stem cells |
EP1442115B9 (en) * | 2001-11-15 | 2009-12-16 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
US20030232430A1 (en) | 2001-11-26 | 2003-12-18 | Advanced Cell Technology | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
CN102008503B (zh) | 2001-12-07 | 2018-10-09 | 阿斯特利亚斯生物治疗股份公司 | 人胚胎干细胞衍生的造血细胞 |
EP1490107A4 (en) | 2002-03-21 | 2005-11-09 | Univ Florida | MODULATION OF ANGIOGENESIS |
WO2004007698A1 (en) | 2002-07-12 | 2004-01-22 | National University Of Singapore | Hemangioblast progenitor cells |
US20040052771A1 (en) | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
WO2004029231A1 (en) | 2002-09-26 | 2004-04-08 | Institut National De La Sante Et De La Recherche Medicale | Compositions and methods for amplification of human stem cells |
WO2004029200A2 (en) | 2002-09-26 | 2004-04-08 | Children's Medical Center Corporation | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells |
US20050054096A1 (en) | 2002-11-06 | 2005-03-10 | Piniella Carlos J. | Pluripotent cells from monocytes, and methods of making and using pluripotent cells |
US20040156878A1 (en) | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
US20050032210A1 (en) | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
WO2004098285A2 (en) | 2003-05-08 | 2004-11-18 | Cellartis Ab | Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method |
US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
WO2005040391A1 (en) | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
WO2005049812A1 (en) | 2003-11-19 | 2005-06-02 | Australian Stem Cell Centre Limited | Methods for producing blood products from pluripotent cells in cell culture |
CA2550326A1 (en) | 2003-12-19 | 2005-07-14 | Viacell, Inc. | Use of human cord blood-derived pluripotent cells for the treatment of disease |
CN1286970C (zh) | 2003-12-30 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 由脐血cd34+细胞体外诱导生成巨核细胞的方法 |
CA2852122A1 (en) | 2004-01-02 | 2005-07-28 | Advanced Cell Technology, Inc. | Novel culture systems for ex vivo development |
KR100535326B1 (ko) | 2004-01-20 | 2005-12-09 | 한국생명공학연구원 | 줄기 세포로부터 자연살해 세포로의 분화 조절용 유전자를유효성분으로 포함하는 분화 조절제 |
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
CA2937099A1 (en) | 2004-01-23 | 2005-08-04 | Astellas Institute For Regenerative Medicine | Improved modalities for the treatment of degenerative diseases of the retina |
WO2005078073A2 (en) | 2004-02-09 | 2005-08-25 | Indiana University Research And Technology Corporation | Isolation, expansion and of clonogenic endothelial progenitor cells |
EP2824174B1 (en) | 2004-03-22 | 2018-11-28 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
US20050221482A1 (en) | 2004-03-31 | 2005-10-06 | Burt Richard K | Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof |
GB2428044B (en) | 2004-05-07 | 2008-08-06 | Wisconsin Alumni Res Found | Method of forming mesenchymal stem cells from embryonic stem cells |
US8741635B2 (en) | 2004-05-12 | 2014-06-03 | The Walter And Eliza Hall Institute Of Medical Research | Method of cell isolation |
US8206979B2 (en) | 2004-06-04 | 2012-06-26 | Universite Pierre et Marie Curie — Paris VI | Method for producing red blood cells |
JP5296983B2 (ja) | 2004-06-24 | 2013-09-25 | 株式会社ディナベック研究所 | Rnaウイルスが導入された樹状細胞を含む抗癌剤 |
CN101506355B (zh) | 2004-09-24 | 2012-06-27 | 成血管细胞系统公司 | 多能扩增间充质前体细胞子代(memp)及其应用 |
