PT2139986T - Utilização de temperatura baixa e/ou ph baixo em cultura de células - Google Patents
Utilização de temperatura baixa e/ou ph baixo em cultura de célulasInfo
- Publication number
- PT2139986T PT2139986T PT87465266T PT08746526T PT2139986T PT 2139986 T PT2139986 T PT 2139986T PT 87465266 T PT87465266 T PT 87465266T PT 08746526 T PT08746526 T PT 08746526T PT 2139986 T PT2139986 T PT 2139986T
- Authority
- PT
- Portugal
- Prior art keywords
- low
- cell culture
- low temperature
- temperature
- culture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91338207P | 2007-04-23 | 2007-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2139986T true PT2139986T (pt) | 2017-11-14 |
Family
ID=39493848
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87465266T PT2139986T (pt) | 2007-04-23 | 2008-04-22 | Utilização de temperatura baixa e/ou ph baixo em cultura de células |
PT87465282T PT2139987E (pt) | 2007-04-23 | 2008-04-22 | Métodos para a produção de proteína usando compostos antisenescência |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87465282T PT2139987E (pt) | 2007-04-23 | 2008-04-22 | Métodos para a produção de proteína usando compostos antisenescência |
Country Status (26)
Country | Link |
---|---|
US (2) | US20080274507A1 (pt) |
EP (2) | EP2139986B1 (pt) |
JP (3) | JP5557736B2 (pt) |
KR (3) | KR101560421B1 (pt) |
CN (3) | CN101679943A (pt) |
AR (2) | AR066238A1 (pt) |
AU (2) | AU2008242632B2 (pt) |
BR (2) | BRPI0810511A2 (pt) |
CA (2) | CA2684727C (pt) |
CL (2) | CL2008001156A1 (pt) |
CO (2) | CO6241165A2 (pt) |
DK (2) | DK2139986T3 (pt) |
ES (2) | ES2424217T3 (pt) |
HK (2) | HK1142095A1 (pt) |
HU (1) | HUE034776T2 (pt) |
IL (2) | IL201720A (pt) |
MX (2) | MX2009011363A (pt) |
PA (2) | PA8777701A1 (pt) |
PE (2) | PE20090731A1 (pt) |
PL (2) | PL2139986T3 (pt) |
PT (2) | PT2139986T (pt) |
RU (2) | RU2009138226A (pt) |
SI (2) | SI2139987T1 (pt) |
TW (2) | TW200902708A (pt) |
WO (2) | WO2008131374A1 (pt) |
ZA (1) | ZA200907426B (pt) |
Families Citing this family (48)
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EP2527425A1 (en) | 2006-09-13 | 2012-11-28 | Abbott Laboratories | Cell culture improvements |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
ES2541454T3 (es) | 2007-03-02 | 2015-07-20 | Wyeth Llc | Uso de cobre y glutamato en cultivos celulares para producción de polipéptidos |
ES2657055T3 (es) * | 2007-08-09 | 2018-03-01 | Wyeth Llc | Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores |
WO2010034015A2 (en) | 2008-09-22 | 2010-03-25 | The Regents Of The University Of Colorado, A Body Corporate | Modulating the alternative complement pathway |
AU2009307737B2 (en) | 2008-10-20 | 2015-07-23 | Abbvie Inc. | Viral inactivation during purification of antibodies |
SG10201702922VA (en) * | 2008-10-20 | 2017-06-29 | Abbvie Inc | Isolation and purification of antibodies using protein a affinity chromatography |
RU2012127383A (ru) * | 2009-12-02 | 2014-01-10 | Акселерон Фарма Инк. | Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке |
EP3330370B1 (en) | 2010-04-26 | 2021-02-24 | Novartis AG | Process for cultivation of cho cells |
SG191371A1 (en) | 2010-12-28 | 2013-08-30 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
