SI1941027T1 - Postopki in sredstva za proliferacijo zarodnih celic in kasnejšo generacijo in ekspanzijo progenitorskih celic, kot tudi izdelava efektor celic kot kliničnih zdravil - Google Patents

Postopki in sredstva za proliferacijo zarodnih celic in kasnejšo generacijo in ekspanzijo progenitorskih celic, kot tudi izdelava efektor celic kot kliničnih zdravil

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Publication number
SI1941027T1
SI1941027T1 SI200631825T SI200631825T SI1941027T1 SI 1941027 T1 SI1941027 T1 SI 1941027T1 SI 200631825 T SI200631825 T SI 200631825T SI 200631825 T SI200631825 T SI 200631825T SI 1941027 T1 SI1941027 T1 SI 1941027T1
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SI
Slovenia
Prior art keywords
expansion
production
methods
well
stem cell
Prior art date
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SI200631825T
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English (en)
Inventor
Jan Spanholtz
Original Assignee
Ipd-Theapeutics B.V.
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Publication date
Application filed by Ipd-Theapeutics B.V. filed Critical Ipd-Theapeutics B.V.
Publication of SI1941027T1 publication Critical patent/SI1941027T1/sl

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SI200631825T 2005-09-28 2006-09-28 Postopki in sredstva za proliferacijo zarodnih celic in kasnejšo generacijo in ekspanzijo progenitorskih celic, kot tudi izdelava efektor celic kot kliničnih zdravil SI1941027T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05077221 2005-09-28
EP20060799473 EP1941027B1 (en) 2005-09-28 2006-09-28 Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.
PCT/NL2006/000484 WO2007037682A1 (en) 2005-09-28 2006-09-28 Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.

Publications (1)

Publication Number Publication Date
SI1941027T1 true SI1941027T1 (sl) 2014-11-28

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Application Number Title Priority Date Filing Date
SI200631825T SI1941027T1 (sl) 2005-09-28 2006-09-28 Postopki in sredstva za proliferacijo zarodnih celic in kasnejšo generacijo in ekspanzijo progenitorskih celic, kot tudi izdelava efektor celic kot kliničnih zdravil

Country Status (8)

Country Link
US (1) US9109202B2 (sl)
EP (1) EP1941027B1 (sl)
DK (1) DK1941027T3 (sl)
ES (1) ES2502841T3 (sl)
PL (1) PL1941027T3 (sl)
PT (1) PT1941027E (sl)
SI (1) SI1941027T1 (sl)
WO (1) WO2007037682A1 (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120811A2 (en) 2006-04-14 2007-10-25 Advanced Cell Technology, Inc. Hemangio-colony forming cells
WO2008118020A1 (en) * 2007-03-27 2008-10-02 Ipd-Therapeutics B.V. Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics
KR20210022148A (ko) 2007-09-28 2021-03-02 안트로제네시스 코포레이션 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
US20120003738A1 (en) * 2007-10-04 2012-01-05 University Hospitals Of Cleveland Method For Amplification And Functional Enhancment Of Blood Derived Progenitor Cells Using A Closed Culture System
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
ES2324011B1 (es) * 2009-01-02 2010-03-15 Banc De Sang I Teixits Procedimiento para la obtencion de celulas madre mesenquimales a partir de la fraccion mononuclear de la medula osea humana.
KR20210120136A (ko) * 2009-12-04 2021-10-06 아스텔라스 인스티튜트 포 리제너러티브 메디슨 인간 배아줄기세포 유래된 혈액모세포로부터 자연 살해 세포 및 수지상 세포를 생성하는 방법
EP2593542B1 (en) 2010-07-13 2018-01-03 Anthrogenesis Corporation Methods of generating natural killer cells
ES2856825T3 (es) * 2011-03-18 2021-09-28 Glycostem Therapeutics B V Generación de células NK y progenitores de células NK
KR20230059838A (ko) 2011-11-30 2023-05-03 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
WO2013119118A1 (en) * 2012-02-08 2013-08-15 Ipd-Therapeutics B.V. Ex vivo nk cell differentiation from cd34+ hematopoietic cells
EP2934555B1 (en) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells
CN105142651A (zh) 2013-02-05 2015-12-09 人类起源公司 来自胎盘的自然杀伤细胞
CA2951746C (en) * 2014-06-10 2023-08-22 Polybiocept Ab Culture medium for cellular immunotherapy
EP3256569B2 (en) * 2015-02-11 2024-04-17 The Hospital for Sick Children Alveolar-like macrophages and method of generating same
ES2815552T3 (es) 2015-08-24 2021-03-30 Vitrolife Sweden Ab Medio de cultivo
BR112020015512A2 (pt) 2018-02-01 2021-01-26 Nkmax Co., Ltd. método de produção de células exterminadoras naturais e composição para tratamento de câncer
WO2021178890A1 (en) 2020-03-06 2021-09-10 Sorrento Therapeutics, Inc. Innate immunity killer cells targeting psma positive tumor cells
CN113801846B (zh) * 2021-09-22 2024-06-04 南京艾尔普再生医学科技有限公司 一种从人诱导多能干细胞分化为自然杀伤细胞的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206223A (en) * 1986-06-26 1993-04-27 Yeda Research And Development Co. Ltd. Method for inhibiting heparanase activity
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US6316257B1 (en) * 1996-03-04 2001-11-13 Targeted Genetics Corporation Modified rapid expansion methods (“modified-REM”) for in vitro propagation of T lymphocytes
EP1390076A4 (en) * 2001-04-27 2004-12-15 Xcyte Therapies Inc Maturation of antigen-presenting cells with activated cells

Also Published As

Publication number Publication date
EP1941027B1 (en) 2014-08-20
EP1941027A1 (en) 2008-07-09
PT1941027E (pt) 2014-10-09
PL1941027T3 (pl) 2015-01-30
DK1941027T3 (da) 2014-10-13
US20090017539A1 (en) 2009-01-15
ES2502841T3 (es) 2014-10-06
WO2007037682A1 (en) 2007-04-05
US9109202B2 (en) 2015-08-18

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