AR085651A1 - Metodos para tratar cancer usando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidin-2,6-diona - Google Patents

Metodos para tratar cancer usando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidin-2,6-diona

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Publication number
AR085651A1
AR085651A1 ARP120100782A AR085651A1 AR 085651 A1 AR085651 A1 AR 085651A1 AR P120100782 A ARP120100782 A AR P120100782A AR 085651 A1 AR085651 A1 AR 085651A1
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AR
Argentina
Prior art keywords
carcinoma
cancer
prostate cancer
malignant
lymphoma
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English (en)
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Celgene Corp
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Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AR085651A1 publication Critical patent/AR085651A1/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Métodos para tratar, prevenir y/o controlar cánceres, que comprenden administrar a un paciente 3-(5-amino-2-metil-4-oxo-4H-quinazolin-3-il)-piperidin-2,6-diona, o un enantiómero o una mezcla de enantiómeros del mismo, o una sal aceptable para uso farmacéutico, solvato, hidrato, co-cristal, clatrato, o polimorfo farmacéuticamente aceptable.Reivindicación 1: Un método para tratar o controlar el cáncer, caracterizado porque comprende administrar a un paciente necesitado de dicho tratamiento o control una cantidad efectiva para uso terapéutico de 3-(5-amino-2-metil-4-oxo-4H-quinazolin-3-il)-piperidin-2,6-diona, que tiene la estructura de fórmula (1), o un enantiómero o mezcla de enantiómeros del mismo, o una sal aceptable para uso farmacéutico, solvato, hidrato, co-cristal, clatrato, o polimorfo del mismo. Reivindicación 2: El método de la reivindicación 1, caracterizado porque el cáncer es malignidad avanzada, amiloidosis, neuroblastoma, meningioma, hemangiopericitoma, metástasis cerebral múltiple, glioblastoma multiforme, glioblastoma, glioma del tronco encefálico, tumor cerebral maligno con pronóstico pobre, glioma maligno, astrocitoma anaplásico, oligodendroglioma anaplásico, tumor neuroendocrino, adenocarcinoma rectal, cáncer colorrectal C y D de Dukes, carcinoma colorrectal inoperable, carcinoma hepatocelular metastásico, sarcoma de Kaposi, leucemia mieloblástica aguda de cariotipo, linfoma de Hodgkin, linfoma no Hodgkin, linfoma cutáneo de células T, linfoma grande difuso de células T, linfoma folicular de bajo grado, melanoma maligno, mesotelioma maligno, síndrome de mesotelioma maligno con efusión pleural, carcinoma peritoneal, carcinoma seroso papilar, sarcoma ginecológico, sarcoma del tejido blando, escleroderma, vasculitis cutánea, histiocitosis de células de Langerhans, leiomiosarcoma, fibrodisplasia osificante progresiva, cáncer de próstata refractario a hormonas, sarcoma del tejido blando de alto riesgo operado, carcinoma hepatocelular inoperable, Macroglobulinemia de Waldenstrom, mieloma múltiple, mieloma indolente, cáncer del tubo falopiano, cáncer de próstata independiente de andrógenos, cáncer de próstata no metastásico de etapa IV dependiente de andrógenos, cáncer de próstata insensible a hormonas, cáncer de próstata insensible a la quimioterapia, carcinoma papilar tiroideo, carcinoma folicular tiroideo, carcinoma medular tiroideo, o leiomioma.
ARP120100782 2011-03-11 2012-03-09 Metodos para tratar cancer usando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidin-2,6-diona AR085651A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161451995P 2011-03-11 2011-03-11
US201161480272P 2011-04-28 2011-04-28

Publications (1)

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AR085651A1 true AR085651A1 (es) 2013-10-16

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ARP120100782 AR085651A1 (es) 2011-03-11 2012-03-09 Metodos para tratar cancer usando 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidin-2,6-diona

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US (6) US8906932B2 (es)
EP (3) EP3025715A1 (es)
JP (5) JP6118273B2 (es)
KR (2) KR20140025374A (es)
CN (3) CN103561744A (es)
AR (1) AR085651A1 (es)
AU (4) AU2012229300B2 (es)
BR (2) BR112013023277A2 (es)
CA (2) CA2829592A1 (es)
CY (1) CY1117430T1 (es)
DK (1) DK2683384T3 (es)
EA (2) EA201391319A1 (es)
ES (2) ES2562332T3 (es)
HK (1) HK1191858A1 (es)
HR (1) HRP20160056T1 (es)
HU (1) HUE027481T2 (es)
IL (2) IL227990B (es)
MX (2) MX2013010217A (es)
NI (2) NI201300081A (es)
PL (1) PL2683384T3 (es)
PT (1) PT2683384E (es)
RS (1) RS54553B1 (es)
RU (3) RU2013145556A (es)
SG (2) SG192947A1 (es)
SI (1) SI2683384T1 (es)
SM (1) SMT201600034B (es)
TW (2) TW201700100A (es)
WO (2) WO2012125475A1 (es)
ZA (2) ZA201306148B (es)

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TWI601722B (zh) 2011-03-11 2017-10-11 西建公司 ３-（５-胺基-２-甲基-４-氧基-４ｈ-喹唑啉-３-基）-六氫吡啶-２，６-二酮之固體型式及其醫藥組合物及用途
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