PT2683384E - Métodos de tratamento de cancro utilizando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona - Google Patents

Métodos de tratamento de cancro utilizando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona Download PDF

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Publication number
PT2683384E
PT2683384E PT127108363T PT12710836T PT2683384E PT 2683384 E PT2683384 E PT 2683384E PT 127108363 T PT127108363 T PT 127108363T PT 12710836 T PT12710836 T PT 12710836T PT 2683384 E PT2683384 E PT 2683384E
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PT
Portugal
Prior art keywords
pyeridine
diona
quinazolin
oxo
amino
Prior art date
Application number
PT127108363T
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English (en)
Portuguese (pt)
Inventor
Man Hon-Wah
H Schafer Peter
W Muller George
Zhang Ling-Hua
Gandhi Anita
Chopra Rajesh
Original Assignee
Celgene Corp
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Application filed by Celgene Corp filed Critical Celgene Corp
Publication of PT2683384E publication Critical patent/PT2683384E/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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PT127108363T 2011-03-11 2012-03-09 Métodos de tratamento de cancro utilizando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona PT2683384E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161451995P 2011-03-11 2011-03-11
US201161480272P 2011-04-28 2011-04-28

Publications (1)

Publication Number Publication Date
PT2683384E true PT2683384E (pt) 2016-03-11

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PT127108363T PT2683384E (pt) 2011-03-11 2012-03-09 Métodos de tratamento de cancro utilizando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona

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US (6) US8906932B2 (cg-RX-API-DMAC7.html)
EP (3) EP2683384B1 (cg-RX-API-DMAC7.html)
JP (5) JP6118273B2 (cg-RX-API-DMAC7.html)
KR (2) KR20140019364A (cg-RX-API-DMAC7.html)
CN (3) CN107375293A (cg-RX-API-DMAC7.html)
AR (1) AR085651A1 (cg-RX-API-DMAC7.html)
AU (4) AU2012229316B2 (cg-RX-API-DMAC7.html)
BR (2) BR112013023280A2 (cg-RX-API-DMAC7.html)
CA (2) CA2829593A1 (cg-RX-API-DMAC7.html)
CY (1) CY1117430T1 (cg-RX-API-DMAC7.html)
DK (1) DK2683384T3 (cg-RX-API-DMAC7.html)
EA (2) EA201691939A1 (cg-RX-API-DMAC7.html)
ES (2) ES2562332T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20160056T1 (cg-RX-API-DMAC7.html)
HU (1) HUE027481T2 (cg-RX-API-DMAC7.html)
IL (2) IL227990B (cg-RX-API-DMAC7.html)
MX (2) MX2013010153A (cg-RX-API-DMAC7.html)
NI (2) NI201300082A (cg-RX-API-DMAC7.html)
PH (2) PH12013501820A1 (cg-RX-API-DMAC7.html)
PL (1) PL2683384T3 (cg-RX-API-DMAC7.html)
PT (1) PT2683384E (cg-RX-API-DMAC7.html)
RS (1) RS54553B1 (cg-RX-API-DMAC7.html)
RU (3) RU2017120977A (cg-RX-API-DMAC7.html)
SG (2) SG193320A1 (cg-RX-API-DMAC7.html)
SI (1) SI2683384T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201600034B (cg-RX-API-DMAC7.html)
TW (2) TW201700100A (cg-RX-API-DMAC7.html)
WO (2) WO2012125459A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201306148B (cg-RX-API-DMAC7.html)

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SMT201800032T1 (it) 2011-03-11 2018-03-08 Celgene Corp Forme solide di 3-(5-ammino-2-metil-4-osso-4h-chinazolin-3-il)-piperidina-2,6-dione, e loro composizioni farmaceutiche e usi
AU2012236655B2 (en) 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
WO2012149299A2 (en) * 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
JP6318152B2 (ja) 2012-06-29 2018-04-25 セルジーン コーポレイション セレブロン関連タンパク質を利用して薬物効能を決定する方法
EP3949968A1 (en) * 2012-08-09 2022-02-09 Celgene Corporation Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
AU2013312188A1 (en) * 2012-09-10 2015-03-26 Celgene Corporation Methods for the treatment of locally advanced breast cancer
WO2014110558A1 (en) 2013-01-14 2014-07-17 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
EP2968334A4 (en) 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
CN105392499B (zh) * 2013-04-17 2018-07-24 西格诺药品有限公司 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法
KR102240356B1 (ko) * 2013-04-17 2021-04-14 시그날 파마소티칼 엘엘씨 Ｔｏｒ 키나제 억제제와 5-치환된 퀴나졸리논 화합물을 포함하는 암 치료용 조합 요법
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US9119854B2 (en) 2013-05-03 2015-09-01 Celgene Corporation Methods for treating cancer using combination therapy
US20160282354A1 (en) 2013-11-08 2016-09-29 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias
WO2015085172A2 (en) * 2013-12-06 2015-06-11 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
TW201540323A (zh) * 2014-01-15 2015-11-01 Celgene Corp ３－（５－胺基－２－甲基－４－側氧基－４ｈ－喹唑啉－３－基）－哌啶－２，６－二酮之調配物
JP6640126B2 (ja) 2014-06-27 2020-02-05 セルジーン コーポレイション セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法
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