PL2139986T3 - ZASTOSOWANIE NISKIEJ TEMPERATURY I/LUB NISKIEGO pH W HODOWLI KOMÓRKOWEJ - Google Patents

ZASTOSOWANIE NISKIEJ TEMPERATURY I/LUB NISKIEGO pH W HODOWLI KOMÓRKOWEJ

Info

Publication number
PL2139986T3
PL2139986T3 PL08746526T PL08746526T PL2139986T3 PL 2139986 T3 PL2139986 T3 PL 2139986T3 PL 08746526 T PL08746526 T PL 08746526T PL 08746526 T PL08746526 T PL 08746526T PL 2139986 T3 PL2139986 T3 PL 2139986T3
Authority
PL
Poland
Prior art keywords
low
cell culture
low temperature
temperature
culture
Prior art date
Application number
PL08746526T
Other languages
English (en)
Inventor
Jose Manuel Gomes
Gregory Walter Hiller
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39493848&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2139986(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of PL2139986T3 publication Critical patent/PL2139986T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL08746526T 2007-04-23 2008-04-22 ZASTOSOWANIE NISKIEJ TEMPERATURY I/LUB NISKIEGO pH W HODOWLI KOMÓRKOWEJ PL2139986T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91338207P 2007-04-23 2007-04-23
PCT/US2008/061123 WO2008131374A1 (en) 2007-04-23 2008-04-22 Use of low temperature and/or low ph in cell culture
EP08746526.6A EP2139986B1 (en) 2007-04-23 2008-04-22 Use of low temperature and/or low ph in cell culture

Publications (1)

Publication Number Publication Date
PL2139986T3 true PL2139986T3 (pl) 2018-01-31

Family

ID=39493848

Family Applications (2)

Application Number Title Priority Date Filing Date
PL08746528T PL2139987T3 (pl) 2007-04-23 2008-04-22 Sposoby wytwarzania białek z zastosowaniem związków przeciw starzeniu
PL08746526T PL2139986T3 (pl) 2007-04-23 2008-04-22 ZASTOSOWANIE NISKIEJ TEMPERATURY I/LUB NISKIEGO pH W HODOWLI KOMÓRKOWEJ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL08746528T PL2139987T3 (pl) 2007-04-23 2008-04-22 Sposoby wytwarzania białek z zastosowaniem związków przeciw starzeniu

Country Status (26)

