SI2683384T1 - Metode zdravljenja raka z uporabo 3-(5-amino-2-metil-4-okso-4H-kinazolin-3-il)-piperidin-2,6-diona - Google Patents

Metode zdravljenja raka z uporabo 3-(5-amino-2-metil-4-okso-4H-kinazolin-3-il)-piperidin-2,6-diona

Info

Publication number
SI2683384T1
SI2683384T1 SI201230451A SI201230451A SI2683384T1 SI 2683384 T1 SI2683384 T1 SI 2683384T1 SI 201230451 A SI201230451 A SI 201230451A SI 201230451 A SI201230451 A SI 201230451A SI 2683384 T1 SI2683384 T1 SI 2683384T1
Authority
SI
Slovenia
Prior art keywords
quinazolin
dione
piperidine
oxo
amino
Prior art date
Application number
SI201230451A
Other languages
English (en)
Inventor
George W. Muller
Peter H. Schafer
Hon-Wah Man
Ling-Hua Zhang
Anita Gandhi
Rajesh Chopra
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of SI2683384T1 publication Critical patent/SI2683384T1/sl

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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SI201230451A 2011-03-11 2012-03-09 Metode zdravljenja raka z uporabo 3-(5-amino-2-metil-4-okso-4H-kinazolin-3-il)-piperidin-2,6-diona SI2683384T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161451995P 2011-03-11 2011-03-11
US201161480272P 2011-04-28 2011-04-28
PCT/US2012/028498 WO2012125459A1 (en) 2011-03-11 2012-03-09 Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
EP12710836.3A EP2683384B1 (en) 2011-03-11 2012-03-09 Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione

Publications (1)

Publication Number Publication Date
SI2683384T1 true SI2683384T1 (sl) 2016-05-31

Family

ID=45876915

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201230451A SI2683384T1 (sl) 2011-03-11 2012-03-09 Metode zdravljenja raka z uporabo 3-(5-amino-2-metil-4-okso-4H-kinazolin-3-il)-piperidin-2,6-diona

Country Status (29)

Country Link
US (6) US20140148473A1 (sl)
EP (3) EP2683383B1 (sl)
JP (5) JP2014510078A (sl)
KR (2) KR20140019364A (sl)
CN (3) CN107375293A (sl)
AR (1) AR085651A1 (sl)
AU (4) AU2012229300B2 (sl)
BR (2) BR112013023280A2 (sl)
CA (2) CA2829592A1 (sl)
CY (1) CY1117430T1 (sl)
DK (1) DK2683384T3 (sl)
EA (2) EA201391319A1 (sl)
ES (2) ES2659205T3 (sl)
HK (1) HK1191858A1 (sl)
HR (1) HRP20160056T1 (sl)
HU (1) HUE027481T2 (sl)
IL (2) IL227990B (sl)
MX (2) MX2013010153A (sl)
NI (2) NI201300082A (sl)
PL (1) PL2683384T3 (sl)
PT (1) PT2683384E (sl)
RS (1) RS54553B1 (sl)
RU (3) RU2013145556A (sl)
SG (2) SG192947A1 (sl)
SI (1) SI2683384T1 (sl)
SM (1) SMT201600034B (sl)
TW (2) TW201700100A (sl)
WO (2) WO2012125475A1 (sl)
ZA (2) ZA201306148B (sl)

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AU2012236655B2 (en) 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
JP6016892B2 (ja) * 2011-04-29 2016-10-26 セルジーン コーポレイション セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法
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BR112015005243A2 (pt) * 2012-09-10 2017-07-04 Celgene Corp métodos para o tratamento de câncer de mama localmente avançado
CA2935495C (en) * 2013-01-14 2021-04-20 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
EP2968334A4 (en) 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
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CN105392499B (zh) * 2013-04-17 2018-07-24 西格诺药品有限公司 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法
SI2991976T1 (sl) * 2013-05-01 2017-11-30 Celgene Corporation Sintheza 3-(5-amino-2-metil-4-oksokvinazolin-3(4H)-il)piperidin-2,6- diona
TW201534305A (zh) * 2013-05-03 2015-09-16 Celgene Corp 使用組合療法治療癌症之方法
WO2015077058A2 (en) 2013-11-08 2015-05-28 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias
EA201691144A1 (ru) * 2013-12-06 2016-11-30 Селджин Корпорейшн Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка
AR099385A1 (es) * 2014-01-15 2016-07-20 Celgene Corp Formulaciones de 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidina-2,6-diona
ES2843973T3 (es) 2014-06-27 2021-07-21 Celgene Corp Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
CN107073122A (zh) * 2014-07-11 2017-08-18 细胞基因公司 恶性肿瘤的联合治疗
HUE061382T2 (hu) 2014-08-22 2023-06-28 Celgene Corp Eljárás myeloma multiplex kezelésére immunomoduláló vegyületekkel, antestekkel kombinálva
MX2017005163A (es) 2014-11-17 2018-01-18 Arno Therapeutics Inc Composiciones de liberación prolongada de onapristona y métodos.
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