KR20150043523A (ko) | 2012-09-02 | 2015-04-22 | 애브비 인코포레이티드 | 단백질 불균일성의 제어 방법 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
PL2970875T3 (pl) | 2013-03-15 | 2020-08-10 | F.Hoffmann-La Roche Ag | Kompozycje do hodowli komórkowych z przeciwutleniaczami i sposoby wytwarzania polipeptydów |
WO2014160790A1 (en) | 2013-03-26 | 2014-10-02 | Coherus Biosciences, Inc. | Protein production method |
WO2014182658A1 (en) * | 2013-05-06 | 2014-11-13 | Abbvie Inc. | Compositions for cell culture and methods of using the same |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
USD759075S1 (en) * | 2014-04-11 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
USD759076S1 (en) * | 2014-04-18 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
WO2016061065A1 (en) | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of shifting an isoelectric profile of a protein product and uses thereof |
AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
WO2017065559A1 (ko) * | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
KR101936049B1 (ko) * | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
CN107460221B (zh) * | 2016-06-02 | 2021-01-15 | 正大天晴药业集团股份有限公司 | 一种降低抗pd-l1抗体中蛋白聚合物的细胞培养方法 |
EP3529350A1 (en) | 2016-10-19 | 2019-08-28 | H. Hoffnabb-La Roche Ag | Method for producing an immunoconjugate |
KR20190117624A (ko) * | 2017-02-17 | 2019-10-16 | 론자 리미티드 | 생물학적 생성물 변이체의 생산 방법 |
JP2020536497A (ja) * | 2017-10-16 | 2020-12-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 細胞培養におけるプロセス変量を制御するためのインサイチュラマン分光システム及び方法 |
CA3118398A1 (en) * | 2018-11-02 | 2020-05-07 | WuXi Biologics Ireland Limited | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
WO2020180967A1 (en) * | 2019-03-04 | 2020-09-10 | Amgen Inc. | In vivo reversibility of high molecular weight species |
CN115884793A (zh) | 2020-01-09 | 2023-03-31 | 梅尔莎纳医疗公司 | 具有含肽接头的位点特异性抗体-药物缀合物 |
WO2022254319A1 (en) * | 2021-06-01 | 2022-12-08 | Pfizer Inc. | Cell culture method for producing sfgfr3 polypeptide |
KR102682066B1 (ko) * | 2021-10-12 | 2024-07-05 | 프레스티지바이오로직스 주식회사 | 항체 집단의 제조 방법 |
CN118006716A (zh) * | 2024-03-15 | 2024-05-10 | 通化安睿特生物制药股份有限公司 | 制备高表达且低o-糖基化水平的重组人白蛋白的方法 |
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ES2657055T3 (es) | 2007-08-09 | 2018-03-01 | Wyeth Llc | Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores |
-
2008
- 2008-04-10 TW TW097112974A patent/TW200902708A/zh unknown
- 2008-04-21 PE PE2008000686A patent/PE20090731A1/es not_active Application Discontinuation
- 2008-04-22 CN CN200880013275A patent/CN101679943A/zh active Pending
- 2008-04-22 TW TW097114607A patent/TW200902709A/zh unknown
- 2008-04-22 EP EP08746526.6A patent/EP2139986B1/en not_active Revoked
- 2008-04-22 CL CL2008001156A patent/CL2008001156A1/es unknown
- 2008-04-22 KR KR1020097024259A patent/KR101560421B1/ko active IP Right Grant
- 2008-04-22 BR BRPI0810511-1A2A patent/BRPI0810511A2/pt not_active Application Discontinuation
- 2008-04-22 JP JP2010506424A patent/JP5557736B2/ja active Active
- 2008-04-22 PL PL08746526T patent/PL2139986T3/pl unknown
- 2008-04-22 WO PCT/US2008/061123 patent/WO2008131374A1/en active Application Filing
- 2008-04-22 SI SI200830998T patent/SI2139987T1/sl unknown
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