BR112015001435A2 - métodos para geração de células-tronco mesenquimais que secretam fatores neurotróficos - Google Patents

métodos para geração de células-tronco mesenquimais que secretam fatores neurotróficos

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Publication number
BR112015001435A2
BR112015001435A2 BR112015001435A BR112015001435A BR112015001435A2 BR 112015001435 A2 BR112015001435 A2 BR 112015001435A2 BR 112015001435 A BR112015001435 A BR 112015001435A BR 112015001435 A BR112015001435 A BR 112015001435A BR 112015001435 A2 BR112015001435 A2 BR 112015001435A2
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Brazil
Prior art keywords
methods
stem cells
mesenchymal stem
neurotrophic factors
secrete neurotrophic
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BR112015001435A
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English (en)
Other versions
BR112015001435B1 (pt
Inventor
Burshtein Alex
Gothelf Yael
Levy Yosef
Original Assignee
Brainstorm Cell Therapeutics Ltd
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Publication date
Application filed by Brainstorm Cell Therapeutics Ltd filed Critical Brainstorm Cell Therapeutics Ltd
Publication of BR112015001435A2 publication Critical patent/BR112015001435A2/pt
Publication of BR112015001435B1 publication Critical patent/BR112015001435B1/pt

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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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BR112015001435-6A 2012-08-06 2013-08-04 Métodos para geração de células que secretam fator neurotrófico derivado do cérebro (bdnf), fator neurotrófico derivado da glia (gdnf), fator de crescimento de hepatócitos (hgf) e fator de crescimento endotelial vascular (vegf) em que as referidas células não secretam fator de crescimento do nervo(ngf) BR112015001435B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261679822P 2012-08-06 2012-08-06
US61/679,822 2012-08-06
PCT/IL2013/050660 WO2014024183A1 (en) 2012-08-06 2013-08-04 Methods of generating mesenchymal stem cells which secrete neurotrophic factors

Publications (2)

Publication Number Publication Date
BR112015001435A2 true BR112015001435A2 (pt) 2018-07-31
BR112015001435B1 BR112015001435B1 (pt) 2022-01-18

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Application Number Title Priority Date Filing Date
BR112015001435-6A BR112015001435B1 (pt) 2012-08-06 2013-08-04 Métodos para geração de células que secretam fator neurotrófico derivado do cérebro (bdnf), fator neurotrófico derivado da glia (gdnf), fator de crescimento de hepatócitos (hgf) e fator de crescimento endotelial vascular (vegf) em que as referidas células não secretam fator de crescimento do nervo(ngf)

Country Status (10)

Country Link
US (3) US10046010B2 (pt)
EP (1) EP2880151B1 (pt)
JP (2) JP6362596B2 (pt)
BR (1) BR112015001435B1 (pt)
CA (1) CA2877223C (pt)
DK (1) DK2880151T3 (pt)
ES (1) ES2813407T3 (pt)
HK (1) HK1209453A1 (pt)
IL (1) IL261441B (pt)
WO (1) WO2014024183A1 (pt)

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TWI648273B (zh) 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（三）
JP6628253B2 (ja) 2014-02-11 2020-01-08 ブレインストーム セル セラペウティクス リミテッド 細胞の適性を判定する方法
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CA2983764A1 (en) 2015-04-24 2016-10-27 University Of Copenhagen Isolation of bona fide pancreatic progenitor cells
CN105169486B (zh) * 2015-10-11 2018-04-03 温州医科大学 一种结合去细胞神经应用的神经修复材料
GB2605113A (en) * 2016-05-09 2022-09-21 Sistemic Scotland Ltd Functional prediction
EP3455367A1 (en) 2016-05-09 2019-03-20 Sistemic Scotland Ltd Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
GB2550136A (en) * 2016-05-09 2017-11-15 Sistemic Scotland Ltd Functional prediction
AU2017301035A1 (en) 2016-07-18 2019-02-07 Brainstorm Cell Therapeutics Ltd Methods for treating amyotrophic lateral sclerosis (ALS)
KR20240001721A (ko) * 2016-09-12 2024-01-03 제네똥 산-알파 글루코시다제 변이체 및 이의 용도
SG11201903928WA (en) 2016-11-03 2019-05-30 Exostem Biotec Ltd Mesenchymal stem cells populations, their products, and use thereof
WO2018198012A1 (en) * 2017-04-24 2018-11-01 Pluristem Ltd. Methods and compositions for treating neurological disorders
US20190054144A1 (en) * 2017-08-15 2019-02-21 Meridigen Biotech Co., Ltd. Pharmaceutical composition for treating ischemic stroke and method thereof
US11286462B2 (en) 2017-09-14 2022-03-29 University Of Kansas Materials and methods for generating therapeutic mesenchymal stem cells
WO2019051536A1 (en) * 2017-09-15 2019-03-21 Cynata Therapeutics Limited METHOD OF TREATING ALLERGIC RESPIRATORY TRACT DISEASE (DAA) / ASTHMA
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
CA3095716A1 (en) 2018-04-10 2019-10-17 Brainstorm Cell Therapeutics Ltd. Cell-type specific exosomes and use thereof
US20200000886A1 (en) * 2018-06-29 2020-01-02 University Of Washington Engineering the rrm2 subunit of ribonucleotide reductase to resist degradation
CN111484978A (zh) * 2019-01-28 2020-08-04 深圳市第二人民医院 miR-140-5p过表达修饰的人脐带间充质干细胞、其治疗制剂、制备方法和应用
EP3939660A4 (en) * 2019-03-14 2022-12-28 Sapporo Medical University PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
KR102323056B1 (ko) * 2019-05-02 2021-11-09 에스씨엠생명과학 주식회사 hPL 함유 배지에서 배양된 중간엽 줄기세포의 배양액을 포함하는 화장료 조성물
JP7541700B2 (ja) * 2019-06-11 2024-08-29 国立大学法人京都大学 腎間質細胞の製造方法
EP4093859A4 (en) * 2020-03-11 2023-06-14 Remotor Therapeutics, Inc. METHODS AND MATERIALS FOR DISSEMINATING PROTEIN THROUGH THE CENTRAL NERVOUS SYSTEM
EP4232565A4 (en) * 2020-10-26 2024-08-14 Hadasit Medical Res Services&Development Ltd MESENCHYMAL STEM CELLS AND THEIR CULTURE
JPWO2022210514A1 (pt) 2021-03-30 2022-10-06
CN113367123B (zh) * 2021-06-07 2022-05-13 南京三生生物技术股份有限公司 一种细胞冻存方法
CN113789333B (zh) * 2021-09-07 2023-07-14 中国人民解放军军事科学院军事医学研究院 Chi3l1在调控hUC-MSCs抑制Th17分化介导的免疫调节作用上的应用
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US20210338739A1 (en) 2021-11-04
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