PT2621526T - Conjugados de anticorpo com fármaco (adc) que se ligam a proteínas 191pad12 - Google Patents

Conjugados de anticorpo com fármaco (adc) que se ligam a proteínas 191pad12

Info

Publication number
PT2621526T
PT2621526T PT118313451T PT11831345T PT2621526T PT 2621526 T PT2621526 T PT 2621526T PT 118313451 T PT118313451 T PT 118313451T PT 11831345 T PT11831345 T PT 11831345T PT 2621526 T PT2621526 T PT 2621526T
Authority
PT
Portugal
Prior art keywords
191pad12
conjugates
adc
bind
antibody
Prior art date
Application number
PT118313451T
Other languages
English (en)
Portuguese (pt)
Inventor
Satpaev Daulet
Kendall Morrison Robert
Jane Meyrick Morrison Karen
Gudas Jean
Jakobovits Aya
Torgov Michael
An Zili
Original Assignee
Seattle Genetics Inc
Agensys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2621526(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Genetics Inc, Agensys Inc filed Critical Seattle Genetics Inc
Publication of PT2621526T publication Critical patent/PT2621526T/pt

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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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