AU2005302258B2 (en) | 2004-11-01 | 2010-10-21 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
US20080166751A1 (en) | 2005-02-23 | 2008-07-10 | Takayuki Asahara | Method of Analyzing Dynamics in the Differentiation of Vascular Endothelial Progenitor Cells |
US8492148B2 (en) | 2005-02-23 | 2013-07-23 | Foundation For Biomedical Research & Innovation | Method for amplification of endothelial progenitor cell in vitro |
JP2006230316A (ja) * | 2005-02-25 | 2006-09-07 | Japan Health Science Foundation | 瘢痕のない創傷治癒能を有する細胞およびその調製方法 |
DK1863905T3 (en) | 2005-03-17 | 2016-04-04 | Ucl Business Plc | PROCEDURE FOR ACTIVATING NATURAL KILLER CELLS USING VITRO TUMOR CELL PREPARATIONS |
CN101155914B (zh) | 2005-04-08 | 2013-03-06 | 阿戈斯治疗公司 | 树状细胞组合物和方法 |
US20090215640A1 (en) | 2005-05-27 | 2009-08-27 | West Michael D | Methods for identifying ligands for stem cells and cells derived therefrom |
WO2006130651A2 (en) | 2005-06-01 | 2006-12-07 | Wisconsin Alumni Research Foundation | Method of forming dendritic cells from embryonic stem cells |
WO2007005595A1 (en) | 2005-07-05 | 2007-01-11 | The New England Medical Center Hospitals, Inc. | Pregnancy-associated progenitor cells |
US20100167404A1 (en) | 2005-08-03 | 2010-07-01 | Advanced Cell Technology, Inc. | Methods of Reprogramming Animal Somatic Cells |
EP1909565A2 (en) | 2005-08-03 | 2008-04-16 | Interface Multigrad Technology (IMT) Ltd. | Somatic cells for use in cell therapy |
US9121008B2 (en) | 2005-08-31 | 2015-09-01 | University Of Utah Research Foundation | Development of natural killer cells and functional natural killer cell lines |
WO2008020815A1 (en) | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
EP1789435B1 (en) | 2005-09-12 | 2010-02-24 | Industry Foundation of Chonnam National University | A method for production of mature natural killer cell |
JP2007089432A (ja) | 2005-09-27 | 2007-04-12 | Reprocell Inc | 幹細胞由来血小板産生増加法 |
US9109202B2 (en) | 2005-09-28 | 2015-08-18 | Ipd-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics |
US20090271335A1 (en) | 2005-10-20 | 2009-10-29 | Advanced Cell Technology, Inc. | Totipotent, Nearly Totipotent or Pluripotent Mammalian Cells Homozygous or Hemizygous for One or More Histocompatibility Antigent Genes |
JP5087004B2 (ja) | 2005-10-24 | 2012-11-28 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 中胚葉、内胚葉及び中内胚葉細胞の細胞運命を指定する方法 |
WO2007062198A1 (en) | 2005-11-21 | 2007-05-31 | Advanced Cell Technology, Inc. | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
AU2007208504B2 (en) | 2006-01-13 | 2011-04-21 | Mesoblast International Sarl | Mesenchymal stem cells expressing TNF-alpha receptor |
AU2007215276B2 (en) | 2006-02-09 | 2013-09-19 | Maryna E. Gumenyuk | Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells |
EP1991664B1 (en) | 2006-02-16 | 2018-03-28 | Ospedale San Raffaele S.r.l. | Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof |
EP1996698A1 (en) | 2006-03-01 | 2008-12-03 | Cartela R&D AB | Expansion and differentiation of mesenchymal stem cells |
CN101045914A (zh) | 2006-03-29 | 2007-10-03 | 中国人民解放军军事医学科学院野战输血研究所 | 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用 |
CN101045915A (zh) | 2006-03-29 | 2007-10-03 | 旭日干 | 一种卵母细胞生发泡移植技术 |
AU2013201444B2 (en) | 2006-04-14 | 2015-01-22 | Astellas Institute For Regenerative Medicine | Hemangio-colony forming cells |
EP2377923A1 (en) | 2006-04-14 | 2011-10-19 | Advanced Cell Technology, Inc. | Hemangio-colony forming cells |