Country Link
US (2) US9988662B2 (pl)
EP (2) EP2139986B1 (pl)
JP (3) JP5557736B2 (pl)
KR (3) KR101560421B1 (pl)
CN (3) CN105039473A (pl)
AR (2) AR066239A1 (pl)
AU (2) AU2008242632B2 (pl)
BR (2) BRPI0810511A2 (pl)
CA (2) CA2684727C (pl)
CL (2) CL2008001156A1 (pl)
CO (2) CO6241165A2 (pl)
DK (2) DK2139987T5 (pl)
ES (2) ES2424217T3 (pl)
HK (1) HK1216261A1 (pl)
HU (1) HUE034776T2 (pl)
IL (2) IL201720A (pl)
MX (2) MX2009011362A (pl)
PA (2) PA8777701A1 (pl)
PE (2) PE20090731A1 (pl)
PL (2) PL2139987T3 (pl)
PT (2) PT2139987E (pl)
RU (2) RU2478702C2 (pl)
SI (2) SI2139987T1 (pl)
TW (2) TW200902708A (pl)
WO (2) WO2008131374A1 (pl)
ZA (1) ZA200907426B (pl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
CA2842964A1 (en) 2006-09-13 2008-03-20 Abbvie Inc. Cell culture improvements
US9012180B2 (en) 2007-03-02 2015-04-21 Wyeth Llc Use of copper and glutamate in cell culture for production of polypeptides
EP2188371B1 (en) 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2010034015A2 (en) 2008-09-22 2010-03-25 The Regents Of The University Of Colorado, A Body Corporate Modulating the alternative complement pathway
NZ592095A (en) 2008-10-20 2013-01-25 Abbott Lab Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
AU2009307737B2 (en) 2008-10-20 2015-07-23 Abbvie Inc. Viral inactivation during purification of antibodies
JP2013512674A (ja) * 2009-12-02 2013-04-18 アクセルロン ファーマ， インコーポレイテッド Ｆｃ融合タンパク質の血清半減期を増加させるための組成物および方法
LT3330370T (lt) 2010-04-26 2021-06-10 Novartis Ag Cho ląstelių auginimo būdas
NZ611862A (en) 2010-12-28 2015-05-29 Chugai Pharmaceutical Co Ltd Animal cell culturing method
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2012170938A1 (en) 2011-06-08 2012-12-13 Acceleron Pharma Inc. Compositions and methods for increasing serum half-life
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2890782A1 (en) 2012-09-02 2015-07-08 AbbVie Inc. Methods to control protein heterogeneity
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
BR112015021993A8 (pt) * 2013-03-15 2019-12-03 Genentech Inc polipeptídeo, métodos para sua produção, métodos para cultivo de uma célula, composição farmacêutica, kit, e meio de cultura celular
EP2978498B1 (en) * 2013-03-26 2019-07-03 Coherus Biosciences, Inc. Protein production method
WO2014182658A1 (en) * 2013-05-06 2014-11-13 Abbvie Inc. Compositions for cell culture and methods of using the same
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
USD759075S1 (en) * 2014-04-11 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
USD759076S1 (en) * 2014-04-18 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
EP3207132B1 (en) 2014-10-15 2019-07-31 Alexion Pharmaceuticals, Inc. Methods of shifting an isoelectric profile of a protein product and uses thereof
AR104050A1 (es) 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
WO2017065559A1 (ko) * 2015-10-15 2017-04-20 (주)알테오젠 Igg fc 도메인을 가지는 융합 단백질의 생산방법
CN107460221B (zh) * 2016-06-02 2021-01-15 正大天晴药业集团股份有限公司 一种降低抗pd-l1抗体中蛋白聚合物的细胞培养方法
WO2018073365A1 (en) 2016-10-19 2018-04-26 F. Hoffmann-La Roche Ag Method for producing an immunoconjugate
EP3571289A1 (en) * 2017-02-17 2019-11-27 Lonza Ltd A method for producing biologic product variants
KR20240149973A (ko) * 2017-10-16 2024-10-15 리제너론 파마슈티칼스 인코포레이티드 세포 배양에서 공정 변수를 제어하기 위한 원위치 라만 분광법 시스템 및 방법
AR113816A1 (es) 2017-11-01 2020-06-17 Chugai Pharmaceutical Co Ltd Variantes e isoformas de anticuerpos con actividad biológica reducida
US20220364034A1 (en) * 2018-11-02 2022-11-17 WuXi Biologics Ireland Limited Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
MX2021010414A (es) * 2019-03-04 2021-09-14 Amgen Inc Reversibilidad in vivo de especies de alto peso molecular.
AU2021205312A1 (en) 2020-01-09 2022-07-14 Mersana Therapeutics, Inc. Site specific antibody-drug conjugates with peptide-containing linkers
JP2022184798A (ja) * 2021-06-01 2022-12-13 ファイザー・インク ｓＦＧＦＲ３ポリペプチドを生産するための細胞培養方法
KR102682066B1 (ko) * 2021-10-12 2024-07-05 프레스티지바이오로직스 주식회사 항체 집단의 제조 방법
AU2023411740A1 (en) * 2022-12-23 2025-07-31 Cell Exosome Therapeutics Inc. Utilization of mesenchymal stem cells or culture supernatant thereof
CN120752329A (zh) * 2023-02-03 2025-10-03 安进公司 细胞培养方法
CN118166053B (zh) * 2024-03-15 2025-02-07 通化安睿特生物制药股份有限公司 一种制备低o-糖基化水平的重组人白蛋白的方法
CN118006716B (zh) * 2024-03-15 2024-09-10 通化安睿特生物制药股份有限公司 制备高表达且低o-糖基化水平的重组人白蛋白的方法
TWI891362B (zh) * 2024-05-10 2025-07-21 國立臺灣大學 鴨蛋白水解物及其製備方法及增強肌肉耐力與抗疲勞用途
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
DE768377T1 (de) 1988-09-02 1998-01-02 Dyax Corp Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
JPH0396383A (ja) 1989-09-08 1991-04-22 Riso Kagaku Corp 画像形成装置
DE10399023I2 (de) * 1989-09-12 2006-11-23 Ahp Mfg B V TFN-bindende Proteine
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5610033A (en) 1990-04-25 1997-03-11 Novo Nordisk A/S Method of producing proteins with FVIII activity and/or FVIII derivatives
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
WO1992009298A1 (en) 1990-11-23 1992-06-11 Peptide Technology Ltd. The delay, prevention and/or reversal of cell senescence
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
ES2287206T3 (es) 1991-03-01 2007-12-16 Dyax Corporation Proceso para el desarrollo de mini-proteinas de union.
WO1992018619A1 (en) 1991-04-10 1992-10-29 The Scripps Research Institute Heterodimeric receptor libraries using phagemids
EP0940468A1 (en) * 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
DE69330523D1 (de) 1992-08-21 2001-09-06 Vrije Universiteit Brussel Bru Immunoglobuline ohne leichte ketten
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
US5516964A (en) * 1994-01-21 1996-05-14 Sun Company, Inc. (R&M) Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US5830761A (en) * 1995-06-07 1998-11-03 Genetics Institute, Inc. Medium and methods for culturing mammalian cho cells
ES2176484T3 (es) * 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
JP4306813B2 (ja) 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
US6146847A (en) * 1996-11-01 2000-11-14 Genespan Corporation Stabilized transient gene expression
EP1500329B1 (en) * 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
ATE319745T1 (de) 1997-05-21 2006-03-15 Biovation Ltd Verfahren zur herstellung von nicht-immunogenen proteinen
WO1999035255A2 (en) 1998-01-12 1999-07-15 Betagene, Inc. Compositions and methods for regulated secretion from neuroendocrine cell lines
AU776910B2 (en) 1998-12-08 2004-09-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Modifying protein immunogenicity
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
BR0010361A (pt) 1999-04-30 2003-06-10 Chiron Corp Seq ências genÈmicas de neisseria e uso destas
