EA201591913A1 - Ингибиторы протеинкиназы - Google Patents

Ингибиторы протеинкиназы

Info

Publication number
EA201591913A1
EA201591913A1 EA201591913A EA201591913A EA201591913A1 EA 201591913 A1 EA201591913 A1 EA 201591913A1 EA 201591913 A EA201591913 A EA 201591913A EA 201591913 A EA201591913 A EA 201591913A EA 201591913 A1 EA201591913 A1 EA 201591913A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
formula
proteinkinase inhibitors
proteinkinase
fgfr
Prior art date
Application number
EA201591913A
Other languages
English (en)
Other versions
EA031076B1 (ru
Inventor
Сринивасан Раджагопалан
Прасад Аппукуттан
Картхикейан Нарасингапурам Арумугам
Рави Котрабасаиах Уджинаматада
Шила Джордж
Теро Линнанен
Original Assignee
Орион Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орион Корпорейшн filed Critical Орион Корпорейшн
Publication of EA201591913A1 publication Critical patent/EA201591913A1/ru
Publication of EA031076B1 publication Critical patent/EA031076B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описано соединение формулы (I)где R-R, A, B, Z, Zи Zявляются такими, как определено в пунктах формулы изобретения, и его фармацевтически приемлемые соли. Соединения формулы (I) предложены для применения в качестве ингибиторов FGFR и пригодны для лечения состояния, при котором требуется ингибирование FGFR киназы, такого как рак.
EA201591913A 2013-04-04 2014-04-03 Ингибиторы протеинкиназы EA031076B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN382KO2013 2013-04-04
PCT/FI2014/000003 WO2014162039A1 (en) 2013-04-04 2014-04-03 Protein kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201591913A1 true EA201591913A1 (ru) 2016-03-31
EA031076B1 EA031076B1 (ru) 2018-11-30

Family

ID=50685938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591913A EA031076B1 (ru) 2013-04-04 2014-04-03 Ингибиторы протеинкиназы

Country Status (34)

Country Link
US (1) US20160031855A1 (ru)
EP (1) EP2981533B1 (ru)
JP (1) JP6356782B2 (ru)
KR (1) KR20150138383A (ru)
CN (1) CN105073733B (ru)
AR (1) AR095781A1 (ru)
AU (1) AU2014246961B2 (ru)
BR (1) BR112015025413A2 (ru)
CA (1) CA2907855A1 (ru)
CL (1) CL2015002932A1 (ru)
CY (1) CY1120306T1 (ru)
DK (1) DK2981533T3 (ru)
EA (1) EA031076B1 (ru)
ES (1) ES2658183T3 (ru)
HK (1) HK1217198A1 (ru)
HR (1) HRP20180382T1 (ru)
HU (1) HUE036692T2 (ru)
LT (1) LT2981533T (ru)
MA (1) MA38454B1 (ru)
MX (1) MX2015013776A (ru)
MY (1) MY184528A (ru)
NO (1) NO2981533T3 (ru)
NZ (1) NZ713410A (ru)
PE (1) PE20160115A1 (ru)
PH (1) PH12015502284A1 (ru)
PL (1) PL2981533T3 (ru)
PT (1) PT2981533T (ru)
RS (1) RS56942B1 (ru)
SA (1) SA515361260B1 (ru)
SG (1) SG11201508125XA (ru)
SI (1) SI2981533T1 (ru)
TW (1) TWI628176B (ru)
UA (1) UA115176C2 (ru)
WO (1) WO2014162039A1 (ru)

