PL407152A1 - Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie - Google Patents

Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie

Info

Publication number
PL407152A1
PL407152A1 PL407152A PL40715214A PL407152A1 PL 407152 A1 PL407152 A1 PL 407152A1 PL 407152 A PL407152 A PL 407152A PL 40715214 A PL40715214 A PL 40715214A PL 407152 A1 PL407152 A1 PL 407152A1
Authority
PL
Poland
Prior art keywords
dideoxy
derivatives
preparation
general formula
fluorouridine derivatives
Prior art date
Application number
PL407152A
Other languages
English (en)
Other versions
PL225348B1 (pl
Inventor
Lech Celewicz
Karol Kacprzak
Dagmara Baraniak
Marta Lewandowska
Piotr Ruszkowski
Original Assignee
Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Im. Adama Mickiewicza W Poznaniu filed Critical Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority to PL407152A priority Critical patent/PL225348B1/pl
Priority to EP14716996.5A priority patent/EP3105243B1/en
Priority to US14/413,560 priority patent/US9388209B2/en
Priority to PL14716996T priority patent/PL3105243T3/pl
Priority to CA2887039A priority patent/CA2887039C/en
Priority to JP2015544027A priority patent/JP5894350B2/ja
Priority to PCT/PL2014/050009 priority patent/WO2015050467A1/en
Publication of PL407152A1 publication Critical patent/PL407152A1/pl
Priority to CN201410614221.8A priority patent/CN104829670A/zh
Publication of PL225348B1 publication Critical patent/PL225348B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem wynalazku są nowe pochodne 2',3'-dideoksy-5-fluorourydyny o ogólnym wzorze 1, gdzie R1 stanowi fragment alkaloidu chinowca o zdefiniowanej konfiguracji absolutnej na atomach C-8 i C-9, a także sposób wytwarzania tych pochodnych. Wynalazek obejmuje również sole związków o wzorze ogólnym 1 i zastosowanie pochodnych 2',3'-dideoksy-5-fluorourydyny o ogólnym wzorze 1 w terapii przeciwnowotworowej raka piersi, szyjki macicy oraz wątroby.
PL407152A 2014-02-12 2014-02-12 Pochodne 2’,3’-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie PL225348B1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL407152A PL225348B1 (pl) 2014-02-12 2014-02-12 Pochodne 2’,3’-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie
EP14716996.5A EP3105243B1 (en) 2014-02-12 2014-03-04 2',3'-dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof
US14/413,560 US9388209B2 (en) 2014-02-12 2014-03-04 2′, 3′-dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof
PL14716996T PL3105243T3 (pl) 2014-02-12 2014-03-04 Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie
CA2887039A CA2887039C (en) 2014-02-12 2014-03-04 2',3'-dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof
JP2015544027A JP5894350B2 (ja) 2014-02-12 2014-03-04 ２’，３’−ジデオキシ−５−フルオロウリジン誘導体、それらの製造プロセスおよびそれらの利用
PCT/PL2014/050009 WO2015050467A1 (en) 2014-02-12 2014-03-04 2',3'-dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof
CN201410614221.8A CN104829670A (zh) 2014-02-12 2014-11-04 2’,3’-双脱氧-5-氟尿苷衍生物、其制备方法及其应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL407152A PL225348B1 (pl) 2014-02-12 2014-02-12 Pochodne 2’,3’-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie

Publications (2)

Publication Number Publication Date
PL407152A1 true PL407152A1 (pl) 2014-09-01
PL225348B1 PL225348B1 (pl) 2017-03-31

Family

ID=50478926

Family Applications (2)

Application Number Title Priority Date Filing Date
PL407152A PL225348B1 (pl) 2014-02-12 2014-02-12 Pochodne 2’,3’-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie
PL14716996T PL3105243T3 (pl) 2014-02-12 2014-03-04 Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14716996T PL3105243T3 (pl) 2014-02-12 2014-03-04 Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie

Country Status (7)