JP3090657B1 (ja) 1999-08-09 2000-09-25 伸子 蓮山 ゼオライト製造方法およびゼオライト製造装置
EP1103615A1 (en) 1999-11-25 2001-05-30 Universite De Geneve Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors
AUPR038200A0 (en) * 2000-09-26 2000-10-19 Beta Peptide Foundation Pty Ltd, The Compositions and methods for delaying, preventing, rejuvenating or reversing senescence
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030040095A1 (en) * 2001-03-16 2003-02-27 Achille Arini Method for the production of pharmaceutically active recombinant proteins
US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
US6544076B2 (en) 2001-07-10 2003-04-08 Alan L. Pocrass Dual function RJ connector
CA2464616C (en) * 2001-11-19 2012-07-24 Are Bogsnes Process for preparing insulin compounds
CA2417689C (en) 2002-03-05 2006-05-09 F. Hoffmann-La Roche Ag Improved methods for growing mammalian cells in vitro
MXPA04009381A (es) * 2002-03-27 2005-01-25 Immunex Corp Metodos para incrementar la produccion de polipeptidos.
GB0208041D0 (en) 2002-04-08 2002-05-22 Lonza Biologics Plc Method of culturing animal cells
JP2005532057A (ja) 2002-07-09 2005-10-27 バクスター・インターナショナル・インコーポレイテッド 細胞を培養するための動物性タンパク質非含有培地
SI1543106T1 (sl) 2002-07-15 2007-08-31 Immunex Corp Postopki in mediji za nadziranje sialilacije proteinov, ki jih proizvajajo sesalske celice
US6924124B1 (en) 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
JP4541157B2 (ja) 2002-12-23 2010-09-08 ブリストル−マイヤーズ スクイブ カンパニー タンパク質を製造するための哺乳類細胞培養法
JP2007525176A (ja) 2003-04-25 2007-09-06 イミュネックス・コーポレーション 組換えタンパク質発現の誘導剤
CN1565631A (zh) * 2003-06-27 2005-01-19 上海中信国健药业有限公司 肿瘤坏死因子受体－免疫球蛋白的融合蛋白用于急性肺损伤药物的用途
KR101221862B1 (ko) 2003-10-27 2013-01-14 와이어쓰 엘엘씨 하이드록시아파타이트 크로마토그래피를 사용한 고분자량응집체의 제거
WO2005064013A1 (en) 2003-12-23 2005-07-14 Bart Janssen The use of carnosine metabolism-associated genes to determine genetic predisposition/susceptibility to diabetic nephropathy
EP2156852B1 (en) * 2004-07-07 2011-04-13 Coloplast A/S Catheter comprising ESTANE 58212.
JP2008505174A (ja) 2004-07-15 2008-02-21 ゼンコー・インコーポレイテッド 最適化Ｆｃ変異体
US7700318B2 (en) 2004-08-25 2010-04-20 Amprotein Corporation Chimeric polypeptide and use thereof
US7335491B2 (en) * 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
TWI364458B (en) * 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
US7426440B2 (en) * 2004-09-24 2008-09-16 Nutritional Bioscience Ltd. Repair and protection factor scoring method for bioactive agents
US20070102622A1 (en) 2005-07-01 2007-05-10 Olsen Richard I Apparatus for multiple camera devices and method of operating same
WO2007011595A2 (en) 2005-07-15 2007-01-25 Neuren Pharmaceuticals Limited Neural regeneration peptides and antioxidants protect neurons from degeneration
DE102005034616B4 (de) * 2005-07-18 2008-07-03 Elringklinger Ag Brennstoffzelleneinheit und Brennstoffzellenstapel
AR058140A1 (es) * 2005-10-24 2008-01-23 Wyeth Corp Metodo de produccion proteica utilizando compuestos anti-senescencia
DK2041270T3 (da) * 2006-07-13 2014-01-27 Wyeth Llc Fremstilling af glycoproteiner
US9012180B2 (en) 2007-03-02 2015-04-21 Wyeth Llc Use of copper and glutamate in cell culture for production of polypeptides
EP2188371B1 (en) 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
KR102889975B1 (ko) 2021-09-15 2025-11-24 컨템포러리 엠퍼렉스 테크놀로지 (홍콩) 리미티드 배터리 셀, 배터리, 전기 장치, 배터리 셀의 제조 방법 및 기기

