CL2008001159A1 - Metodo para producir una proteina en un cultivo de celulas que comprende cultivar celulas a una temperatura reducida y/o cultivar celulas a un ph reducido para minimizar la produccion de proteinas mal plegadas y/o proteinas agregadas. - Google Patents

Metodo para producir una proteina en un cultivo de celulas que comprende cultivar celulas a una temperatura reducida y/o cultivar celulas a un ph reducido para minimizar la produccion de proteinas mal plegadas y/o proteinas agregadas.

Info

Publication number
CL2008001159A1
CL2008001159A1 CL2008001159A CL2008001159A CL2008001159A1 CL 2008001159 A1 CL2008001159 A1 CL 2008001159A1 CL 2008001159 A CL2008001159 A CL 2008001159A CL 2008001159 A CL2008001159 A CL 2008001159A CL 2008001159 A1 CL2008001159 A1 CL 2008001159A1
Authority
CL
Chile
Prior art keywords
culturing cells
reduced
proteins
protein
producing
Prior art date
Application number
CL2008001159A
Other languages
English (en)
Inventor
Jose Manuel Gomes
Gregory Walter Hiller
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39493848&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001159(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2008001159A1 publication Critical patent/CL2008001159A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Método para producir una proteína en un cultivo de células que comprende cultivar células a una temperatura reducida y/o cultivar células a un Ph reducido para reducir la producción de proteínas mal plegadas y/o proteínas agregadas.
CL2008001159A 2007-04-23 2008-04-22 Metodo para producir una proteina en un cultivo de celulas que comprende cultivar celulas a una temperatura reducida y/o cultivar celulas a un ph reducido para minimizar la produccion de proteinas mal plegadas y/o proteinas agregadas. CL2008001159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91338207P 2007-04-23 2007-04-23

Publications (1)

Publication Number Publication Date
CL2008001159A1 true CL2008001159A1 (es) 2008-11-03

Family

ID=39493848

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2008001156A CL2008001156A1 (es) 2007-04-23 2008-04-22 Metodo para producir una proteina de fusion tnfr en un cultivo celular que comprende cultivar celulas de mamifero que contienen un gen que codifica la proteina de fusion en un medio de cultivo de celulas que comprende un compuesto anti-envejecimiento.
CL2008001159A CL2008001159A1 (es) 2007-04-23 2008-04-22 Metodo para producir una proteina en un cultivo de celulas que comprende cultivar celulas a una temperatura reducida y/o cultivar celulas a un ph reducido para minimizar la produccion de proteinas mal plegadas y/o proteinas agregadas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2008001156A CL2008001156A1 (es) 2007-04-23 2008-04-22 Metodo para producir una proteina de fusion tnfr en un cultivo celular que comprende cultivar celulas de mamifero que contienen un gen que codifica la proteina de fusion en un medio de cultivo de celulas que comprende un compuesto anti-envejecimiento.

Country Status (26)

Country Link
US (2) US20080274507A1 (es)
EP (2) EP2139986B1 (es)
JP (3) JP5557736B2 (es)
KR (3) KR20140132016A (es)
CN (3) CN105039473A (es)
AR (2) AR066238A1 (es)
AU (2) AU2008242632B2 (es)
BR (2) BRPI0810511A2 (es)
CA (2) CA2684727C (es)
CL (2) CL2008001156A1 (es)
CO (2) CO6241165A2 (es)
DK (2) DK2139987T5 (es)
ES (2) ES2424217T3 (es)
HK (2) HK1142095A1 (es)
HU (1) HUE034776T2 (es)
IL (2) IL201719A (es)
MX (2) MX2009011362A (es)
PA (2) PA8777701A1 (es)
PE (2) PE20090731A1 (es)
PL (2) PL2139986T3 (es)
PT (2) PT2139986T (es)
RU (2) RU2478702C2 (es)
SI (2) SI2139986T1 (es)
TW (2) TW200902708A (es)
WO (2) WO2008131375A1 (es)
ZA (1) ZA200907426B (es)

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Also Published As

Publication number Publication date
ZA200907426B (en) 2010-08-25
WO2008131374A1 (en) 2008-10-30
IL201719A0 (en) 2011-08-01
AU2008242632A1 (en) 2008-10-30
HK1216261A1 (zh) 2016-10-28
CN101679943A (zh) 2010-03-24
CO6241166A2 (es) 2011-01-20
JP2014113161A (ja) 2014-06-26
DK2139987T3 (da) 2013-09-02
IL201720A (en) 2016-03-31
MX2009011362A (es) 2009-11-05
ES2424217T3 (es) 2013-09-30
ES2424217T9 (es) 2014-01-27
IL201720A0 (en) 2011-08-01
CA2684727C (en) 2018-09-04
EP2139987A1 (en) 2010-01-06
CO6241165A2 (es) 2011-01-20
TW200902709A (en) 2009-01-16
EP2139986B1 (en) 2017-09-06
CN101668845B (zh) 2015-11-25
PA8777701A1 (es) 2008-11-19
CA2685552A1 (en) 2008-10-30
PE20090731A1 (es) 2009-07-15
TW200902708A (en) 2009-01-16
KR20100016271A (ko) 2010-02-12
MX2009011363A (es) 2009-11-05
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CA2684727A1 (en) 2008-10-30
AU2008242632B2 (en) 2013-11-28
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US9988662B2 (en) 2018-06-05
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JP5557736B2 (ja) 2014-07-23
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AU2008242633A1 (en) 2008-10-30
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US20080269132A1 (en) 2008-10-30
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SI2139986T1 (sl) 2017-11-30
AR066239A1 (es) 2009-08-05
PT2139986T (pt) 2017-11-14
PL2139987T3 (pl) 2013-11-29
BRPI0810482A2 (pt) 2014-10-07
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IL201719A (en) 2015-09-24
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SI2139987T1 (sl) 2013-09-30
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PA8778001A1 (es) 2008-11-19
KR20100017211A (ko) 2010-02-16
WO2008131375A1 (en) 2008-10-30
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