IL227990B - Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione for preparation of medicaments for treatment of immune-related and inflammatory diseases - Google Patents

Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione for preparation of medicaments for treatment of immune-related and inflammatory diseases

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Publication number
IL227990B
IL227990B IL227990A IL22799013A IL227990B IL 227990 B IL227990 B IL 227990B IL 227990 A IL227990 A IL 227990A IL 22799013 A IL22799013 A IL 22799013A IL 227990 B IL227990 B IL 227990B
Authority
IL
Israel
Prior art keywords
oxoquinlosin
dinone
piperidine
drugs
amino
Prior art date
Application number
IL227990A
Other languages
English (en)
Hebrew (he)
Other versions
IL227990A0 (en
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of IL227990A0 publication Critical patent/IL227990A0/en
Publication of IL227990B publication Critical patent/IL227990B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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  • Pain & Pain Management (AREA)
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  • Heart & Thoracic Surgery (AREA)
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IL227990A 2011-03-11 2013-08-15 Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione for preparation of medicaments for treatment of immune-related and inflammatory diseases IL227990B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161451995P 2011-03-11 2011-03-11
US201161480272P 2011-04-28 2011-04-28
PCT/US2012/028538 WO2012125475A1 (en) 2011-03-11 2012-03-09 Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2-6-dione in treatment of immune-related and inflammatory diseases

Publications (2)

Publication Number Publication Date
IL227990A0 IL227990A0 (en) 2013-09-30
IL227990B true IL227990B (en) 2018-02-28

Family

ID=45876915

Family Applications (2)

Application Number Title Priority Date Filing Date
IL227990A IL227990B (en) 2011-03-11 2013-08-15 Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione for preparation of medicaments for treatment of immune-related and inflammatory diseases
IL228230A IL228230A (en) 2011-03-11 2013-09-01 Use of 3- (5-amino-2-methyl-4-oxo-h4-quinazolin-3-yl) -pipridine-2, 6-discussion of the production of a cancer drug

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL228230A IL228230A (en) 2011-03-11 2013-09-01 Use of 3- (5-amino-2-methyl-4-oxo-h4-quinazolin-3-yl) -pipridine-2, 6-discussion of the production of a cancer drug

Country Status (29)

Country Link
US (6) US8906932B2 (cg-RX-API-DMAC7.html)
EP (3) EP2683384B1 (cg-RX-API-DMAC7.html)
JP (5) JP6118273B2 (cg-RX-API-DMAC7.html)
KR (2) KR20140019364A (cg-RX-API-DMAC7.html)
CN (3) CN107375293A (cg-RX-API-DMAC7.html)
AR (1) AR085651A1 (cg-RX-API-DMAC7.html)
AU (4) AU2012229316B2 (cg-RX-API-DMAC7.html)
BR (2) BR112013023280A2 (cg-RX-API-DMAC7.html)
CA (2) CA2829593A1 (cg-RX-API-DMAC7.html)
CY (1) CY1117430T1 (cg-RX-API-DMAC7.html)
DK (1) DK2683384T3 (cg-RX-API-DMAC7.html)
EA (2) EA201691939A1 (cg-RX-API-DMAC7.html)
ES (2) ES2562332T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20160056T1 (cg-RX-API-DMAC7.html)
HU (1) HUE027481T2 (cg-RX-API-DMAC7.html)
IL (2) IL227990B (cg-RX-API-DMAC7.html)
MX (2) MX2013010153A (cg-RX-API-DMAC7.html)
NI (2) NI201300082A (cg-RX-API-DMAC7.html)
PH (2) PH12013501820A1 (cg-RX-API-DMAC7.html)
PL (1) PL2683384T3 (cg-RX-API-DMAC7.html)
PT (1) PT2683384E (cg-RX-API-DMAC7.html)
RS (1) RS54553B1 (cg-RX-API-DMAC7.html)
RU (3) RU2017120977A (cg-RX-API-DMAC7.html)
SG (2) SG193320A1 (cg-RX-API-DMAC7.html)
SI (1) SI2683384T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201600034B (cg-RX-API-DMAC7.html)
TW (2) TW201700100A (cg-RX-API-DMAC7.html)
WO (2) WO2012125459A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201306148B (cg-RX-API-DMAC7.html)

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SMT201800032T1 (it) 2011-03-11 2018-03-08 Celgene Corp Forme solide di 3-(5-ammino-2-metil-4-osso-4h-chinazolin-3-il)-piperidina-2,6-dione, e loro composizioni farmaceutiche e usi
AU2012236655B2 (en) 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
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JP6318152B2 (ja) 2012-06-29 2018-04-25 セルジーン コーポレイション セレブロン関連タンパク質を利用して薬物効能を決定する方法
EP3949968A1 (en) * 2012-08-09 2022-02-09 Celgene Corporation Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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EP2968334A4 (en) 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
CN105392499B (zh) * 2013-04-17 2018-07-24 西格诺药品有限公司 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法
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