Country Link
US (1) US9388209B2 (pl)
EP (1) EP3105243B1 (pl)
JP (1) JP5894350B2 (pl)
CN (1) CN104829670A (pl)
CA (1) CA2887039C (pl)
PL (2) PL225348B1 (pl)
WO (1) WO2015050467A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN109942547B (zh) * 2019-05-06 2021-08-27 河南师范大学 具有生物活性的新型喹啉取代三氮唑类化合物及其合成方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2587647B2 (ja) * 1987-09-07 1997-03-05 大鵬薬品工業株式会社 ３′−置換トリアゾール−２′，３′−ジデオキシ−５−置換ピリミジンヌクレオシド誘導体
TWI298067B (en) 2002-01-31 2008-06-21 Daiso Co Ltd New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof
CN102617676B (zh) * 2012-02-24 2014-10-29 华中科技大学 齐多夫定喹啉共轭化合物及其制备方法和抗肝癌之应用

Also Published As

Publication number Publication date
PL225348B1 (pl) 2017-03-31
EP3105243B1 (en) 2018-02-21
US20160152655A1 (en) 2016-06-02
CA2887039A1 (en) 2015-04-09
US9388209B2 (en) 2016-07-12
CA2887039C (en) 2016-01-05
CN104829670A (zh) 2015-08-12
JP2016500100A (ja) 2016-01-07
EP3105243A1 (en) 2016-12-21
JP5894350B2 (ja) 2016-03-30
PL3105243T3 (pl) 2018-08-31
WO2015050467A1 (en) 2015-04-09

Similar Documents

Publication Publication Date Title
CY1122712T1 (el) ΧΡΗΣΗ ΠΑΡΑΓΩΓΩΝ ΠΥΡΑΖΟΛΟΠΥΡΙΜΙΔΙΝΗΣ ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΣΧΕΤΙΚΩΝ ΜΕ PI3Kδ ΔΙΑΤΑΡΑΧΩΝ
CY1122222T1 (el) Συνθεση βορονικων αλατων και χρησεις αυτων
CY1120306T1 (el) Αναστολεις πρωτεϊνικων kinασων
MX2021013118A (es) Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton.
MX2015010125A (es) Derivados de piridazinona-amidas.
PH12015502018A1 (en) 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
EA201692095A1 (ru) Имидазо[4,5-c]хинолин-2-оновые соединения и их применение в лечении рака
MY182386A (en) Pyrimidine-2,4-diamine derivatives for treatment of cancer
MX2015017201A (es) Derivados de pirazolopiridina para uso en el tratamiento del cancer de vejiga.
EA201600204A1 (ru) Производные хиназолина, фармацевтическая композиция на их основе и их применение для профилактики или лечения опухоли
EA201790085A1 (ru) Ингибиторы лизин-специфической деметилазы-1
MX2015014298A (es) Compuestos de dihidropirido pirimidina como inhibidores de autotaxina.
MD4643B1 (ro) Noi compuşi de indolizină, procedeu de obţinere a lor şi compoziţii farmaceutice care le conţin
PH12016502394A1 (en) 1, 3, 4-thiadiazole compounds and their use in treating cancer
MX2019010875A (es) Derivados de uncialamicina, metodos de sintesis y su uso como agentes antitumor.
EA201600434A1 (ru) Применение производных бензимидазолпролина
MD20170011A2 (ro) Compuşi imidazopiridazinici
CR20150245A (es) Proceso novedoso para la elaboración de compuestos para uso en el tratamiento de cáncer
MX2016009663A (es) Derivados de icariina.
EA201790603A1 (ru) Ингибиторы гистондеметилазы
EA201691385A1 (ru) Комбинированная терапия рака
TN2015000542A1 (en) Novel compounds for the treatment of cancer
MX359069B (es) Sal y formas cristalinas de inhibidor de quinasa tipo polo-4.
PL407153A1 (pl) Pochodne 2',5'-dideoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób ich wytwarzania i zastosowanie
PL407152A1 (pl) Pochodne 2',3'-dideoksy-5-fluorourydyny, sposób ich wytwarzania i zastosowanie