NZ572842A (en) | 2006-04-14 | 2012-01-12 | Advanced Cell Tech Inc | Hemangio-colony forming cells |
KR100791487B1 (ko) | 2006-05-29 | 2008-01-03 | 연세대학교 산학협력단 | 제대혈로부터 간엽줄기세포의 분리 및 배양 방법 |
US20070298496A1 (en) | 2006-06-23 | 2007-12-27 | Hung-Chih Kuo | Method of deriving pluripotent stem cells from a single blastomere |
WO2008060788A2 (en) | 2006-10-11 | 2008-05-22 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
US20080108044A1 (en) | 2006-11-08 | 2008-05-08 | Deepika Rajesh | In vitro differentiation of hematopoietic cells from primate embryonic stem cells |
EP2088190A4 (en) | 2006-11-09 | 2011-01-05 | Japan Government | METHOD FOR THE CULTURE AND PASSAGE OF PRIMATE EMBRYONIC STRAIN CELL, AND METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELL |
DE102006054041B3 (de) | 2006-11-16 | 2008-05-08 | Pierburg Gmbh | Regelvorrichtung für eine Verbrennungskraftmaschine |
JP2010518857A (ja) | 2007-02-23 | 2010-06-03 | アドバンスド セル テクノロジー, インコーポレイテッド | 分化した細胞の再プログラムおよび再プログラムされた細胞からの動物および胚幹細胞の生成のための高能率的な方法 |
EP2851422A3 (en) | 2007-05-24 | 2015-06-24 | Apceth GmbH & Co. KG | CD34neg stem cells for the treatment of gastrointestinal disorders |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
WO2008151386A1 (en) | 2007-06-15 | 2008-12-18 | Australian Stem Cell Centre Ltd | Megakaryocyte differentiation |
US9095562B2 (en) | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
ES2923016T3 (es) | 2007-08-06 | 2022-09-22 | Mesoblast Inc | Células precursoras mesenquimales TNAP+ para el tratamiento de enfermedades del tejido conectivo |
KR101039235B1 (ko) * | 2007-08-29 | 2011-06-07 | 메디포스트(주) | 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물 |
US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
KR20210127819A (ko) | 2007-09-28 | 2021-10-22 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
EP3636748A1 (en) | 2007-10-12 | 2020-04-15 | Astellas Institute for Regenerative Medicine | Improved methods of producing rpe cells and compositions of rpe cells |
US20100304480A1 (en) | 2007-10-19 | 2010-12-02 | Goodell Margaret A | Hematopoietic Fingerprints: Methods of Use |
US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
US10046011B2 (en) | 2008-01-31 | 2018-08-14 | Rutgers, The State University Of New Jersey | Compositions for inducing or suppressing an immune response |
US8685728B2 (en) | 2008-01-31 | 2014-04-01 | Rutgers The State University Of New Jersey | Kit containing stem cells and cytokines for use in attenuating immune responses |
AU2009214044B2 (en) | 2008-02-15 | 2014-08-14 | Bone Therapeutics | Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases |
WO2009104825A1 (en) * | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
CN102083960B (zh) | 2008-05-06 | 2014-12-03 | 先进细胞技术公司 | 用于制备衍生自多能干细胞的去核类红细胞的方法 |
KR20110016913A (ko) | 2008-05-06 | 2011-02-18 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 혈관 콜로니 형성 세포 및 비-생착성 혈관 세포 |
US9371515B2 (en) * | 2008-05-07 | 2016-06-21 | Bone Therapeutics S.A. | Mesenchymal stem cells and bone-forming cells |
JP2011529706A (ja) * | 2008-08-04 | 2011-12-15 | アローキュア インコーポレイテッド | 間充織間質細胞集団、ならびにそれを単離および使用する方法 |
SG193888A1 (en) | 2008-09-03 | 2013-10-30 | Mesoblast Inc | Expansion of haemopoietic precursors |
FR2938947B1 (fr) | 2008-11-25 | 2012-08-17 | A Volute | Procede de traitement du signal, notamment audionumerique. |
