CY1120306T1 - Αναστολεις πρωτεϊνικων kinασων - Google Patents
Αναστολεις πρωτεϊνικων kinασωνInfo
- Publication number
- CY1120306T1 CY1120306T1 CY20181100204T CY181100204T CY1120306T1 CY 1120306 T1 CY1120306 T1 CY 1120306T1 CY 20181100204 T CY20181100204 T CY 20181100204T CY 181100204 T CY181100204 T CY 181100204T CY 1120306 T1 CY1120306 T1 CY 1120306T1
- Authority
- CY
- Cyprus
- Prior art keywords
- suspensions
- china
- protein
- formula
- fgfr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Αποκαλύπτονται μια ένωση του τύπου (I), όπου τα R1 έως R5, Α, Β, Ζ, Ζ1 και Ζ2 είναι όπως ορίζονται στις αξιώσεις, καθώς και φαρμακευτικώς αποδεκτά άλατα αυτής. Οι ενώσεις του τύπου (I) έχουν χρησιμότητα ως αναστολείς των FGFR και είναι χρήσιμες στη θεραπεία μιας πάθησης στην οποία είναι επιθυμητή η αναστολή της κινάσης FGFR, όπως ο καρκίνος.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN382KO2013 | 2013-04-04 | ||
| PCT/FI2014/000003 WO2014162039A1 (en) | 2013-04-04 | 2014-04-03 | Protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120306T1 true CY1120306T1 (el) | 2019-07-10 |
Family
ID=50685938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100204T CY1120306T1 (el) | 2013-04-04 | 2018-02-21 | Αναστολεις πρωτεϊνικων kinασων |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US20160031855A1 (el) |
| EP (1) | EP2981533B1 (el) |
| JP (1) | JP6356782B2 (el) |
| KR (1) | KR20150138383A (el) |
| CN (1) | CN105073733B (el) |
| AR (1) | AR095781A1 (el) |
| AU (1) | AU2014246961B2 (el) |
| BR (1) | BR112015025413A2 (el) |
| CA (1) | CA2907855A1 (el) |
| CL (1) | CL2015002932A1 (el) |
| CY (1) | CY1120306T1 (el) |
| DK (1) | DK2981533T3 (el) |
| EA (1) | EA031076B1 (el) |
| ES (1) | ES2658183T3 (el) |
| HK (1) | HK1217198A1 (el) |
| HR (1) | HRP20180382T1 (el) |
| HU (1) | HUE036692T2 (el) |
| LT (1) | LT2981533T (el) |
| MA (1) | MA38454B1 (el) |
| MX (1) | MX2015013776A (el) |
| MY (1) | MY184528A (el) |
| NO (1) | NO2981533T3 (el) |
| NZ (1) | NZ713410A (el) |
| PE (1) | PE20160115A1 (el) |
| PH (1) | PH12015502284B1 (el) |
| PL (1) | PL2981533T3 (el) |
| PT (1) | PT2981533T (el) |
| RS (1) | RS56942B1 (el) |
| SA (1) | SA515361260B1 (el) |
| SG (1) | SG11201508125XA (el) |
| SI (1) | SI2981533T1 (el) |
| TW (1) | TWI628176B (el) |
| UA (1) | UA115176C2 (el) |
| WO (1) | WO2014162039A1 (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP3822273B1 (en) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| TWI649318B (zh) | 2013-04-19 | 2019-02-01 | 英塞特控股公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| BR112017002268B1 (pt) | 2014-08-18 | 2022-11-08 | Eisai R&D Management Co., Ltd | Sal de derivado de piridina monocíclica e cristal do mesmo |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US10487863B2 (en) * | 2017-02-17 | 2019-11-26 | Ford Global Technologies, Llc | Castellated joint for improved adhesive coverage when using mechanical fixings and adhesive in one joint |
| UA125592C2 (uk) | 2017-03-16 | 2022-04-27 | Джянгсу Хенгруй Медісін Ко., Лтд. | ПОХІДНА ГЕТЕРОАРИЛ[4,3-c]ПІРИМІДИН-5-АМІНУ, СПОСІБ ЇЇ ОТРИМАННЯ ТА ЇЇ МЕДИЧНІ ЗАСТОСУВАННЯ |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| KR20200135945A (ko) | 2018-03-28 | 2020-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포 암종 치료제 |
| CR20200591A (es) | 2018-05-04 | 2021-03-31 | Incyte Corp | Sales de un inhibidor de fgfr |
| AU2019262195A1 (en) | 2018-05-04 | 2020-12-24 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| JP7343622B2 (ja) * | 2019-06-14 | 2023-09-12 | シージーンテック （スーチョウ， チャイナ） カンパニー リミテッド | Ｆｇｆｒとｖｅｇｆｒ二重阻害剤としての縮合環系化合物 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| AU2020320997B2 (en) * | 2019-07-26 | 2023-07-27 | Cgenetech (Suzhou, China) Co., Ltd. | Pyridine derivative as FGFR and VEGFR dual inhibitors |
| MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| KR102655210B1 (ko) * | 2021-03-26 | 2024-04-08 | 주식회사 스탠다임 | 아데노신 a2a 수용체 길항제 및 이의 용도 |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000207A1 (en) * | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| WO2001000214A1 (en) * | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| MXPA06002018A (es) * | 2003-08-21 | 2006-05-31 | Osi Pharm Inc | Bencimidazolilo n-sustituidos inhibidores de c-kit. |
| JP2010506879A (ja) * | 2006-10-16 | 2010-03-04 | ノバルティス アーゲー | プロテインキナーゼ阻害剤として有用なフェニルアセトアミド |
| AU2007337886C1 (en) * | 2006-12-22 | 2014-10-16 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
| CA2672213C (en) * | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| GB0906472D0 (en) * | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| WO2011038579A1 (en) * | 2009-09-30 | 2011-04-07 | Zhejiang Beta Pharma Inc. | Compounds and compositions as protein kinase inhibitors |
| UA111382C2 (uk) * | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
-
2014
- 2014-04-02 TW TW103112259A patent/TWI628176B/zh not_active IP Right Cessation
- 2014-04-03 LT LTEP14722686.4T patent/LT2981533T/lt unknown
- 2014-04-03 WO PCT/FI2014/000003 patent/WO2014162039A1/en active Application Filing
- 2014-04-03 SI SI201430589T patent/SI2981533T1/en unknown
- 2014-04-03 EA EA201591913A patent/EA031076B1/ru not_active IP Right Cessation
- 2014-04-03 PL PL14722686T patent/PL2981533T3/pl unknown
- 2014-04-03 PE PE2015002104A patent/PE20160115A1/es not_active Application Discontinuation
- 2014-04-03 US US14/782,020 patent/US20160031855A1/en not_active Abandoned
- 2014-04-03 MA MA38454A patent/MA38454B1/fr unknown
- 2014-04-03 KR KR1020157031629A patent/KR20150138383A/ko not_active Application Discontinuation
- 2014-04-03 BR BR112015025413A patent/BR112015025413A2/pt not_active Application Discontinuation
- 2014-04-03 DK DK14722686.4T patent/DK2981533T3/en active
- 2014-04-03 CA CA2907855A patent/CA2907855A1/en not_active Abandoned
- 2014-04-03 SG SG11201508125XA patent/SG11201508125XA/en unknown
- 2014-04-03 NZ NZ713410A patent/NZ713410A/en not_active IP Right Cessation
- 2014-04-03 NO NO14722686A patent/NO2981533T3/no unknown
- 2014-04-03 RS RS20180257A patent/RS56942B1/sr unknown
- 2014-04-03 MY MYPI2015703505A patent/MY184528A/en unknown
- 2014-04-03 JP JP2016505869A patent/JP6356782B2/ja not_active Expired - Fee Related
- 2014-04-03 CN CN201480019409.6A patent/CN105073733B/zh not_active Expired - Fee Related
- 2014-04-03 EP EP14722686.4A patent/EP2981533B1/en active Active
- 2014-04-03 HU HUE14722686A patent/HUE036692T2/hu unknown
- 2014-04-03 AU AU2014246961A patent/AU2014246961B2/en not_active Ceased
- 2014-04-03 PT PT147226864T patent/PT2981533T/pt unknown
- 2014-04-03 UA UAA201510726A patent/UA115176C2/uk unknown
- 2014-04-03 MX MX2015013776A patent/MX2015013776A/es unknown
- 2014-04-03 ES ES14722686.4T patent/ES2658183T3/es active Active
- 2014-04-04 AR ARP140101492A patent/AR095781A1/es unknown
-
2015
- 2015-10-01 PH PH12015502284A patent/PH12015502284B1/en unknown
- 2015-10-02 CL CL2015002932A patent/CL2015002932A1/es unknown
- 2015-10-04 SA SA515361260A patent/SA515361260B1/ar unknown
-
2016
- 2016-05-09 HK HK16105244.5A patent/HK1217198A1/zh not_active IP Right Cessation
-
2018
- 2018-02-21 CY CY20181100204T patent/CY1120306T1/el unknown
- 2018-03-05 HR HRP20180382TT patent/HRP20180382T1/hr unknown
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