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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
SG11201408238WA (en) 2012-06-13 2015-01-29 Incyte Corp Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
ES2914072T3 (es) 2014-08-18 2022-06-07 Eisai R&D Man Co Ltd Sal de derivado de piridina monocíclico y su cristal
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
US10487863B2 (en) * 2017-02-17 2019-11-26 Ford Global Technologies, Llc Castellated joint for improved adhesive coverage when using mechanical fixings and adhesive in one joint
WO2018166493A1 (zh) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN111712245A (zh) 2018-03-28 2020-09-25 卫材R&D管理有限公司 用于肝细胞癌的治疗剂
SG11202010636VA (en) 2018-05-04 2020-11-27 Incyte Corp Solid forms of an fgfr inhibitor and processes for preparing the same
WO2019213506A1 (en) 2018-05-04 2019-11-07 Incyte Corporation Salts of an fgfr inhibitor
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220020918A (ko) * 2019-06-14 2022-02-21 메드샤인 디스커버리 아이엔씨. Fgfr 및 vegfr 이중 억제제로서의 축합고리 화합물
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
AU2020320997B2 (en) * 2019-07-26 2023-07-27 Cgenetech (Suzhou, China) Co., Ltd. Pyridine derivative as FGFR and VEGFR dual inhibitors
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
CA3162010A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022203399A1 (ko) * 2021-03-26 2022-09-29 주식회사 스탠다임 아데노신 a2a 수용체 길항제 및 이의 용도
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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JP2003503351A (ja) * 1999-06-30 2003-01-28 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害化合物
CA2376951A1 (en) * 1999-06-30 2001-01-04 Peter J. Sinclair Src kinase inhibitor compounds
KR20060121818A (ko) * 2003-08-21 2006-11-29 오에스아이 파마슈티컬스, 인코포레이티드 Ｎ-치환된 벤즈이미다졸릴 ｃ-ｋｉｔ 억제제
KR20090064602A (ko) * 2006-10-16 2009-06-19 노파르티스 아게 단백질 키나제 억제제로서 유용한 페닐아세트아미드
JP5442449B2 (ja) * 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
AU2007337886C1 (en) * 2006-12-22 2014-10-16 Astex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
GB0906472D0 (en) * 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
WO2011038579A1 (en) * 2009-09-30 2011-04-07 Zhejiang Beta Pharma Inc. Compounds and compositions as protein kinase inhibitors
UA111382C2 (uk) * 2011-10-10 2016-04-25 Оріон Корпорейшн Інгібітори протеїнкінази

Also Published As

Publication number Publication date
BR112015025413A2 (pt) 2017-07-18
MA38454B1 (fr) 2018-11-30
AU2014246961B2 (en) 2017-09-28
CN105073733A (zh) 2015-11-18
CA2907855A1 (en) 2014-10-09
EA031076B1 (ru) 2018-11-30
HUE036692T2 (hu) 2018-07-30
MX2015013776A (es) 2016-02-26
NO2981533T3 (ru) 2018-05-05
LT2981533T (lt) 2018-02-26
PH12015502284B1 (en) 2016-02-01
SA515361260B1 (ar) 2017-08-27
PL2981533T3 (pl) 2018-04-30
MY184528A (en) 2021-04-01
HK1217198A1 (zh) 2016-12-30
KR20150138383A (ko) 2015-12-09
CN105073733B (zh) 2017-06-27
AR095781A1 (es) 2015-11-11
MA38454A1 (fr) 2018-02-28
HRP20180382T1 (hr) 2018-04-06
PE20160115A1 (es) 2016-03-03
TW201524970A (zh) 2015-07-01
JP6356782B2 (ja) 2018-07-11
PT2981533T (pt) 2018-02-27
NZ713410A (en) 2018-07-27
AU2014246961A1 (en) 2015-10-22
SG11201508125XA (en) 2015-10-29
SI2981533T1 (en) 2018-04-30
PH12015502284A1 (en) 2016-02-01
EP2981533B1 (en) 2017-12-06
DK2981533T3 (en) 2018-02-12
UA115176C2 (uk) 2017-09-25
CY1120306T1 (el) 2019-07-10
CL2015002932A1 (es) 2016-04-22
US20160031855A1 (en) 2016-02-04
WO2014162039A1 (en) 2014-10-09
TWI628176B (zh) 2018-07-01
ES2658183T3 (es) 2018-03-08
RS56942B1 (sr) 2018-05-31
JP2016515604A (ja) 2016-05-30
EP2981533A1 (en) 2016-02-10

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU