DK2139987T3 - Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelser - Google Patents
Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelserInfo
- Publication number
- DK2139987T3 DK2139987T3 DK08746528.2T DK08746528T DK2139987T3 DK 2139987 T3 DK2139987 T3 DK 2139987T3 DK 08746528 T DK08746528 T DK 08746528T DK 2139987 T3 DK2139987 T3 DK 2139987T3
- Authority
- DK
- Denmark
- Prior art keywords
- senescen
- relations
- procedures
- protein preparation
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91338207P | 2007-04-23 | 2007-04-23 | |
PCT/US2008/061125 WO2008131375A1 (en) | 2007-04-23 | 2008-04-22 | Methods of protein production using anti-senescence compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DK2139987T3 true DK2139987T3 (da) | 2013-09-02 |
DK2139987T5 DK2139987T5 (da) | 2014-01-27 |
Family
ID=39493848
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08746526.6T DK2139986T3 (da) | 2007-04-23 | 2008-04-22 | Anvendelse af lav temperatur og/eller lav pH-værdi i cellekultur |
DK08746528.2T DK2139987T5 (da) | 2007-04-23 | 2008-04-22 | Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08746526.6T DK2139986T3 (da) | 2007-04-23 | 2008-04-22 | Anvendelse af lav temperatur og/eller lav pH-værdi i cellekultur |
Country Status (26)
Country | Link |
---|---|
US (2) | US12054762B2 (da) |
EP (2) | EP2139986B1 (da) |
JP (3) | JP5557736B2 (da) |
KR (3) | KR101560421B1 (da) |
CN (3) | CN101679943A (da) |
AR (2) | AR066238A1 (da) |
AU (2) | AU2008242632B2 (da) |
BR (2) | BRPI0810482A2 (da) |
CA (2) | CA2685552C (da) |
CL (2) | CL2008001159A1 (da) |
CO (2) | CO6241165A2 (da) |
DK (2) | DK2139986T3 (da) |
ES (2) | ES2646090T3 (da) |
HK (2) | HK1142095A1 (da) |
HU (1) | HUE034776T2 (da) |
IL (2) | IL201719A (da) |
MX (2) | MX2009011363A (da) |
PA (2) | PA8777701A1 (da) |
PE (2) | PE20090731A1 (da) |
PL (2) | PL2139987T3 (da) |
PT (2) | PT2139986T (da) |
RU (2) | RU2478702C2 (da) |
SI (2) | SI2139987T1 (da) |
TW (2) | TW200902708A (da) |
WO (2) | WO2008131375A1 (da) |
ZA (1) | ZA200907426B (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2910619A1 (en) | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
JP5586235B2 (ja) | 2007-03-02 | 2014-09-10 | ワイス・エルエルシー | ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用 |
EP2188371B1 (en) | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
WO2010034015A2 (en) | 2008-09-22 | 2010-03-25 | The Regents Of The University Of Colorado, A Body Corporate | Modulating the alternative complement pathway |
NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
NZ592095A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography |
KR20140015152A (ko) * | 2009-12-02 | 2014-02-06 | 악셀레론 파마 인코포레이티드 | Fc 융합 단백질의 혈청 반감기를 증가시키는 조성물들 및 방법들 |
SG185014A1 (en) | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell cultivation process |
WO2012091124A1 (ja) * | 2010-12-28 | 2012-07-05 | 中外製薬株式会社 | 動物細胞の培養方法 |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
EP2970875B1 (en) | 2013-03-15 | 2020-04-15 | F.Hoffmann-La Roche Ag | Cell culture compositions with antioxidants and methods for polypeptide production |
EP2978498B1 (en) | 2013-03-26 | 2019-07-03 | Coherus Biosciences, Inc. | Protein production method |
US9416181B2 (en) | 2013-05-06 | 2016-08-16 | Abbvie Inc. | Compositions for cell culture and methods of using the same |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
USD759075S1 (en) * | 2014-04-11 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
USD759076S1 (en) * | 2014-04-18 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
JP6948942B2 (ja) * | 2014-10-15 | 2021-10-13 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | タンパク質産物の等電性プロファイルをシフトさせる方法およびその使用 |
AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
WO2017065559A1 (ko) * | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
KR101936049B1 (ko) * | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
CN107460221B (zh) * | 2016-06-02 | 2021-01-15 | 正大天晴药业集团股份有限公司 | 一种降低抗pd-l1抗体中蛋白聚合物的细胞培养方法 |
EP3529350A1 (en) | 2016-10-19 | 2019-08-28 | H. Hoffnabb-La Roche Ag | Method for producing an immunoconjugate |
KR102701102B1 (ko) * | 2017-02-17 | 2024-08-29 | 론자 리미티드 | 생물학적 생성물 변이체의 생산 방법 |
JP2020536497A (ja) * | 2017-10-16 | 2020-12-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 細胞培養におけるプロセス変量を制御するためのインサイチュラマン分光システム及び方法 |
KR102597919B1 (ko) * | 2018-11-02 | 2023-11-06 | 우시 바이올로직스 아일랜드 리미티드 | 지속적으로 수확하고 세포 출혈없는 강화된 관류에 의한 세포 배양 과정 |
MX2021010414A (es) * | 2019-03-04 | 2021-09-14 | Amgen Inc | Reversibilidad in vivo de especies de alto peso molecular. |
TW202140075A (zh) | 2020-01-09 | 2021-11-01 | 美商梅爾莎納醫療公司 | 具有含肽之連接子的位置特異性抗體-藥物共軛體 |
JP2022184798A (ja) * | 2021-06-01 | 2022-12-13 | ファイザー・インク | sFGFR3ポリペプチドを生産するための細胞培養方法 |
KR102682066B1 (ko) * | 2021-10-12 | 2024-07-05 | 프레스티지바이오로직스 주식회사 | 항체 집단의 제조 방법 |
WO2024163242A1 (en) * | 2023-02-03 | 2024-08-08 | Amgen Inc. | Cell culture methods |
CN118166053A (zh) * | 2024-03-15 | 2024-06-11 | 通化安睿特生物制药股份有限公司 | 一种制备低o-糖基化水平的重组人白蛋白的方法 |
CN118006716B (zh) * | 2024-03-15 | 2024-09-10 | 通化安睿特生物制药股份有限公司 | 制备高表达且低o-糖基化水平的重组人白蛋白的方法 |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
DE768377T1 (de) | 1988-09-02 | 1998-01-02 | Dyax Corp | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
JPH0396383A (ja) | 1989-09-08 | 1991-04-22 | Riso Kagaku Corp | 画像形成装置 |
DE59010908D1 (de) * | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5610033A (en) | 1990-04-25 | 1997-03-11 | Novo Nordisk A/S | Method of producing proteins with FVIII activity and/or FVIII derivatives |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
EP0571390B1 (en) | 1990-11-23 | 2000-03-08 | Peptech Limited | The delay, prevention and/or reversal of cell senescence |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
JP4146512B2 (ja) | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | 小型タンパク質 |
PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
EP1400536A1 (en) * | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
DK0656946T4 (da) | 1992-08-21 | 2010-07-26 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
SG47030A1 (en) | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
US5516964A (en) | 1994-01-21 | 1996-05-14 | Sun Company, Inc. (R&M) | Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal |
EP1978033A3 (en) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US5830761A (en) * | 1995-06-07 | 1998-11-03 | Genetics Institute, Inc. | Medium and methods for culturing mammalian cho cells |
JP4436457B2 (ja) * | 1995-08-18 | 2010-03-24 | モルフォシス アイピー ゲーエムベーハー | 蛋白質/(ポリ)ペプチドライブラリー |
JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
US5710023A (en) | 1996-03-01 | 1998-01-20 | Genetics Institute, Inc. | IL-13 cytokine receptor chain |
US6146847A (en) | 1996-11-01 | 2000-11-14 | Genespan Corporation | Stabilized transient gene expression |
ATE549918T1 (de) * | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
AU736549B2 (en) | 1997-05-21 | 2001-08-02 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method for the production of non-immunogenic proteins |
AU2113199A (en) | 1998-01-12 | 1999-07-26 | Betagene, Inc. | Media for neuroendocrine cells |
DE69934967T2 (de) | 1998-12-08 | 2007-12-06 | Biovation Ltd. | Verfahren zur verminderung der immunogenität von proteinen |
TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
US7294481B1 (en) | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
CN101033467A (zh) | 1999-04-30 | 2007-09-12 | 希龙公司 | 奈瑟球菌基因组序列及其用法 |
JP3090657B1 (ja) | 1999-08-09 | 2000-09-25 | 伸子 蓮山 | ゼオライト製造方法およびゼオライト製造装置 |
EP1103615A1 (en) | 1999-11-25 | 2001-05-30 | Universite De Geneve | Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors |
AUPR038200A0 (en) * | 2000-09-26 | 2000-10-19 | Beta Peptide Foundation Pty Ltd, The | Compositions and methods for delaying, preventing, rejuvenating or reversing senescence |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030040095A1 (en) * | 2001-03-16 | 2003-02-27 | Achille Arini | Method for the production of pharmaceutically active recombinant proteins |
US20040058445A1 (en) | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
US6544076B2 (en) | 2001-07-10 | 2003-04-08 | Alan L. Pocrass | Dual function RJ connector |
ATE464390T1 (de) * | 2001-11-19 | 2010-04-15 | Novo Nordisk As | Verfahren zur herstellung von insulinverbindungen |
CA2417689C (en) | 2002-03-05 | 2006-05-09 | F. Hoffmann-La Roche Ag | Improved methods for growing mammalian cells in vitro |
WO2003083066A2 (en) * | 2002-03-27 | 2003-10-09 | Immunex Corporation | Methods for increasing polypeptide production |
GB0208041D0 (en) | 2002-04-08 | 2002-05-22 | Lonza Biologics Plc | Method of culturing animal cells |
DK1520008T3 (da) | 2002-07-09 | 2012-10-15 | Baxter Int | Medium frit for dyreprotein til dyrkning af celler |
PT1543106E (pt) | 2002-07-15 | 2007-05-31 | Immunex Corp | Métodos e meios para controlar a sialilação de proteínas produzidas por células de mamíferos |
US6924124B1 (en) | 2002-08-23 | 2005-08-02 | Immunex Corporation | Feeding strategies for cell culture |
US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
WO2004058800A2 (en) | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
JP2007525176A (ja) | 2003-04-25 | 2007-09-06 | イミュネックス・コーポレーション | 組換えタンパク質発現の誘導剤 |
CN1565631A (zh) * | 2003-06-27 | 2005-01-19 | 上海中信国健药业有限公司 | 肿瘤坏死因子受体-免疫球蛋白的融合蛋白用于急性肺损伤药物的用途 |
EP1678208B1 (en) | 2003-10-27 | 2013-05-15 | Wyeth LLC | Removal of high molecular weight aggregates using hydroxyapatite chromatography |
WO2005064013A1 (en) | 2003-12-23 | 2005-07-14 | Bart Janssen | The use of carnosine metabolism-associated genes to determine genetic predisposition/susceptibility to diabetic nephropathy |
DK1765427T3 (da) * | 2004-07-07 | 2010-08-23 | Coloplast As | Fremstilling af hydrofile belægninger ved anvendelse af en 1,3-dioxolansammensætning |
CN101014619B (zh) | 2004-07-15 | 2010-11-03 | 赞科股份有限公司 | 优化的Fc变体 |
WO2005021578A2 (en) | 2004-08-25 | 2005-03-10 | Amprotein Corporation | A novel chimeric polypeptide and use thereof |
US7335491B2 (en) * | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
US7426440B2 (en) * | 2004-09-24 | 2008-09-16 | Nutritional Bioscience Ltd. | Repair and protection factor scoring method for bioactive agents |
US20070102622A1 (en) | 2005-07-01 | 2007-05-10 | Olsen Richard I | Apparatus for multiple camera devices and method of operating same |
WO2007011595A2 (en) | 2005-07-15 | 2007-01-25 | Neuren Pharmaceuticals Limited | Neural regeneration peptides and antioxidants protect neurons from degeneration |
DE102005034616B4 (de) * | 2005-07-18 | 2008-07-03 | Elringklinger Ag | Brennstoffzelleneinheit und Brennstoffzellenstapel |
AR058140A1 (es) * | 2005-10-24 | 2008-01-23 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
PL2495307T3 (pl) * | 2006-07-13 | 2018-07-31 | Wyeth Llc | Wytwarzanie czynnika krzepliwości krwi IX o polepszonym wzorze glikozylacji |
JP5586235B2 (ja) | 2007-03-02 | 2014-09-10 | ワイス・エルエルシー | ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用 |
EP2188371B1 (en) | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
JP2023544949A (ja) | 2021-09-15 | 2023-10-26 | 寧徳時代新能源科技股▲分▼有限公司 | 電池セル、電池、電力消費装置、電池セルの製造方法及び設備 |
-
2008
- 2008-04-10 TW TW097112974A patent/TW200902708A/zh unknown
- 2008-04-21 PE PE2008000686A patent/PE20090731A1/es not_active Application Discontinuation
- 2008-04-22 CN CN200880013275A patent/CN101679943A/zh active Pending
- 2008-04-22 CN CN200880013317.1A patent/CN101668845B/zh active Active
- 2008-04-22 SI SI200830998T patent/SI2139987T1/sl unknown
- 2008-04-22 AR ARP080101677A patent/AR066238A1/es unknown
- 2008-04-22 JP JP2010506424A patent/JP5557736B2/ja active Active
- 2008-04-22 MX MX2009011363A patent/MX2009011363A/es active IP Right Grant
- 2008-04-22 HU HUE08746526A patent/HUE034776T2/en unknown
- 2008-04-22 AU AU2008242632A patent/AU2008242632B2/en active Active
- 2008-04-22 CA CA2685552A patent/CA2685552C/en not_active Expired - Fee Related
- 2008-04-22 EP EP08746526.6A patent/EP2139986B1/en not_active Revoked
- 2008-04-22 WO PCT/US2008/061125 patent/WO2008131375A1/en active Application Filing
- 2008-04-22 PL PL08746528T patent/PL2139987T3/pl unknown
- 2008-04-22 PT PT87465266T patent/PT2139986T/pt unknown
- 2008-04-22 DK DK08746526.6T patent/DK2139986T3/da active
- 2008-04-22 ES ES08746526.6T patent/ES2646090T3/es active Active
- 2008-04-22 KR KR1020097024259A patent/KR101560421B1/ko active IP Right Grant
- 2008-04-22 CL CL2008001159A patent/CL2008001159A1/es unknown
- 2008-04-22 KR KR20147030274A patent/KR20140132016A/ko not_active Application Discontinuation
- 2008-04-22 WO PCT/US2008/061123 patent/WO2008131374A1/en active Application Filing
- 2008-04-22 CN CN201510351048.1A patent/CN105039473A/zh active Pending
- 2008-04-22 RU RU2009139054/10A patent/RU2478702C2/ru active
- 2008-04-22 US US12/107,533 patent/US12054762B2/en active Active
- 2008-04-22 BR BRPI0810482-4A2A patent/BRPI0810482A2/pt not_active Application Discontinuation
- 2008-04-22 EP EP08746528.2A patent/EP2139987B9/en active Active
- 2008-04-22 MX MX2009011362A patent/MX2009011362A/es active IP Right Grant
- 2008-04-22 US US12/107,264 patent/US9988662B2/en active Active
- 2008-04-22 PL PL08746526T patent/PL2139986T3/pl unknown
- 2008-04-22 CL CL2008001156A patent/CL2008001156A1/es unknown
- 2008-04-22 RU RU2009138226/10A patent/RU2009138226A/ru not_active Application Discontinuation
- 2008-04-22 CA CA2684727A patent/CA2684727C/en active Active
- 2008-04-22 PE PE2008000691A patent/PE20090153A1/es not_active Application Discontinuation
- 2008-04-22 DK DK08746528.2T patent/DK2139987T5/da active
- 2008-04-22 BR BRPI0810511-1A2A patent/BRPI0810511A2/pt not_active Application Discontinuation
- 2008-04-22 ES ES08746528T patent/ES2424217T3/es active Active
- 2008-04-22 AU AU2008242633A patent/AU2008242633B2/en active Active
- 2008-04-22 SI SI200831866T patent/SI2139986T1/sl unknown
- 2008-04-22 PA PA20088777701A patent/PA8777701A1/es unknown
- 2008-04-22 KR KR1020097023172A patent/KR101540124B1/ko active IP Right Grant
- 2008-04-22 TW TW097114607A patent/TW200902709A/zh unknown
- 2008-04-22 JP JP2010506425A patent/JP2010524504A/ja active Pending
- 2008-04-22 PT PT87465282T patent/PT2139987E/pt unknown
- 2008-04-22 AR ARP080101678A patent/AR066239A1/es unknown
- 2008-04-23 PA PA20088778001A patent/PA8778001A1/es unknown
-
2009
- 2009-10-21 CO CO09117978A patent/CO6241165A2/es not_active Application Discontinuation
- 2009-10-22 CO CO09118627A patent/CO6241166A2/es not_active Application Discontinuation
- 2009-10-22 IL IL201719A patent/IL201719A/en active IP Right Grant
- 2009-10-22 ZA ZA200907426A patent/ZA200907426B/xx unknown
- 2009-10-22 IL IL201720A patent/IL201720A/en active IP Right Grant
-
2010
- 2010-09-08 HK HK10108504.0A patent/HK1142095A1/zh unknown
-
2014
- 2014-01-31 JP JP2014016511A patent/JP5881755B2/ja active Active
-
2016
- 2016-04-13 HK HK16104245.7A patent/HK1216261A1/zh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2139987T5 (da) | Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelser | |
DK3118220T3 (da) | Protein | |
DK3067064T3 (da) | Modificerede rsv-f-proteiner og fremgangsmåder til anvendelse deraf | |
DK2207428T3 (da) | Fremgangsmåde til at fremstille laktosefri mælk | |
DK2231565T3 (da) | Fremgangsmåder til fremstilling af clorerede carbonhydrider | |
DK2046819T3 (da) | Fremgangsmåder til forøgelse af secernering af polypeptider med biologisk aktivitet | |
DK2046826T3 (da) | Exendin-fusionsproteiner | |
BRPI0814971A2 (pt) | Proteína | |
BRPI0807453A2 (pt) | Preparação sólida | |
BRPI0910668A2 (pt) | inibidores de proteína quinases | |
BRPI0812350A2 (pt) | Conexão | |
DK2125048T3 (da) | Præparat | |
DK2837348T3 (da) | Kryokirurgiske fremgangsmåder | |
BRPI0814876A2 (pt) | Análogos de pirona fosforilados e métodos | |
NO20060919L (no) | Boyle til barnestol | |
NO2022038I1 (no) | ropeginterferon alfa-2b | |
BRPI0913429A2 (pt) | isolado de proteína de canola | |
DK1927646T3 (da) | Odoriseringsmiddel med forbedret stabilitet | |
DK2276850T3 (da) | Irx-2-modificeret fremstillingsfremgangsmåde | |
DE502007002482D1 (de) | Injektor | |
FI20075156A0 (fi) | Venttiili | |
FR2924101B1 (fr) | Valve amelioree | |
NO20081658L (no) | Festeanordning for stol | |
ES1065138Y (es) | Chancla desechable | |
DK2219663T3 (da) | Revers-protein |