Also Published As

Publication number Publication date
MX2009011363A (es) 2009-11-05
PT2139987E (pt) 2013-08-22
ZA200907426B (en) 2010-08-25
RU2009138226A (ru) 2011-05-27
AR066238A1 (es) 2009-08-05
KR101560421B1 (ko) 2015-10-15
IL201719A (en) 2015-09-24
CN105039473A (zh) 2015-11-11
EP2139987A1 (en) 2010-01-06
AU2008242633A1 (en) 2008-10-30
ES2646090T3 (es) 2017-12-12
EP2139987B9 (en) 2013-11-13
AR066239A1 (es) 2009-08-05
WO2008131375A1 (en) 2008-10-30
CN101668845B (zh) 2015-11-25
EP2139986A1 (en) 2010-01-06
JP5881755B2 (ja) 2016-03-09
PL2139987T3 (pl) 2013-11-29
SI2139986T1 (sl) 2017-11-30
CL2008001156A1 (es) 2009-01-16
AU2008242632B2 (en) 2013-11-28
IL201719A0 (en) 2011-08-01
EP2139987B1 (en) 2013-07-03
PE20090731A1 (es) 2009-07-15
CA2684727A1 (en) 2008-10-30
TW200902709A (en) 2009-01-16
CN101679943A (zh) 2010-03-24
BRPI0810511A2 (pt) 2014-10-07
CN101668845A (zh) 2010-03-10
CA2684727C (en) 2018-09-04
KR20100016271A (ko) 2010-02-12
AU2008242633B2 (en) 2014-09-18
CA2685552C (en) 2016-02-23
CL2008001159A1 (es) 2008-11-03
US20080274507A1 (en) 2008-11-06
RU2009139054A (ru) 2011-05-27
HUE034776T2 (en) 2018-02-28
JP2014113161A (ja) 2014-06-26
CA2685552A1 (en) 2008-10-30
BRPI0810482A2 (pt) 2014-10-07
PA8777701A1 (es) 2008-11-19
US12054762B2 (en) 2024-08-06
HK1216261A1 (zh) 2016-10-28
JP2010524503A (ja) 2010-07-22
IL201720A0 (en) 2011-08-01
JP2010524504A (ja) 2010-07-22
PA8778001A1 (es) 2008-11-19
ES2424217T9 (es) 2014-01-27
SI2139987T1 (sl) 2013-09-30
TW200902708A (en) 2009-01-16
DK2139987T3 (da) 2013-09-02
DK2139986T3 (en) 2017-10-02
AU2008242632A1 (en) 2008-10-30
MX2009011362A (es) 2009-11-05
WO2008131374A1 (en) 2008-10-30
PE20090153A1 (es) 2009-04-23
JP5557736B2 (ja) 2014-07-23
ES2424217T3 (es) 2013-09-30
EP2139986B1 (en) 2017-09-06
KR101540124B1 (ko) 2015-07-28
DK2139987T5 (da) 2014-01-27
KR20140132016A (ko) 2014-11-14
CO6241166A2 (es) 2011-01-20
KR20100017211A (ko) 2010-02-16
US9988662B2 (en) 2018-06-05
IL201720A (en) 2016-03-31
US20080269132A1 (en) 2008-10-30
CO6241165A2 (es) 2011-01-20
PT2139986T (pt) 2017-11-14
RU2478702C2 (ru) 2013-04-10
HK1142095A1 (zh) 2010-11-26

Similar Documents

Publication Publication Date Title
IL201720A0 (en) Use of low temperature and/or low ph in cell culture
IL197684A0 (en) Stem cell culture medium and methods of use thereof
IL195826A0 (en) Placental niche and use thereof to culture stem cells
PL3323883T3 (pl) Zdefiniowane powierzchnie do hodowli komórkowej i sposoby użycia
PL2132562T3 (pl) Sposób oceniania komórek i hodowli komórkowych
ZA200906061B (en) Use of copper and glutamate in cell culture for production of polypeptides
HUE041510T2 (hu) Biológiai sejtek és szövetek krioprezervációja
IL221384A0 (en) Improving il-15 and il-15r-alpha for expression in mammalian cells
SI2494039T1 (sl) Postopek reprogramiranja celic in njihova uporaba
EP2064324A4 (en) SUBSTRATES FOR CELL CULTURE AND MANUFACTURING METHOD THEREFOR
ZA200901914B (en) Stem cell culture medium and method
IL184262A0 (en) Cell culture method and utilization of the same
GB2460552B (en) Stem cell culture media and methods
SG10201401999SA (en) Device for cultivating cells and/or microorganisms
GB2442084B (en) Flow-through cell and method of use
GB0704892D0 (en) Improvements in and relating to temperature control of liquids
GB2450337B (en) Cell culture and mixing vessel
ZA201101137B (en) Prf in cell and tissue culture
GB0608054D0 (en) Production and use of regulatory t cells
EP2115127A4 (en) METHOD AND COMPOSITIONS FOR IMPROVING CELL HEALTH IN CULTURES
EP2334693A4 (en) METHODS OF LONG-TERM CULTURE OF EUKARYOTIC CELLS AND USES THEREOF
AU2007906441A0 (en) Cell culture vessel and method of use
AU2007905979A0 (en) Cell culture media and methods of use thereof
AU2007905966A0 (en) Cell culture media and methods of use thereof
AU2007905987A0 (en) Cell culture media and methods of use thereof