EP2221362A1 (en) | 2009-02-19 | 2010-08-25 | Naturin GmbH & Co | Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies |
CN102388130B (zh) | 2009-02-27 | 2014-08-27 | 细胞动力国际有限公司 | 多能细胞的分化 |
EP2411505A4 (en) | 2009-03-26 | 2013-01-30 | Univ California | MESENCHYMAL STEM CELLS PRODUCING INHIBITORY RNA WHICH CAN BE USED TO ACT IN THE COURSE OF A DISEASE |
JP2010252778A (ja) * | 2009-04-02 | 2010-11-11 | Shizui Bank Kk | 歯髄由来間葉系幹細胞の分離方法及び分離した幹細胞並びにそれらを用いた肝細胞系譜への分化 |
CN107007626A (zh) | 2009-07-09 | 2017-08-04 | 蒂盖尼克斯公司 | 用于细胞治疗的方法和组合物 |
EP2485741A4 (en) | 2009-10-06 | 2013-07-24 | Cohen Mcniece Foundation | PREPARATION AND USE OF STROMAL CELLS FOR THE TREATMENT OF CARDIAC DISORDERS |
US20120201791A1 (en) | 2009-10-15 | 2012-08-09 | Tai June Yoo | Methods of treating diseases or conditions using mesenchymal stem cells |
US20120269779A1 (en) | 2009-10-30 | 2012-10-25 | Allocure, Inc. | Mesenchymal stromal cell populations and methods of using same |
KR20120102709A (ko) | 2009-11-17 | 2012-09-18 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 인간 rpe 세포의 생산 방법 및 인간 rpe 세포의 제약 제제 |
US8900860B2 (en) * | 2009-11-30 | 2014-12-02 | National Yang-Ming University | Method for expanding mesenchymal stem cells in low-density and hypoxic culture |
AU2010325811A1 (en) | 2009-12-04 | 2012-06-21 | Stem Cell & Regenerative Medicine International, Inc. | Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions |
IN2012DN05053A (es) | 2009-12-04 | 2015-10-09 | Stem Cell & Regenerative Medicine Internatioinal Inc | |
US20120294837A1 (en) * | 2010-02-02 | 2012-11-22 | University Of Rochester | Methods of isolating and culturing mesenchymal stem cells |
EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
KR101443478B1 (ko) | 2010-03-10 | 2014-09-22 | 가부시키가이샤 투셀 | 간엽계 줄기 세포를 포함한 세포 제제 및 그의 제조 방법 |
WO2011124741A1 (es) | 2010-04-08 | 2011-10-13 | Fundación Progreso Y Salud | Uso de un medio de cultivo condicionado por células madre mesenquimales para la diferenciación de células madre pluripotentes humanas |
WO2011139132A2 (ko) | 2010-05-07 | 2011-11-10 | 한국생명공학연구원 | 줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법 |
CN105727250B (zh) | 2010-08-23 | 2023-11-07 | 康干细胞生物科技有限公司 | 预防和治疗免疫病变和炎性疾病的药物组合物 |
WO2012048093A2 (en) | 2010-10-08 | 2012-04-12 | Osiris Therapeutics, Inc. | Enhanced msc preparations |
KR20120095022A (ko) | 2011-02-18 | 2012-08-28 | 가톨릭대학교 산학협력단 | 간엽줄기세포 및 면역조절 t 세포를 유효성분으로 포함하는 이식편대숙주질환 예방 또는 치료용 세포치료제 조성물 |
US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
CA2857545A1 (en) | 2011-11-30 | 2013-06-06 | Advanced Cell Technology, Inc. | Mesenchymal stromal cells and uses related thereto |
KR101477016B1 (ko) | 2012-01-19 | 2014-12-29 | (주)차바이오텍 | 인간 배아줄기세포 유래 혈관주위 전구세포의 제조방법 및 이를 포함하는 세포치료 조성물 |
CN104471059B (zh) * | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
DK2931877T3 (da) | 2012-12-14 | 2019-11-04 | Univ Rutgers | Fremgangsmåder, som modulerer stamcellers immunregulerende virkning |
WO2014131877A1 (en) | 2013-03-01 | 2014-09-04 | Apceth Gmbh & Co. Kg | Protection of the vascular endothelium from immunologically mediated cytotoxic reactions with human cd34-negative progenitor cells |
KR101669124B1 (ko) | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
CN106255884B (zh) | 2013-10-04 | 2019-01-11 | 赛尔爱迪尔私人有限公司 | 用于细胞治疗的生物标志物 |
US10047344B2 (en) | 2014-02-18 | 2018-08-14 | National University Of Singapore | Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (MSCs) |
EP4137146A1 (en) | 2014-06-10 | 2023-02-22 | Mesoblast International Sàrl | Treatment of immune disorders |
JP6459257B2 (ja) | 2014-07-08 | 2019-01-30 | 富士ゼロックス株式会社 | 画像形成装置 |
WO2016018761A1 (en) | 2014-07-28 | 2016-02-04 | The Texas A&M University System | Mesenchymal stem cells expressing biomarkers that predict the effectiveness of the mesenchymal stem cells for treating diseases and disorders |
WO2017038784A1 (ja) | 2015-08-28 | 2017-03-09 | ロート製薬株式会社 | Ror1陽性の間葉系幹細胞及びその調製方法、ror1陽性の間葉系幹細胞を含む医薬組成物及びその調製方法、並びにror1陽性の間葉系幹細胞を用いる疾患の予防又は治療方法 |
JPWO2017073656A1 (ja) | 2015-10-27 | 2018-08-16 | 国立研究開発法人国立循環器病研究センター | 間葉系幹細胞を含む細胞集団の製造方法、間葉系幹細胞、細胞集団、並びに医薬組成物 |
EP3385368B1 (en) | 2015-12-03 | 2023-03-01 | Takara Bio Inc. | Method for producing mesenchymal stem cells |
CA3017772C (en) | 2016-03-16 | 2023-02-21 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
US11179420B2 (en) | 2016-04-27 | 2021-11-23 | Rohto Pharmaceutical Co., Ltd. | Method for treating a disease, comprising administering mesenchymal stem cells or culture supernatant thereof to a subject |
KR101816246B1 (ko) | 2016-09-07 | 2018-01-08 | 에스씨엠생명과학 주식회사 | 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물 |
KR20190085000A (ko) | 2016-10-27 | 2019-07-17 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 면역억제성 간엽 세포 및 그것의 형성 방법 |
US12053492B2 (en) | 2016-12-12 | 2024-08-06 | Health And Biotech France (H & B France) | Perinatal tissue derived mesenchymal stem cells: method of preparation and uses thereof |
EP3608400A4 (en) | 2017-04-03 | 2021-01-06 | Kaneka Corporation | CELL POPULATION WITH MESENCHYMAL STEM CELLS, METHOD OF MANUFACTURING THEREFORE AND PHARMACEUTICAL COMPOSITION |
JP7132908B2 (ja) | 2017-04-03 | 2022-09-07 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
EP3619294A1 (en) | 2017-05-04 | 2020-03-11 | Mesoblast International Sàrl | Mesenchymal lineage precursor or stem cells with enhanced immunosuppression |
-
2012
- 2012-11-30 CA CA2857545A patent/CA2857545A1/en active Pending
- 2012-11-30 TW TW112104480A patent/TW202344258A/zh unknown
- 2012-11-30 RS RS20181203A patent/RS57886B1/sr unknown
- 2012-11-30 KR KR1020147017312A patent/KR102108245B1/ko active Application Filing
- 2012-11-30 EP EP12854438.4A patent/EP2785359B1/en active Active
- 2012-11-30 KR KR1020217010975A patent/KR102525175B1/ko active IP Right Grant
- 2012-11-30 KR KR1020237013378A patent/KR20230059838A/ko not_active Application Discontinuation
- 2012-11-30 AU AU2012345630A patent/AU2012345630A1/en not_active Abandoned
- 2012-11-30 DK DK12854438.4T patent/DK2785359T3/en active
- 2012-11-30 SI SI201231414T patent/SI2785359T1/sl unknown
- 2012-11-30 WO PCT/US2012/067464 patent/WO2013082543A1/en unknown
- 2012-11-30 ES ES12854438T patent/ES2690212T3/es active Active
- 2012-11-30 EP EP18186151.9A patent/EP3449929A1/en active Pending
- 2012-11-30 CN CN201280067692.0A patent/CN104136034B/zh active Active
- 2012-11-30 LT LTEP12854438.4T patent/LT2785359T/lt unknown
- 2012-11-30 TW TW106124778A patent/TWI698242B/zh active
- 2012-11-30 HU HUE12854438A patent/HUE040566T2/hu unknown
- 2012-11-30 US US13/691,349 patent/US8962321B2/en active Active
- 2012-11-30 CN CN201810244786.XA patent/CN108478599B/zh active Active
- 2012-11-30 JP JP2014544956A patent/JP2015500810A/ja active Pending
