BRPI0810482A2 - Métodos de produção de proteína usando compostos antissenescência - Google Patents
Métodos de produção de proteína usando compostos antissenescênciaInfo
- Publication number
- BRPI0810482A2 BRPI0810482A2 BRPI0810482-4A2A BRPI0810482A BRPI0810482A2 BR PI0810482 A2 BRPI0810482 A2 BR PI0810482A2 BR PI0810482 A BRPI0810482 A BR PI0810482A BR PI0810482 A2 BRPI0810482 A2 BR PI0810482A2
- Authority
- BR
- Brazil
- Prior art keywords
- sensence
- compounds
- production methods
- protein production
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91338207P | 2007-04-23 | 2007-04-23 | |
PCT/US2008/061125 WO2008131375A1 (en) | 2007-04-23 | 2008-04-22 | Methods of protein production using anti-senescence compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0810482A2 true BRPI0810482A2 (pt) | 2014-10-07 |
Family
ID=39493848
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0810482-4A2A BRPI0810482A2 (pt) | 2007-04-23 | 2008-04-22 | Métodos de produção de proteína usando compostos antissenescência |
BRPI0810511-1A2A BRPI0810511A2 (pt) | 2007-04-23 | 2008-04-22 | Utilização de baixa temperatura e / ou baixo ph em cultura celular |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0810511-1A2A BRPI0810511A2 (pt) | 2007-04-23 | 2008-04-22 | Utilização de baixa temperatura e / ou baixo ph em cultura celular |
Country Status (26)
Country | Link |
---|---|
US (2) | US9988662B2 (pt) |
EP (2) | EP2139986B1 (pt) |
JP (3) | JP5557736B2 (pt) |
KR (3) | KR20140132016A (pt) |
CN (3) | CN101679943A (pt) |
AR (2) | AR066238A1 (pt) |
AU (2) | AU2008242633B2 (pt) |
BR (2) | BRPI0810482A2 (pt) |
CA (2) | CA2685552C (pt) |
CL (2) | CL2008001156A1 (pt) |
CO (2) | CO6241165A2 (pt) |
DK (2) | DK2139987T5 (pt) |
ES (2) | ES2646090T3 (pt) |
HK (2) | HK1142095A1 (pt) |
HU (1) | HUE034776T2 (pt) |
IL (2) | IL201719A (pt) |
MX (2) | MX2009011363A (pt) |
PA (2) | PA8777701A1 (pt) |
PE (2) | PE20090731A1 (pt) |
PL (2) | PL2139987T3 (pt) |
PT (2) | PT2139986T (pt) |
RU (2) | RU2009138226A (pt) |
SI (2) | SI2139987T1 (pt) |
TW (2) | TW200902708A (pt) |
WO (2) | WO2008131375A1 (pt) |
ZA (1) | ZA200907426B (pt) |
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US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
TWI548747B (zh) | 2006-09-13 | 2016-09-11 | 艾伯維有限公司 | 細胞培養改良 |
CN101679941A (zh) | 2007-03-02 | 2010-03-24 | 惠氏公司 | 在细胞培养物中使用铜和谷氨酸盐生产多肽 |
US20090042253A1 (en) * | 2007-08-09 | 2009-02-12 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
US8937046B2 (en) | 2008-09-22 | 2015-01-20 | The Regents Of The University Of Colorado, A Body Corporate | Modulating the alternative complement pathway |
ES2535734T3 (es) | 2008-10-20 | 2015-05-14 | Abbvie Inc. | Aislamiento y purificación de anticuerpos mediante cromatografía de afinidad con la proteína A |
TW201028433A (en) | 2008-10-20 | 2010-08-01 | Abbott Lab | Viral inactivation during purification of antibodies |
WO2011068993A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins. |
PT2563906T (pt) | 2010-04-26 | 2018-02-16 | Novartis Ag | Processo para cultivo de células cho |
BR112013018751B1 (pt) * | 2010-12-28 | 2021-01-05 | Chugai Seiyaku Kabushiki Kaisha (Chugai Pharmaceutical Co., Ltd.) | método para modular o nível de componentes de homogeneidade de uma proteína, método para produzir uma proteína desejada, medicamento e método para preparação do mesmo |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US8883982B2 (en) | 2011-06-08 | 2014-11-11 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
RU2718986C2 (ru) * | 2013-03-15 | 2020-04-15 | Дженентек, Инк. | Композиции клеточных культур с антиоксидантами и способы получения полипептидов |
US9765139B2 (en) * | 2013-03-26 | 2017-09-19 | Coherus Biosciences, Inc. | Perfusion method for manufacturing etanercept |
US9416181B2 (en) | 2013-05-06 | 2016-08-16 | Abbvie Inc. | Compositions for cell culture and methods of using the same |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
USD759075S1 (en) * | 2014-04-11 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
USD759076S1 (en) * | 2014-04-18 | 2016-06-14 | Nutonian, Inc. | Display screen with graphical user interface |
TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
US9908932B2 (en) | 2014-10-15 | 2018-03-06 | Alexion Pharmaceuticals, Inc. | Methods of shifting an isoelectric profile of a protein product and uses thereof |
AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
KR101936049B1 (ko) * | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
WO2017065559A1 (ko) * | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
CN107460221B (zh) * | 2016-06-02 | 2021-01-15 | 正大天晴药业集团股份有限公司 | 一种降低抗pd-l1抗体中蛋白聚合物的细胞培养方法 |
WO2018073365A1 (en) | 2016-10-19 | 2018-04-26 | F. Hoffmann-La Roche Ag | Method for producing an immunoconjugate |
EP3571289A1 (en) * | 2017-02-17 | 2019-11-27 | Lonza Ltd | A method for producing biologic product variants |
WO2019079165A1 (en) * | 2017-10-16 | 2019-04-25 | Regeneron Pharmaceuticals, Inc. | RAMAN IN SITU SPECTROSCOPY SYSTEMS AND METHODS FOR CONTROLLING PROCESSING VARIABLES IN CELL CULTURES |
CA3118398A1 (en) * | 2018-11-02 | 2020-05-07 | WuXi Biologics Ireland Limited | Cell culture process by intensified perfusion with continuous harvest and without cell bleeding |
JP2022522816A (ja) * | 2019-03-04 | 2022-04-20 | アムジエン・インコーポレーテツド | 高分子量種のインビボでの可逆性 |
BR112022013255A2 (pt) | 2020-01-09 | 2022-09-06 | Mersana Therapeutics Inc | Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo |
WO2022254319A1 (en) * | 2021-06-01 | 2022-12-08 | Pfizer Inc. | Cell culture method for producing sfgfr3 polypeptide |
KR20230051921A (ko) * | 2021-10-12 | 2023-04-19 | 프레스티지바이오로직스 주식회사 | 항체 집단의 제조 방법 |
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US20090042253A1 (en) | 2007-08-09 | 2009-02-12 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
-
2008
- 2008-04-10 TW TW097112974A patent/TW200902708A/zh unknown
- 2008-04-21 PE PE2008000686A patent/PE20090731A1/es not_active Application Discontinuation
- 2008-04-22 US US12/107,264 patent/US9988662B2/en active Active
- 2008-04-22 KR KR20147030274A patent/KR20140132016A/ko not_active Application Discontinuation
- 2008-04-22 CN CN200880013275A patent/CN101679943A/zh active Pending
- 2008-04-22 WO PCT/US2008/061125 patent/WO2008131375A1/en active Application Filing
- 2008-04-22 AR ARP080101677A patent/AR066238A1/es unknown
- 2008-04-22 EP EP08746526.6A patent/EP2139986B1/en not_active Revoked
- 2008-04-22 PA PA20088777701A patent/PA8777701A1/es unknown
- 2008-04-22 EP EP08746528.2A patent/EP2139987B9/en active Active
- 2008-04-22 PT PT87465266T patent/PT2139986T/pt unknown
- 2008-04-22 WO PCT/US2008/061123 patent/WO2008131374A1/en active Application Filing
- 2008-04-22 PE PE2008000691A patent/PE20090153A1/es not_active Application Discontinuation
- 2008-04-22 BR BRPI0810482-4A2A patent/BRPI0810482A2/pt not_active Application Discontinuation
- 2008-04-22 PL PL08746528T patent/PL2139987T3/pl unknown
- 2008-04-22 RU RU2009138226/10A patent/RU2009138226A/ru not_active Application Discontinuation
- 2008-04-22 DK DK08746528.2T patent/DK2139987T5/da active
- 2008-04-22 BR BRPI0810511-1A2A patent/BRPI0810511A2/pt not_active Application Discontinuation
- 2008-04-22 JP JP2010506424A patent/JP5557736B2/ja active Active
- 2008-04-22 SI SI200830998T patent/SI2139987T1/sl unknown
- 2008-04-22 KR KR1020097023172A patent/KR101540124B1/ko active IP Right Grant
- 2008-04-22 CA CA2685552A patent/CA2685552C/en not_active Expired - Fee Related
- 2008-04-22 MX MX2009011363A patent/MX2009011363A/es active IP Right Grant
- 2008-04-22 PL PL08746526T patent/PL2139986T3/pl unknown
- 2008-04-22 TW TW097114607A patent/TW200902709A/zh unknown
- 2008-04-22 MX MX2009011362A patent/MX2009011362A/es active IP Right Grant
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