- 2012-11-30 TW TW101145218A patent/TWI698527B/zh active
- 2012-11-30 PL PL12854438T patent/PL2785359T3/pl unknown
- 2012-11-30 KR KR1020207012502A patent/KR102246369B1/ko active IP Right Grant
- 2012-11-30 TW TW109121434A patent/TWI812867B/zh active
- 2012-11-30 PT PT12854438T patent/PT2785359T/pt unknown
-
2014
- 2014-10-01 US US14/504,351 patent/US20160038543A1/en not_active Abandoned
-
2015
- 2015-04-01 HK HK15103332.4A patent/HK1202798A1/xx unknown
-
2017
- 2017-03-23 US US15/467,201 patent/US20170252374A1/en not_active Abandoned
- 2017-09-08 JP JP2017172589A patent/JP6526130B2/ja active Active
- 2017-10-04 AU AU2017239526A patent/AU2017239526B2/en active Active
-
2018
- 2018-09-25 HR HRP20181515TT patent/HRP20181515T1/hr unknown
- 2018-10-25 CY CY20181101104T patent/CY1122275T1/el unknown
-
2019
- 2019-05-07 JP JP2019087857A patent/JP6983195B2/ja active Active
- 2019-11-14 AU AU2019264631A patent/AU2019264631B2/en active Active
-
2020
- 2020-09-16 US US17/022,807 patent/US12097223B2/en active Active
-
2021
- 2021-11-22 JP JP2021189684A patent/JP2022027796A/ja active Pending
-
2022
- 2022-04-20 AU AU2022202639A patent/AU2022202639A1/en active Pending
-
2023
- 2023-12-14 JP JP2023211105A patent/JP2024067032A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2690212T3 (es) | Células estromales mesenquimales y usos relacionados con las mismas | |
ECSP14005975A (es) | Anticuerpos anti-PHF-tau y sus usos | |
BR112015001435A2 (pt) | métodos para geração de células-tronco mesenquimais que secretam fatores neurotróficos | |
UY34100A (es) | INMUNOCONJUGADOS DEL PROFARMACO seco-MGBA, COMPOSICIONES Y MÉTODOS PARA PREPARARLOS, Y SUS USOS | |
HK1199905A1 (en) | Culturing of mesenchymal stem cells | |
UY34822A (es) | Composiciones y métodos para silenciar la expresión genética | |
UY34484A (es) | Benzotienilo-pirrolotriazinas disustituidas y sus usos | |
PT2893001T (pt) | Método para cultura de células estaminais mesenquimatosas | |
DK2718422T3 (da) | Dyrkningsmedier til stamceller | |
MX2020009670A (es) | Metodos de cultivo por perfusion y usos de los mismos. | |
IL240871A0 (en) | Preparations and methods for obtaining cell cultures from tens of mesenchymal stem cells | |
UY34167A (es) | Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos | |
SG10201811616SA (en) | Cell culture media | |
UY34749A (es) | Proceso para producir biocombustible y componentes de biocombustible. | |
GB2548740A (en) | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same | |
UY34726A (es) | Proceso de montaje de tanques y dispositivos para realizarlo | |
AR095348A1 (es) | Medios de cultivo celular y métodos de producción de anticuerpos | |
UY34377A (es) | Proceso para producir peróxido de hidrógeno | |
IN2014DN10038A (es) | ||
UY34378A (es) | Proceso para producir peróxido de hidrógeno | |
EA201690684A1 (ru) | Способ осветления выросшей клеточной массы неочищенной культуры клеток с высокой плотностью клеток | |
HK1195100A1 (zh) | 用於人間充質幹細胞的培養基 | |
CL2011002642A1 (es) | Uso de una composicion formada por un glucocorticoide y una tiazolinediona que sirve para inducir la diferenciacion adipogenica en celulas madres. | |
BR112017012695A2 (pt) | biorreator e processo de fermentação para produção de hidrogênio | |
SG11201508796SA (en) | Method for producing induced pluripotent stem cell from mesenchymal stem cell and induced pluripotent stem cell produced by the method |